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| 1 | Role of bacterial and genetic factors in gastric cancer in Costa Rica显示文摘AIM: To evaluate several risk factors for gastric cancer (GC) in Costa Rican regions with contrasting GC incidence rate (GCIR). METHODS: According to GCIR, 191 Helicobacter pylori (H pylori)-positive patients were classified into groups A (high GCIR, n = 101) and B (low GCIR, n = 90). Human DNA obtained from biopsy specimens was used in the determination of polymorphisms of the genes coding for interleukin (IL)-1β and IL-10 by PCR-RFLP, and IL-1RN by PCR. H pylori DNA extractions obtained from clinical isolates of 83 patients were used for PCR-based genotyping of H pylori cagA, vacA and babA2. Human DNA from gastric biopsies of 52 GC patients was utilized for comparative purposes. RESULTS: Cytokine polymorphisms showed no association with GCIR variability. However, gastric atrophy, intestinal metaplasia and strains with different vacA genotypes in the same stomach (mixed strain infection) were more frequently found in group A than in group B, and cagA and vacA s1b were signif icantly associated with high GCIR (P = 0.026 and 0.041, respectively). IL- 1β+3954_T/C (OR 2.1, 1.0-4.3), IL-1RN*2/L (OR 3.5, 1.7-7.3) and IL-10-592_C/A (OR 3.2, 1.5-6.8) were individually associated with GC, and a combination of these cytokine polymorphisms with H pylori vacA s1b and m1 further increased the risk (OR 7.2, 1.4-36.4). CONCLUSION: Although a proinflammatory cytokine genetic profile showed an increased risk for developing GC, the characteristics of H pylori infection, in particular the status of cagA and vacA genotype distribution seemed to play a major role in GCIR variability in Costa Rica. | Sergio A Con Hiroaki Takeuchi Gil R Con-Chin Vicky G Con-Chin Nobufumi Yasuda Reinaldo Con-Wong | 2009 | World Journal of Gastroenterology2009，15，2： | 9 |
| 2 | Effectof slag composition on the kinetics of formation ofAl2 03-Mg0 inclusions in aluminum killed ferriticstainless steel显示文摘 | Okuyama G Yamaguchi K Takeuchi S | 2000 | ISIJ International2000，40，2： | 1 |
| 3 | Global sta- bility for delay SIR and SEIR epidemic models with non- linear incidence rate 显示文摘 | HUANG G TAKEUCHI Y MA W B | 2010 | Bulletin of Mathematical Biolo- gy2010，72，： | 1 |
| 4 | Optimal dietary taurine level for growth of juvenile Japanese flounder Paralichthys oliva-ceus显示文摘 | Park G S Takeuchi T Yoloyama M | 2002 | Fisheries Science2002，68，4： | 1 |
| 5 | Mechanism of photoinduced superhydrophilicity on the TiO2 photocatalyst surface显示文摘 | Takeuchi M Sakamoto K Martra G | | 0，，32： | 1 |
| 6 | Calculation of ocular single-pass modulation transfer function and retinal image simulation from measurements of the polarized double-pass ocular point spread function显示文摘 | Kabayashi K Shibutani M Takeuchi G | 2004 | J Biomed Opt2004，9，1： | 1 |
| 7 | Technical approaches to correction of oocyte aneuploidy 显示文摘 | Palermo G D Takeuchi T Rosenwaks Z | 2002 | Hum Reprod2002，17，： | 1 |
| 8 | Effect of slag composition on the kinetics of formation of Al2O3-MgO inclusions in aluminum killed ferritic stainless steel显示文摘 | Okuyama G Yamaguehi K Takeuchi S | 2000 | ISIJ International2000，40，2： | 1 |
| 9 | Shape-selective synthesis of 2,6-diisopropylnaphthalene over H-mordenite catalyst显示文摘 | KATAYAMA A TOBA M TAKEUCHI G et a1 | 1991 | J Chem Soc Chem Commun1991，40，： | 1 |
| 10 | Extending the Chain of Relationships Among Organizational Justice,Social Exchange,and Employee Reactions:The Role of Contract Violation显示文摘 | TEKLEAB A G TAKEUCHI R TAYLOR M S | 2005 | Academy of Management Journal2005，48，3： | 1 |
| 11 | The effects of dietary taurine on growth and taurine levels in whole body of juvenile Japanese flounder Paralichthys olivaceus显示文摘 | Park G S Takeuchi T Seikai T | 2001 | Nippon Sulsan Gakkaishi2001，67，： | 1 |
| 12 | 'Stereovectorcardiogram' made by stereolithography显示文摘 | Kinoshita S Konishi G Takeuchi S | 1990 | Cardiology1990，77，4： | 1 |
| 13 | Calculation of ocular single-pass modulation transfer function and retinal image simulation from measurements of the polarized double-pass ocular point spread function显示文摘 | Kobayashi K Shibutani M Takeuchi G | 2004 | J Biomed Opt2004，9，1： | 1 |
| 14 | Optimal dietary taurine level for growth of juvenile Japanese flounder Paralichthys oli vaceus显示文摘 | Park G S Takeuchi T Yoloyama M | 2002 | Fisheries science2002，68，4： | 1 |
| 15 | Nephrin dissociates from actin,and its expression is reduced in early experimental membranous nephropathy显示文摘 | Yuan H Takeuchi E Taylor G A | 2002 | J Am Soc Nephrol2002，13，4： | 1 |
| 16 | Hepatic cysteine sulphinate decarboxylase activity in fish显示文摘 | Yokoyama M Takeuchi T Park G S | 2001 | Aquacultu Res2001，32，： | 1 |
| 17 | Multiple oxidation states of ruthenium and osmium based on dioxo/diaqua couples显示文摘 | Takeuchi K J Samuels G J Gersten SW | 1983 | Inorg Chem1983，22，9： | 1 |
| 18 | Comparison of fatty acids and lipids of smolting hatchery fed and wild Atlantic salmon, Salmo salar 显示文摘 | Ackman R G Takeuchi T | 1986 | Lipids1986，21，： | 1 |
| 19 | Mechanism of photoinduced superhydrophilicity on the TiO2 photocatalyst surface显示文摘 | Takeuchi M Sakamoto K Martra G Coluccia S | 2005 | J Phys Chem B2005，109，15： | 1 |
| 20 | Coronary artery fistula with giant aneurysm 显示文摘 | Sekita G Fukushima K Takeuchi H | 2012 | J Card Surg2012，27，： | 1 |
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