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| 1 | Sentinel Node Mapping for Gastric Cancer: A Prospective Multicenter Trial in Japan显示文摘 | Yuko Kitagawa Hiroya Takeuchi Yu Takagi Shoji Natsugoe Masanori Terashima Nozomu Murakami Takashi Fujimura Hironori Tsujimoto Hideki Hayashi Nobunari Yoshimizu Akinori Takagane Yasuhiko Mohri Kazuhito Nabeshima Yoshikazu Uenosono Shinichi Kinami Junichi S | 2013 | Journal of Clinical Oncology2013，，29： | 11 |
| 2 | Sequence variation of the rDNA ITS regions within and between anastomosis groups in Rhizoctonia solani 显示文摘 | KUNINAGA S NATSUAKI T TAKEUCHI T | 1997 | Current Genetic1997，32，： | 3 |
| 3 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 4 | Protective effect of Irsogladine on monochloramineinduced gastric mucosallesions in rats:a comparative study with rebamipide显示文摘AIM To examine the effect of irsogladine, a novel antiulcer drug, on the mucosal ulcerogenic response to monochloramine (NH 2Cl) in rat stomach, in comparison with rebamipide, another antiulcer drug with cytoprotective activity. METHODS AND RESULTS Oral administration of NH 2Cl (120*!mM) produced severe hemorrhagic lesions in unanesthetized rat stomachs. Both irsogladine ( 1*!mg/*!kg - 10*!mg/*!kg , po ) and rebamipide ( 30*!mg/*!kg - 100*!mg/*!kg , po ) dose dependently prevented the development of these lesions in response to NH 2Cl, the effect of irsogladine was significant at 3*!mg/*!kg or greater, and that of rebamipide only at 100*!mg/*!kg . The protective effect of irsogladine on NH 2Cl induced gastric lesions was significantly reduced by N G nitro L arginine methyl ester (L NAME) but not by indomethacin, while that of rebamipide was significantly mitigated by indomethacin but not by L NAME. Topical application of NH 2Cl (20*!mM) caused a marked reduction of potential difference (PD) in ex vivo stomachs. This PD reduction was not affected by mucosal application of irsogladine, but significantly prevented by rebamipide. The mucosal exposure to NH 4OH (120*!mM) also caused a marked PD reduction in the ischemic stomach (bleeding from the carotid artery), resulting in gastric lesions. These ulcerogenic and PD responses caused by NH 4OH plus ischemia were also significantly mitigated by rebamipide, in an indomethacin sensitive manner, while irsogladine potently prevented such lesions without affecting the PD response, in a L NAME sensitive manner. CONCLUSION These results suggest that ① NH 2Cl generated either exogenously or endogenously damages the gastric mucosa, ② both irsogladine and rebamipide protect the stomach against injury caused by NH 2Cl, and ③ the mechanism underlying the protective action of irsogladine is partly mediated by endogenous nitric oxide, while that of rebamipide is in part mediated by endogenous prostaglandins. | H Yamamoto, M Umeda, H Mizoguchi, S Kato and K Takeuchi | 1999 | World Journal of Gastroenterology1999，5，6： | 2 |
| 5 | Back analysis of measured displacement of tunnel显示文摘 | SAKURAI S TAKEUCHI K | 1983 | Rock Mech and Rock Eng1983，16，3： | 1 |
| 6 | Role of nitric oxide in mucosal blood flow response and the healing of HCl-induced lesions in the rat stomach显示文摘 | Takeuchi K Kato S Takehara K | 1997 | Digestion1997，58，1： | 1 |
| 7 | Telmisartan is a promising cardiometabolicsartan due to its unique PPAR-gamma-inducing property显示文摘 | Yamagishi S Takeuchi M | 2005 | Med Hypotheses2005，64，3： | 1 |
| 8 | Potential therapeutic implication of nifedipine,a dihydropyridine-based calcium antagonist,in advanced glycation end product (AGE) -related disorders 显示文摘 | Yamagishi S Nakamura K Takeuchi M | 2005 | Med Hypotheses2005，65，2： | 1 |
| 9 | Hepatocyte growth factor levels in the vitreous of patients with proliferative vitreoretinopathy显示文摘 | Takeuchi S Matsuda A | 2000 | Am J Ophthalmol2000，，： | 1 |
| 10 | Pigment epithelium-derived factor inhibits oxidative stress-induced apoptosis and dysfunction of cultured retinal pericytes显示文摘 | Amano S Yamagishi S Inagaki Y Nakamura K Takeuchi M Inoue H | 2005 | Microvasc Res2005，69，12： | 1 |
| 11 | Macrophage migration inhibitory factor levels in the vitreous of patients with proliferative diabetic retinopathy显示文摘 | Mitamura Y Takeuchi S Matsuda A | 2000 | Br J Ophthalmol2000，84，： | 1 |
| 12 | Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells 显示文摘 | Kojima H Katsura E Takeuchi S | 2004 | Environ Health Perspect2004，112，5： | 1 |
| 13 | Biphasic vasodilatoraction of troglitazone on the renal microcirculation显示文摘 | Arima S Kohagura K Takeuchi K | 2002 | J Am SocNephrol2002，13，34： | 1 |
| 14 | Innate immunity to virus infection显示文摘 | Takeuchi O Akira S | 2009 | Immunol Rev2009，227，1： | 1 |
| 15 | Fibrinolytic therapy for acute embolie stroke: intracarotiel and intra arterial 显示文摘 | Sasaki O Takeuchi S Kolike T | 2009 | Neurosurgery2009，36，3： | 1 |
| 16 | Multivariate analysis of predictors of hematoma enlargement in spontaneous intracerebral hemorrhage 显示文摘 | Fujji Y Takeuchi S Sasaki O | 1998 | Stroke1998，29，6： | 1 |
| 17 | Hematoma enlargement in spontaneous intracerebral hemorrhage显示文摘 | Fujii Y Tanaka R Takeuchi S | 1994 | J Neurosurg1994，80，： | 1 |
| 18 | Back analysis in measured displacements of tunnels显示文摘 | SAKURAI S TAKEUCHI K | 1983 | Rock Mechanics Rock Eng1983，16，： | 1 |
| 19 | Role of nitric oxtde in mucosalblood flow responns and the healing of HCL-induced lesions in the ratstomach 显示文摘 | Takeuchi K Kato S Takehara K | 1997 | Digestion1997，58，1： | 1 |
| 20 | Biphasic vasodilator action of troglitazone on the renal microcirculation 显示文摘 | Arima S Kohagura K Takeuchi K | 2002 | J Am Soc Nephrol2002，13，： | 1 |
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