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| 1 | Endoscopic diagnosis for colorectal sessile serrated lesions显示文摘BACKGROUND Hyperplastic polyps are considered non-neoplastic, whereas sessile serrated lesions(SSLs) are precursors of cancer via the ‘‘serrated neoplastic pathway’’. The clinical features of SSLs are tumor size(> 5 mm), location in the proximal colon, coverage with abundant mucus called the ‘‘mucus cap’’, indistinct borders, and a cloud-like surface. The features in magnifying narrow-band imaging are varicose microvascular vessels and expanded crypt openings. However, accurate diagnosis is often difficult.AIM To develop a diagnostic score system for SSLs.METHODS We retrospectively reviewed consecutive patients who underwent endoscopic resection during colonoscopy at the Toyoshima endoscopy clinic. We collected data on serrated polyps diagnosed by endoscopic or pathological examination. The significant factors for the diagnosis of SSLs were assessed using logistic regression analysis. Each item that was significant in multivariate analysis was assigned 1 point, with the sum of these points defined as the endoscopic SSL diagnosis score. The optimal cut-off value of the endoscopic SSL diagnosis score was determined by receiver-operating characteristic curve analysis.RESULTS Among 1288 polyps that were endoscopically removed, we analyzed 232 diagnosed as serrated polyps by endoscopic or pathological examination. In the univariate analysis, the location(proximal colon), size(> 5 mm), mucus cap, indistinct borders, cloud-like surface, and varicose microvascular vessels were significantly associated with the diagnosis of SSLs. In the multivariate analysis, size(> 5 mm;P = 0.033), mucus cap(P = 0.005), and indistinct borders(P = 0.033) were independently associated with the diagnosis of SSLs. Size > 5 mm, mucus cap, and indistinct borders were assigned 1 point each and the sum of these points was defined as the endoscopic SSL diagnosis score. The receiver-operating characteristic curve analysis showed an optimal cut-off score of 3, which predicted pathological SSLs with 75% sensitivity, 80% specificity, and 78.4% accuracy. The pathological SSL rate for an endoscopic SSL diagnosis score of 3 was significantly higher than that for an endoscopic SSL diagnosis score of 0, 1, or 2(P < 0.001).CONCLUSION Size > 5 mm, mucus cap, and indistinct borders were significant endoscopic features for the diagnosis of SSLs. Serrated polyps with these three features should be removed during colonoscopy. | Toshihiro Nishizawa Shuntaro Yoshida Akira Toyoshima Tomoharu Yamada Yoshiki Sakaguchi Taiga Irako Hirotoshi Ebinuma Takanori Kanai Kazuhiko Koike Osamu Toyoshima | 2021 | World Journal of Gastroenterology2021，27，13： | 7 |
| 2 | Radiofrequency ablation vs surgical resection in elderly patients with hepatocellular carcinoma in Milan criteria显示文摘BACKGROUND Surgical resection and radiofrequency ablation(RFA)represent two possible strategy in treatment of hepatocellular carcinoma(HCC)in Milan criteria.AIM To evaluate short-and long-term outcome in elderly patients(>70 years)with HCC in Milan criteria,which underwent liver resection(LR)or RFA.METHODS The study included 594 patients with HCC in Milan criteria(429 in LR group and 165 in RFA group)managed in 10 European centers.Statistical analysis was performed using the Kaplan-Meier method before and after propensity score matching(PSM)and Cox regression.RESULTS After PSM,we compared 136 patients in the LR group with 136 patients in the RFA group.Overall survival at 1,3,and 5 years was 91%,80%,and 76%in the LR group and 97%,67%,and 41%in the RFA group respectively(P=0.001).Diseasefree survival at 1,3,and 5 years was 84%,60%and 44%for the LR group,and 63%,36%,and 25%for the RFA group(P=0.001).Postoperative Clavien-Dindo IIIIV complications were lower in the RFA group(1%vs 11%,P=0.001)in association with a shorter length of stay(2 d vs 7 d,P=0.001).In multivariate analysis,Model for End-stage Liver Disease(MELD)score(>10)[odds ratio(OR)=1.89],increased value of international normalized ratio(>1.3)(OR=1.60),treatment with radiofrequency(OR=1.46),and multiple nodules(OR=1.19)were independent predictors of a poor overall survival while a high MELD score(>10)(OR=1.51)and radiofrequency(OR=1.37)were independent factors associated with a higher recurrence rate.CONCLUSION Despite a longer length of stay and a higher rate of severe postoperative complications,surgery provided better results in long-term oncological outcomes as compared to ablation in elderly patients(>70 years)with HCC in Milan criteria. | Maria Conticchio Riccardo Inchingolo Antonella Delvecchio Letizia Laera Francesca Ratti Maximiliano Gelli Ferdinando Anelli Alexis Laurent Giulio Vitali Paolo Magistri Giacomo Assirati Emanuele Felli Taiga Wakabayashi Patrick Pessaux Tullio Piardi Fabrizio di Benedetto Nicola de'Angelis Javier Briceño AntonioRampoldi RenèAdam Daniel Cherqui Luca Antonio Aldrighetti Riccardo Memeo | 2021 | World Journal of Gastroenterology2021，27，18： | 4 |
| 3 | Low-dose rectal diclofenac for prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: a randomized controlled trial显示文摘 | Taiga Otsuka Seiji Kawazoe Shunya Nakashita Saori Kamachi Satoshi Oeda Chinatsu Sumida Takumi Akiyama Keisuke Ario Masaru Fujimoto Masanobu Tabuchi Takahiro Noda | 2012 | Journal of Gastroenterology2012，，8： | 4 |
| 4 | Outcomes of gastrointestinal defect closure with an overthe-scope clip system in a multicenter experience: An analysis of a successful suction method显示文摘AIM To demonstrate the clinical outcomes of a multicenter experience and to suggest guidelines for choosing a suction method. METHODS This retrospective study at 5 medical centers involved 58 consecutive patients undergoing over-the-scope clips(OTSCs) placement. The overall rates of technical success (TSR), clinical success (CSR), complications, and procedure time were analyzed as major outcomes. Subsequently, 56 patients, excluding two cases that used the Anchor device, were divided into two groups: 14 cases of simple suction (SS-group) and 42 cases using the Twin Grasper (TG-group). Secondary evaluation was performed to clarify the predictors of OTSC success.RESULTS The TSR, CSR, complication rate, and median procedure time were 89.7%, 84.5%, 1.8%, and 8 (range 1-36) min, respectively, demonstrating good outcomes. However, significant differences were observed between the two groups in terms of the mean procedure time (5.9 min vs 14.1 min). The CSR of the SS- and TG-groups among cases with a maximum defect size ≤ 10 mm and immediate or acute refractory bleeding was 100%, which suggests that SS is a better method than TG in terms of time efficacy. The CSR in the SS-group (78.6%), despite the technical success of the SS method (TSR, 100%), tended to decrease due to delayed leakage compared to that in the TG-group (TSR, CSR; 88.1%), indicating that TG may be desirable for leaks and fistulae with defects of the entire layer. CONCLUSION OTSC system is a safe and effective therapeutic option for gastrointestinal defects. Individualized selection of the suction method based on particular clinical conditions may contribute to the improvement of OTSC success. | Hideki Kobara Hirohito Mori Shintaro Fujihara Noriko Nishiyama Taiga Chiyo Takayoshi Yamada Masao Fujiwara Keiichi Okano Yasuyuki Suzuki Masayuki Murota Yoshitaka Ikeda Makoto Oryu Mohamed Abo Ellail Tsutomu Masaki | 2017 | World Journal of Gastroenterology2017，23，9： | 3 |
| 5 | Radiation dose reduction in hepatic multidetector computed tomography with a novel adaptive noise reduction filter显示文摘 | Yoshinori Funama Kazuo Awai Osamu Miyazaki Taiga Goto Yoshiharu Nakayama Masamitchi Shimamura Kumiko Hiraishi Shinichi Hori Yasuyuki Yamashita | 2008 | Radiation Medicine2008，，3： | 1 |
| 6 | Aldosterone Induces Vascular Insulin Resistance by Increasing Insulin-Like Growth Factor-1 Receptor and Hybrid Receptor显示文摘 | Shamshad J. Sherajee Yoshiko Fujita Kazi Rafiq Daisuke Nakano Hirohito Mori Tsutomu Masaki Taiga Hara Masakazu Kohno Akira Nishiyama Hirofumi Hitomi | 2012 | Arteriosclerosis, Thrombosis, and Vascular Biology2012，，2： | 1 |
| 7 | mi R126 positively regulates mast cell proliferation and cytokine production through suppressing Spred1显示文摘 | Takuma Ishizaki Taiga | 2011 | Genes to cells:devoted to molecular&cellular mechanisms2011，16，7： | 1 |
| 8 | Rhinitis and asthma: evidence for respiratory system integration显示文摘 | Taigas A | 2003 | J Allergy Clin Immunol2003，111，： | 1 |
| 9 | Novel and safer endoscopic cholecystectomy using only a flexible endoscope via single port显示文摘AIM: To apply the laparoscopic and endoscopic cooperative surgery concept, we investigated whether endoscopic cholecystectomy could be performed more safely and rapidly via only 1 port or not.METHODS: Two dogs(11 and 13-mo-old female Beagle) were used in this study. Only 1 blunt port was created, and a flexible endoscope with a tip attachment was inserted between the fundus of gallbladder and liver. After local injection of saline to the gallbladder bed, resection of the gallbladder bed from the liver was performed. After complete resection of the gallbladder bed, the gallbladder was pulled up to resect its neck using the Ring-shaped thread technique. The neck of the gallbladder was cut using scissor forceps. Resected gallbladder was retrieved using endoscopic net forceps via a port. RESULTS: The operation times from general anesthetizing with sevoflurane to finishing the closure of the blunt port site were about 50 min and 60 min respectively. The resection times of gallbladder bed were about 15 min and 13 min respectively without liver injury and bleeding at all. Feed were given just after next day of operation, and they had a good appetite. Two dogs are in good health now and no complications for 1 mo after endoscopic cholecystectomy using only a flexible endoscope via one port.CONCLUSION: We are sure of great feasibility of endoscopic cholecystectomy via single port for human. | Hirohito Mori Nobuya Kobayashi Hideki Kobara Noriko Nishiyama Shintaro Fujihara Taiga Chiyo Maki Ayaki Takashi Nagase Tsutomu Masaki | 2016 | World Journal of Gastroenterology2016，22，13： | 1 |
| 10 | LPS induces gene expression of interleukin-1βin conger eel(Conger myriaster)macrophages:First cytokine sequence within Anguilliformes显示文摘 | Shigeyuki T Taiga I Osamu N | 2007 | Fish&Shellfish Immunology2007，23，4： | 1 |
| 11 | Effectiveness of lifestyle counseling by certified expert nurse of Japan for non- insulin- treated diabetic out- patients: a 1 -year randomized controlled trial显示文摘 | Taiga S Koji K Akiko T | 2007 | Diabetes Research and Clinical Practice2007，76，2： | 1 |
| 12 | Effect of temperature on sex ratios of normal and gynogenetic diploid loach显示文摘 | Tomoko N Katsutoshi A Taiga H | | 0，，05： | 1 |
| 13 | Rhinitis andasthma:evidence for respiratory system integra- tion 显示文摘 | Taigas A | 2003 | J Allergy Clin Immunol2003，111，： | 1 |
| 14 | Brain glucose metabolism difference between bipolar and unipolar mood disorders in depressed and euthymic states显示文摘 | Taiga Hosokawa Toshimitsu Momose Kiyoto Kas | 2009 | Prog Neuro-Psychoph2009，33，2： | 1 |
| 15 | Compari- son between propofol and dexmedetomidine in postoperative sedation after extensive cervical spine surgery 显示文摘 | Yoshiaki Terao Taiga Ichinomiya Ushio Higashijima | 2012 | Journal of anesthesia2012，26，2： | 1 |
| 16 | Fluconazole treatment is effective against a candida albicans erg3/ erg3 mutant in vivo despite in vitro resistance显示文摘 | Taiga Miyazaki Yoshitsugu Miyazaki Koichi Izumikawa | 2006 | antimicrobial a gents and chemotherapy2006，，： | 1 |
| 17 | Suppressors of Cytokine Signaling (SOCS) Proteins and JAK/STAT Pathways: Regulation of T-Cell Inflammation by SOCS1 and SOCS3显示文摘 | Taiga Tamiya Ikko Kashiwagi Reiko Takahashi Hideo Yasukawa Akihiko Yoshimura | 2011 | Arteriosclerosis Thrombosis and Vascular Biology2011，，5： | 1 |
| 18 | Phase reset and dynamic stability during human gait 显示文摘 | YAMASAKI Taiga NOMURA Taishin SATO Shunsuke | 2003 | BioSystems2003，，71： | 1 |
| 19 | Novel hydrolyzable and biodegradable cationic gemini surfactants: bis ( ester - ammonium) dichloride having a butenylene or a butynylene spacer显示文摘 | TAIGA TATSUMI ZHANG WANBIN TOSHIYUKI KIDA | 2001 | Journal of Surfactants and Detergents2001，4，3： | 1 |
| 20 | Novel hydrolyzable and biodegradable cationic gemini surfactants : 1,3 - bis - 2 - hydroxypropane dichloride 显示文摘 | TAIGA TATSUMI ZHANG WANBIN TOSHIYUKI KIDA | 2000 | Journal of Surfactants and Detergents2000，3，2： | 1 |
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