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| 1 | Alpha-fetoprotein before and after pegylated interferon therapy for predicting hepatocellular carcinoma development显示文摘AIM: To investigate factors that accurately predict hepatocellular carcinoma(HCC) development after antiviral therapy in chronic hepatitis C(CHC) patients. METHODS: CHC patients who received pegylated interferon and ribavirin were enrolled in this cohort study that investigated the ability of alpha-fetoprotein(AFP) to predict HCC development after interferon(IFN) therapy. RESULTS: Of 1255 patients enrolled, 665 developed sustained virological response(SVR) during mean follow-up period of 5.4 years. HCC was occurred in 89 patients, and 20 SVR patients were included. Proportional hazard models showed that HCC occurred in SVR patients showing AFP ≥ 5 ng/m L before therapy and in non-SVR patients showing AFP ≥ 5 ng/m L before and 1 year after therapy besides older age, and low platelet counts. SVR patients showing AFP ≥ 5 ng/m L before therapy and no decrease in AFP to < 5 ng/m L 1 year after therapy had significantly higher HCC incidence than non-SVR patients showing AFP ≥ 5 ng/m L before therapy and decreased AFP(P = 0.043). AFP ≥ 5 ng/m L before therapy was significantly associated with low platelet counts and high values of alanine aminotransferase(ALT) in stepwise logistic regression analysis. After age, gender, platelet count, and ALT was matched by propensity score, significantly lower HCC incidence was shown in SVR patients showing AFP < 5 ng/m L before therapy than in those showing AFP ≥ 5 ng/m L.CONCLUSION: The criteria of AFP < 5 ng/m L before and 1 year after IFN therapy is a benefical predictor for HCC development in CHC patients. | Yasuto Takeuchi Fusao Ikeda Toshiya Osawa Yasuyuki Araki Kouichi Takaguchi Youichi Morimoto Noriaki Hashimoto Kousaku Sakaguchi Tatsuro Sakata Masaharu Ando Yasuhiro Makino Shuji Matsumura Hiroki Takayama Hiroyuki Seki Shintarou Nanba Yuki Moritou Tetsuya Yasunaka Hideki Ohnishi Akinobu Takaki Kazuhiro Nouso Yoshiaki Iwasaki Kazuhide Yamamoto | 2015 | World Journal of Hepatology2015，7，19： | 3 |
| 2 | Long-term use of entecavir in nucleoside-na?ve Japanese patients with chronic hepatitis B infection显示文摘 | Osamu Yokosuka Koichi Takaguchi Shinichi Fujioka Michiko Shindo Kazuaki Chayama Haruhiko Kobashi Norio Hayashi Chifumi Sato Kendo Kiyosawa Kyuichi Tanikawa Hiroki Ishikawa Nobuyuki Masaki Taku Seriu Masao Omata | 2010 | Journal of Hepatology2010，，6： | 2 |
| 3 | Daclatasvir plus asunaprevir for chronic HCV genotype 1b infection显示文摘 | Hiromitsu Kumada Yoshiyuki Suzuki Kenji Ikeda Joji Toyota Yoshiyasu Karino Kazuaki Chayama Yoshiiku Kawakami Akio Ido Kazuhide Yamamoto Koichi Takaguchi Namiki Izumi Kazuhiko Koike Tetsuo Takehara Norifumi Kawada Michio Sata Hidetaka Miyagoshi Timothy Ele | 2014 | Hepatology2014，，6： | 2 |
| 4 | Detection of hepatitis B virus DNA in the liver and serum of patients with hepatitis B surface antigen and hepatitis C virus antibody negative chronic liver disease显示文摘 | Takaguchi K Satou A Ando M | 2002 | Hepatol Res2002，22，2： | 1 |
| 5 | Long-term use of entecavir in nucleoside-nai've Japanese patients with chronic hepatitis B infection显示文摘 | Yokosuka O Takaguchi K Fujioka S | 2010 | J Hepatol2010，52，6： | 1 |
| 6 | Tolvaptan for improvement of hepatic edema: A phase 3, multicenter, randomized, double‐blind, placebo‐controlled trial显示文摘 | Isao Sakaida Seiji Kawazoe Kozo Kajimura Takafumi Saito Chiaki Okuse Koichi Takaguchi Mitsuru Okada Kiwamu Okita | 2014 | Hepatol Res2014，，1： | 1 |
| 7 | Multi-funetionalization of gallie aeid towards improved synthesis of a- and fl-DDB显示文摘 | ALAM A TAKAGUCHI Y ITO H | 2005 | Tetrahedron2005，61，7： | 1 |
| 8 | Novel synthesis of,4-arylsulfenyl-3-hydroxy-2-pyrone:One-pot substitution-rearrangement-cyclization reaction of acetonide-protected,4,5-dihydroxy-2-chloroglycidic ester by sodium arylthiolate显示文摘 | Komiyama T Takaguchi Y Tsuboi S | | 0，，： | 1 |
| 9 | Novel synthesis of,4-halo-3-hydroxy-2-pyrone:one pot rearrangement-cyclization reaction by magnesium halide显示文摘 | Komiyama T Takaguchi Y Gubaidullin A T Mamedov V A Litvinov I A Tsuboi S | | 0，，： | 1 |
| 10 | Impact of caveolin expression on clinical pathological parameters in renal cell carcinoma显示文摘 | takaguchi A Asano T Asayama J | 2008 | J Urol2008，172，2： | 1 |
| 11 | Photodimerization of anthracene having dendritic substituent within the vaterite crystal of CaCO3显示文摘 | Takaguchi Y Yanagimoto Y Tajima T | 2002 | Chem Lett2002，31，11： | 1 |
| 12 | Hydriding-dehydriding characteristics of NdNi5 and effects of Sn-substitution显示文摘 | Takaguchi Y Tanaka K | 2000 | Journal of Alloys and Compands2000，297，： | 1 |
| 13 | Detection of hepatitis B virus DNA in the liver and serum of patients with hepatitis B surface antigen and hepatitis C virus antibody negative chronic liver disease显示文摘 | Takaguchi K Saton A Ando M | 2002 | Hepatol Res2002，22，2： | 1 |
| 14 | Preparation and X-ray Structure Analysis of 1,1,5,5,9,9-Hexachloro-1,5,9-tritelluracyclododecane (Cl16aneTe3) and Its Redox Behavior显示文摘 | Yutaka Takaguchi Ernst Horm Naomichi Furukawa | 1996 | Organometallics1996，，15： | 1 |
| 15 | Long-term use of ente- cavir in nucleoside-naive Japanese patients with chronic hepatitis B infection显示文摘 | Yokosuka O Takaguchi K Fujioka S | 2010 | J Hepatology2010，52，6： | 1 |
| 16 | Long-term use of ente- cavir in nucleoside-naive Japanese patients with chronic hepatitis B infection 显示文摘 | Yokosuka Q Takaguchi K Fujioka S | 2010 | J Hepatol2010，52，6： | 1 |
| 17 | Successful treatment of advanced hepatocellular carcinoma by combined administration of 5-fluorouracil and pegylated interferon-a显示文摘We report a case of hepatocellular carcinoma (HCC) treated successfully by transarterial chemoembolization (TACE) followed by combination therapy of 5-fluorouracil (5-FU) and pegylated interferon-α (PEG-IFN-α). In the present case, the patient had massive and advanced HCC with a diameter of over 8 cm located in segment 7 (S7) of the liver. Furthermore, the tumor invaded into the major branch of the portal vein (Vp3). After TACE, combined administration of 5-FU and PEG-IFN-α was performed for 5 mo. HCC was totally eradicated and the serum levels of tumor markers were markedly decreased by the treatment. Although it has been reported that the combined use of conventional IFN-a and 5-FU showed striking effects on HCC in some cases, this case may suggest the more promising effect of PEG-IFN-α with a long-lasting effect, in the combined use with 5-FU for the treatment of massive advanced HCC. | Kazutaka Kurokohchi Kouichi Takaguchi Keiji Kita Tsutomu Masaki Shigeki Kuriyama | 2005 | World Journal of Gastroenterology2005，11，34： | 1 |
| 18 | Hepatitis B e antigen predicts delayed reduction of HBV DNA without viral breakthrough with adefovir dipivoxil and lamivudine:a 5-year study of patients with hepatitis B with lamivudine resistance显示文摘 | Ikeda F Baba N Takaguchi K | | 0，，10： | 1 |
| 19 | Immunoelectron microscopic observation of intrabepatic HBeAg in patients with chronic hepatitis B显示文摘 | Yamada G Takaguchi K Matsueda K | 1990 | Hepatology1990，12，： | 1 |
| 20 | One-pot substi- tution-rearrangement reaction of 2-chloroglyeidic ester; Effective protocol for the preparation of 3-arylsulfenyl-2-keto ester显示文摘 | KOMIYAMA T TAKAGUCHI Y TSUBOI S | 2006 | Synth Commun2006，36，3： | 1 |
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