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| 1 | Effect of longer battery life on small bowel capsule endoscopy显示文摘AIM:To determine if longer battery life improves capsule endoscopy(CE) completion rates.METHODS:A retrospective study was performed at a tertiary,university-affiliated hospital in Vancouver,Canada.Patients who underwent CE with either PillCamTM SB2 or SB2 U between 01/2010 and 12/2013 were considered for inclusion.SB2 and SB2 U share identical physical dimensions but differ in their battery lives(8 h vs 12 h).Exclusion criteria included history of gastric or small bowel surgery,endoscopic placement of CE,interrupted view of major landmarks due to technical difficulty or significant amount of debris,and repeat CE using same system.Basic demographics,comorbidities,medications,baseline bowel habits,and previous surgeries were reviewed.Timing of major landmarks in CE were recorded,and used to calculate gastric transit time,small bowel transit time,and total recording time.A complete CE study was defined as visualization of cecum.Transit times and completion rates were compared.RESULTS:Four hundred and eight patients,including 208(51.0%) males,were included for analysis.The mean age was 55.5 ± 19.3 years.The most common indication for CE was gastrointestinal bleeding(n =254,62.3%),followed by inflammatory bowel disease(n =86,21.1%).There was no difference in gastric transit times(group difference 0.90,95%CI:0.72-1.13,P =0.352) and small bowel transit times(group difference 1.07,95%CI:0.95-1.19,P =0.261) between SB2 U and SB2,but total recording time was about 14% longer in the SB2 U group(95%CI:10%-18%,P < 0.001) and there was a corresponding trend toward higher completion rate(88.2% vs 93.2%,OR =1.78,95%CI 0.88-3.63,P =0.111).There was no statistically significant difference in the rates of positive findings(OR =0.98,95%CI:0.64-1.51,P =0.918).CONCLUSION:Extending the operating time of CE may be a simple method to improve completion rate although it does not affect the rate of positive findings. | George Ou Neal Shahidi Cherry Galorport Oliver Takach Terry Lee Robert Enns | 2015 | World Journal of Gastroenterology2015，21，9： | 13 |
| 2 | FOCUS: Future of fecal calprotectin utility study in inflammatory bowel disease显示文摘AIM To evaluate the perspective of gastroenterologists regarding the impact of fecal calprotectin(FC) on the management of patients with inflammatory bowel disease(IBD).METHODS Patients with known IBD or symptoms suggestive of IBD for whom the physician identified that FC would be clinically useful were recruited. Physicians completed an online 'pre survey' outlining their rationale for the test. After receipt of the test results, the physicians completed an online 'post survey' to portray their perceived impact of the test result on patient management. Clinical outcomes for a subset of patients with follow-up data available beyond the completion of the 'post survey' were collected and analyzed.RESULTS Of 373 test kits distributed, 290 were returned, resulting in 279 fully completed surveys. One hundred and ninety patients were known to have IBD; 147(77%) with Crohn's Disease, 43(21%) Ulcerative Colitis and 5(2%) IBD unclassified. Indications for FC testing included: 90(32.2%) to differentiate a new diagnosis of IBD from Irritable Bowel Syndrome(IBS), 85(30.5%) to distinguish symptoms of IBS from IBD in those known to have IBD and 104(37.2%) as an objective measure of inflammation. FC levels resulted in a change in management 51.3%(143/279) of the time which included a significant reduction in the number of colonoscopies(118) performed(P < 0.001). Overall, 97.5%(272/279) of the time, the physicians found the test sufficiently useful that they would order it again in similar situations. Follow-up data was available for 172 patients with further support for the clinical utility of FC provided.CONCLUSION The FC test effected a change in management 51.3% of the time and receipt of the result was associated with a reduction in the number of colonoscopies performed. | Greg Rosenfeld Astrid-Jane Greenup Andrew Round Oliver Takach Lawrence Halparin Abid Saadeddin Jin Kee Ho Terry Lee Robert Enns Brian Bressler | 2016 | World Journal of Gastroenterology2016，22，36： | 2 |
| 3 | 肺栓塞的诊断和管理显示文摘评价检查前的临床可能性(CPTP)是诊断肺栓塞的第一步
通常需要综合GPTP和检测结果来决定患者是否需要抗凝治疗溶栓治疗
通常用于伴有低血压且无明显出血风险的患者
伴有可逆性危险因素的肺栓塞患者的治疗疗程为3个月
伴有活动性肿瘤或无诱因复发肺栓塞的患者通常需要终身治疗
对于无诱因的肺栓塞患者治疗3个月或终身治疗需通过患者的表现和出血风险决定 | S Takach Lapner C Kearon 许小毛 王辰 | 2013 | 英国医学杂志中文版2013，16，3： | 2 |
| 4 | The diagnosis and treatment of al- lergic rhinitis during pregnancy and lactation显示文摘 | Incaudo GA Takach P | 2006 | Immunol Allergy Clin North Am2006，26，1： | 1 |
| 5 | Spontaneous splanchnic dissection : application and timing of therapeutic options 显示文摘 | Takach TJ Madjarov JM Holleman JH | 2009 | J Vasc Surg2009，50，3： | 1 |
| 6 | Primary cardiac tumors in infants and children:immediate and long-term operative results显示文摘 | Reul GJ Ott DA | 1996 | Ann Thorac Surg1996，62，2： | 1 |
| 7 | Sinus of valsalva aneurysm orfistula:management and outcome显示文摘 | Takach TJ Reul GJ Duncan JM | 1999 | Ann Thorac Surg1999，68，5： | 1 |
| 8 | High-Throughput Quantitation of Amino Acids in Rat and Mouse Biological Matrices Using Stable Isotope Labeling and UPLC-MS/MS Analysis显示文摘 | Edward Takach Thomas O'Shea Hanlan Liu | 2014 | J Chromatogr B2014，04，43： | 1 |
| 9 | The beam and detector for the NA48 neutral kaon CP violation experiment at CERN显示文摘 | V. Fanti A. Lai D. Marras L. Musa A. Nappi R. Batley A. Bevan R.S. Dosanjh R. Galik T. Gershon B. Hay G.E. Kalmus S. Katvars C. Lazzeroni R. Moore D.J. Munday M.D. Needham E. Olaiya M.A. Parker M. Patel M. Slater S. Takach T.O. White S.A. Wotton F. Bal G. | 2007 | Nuclear Inst. and Methods in Physics Research, A2007，，3： | 1 |
| 10 | 13C and ISN nuclear magnetic resonance studies of selected tetrazoles: Relationships with the chemistry of tetrazoles显示文摘 | Nelson J H Takach N E Henry R A | 1986 | Magn Reson Chem1986，24，11： | 1 |
| 11 | Experimental study on fiber sweeps in horizontal and highly deviated configurations 显示文摘 | Ahmed R M Takach N E Savitri M | 2009 | SPE1206442009，，： | 1 |
| 12 | Prediction of natural gas composition in ultra-deep reservoirs显示文摘 | BARKER C TAKACH N E | 1992 | AAPG Bullen-tin1992，76，12： | 1 |
| 13 | Sinus of Valsalva aneurysm or fistula: management and outcome显示文摘 | TAKACH T J REIL G J DUNCAN J M | 1999 | Ann Thorac Surg1999，68，： | 1 |
| 14 | Prediction of natural gas composition in ultradeep sandstone reservoir 显示文摘 | Barker C Takach N E | 1992 | AAPG Bulletin1992，76，12： | 1 |
| 15 | CPRI: a gene encoding a putative signal peptidase that functions in pathogenicity of Colletotrichum graminicola to maize 显示文摘 | Thon M R Nuckles E M Takach J E | 2002 | MPMI2002，15，： | 1 |
| 16 | spontaneous splanchnic dissection:Application and timing of therapeutic options显示文摘 | Takach T J Madjarov J M Holleman J H | | 0，，3： | 1 |
| 17 | Sinus of valaslva aneurysm of fisturla: management and outcome显示文摘 | TAKACH T J REUL G J DUNCAN J M | 1999 | Ann Thorac Sttrg1999，68，5： | 1 |
| 18 | Chemically improved filter cakes for drilling wells显示文摘 | Nandurdikar N S Takach N E Miska S Z | 2002 | Journal of Energy Resources Technology December2002，124，4： | 1 |
| 19 | Impact of Declining Fertility Rates in Canada on Donor Options in Blood and Marrow Transplantation显示文摘 | David S. Allan Sarah Takach Susan Smith Mindy Goldman | 2009 | Biology of Blood and Marrow Transplantation2009，，12： | 1 |
| 20 | Primary cardiac tumors in infants and children:immediate and long-term operative results显示文摘 | Takach TJ Reul GJ Ott DA | 1996 | Ann Thorac Strg1996，62，2： | 1 |
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