|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Enhanced intestinal lymphatic absorption of saquinavir through supersaturated self-microemulsifying drug delivery systems显示文摘The therapeutic potential of saquinavir, a specific inhibitor of human immunodeficiency virus(HIV)-1 and HIV-2 protease enzymes, has been largely limited because of a low solubility and consequnt low bioavailability. Thus, we aimed to design a supersaturated selfmicroemulsifying drug delivery system(S-SMEDDS) that can maintain a high concentration of saquinavir in gastro-intestinal fluid thorugh inhibiting the drug precipitation to enhance the lymphatic transport of saquinavir and to increase the bioavailability of saquinavir considerably. Solubilizing capacity of different oils, surfactants, and cosurfactants for saquinavir was evaluated to select optimal ingredients for preparation of SMEDDS.Through the construction of pseudo-ternary phase diagram, SMEDDS formulations were established. A polymer as a precipitation inhibitor was selected based on its viscosity and drug precipitation inhibiting capacity. The S-SMEDDS and SMEDDS designed were administered at an equal dose to rats. At predetermined time points, levels of saquinavir in lymph collected from the rats were assessed. SMEDDS prepared presented a proper selfmicroemulsification efficiency and dispersion stability. The S-SMEDDS fabricated using the SMEDDS and hydroxypropyl methyl cellulose 2910 as a precipitation inhibitor exhibited a signficantly enhanced solubilizing capacity for saquinavir. The drug concentration in a simulated intestinal fluid evaluated with the S-SMEDDS was also maintained at higher levels for prolonged time than that examined with the SMEDDS. The S-SMEDDS showed a considerably enhanced lymphatic absoprtion of saquinavir in rats compared to the SMEDDS.Therefore, the S-SMEDDS would be usefully exploited to enhance the lymphatic absorption of hydrophobic drugs that need to be targeted to the lymphatic system. | Kanghee Jo Hyeongmin Kim Prakash Khadka Taejun Jang Soo Jin Kim Seong-Ha Hwang Jaehwi Lee | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，3： | 2 |
| 2 | 21 ~-ef- ficient PERL solar cells with plated front contacts on indus- trial 156 mm p-type crystalline silicon wafers显示文摘 | Taejun Kim Jong-Keun Lim Hae-Na-Ra Shin | 2014 | Energy Procedia2014，55，： | 1 |
| 3 | Probabilistjc risk assessment for the construction phases of a bridge construction based on finite element analysis显示文摘 | Cho Taejun Kim Tae Soo | 2008 | Finite Elements in Analysis and Design2008，44，5： | 1 |
| 4 | The finite element analysis of the ultimate behavior of thin-walled carbon steel bolted connections显示文摘 | TaeSoo Kim HaYoung Jeong Taejun Cho | 2011 | Journal of Constructional Steel Research2011，67，7： | 1 |
| 5 | Probabilistic risk assessment for the construction phases of a bridge based on finite element analysis显示文摘 | Cho Taejun Kim Tae Soo | 2008 | Finite Elements in Analysis and Design2008，44，6： | 1 |
| 6 | The finite element analysis of the ultimate behavior of thin-walled carbon steel bolted connections显示文摘 | TaeSoo Kim HaYoung Jeong Taejun Cho | 2011 | Journal of Constructional Steel Research2011，，67： | 1 |
| 7 | Giant chiro-optical responses in multipolar-resonances-based single-layer dielectric metasurfaces显示文摘Chiro-optical effects offer a wide range of potential applications in nanophotonics,such as advanced imaging and molecular sensing and separation.Flat single-layer metasurfaces composed of subwavelength meta-atoms have gained significant attention due to their exceptional characteristics in light–matter interactions.Although metasurface-based devices have manipulated electromagnetic waves,the compact on-chip realization of giant chiro-optical effects remains a challenge at optical frequencies.In this work,we experimentally and numerically demonstrate an all-dielectric metasurface to realize large chiro-optical effects in the visible regime.Notably,the proposed strategy of utilizing achiral nanofins instead of conventional chiral structures provides an extra degree of design freedom.The mutual coupling between carefully engineered nanofins produces constructive and destructive interference,leading to the asymmetric transmission of 70%and average circular dichroism exceeding 60%.We investigate the underlying mechanism behind the chiro-optical effects using the theory of multipolar decomposition.The proposed design mechanism maximizes the chiro-optical response through a single-layer metasurface with potential applications in high-efficiency integrated ultrathin polarization rotators and shapers,chiral polarizers for optical displays,chiral beam splitters,and chiral sensors. | HAFIZ SAAD KHALIQ INKI KIM AIMA ZAHID JOOHOON KIM TAEJUN LEE TREVON BADLOE YESEUL KIM MUHAMMAD ZUBAIR KASHIF RIAZ MUHAMMAD QASIM MEHMOOD JUNSUK RHO | 2021 | Photonics Research2021，9，9： | 1 |
| 8 | Fatigue Reliabili ty Analysis for the Crack Propagation Compared with LRFD Specification显示文摘 | Cho Taejun Kim Tae-Soo Kyung Kab-Soo | | 0，，01： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员