|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Water-soluble lipopolymer delivery of N-methyl-D-aspartic acid receptor 2B siRNA relieves chronic neuropathic pain in rats显示文摘Spinal dorsal horn N-Methyl-D-aspartic acid receptor 2B (NR2B) overexpression plays an important role in the production and maintenance of neuropathic pain.Because small interfering RNA (siRNA) can inhibit NR2B expression,siRNA may provide a novel approach to treat neuropathic pain and possibly nerve injury.However,an efficient and safe vector for NR2B siRNA has not been discov-ered.This study shows that a water soluble lipopolymer (WSLP) comprised of low molecular weight polyethyleneimine (PEI) and cholesterol can deliver siRNA targeting NR2B for the treatment of neuropathic pain.Results show that intrathecal injection of WSLP/siRNA complexes for 3 days in-hibit NR2B gene expression with reductions in mRNA and protein levels by 59% and 54%,respec-tively,compared with control rats (P < 0.01).Injection of WSLP complexed with scrambled siRNA,or PEI with siRNA did not show this inhibitory effect.Moreover,injection of WSLP/siRNA complexes significantly relieved neuropathic pain at 3,7,12,and 21 days,while injection of WSLP with scrambled siRNA or PEI with siRNA did not.These results demonstrate that WSLP can efficiently deliver siRNA targeting NR2B in vivo and relieve neuropathic pain. | Jianhua Lu Yuanxiang Tao Xue Yang Weifeng Tu Hao Chen Jiaxiang Xiong Chungui Hu | 2011 | Neural Regeneration Research2011，6，29： | 1 |
| 2 | Zeolite-confined Fe-site Catalysts for the Hydrogenation of CO_(2) to Produce High-value Chemicals显示文摘Zeolite-confined Fe-site catalysts(ZFCs)have emerged as superior materials for sustainably producing high-value chemicals through CO_(2) hydrogenation,owing to their adaptable framework,customizable composition,and thermal robustness.They excel in activating,adsorbing,and converting CO_(2) with remarkable efficiency and consistency in performance.This has sparked a surge in research interest in recent years.The review delves into the latest advancements in CO_(2) catalytic hydrogenation to olefins,alcohols,aromatics,and other liquid hydrocarbons,examining the synthesis,modification tactics,and the correlation between structure and performance across various ZFCs.Additionally,it underscores the pivotal factors affecting performance and sheds light on the mechanisms behind selectivity control in the CO_(2) hydrogenation process facilitated by ZFCs.To conclude,it presents pressing challenges and strategic recommendations to inspire the development of high-performance,durable ZFCs for CO_(2) hydrogenation applications. | HAN Xiaoyang XIA Huicong TU Weifeng WEI Yifan XUE Dongping LI Minhan YAN Wenfu ZHANG Jia-Nan HAN Yi-Fan | 2024 | Chemical Research in Chinese Universities2024，40，1： | 0 |
| 3 | Decoy Nanozymes Enable Multitarget Blockade of Proinflammatory Cascades for the Treatment of Multi-Drug- Resistant Bacterial Sepsis显示文摘Sepsis is a life-threatening organ dysfunction characterized by severe systemic inflammatory response to infection.Effective treatment of bacterial sepsis remains a paramount clinical challenge,due to its astonishingly rapid progression and the prevalence of bacterial drug resistance. | Xuancheng Du Mingzhen Zhang Huiting Zhou Weijie Wang Chengmei Zhang Lei Zhang Yuanyuan Qu Weifeng Li Xiangdong Liu Mingwen Zhao Kangsheng Tu Yong-Qiang Li | 2023 | Research2023，，2： | 0 |
| 4 | Changes in erythrocyte membrane ATPase and plasma lipid peroxides during perioperative period显示文摘Changes in erythrocyte membrane ATPases and plasma lipid peroxides(LPO) were studiedperioperatively in 15 abdominal surgical patients under intravenous procaine-balanced anesthesia.The resultsrevealed that erythrocyte membrne Na+-K+ATPase,Mg2+ATPase and Ca2+-Mg2+ATPase activities werenot significantly changed at 60~90 min after incision as compared with 30 min before anesthesia,but weredecreased markedly at 10 rain and 24 hours after completion of operation(P<0.01).Plasma LPO wereincreased significantly by 24 hours after surgery(P<0.01) following an initially marked but transientreduction.Plasma LPO changes were not correlated with erythrocyte membrane ATPase activities,r=-0.0396,-0.0097 and-0.4383 respeetively(P>0.05).These correlations are suggested to be inducedby neuroendoerine responses after anesthesia and/or surgical trauma. | Tu Weifeng Lin Guifang Shen Jianfan Department of Anesthesiology,Jinling Hospital,Nanjing,China Department of Anesthesiology,First Affiliated Hospital of Nanjing Medical College,Nanjing,China | 1993 | 医学研究生学报1993，6，S1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员