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| 1 | 前列腺癌治疗前后动态增强MRI评价显示文摘目的 :应用MRI和动态增强MRI药物代谢动力学模型评价前列腺癌治疗前后的疗效 ,确定MRI的价值。方法 :对 16例经组织学证实的前列腺癌分别在治疗前后进行常规和动态增强MRI检查。治疗分别为单纯激素替代治疗 (7例 )和激素替代治疗加外放射治疗 (9例 )。MRI检查常规应用GESignaAdvantage 1.5T超导磁共振成像仪 ,静脉注射Gd DTPA(0 .1mmol/kg体重 )。应用两室药物代谢动力学模型分别计算肿瘤病灶、前列腺良性增生和正常前列腺周围带的最大增强指数、对比剂吸收幅度、对比剂的交换率和对比剂分布指数。结果 :治疗前后PSA由 39.5 4ng/ml降为 10 .39ng/ml(P =0 .0 4 6 ) ,由MRI测量获得的肿瘤体积明显缩小 (2 .85cm3 至 0 .84cm3 ,P =0 .0 1) ,前列腺良性增生和正常前列腺周围带也明显缩小 (P <0 .0 1)。治疗前后肿瘤病灶最大增强指数和对比剂分布指数降低 ,但未见统计学差异 ;对比剂吸收幅度和交换率明显降低 (P =0 .0 0 4 ,0 .0 0 2 )。前列腺良性增生的最大增强指数和对比剂分布指数降低 (P =0 .2 84 ,0 .2 2 1) ;对比剂吸收幅度和交换率明显降低 (P =0 .0 1,0 .0 0 7)。正常周围带的对比剂吸收幅度、交换率和分布指数明显降低 (P=0 .0 0 3,0 .0 1,0 .0 4 )。结论 :动态增强MRI能够全面反映前列腺癌治疗前? | 王滨 Martin LOWRY Lindsay W TURNBULL | 2003 | 医学影像学杂志2003，13，4： | 5 |
| 2 | Formation of bulk metallic glass by fluxing显示文摘 | KUI W H GREER A L TURNBULL D | 1984 | Applied Physics Letters1984，45，6： | 1 |
| 3 | Developing and Protecting Profitable Custorner Relationships显示文摘 | Wilson D T | 1989 | Industrial Marketing Management1989，18，3： | 1 |
| 4 | Formation of bulk metallic glass by fluxing显示文摘 | Kui H W Greer A L Turnbull D | 1984 | Applied Physics Letters1984，45，6： | 1 |
| 5 | The epidemiology of mitochondrial disorders-past,present and future显示文摘 | SCHAEFER A M TAYLOR R W TURNBULL D M | 2004 | Biochimica et Biophysica Acta (BBA)-Bioenergetics2004，1659，23： | 1 |
| 6 | Analysis of hydro- gen diffusion and trapping in a 13% chromium martensiticstainless steel显示文摘 | Turnbull A Carroll M W Ferriss D H | 1989 | Acta Metallurgica1989，37，7： | 1 |
| 7 | Mechanistic studies on three 2-oxoglutarate-dependent oxygenases of flavonoid biosynthesis-anthocyanidin syn- thase, flavonol synthase, and flavanone 3 beta-hydroxy- lase显示文摘 | Turnbull J J Nakajima J Welford R W D | 2004 | Journal of Biological Chemistry2004，279，2： | 1 |
| 8 | A flexible, low-glycemic index mexlcan-style diet in overweight and obese subjects with type 2 diabetes improves metabolic pa- rameters during a 6-week treatment period 显示文摘 | Jimenez-Cruz A Bacardi-Gascon M Turnbull W H | 2003 | Diabetes Care2003，26，7： | 1 |
| 9 | Modal expressions asfacework in refusals to comply with requests:I think I should say 'no' right now显示文摘 | TURNBULL W SAXTON K | 1997 | Journal of Pragmat- ics1997，，27： | 1 |
| 10 | Selective inhibition of mutant human mitochondrial DNA replication in vitro by peptide nucleic acids显示文摘 | TAYLOR R W CHINNERY P F TURNBULL D M | 1997 | Nat Genet1997，15，2： | 1 |
| 11 | Conversational structure and Iacework in arguing显示文摘 | MUNTIGL P TURNBULL W | 1998 | Journal of Pragmatics1998，，29： | 1 |
| 12 | Annealing studies of boron-doped graphite by electron microscopy and X-ray diffraction显示文摘 | Turnbull J A Stagg M S Eeles W T | 1966 | Carbon1966，，3： | 1 |
| 13 | Breast MRI at 3.0 T in a high-risk familial breast cancer screening cohort: comparison with 1.5 T screening studies显示文摘 | M D Pickles L W Turnbull | 2012 | British Journal of Radiology2012，，1015： | 1 |
| 14 | Sap flow rates and sapwood density are critical factors in within-and be- tween-tree variation in CO2 efflux from stems of mature Dacrydi- um cupressirrum trees 显示文摘 | Bowman W P Barbour M M Turnbull M H | 2005 | New Phytologist2005，167，3： | 1 |
| 15 | The impact of complications on outcomes after resection for esophageal and gastroesophageal junction carcinoma显示文摘 | Nabil P Rizk Peter B Bach Deborah Schrag Manjit S Bains Alan D Turnbull Martin Karpeh Murray F Brennan Valerie W Rusch | 2004 | Journal of the American College of Surgeons2004，，1： | 1 |
| 16 | Sap flow rates and sapwood density are critical factors in within-and between-tree variation in CO2 efflux from stems of mature Dacrydium cupressinum trees显示文摘 | Bowman W P Barbour M M Turnbull M H | 2005 | New Phytologist2005，167，3： | 1 |
| 17 | Induction of the heat shock pathway du -ing hypoxia requires regulation of heat shock factor by hypoxia- inducible factor- 1 显示文摘 | Baird N A Turnbull D W Johnson E A | 2006 | J Biol Chem2006，281，38： | 1 |
| 18 | Conversational structure and facework in arguing 显示文摘 | Muntigl P Turnbull W | 1998 | Journal of Pragmatics1998，，3： | 1 |
| 19 | Structureand mechanism of anthocyanidin synthase from Arabidopsis thaliana 显示文摘 | WILMOUTH R C TURNBULL J J WELFORD R W | 2002 | Structure(Camb)2002，10，： | 1 |
| 20 | Information seeking on the Web: An integrated model of browsing and searching显示文摘 | Choo C W Detlor B Turnbull D | 2000 | First Monday2000，5，2： | 1 |
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