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| 1 | Diagnosis and Treatment of Keloids and Hypertrophic Scars—Japan Scar Workshop Consensus Document 2018显示文摘There has been a long-standing need for guidelines on the diagnosis and treatment of keloids and hypertrophic scars that are based on an understanding of the pathomechanisms that underlie these skin fibrotic diseases.This is particularly true for clinicians who deal with Asian and African patients because these ethnicities are highly prone to these diseases.By contrast,Caucasians are less likely to develop keloids and hypertrophic scars,and if they do,the scars tend not to be severe.This ethnic disparity also means that countries vary in terms of their differential diagnostic algorithms.The lack of clear treatment guidelines also means that primary care physicians are currently applying a hotchpotch of treatments,with uneven outcomes.To overcome these issues,the Japan Scar Workshop(JSW)has created a tool that allows clinicians to objectively diagnose and distinguish between keloids,hypertrophic scars,and mature scars.This tool is called the JSW Scar Scale(JSS)and it involves scoring the risk factors of the individual patients and the affected areas.The tool is simple and easy to use.As a result,even physicians who are not accustomed to keloids and hypertrophic scars can easily diagnose them and judge their severity.The JSW has also established a committee that,in cooperation with outside experts in various fields,has prepared a Consensus Document on keloid and hypertrophic scar treatment guidelines.These guidelines are simple and will allow even inexperienced clinicians to choose the most appropriate treatment strategy.The Consensus Document is provided in this article.It describes(1)the diagnostic algorithm for pathological scars and how to differentiate them from clinically similar benign and malignant tumors,(2)the general treatment algorithms for keloids and hypertrophic scars at different medical facilities,(3)the rationale behind each treatment for keloids and hypertrophic scars,and(4)the body site-specific treatment protocols for these scars.We believe that this Consensus Document will be helpful for physicians from all over the world who treat keloids and hypertrophic scars. | Rei Ogawa Sadanori Akita Satoshi Akaishi Noriko Aramaki-Hattori Teruyuki Dohi Toshihiko Hayashi Kazuo Kishi Taro Kono Hajime Matsumura Gan Muneuchi Naoki Murao Munetomo Nagao Keisuke Okabe Fumiaki Shimizu Mamiko Tosa Yasuyoshi Tosa Satoko Yamawaki Shinichi Ansai Norihisa Inazu Toshiko Kamo Reiko Kazki Shigehiko Kuribayashi | 2019 | Burns & Trauma2019，7，1： | 31 |
| 2 | A xanthone from pericarps of Garcinia mangostana显示文摘 | Asai F Tosa H Tanaka T | 1995 | Phytochemistry1995，39，4： | 1 |
| 3 | The characteristics of the microcirculation of bulbar conjunctive in 'Oketsu' syndrome显示文摘 | Terasawa K Itoh T Morimoto Y Hiyama Y Tosa H | | 0，，： | 1 |
| 4 | Improvement of biomical features in fish health by red yeast and synthetic astaxantin显示文摘 | NAKANO T TOSA M TAKCUCH M | 1995 | Journal of Agricultural and Food Chemistry1995，43，6： | 1 |
| 5 | Degradation of sodium anthraquinone sucphonate immobilized Pimelobacter sp显示文摘 | CHIBATA Z TOSA T | 1983 | Appl Biochem Bioeng1983，4，： | 1 |
| 6 | Functional implications of the IL-6 signaling pathway in keloid pathogenesis 显示文摘 | Ghazizadeh M Tosa M Shimizu H | 2007 | J Invest Dermatol2007，127，1： | 1 |
| 7 | hnmobilized aspartase-containing microbial cells : preparation and enzymatic properties 显示文摘 | Chibata I Tosa T Sato T | 1974 | Applied Microbiology1974，27，5： | 1 |
| 8 | Monoclonal antibody to ICAM-1 protects skin flaps against I/p injury显示文摘 | TOSA Y LEE W P KOLLIAS N | 1988 | Plast Reconstr Surg1988，101，： | 1 |
| 9 | Antibacterial activity of xanthones from guttiferaeous plants against methicillin resistant staphylococcus aureus 显示文摘 | Linuma M Tosa H Tanaka T | 1996 | J pharm pharmaco11996，48，8： | 1 |
| 10 | Kinetic resolution of 1-(benzofuran-2-yl)ethanols by lipase-cat alyzed enantiomer selective reactions显示文摘 | Monica Tosa Viktoria Bodai | 2003 | Tetrahedron:Asym metry2003，14，13： | 1 |
| 11 | Production of L-alanine and D-aspartic acid显示文摘 | Takamatsu S Tosa T | 1993 | Bioprocess Technology1993，16，： | 1 |
| 12 | Analysis of host spe- cies specificity of Magnaporthe grisea toward wheat using a genetie cross between isolates form wheat and foxtail millet 显示文摘 | Murakami J Tosa Y Kataoka T | 2000 | Phytopathology2000，90，10： | 1 |
| 13 | Industrial-production of L-alanine from ammonium fumarate using immobilized microbial-cells of 2kinds显示文摘 | Takamatsu S Tosa T Chibata I | 1986 | J Chem Eng Jpn1986，19，1： | 1 |
| 14 | Involvement of gacA gene in the suppression of tomato bacterial wilt by Pseudomonas fluorescens FPT9601显示文摘 | Zhang L Q Yang Q Tosa Y | 2001 | Journal of General Plant Pathology2001，67，2： | 1 |
| 15 | Lipase mediated sequential resolution of aromatic β-hydroxy esters using fatty acid derivatives 显示文摘 | Brem J Naghi M Tosa MI | 2011 | Tetrahedron: Asymmetry2011，22，1617： | 1 |
| 16 | Monoclonal antibody to intercellular adhesion molecule 1 protects skin flaps against ischemia-reperfusion injury: an experimental study in rats显示文摘 | Lee WP Kollias N | 1998 | Plast Reconstr Surg1998，101，6： | 1 |
| 17 | Characterization of an Arena isolate of Magnaporthe grisea and identification of a locus conditioning its specificity on oat 显示文摘 | Oh H S Tosa Y Takabayashi N etal | 2002 | Canadian Journal of Botany2002，80，10： | 1 |
| 18 | Defense reactions of barley cultivars to an inappropriate forma specialis of the powdery mildew fungus of gramineous plants显示文摘 | Tosa Y Shishiyama J | 1984 | Canadian Journal of Botany1984，62，： | 1 |
| 19 | A gerte-for-gene rela- tionship underlying the species-specific parasitism of Arena/ Triticum isolate of Magnaporthe grisea on wheat cuhivars 显示文摘 | Takabayashi N Tosa Y Oh H S | 2002 | Phytopathology2002，92，11： | 1 |
| 20 | One of the two Dicer-like proteins in the filamentous fungi Magnaporthe o- ryzae genome is responsible for hairpin RNA triggered RNA si- lencing and related small interfering RNA accumulation 显示文摘 | KADOTANI N Nakayashiki H Tosa Y | 2004 | Journal of Biology Chemistry2004，279，44： | 1 |
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