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| 1 | Potential role of killer immunoglobulin receptor genes among individuals vaccinated against hepatitis B virus in Lebanon显示文摘AIM To explore the role of killer immunoglobulin receptor(KIR) genes in responsiveness or non-responsiveness to vaccination against hepatitis B virus.METHODS We recruited 101 voluntary participants between March 2010 and December 2011. Sera samples from vaccinated and non-vaccinated participants were tested for the presence of anti-HBs antibodies as a measure of protection against hepatitis B, hepatitis B surface antigen and hepatitis B core antibody as indicators ofinfection by enzyme-linked immunosorbent assay. KIR gene frequencies were determined by polymerase chain reaction.RESULTS Sera samples from 99 participants were tested for the levels of anti-HBs as an indicator of protection(≥ 10 mI U/ml) following vaccination as defined by the World Health Organization international reference standard. Among the vaccinated participants, 47%(35/74) had anti-HBs titers above 100 mI U/ml, 22%(16/74) had antiHBs ranging between 10-100 mI U/ml, and 20%(15/74) had values of less than 10 mI U/ml. We report the lack of significant association between the number of vaccine dosages and the titer of antibodies among our vaccinated participants. The inhibitory KIR2Dl1, KIR2Dl4, KIR3Dl1, KIR3Dl2, and KIR3 Dl were detected in more than 95%, whereas KIR2Dl2, KIR2Dl3, KIR2Dl5(KR2Dl5A and KIR2Dl5B) were expressed in 56%, 84% and 42%(25% and 29%) of participants, respectively. The observed frequency of the activating KIR genes ranged between 35% and 55% except for KIR2DS4, detected in 95% of the study participants(40.6% 2DS4*001/002; 82.2% 2DS4*003/007). KIR2DP1 pseudogene was detected in 99% of our participants, whereas KIR3DP*001/02/04 and KIR3DP1*003 had frequencies of 17% and 100%, respectively. No association between the frequency of KIR genes and anti-HBs antibodies was detected. When we compared the frequency of KIR genes between vaccinated individuals with protective antibodies titers and those who lost their protective antibody levels, we did not detect a significant difference. KIR2Dl5 B was significantly different among different groups of vaccinated participants(group Ⅰ > 100 mI U/ml, group Ⅱ 10-100 mI U/ml, group Ⅲ < 10 mI U/ml and group Ⅳ with undetectable levels of protective antibodies). CONCLUSION To our knowledge, this is the first study screening for the possible role of KIR genes among individuals vaccinated against hepatitis B virus(HBV). Our results can be used to design larger studies to better understand the role of KIR genes in protection against or susceptibility to HBV post vaccination. | Nada M Melhem Rami A Mahfouz Khalil Kreidieh Rabab Abdul-Khalik Rolla El-Khatib Reem Talhouk Umayya Musharrafieh Ghassan Hamadeh | 2016 | World Journal of Hepatology2016，8，29： | 2 |
| 2 | 混合性上皮性卵巢癌的形态学及分子学特征显示文摘上皮性卵巢癌(EOC)有5种主要组织学类型:高级别浆液性癌(HGSC)、子宫内膜样癌(EC)、透明细胞癌(CCC)、黏液癌(MC)和低级别浆液性癌(LGSC)。每种类型均可有多种形态学特征,并且1种类型形态学特征可酷似另一种类型,按≥2种明确的组织学特征来定义混合性EOC, | Mackenzie R Talhouk A Eshragh S 黄爱清 余英豪 | 2016 | 临床与实验病理学杂志2016，32，6： | 2 |
| 3 | Evaluation of enrofloxacin treatment program against Mycoplasma gaIlisepticum infection in broilers显示文摘 | Barbour EK Hamadeh S Talhouk R | 1998 | Prey Vet Med1998，35，2： | 1 |
| 4 | Evaluation of enroflox- acin treatment program against Mycoplasma galliseticum infection in broil- ers显示文摘 | BARBOUR E K HAMADEH S TALHOUK R | 1998 | Prenentive Vet Med1998，35，2： | 1 |
| 5 | Gap junctional intercellular communication in hypoxia-ischemia-induced neuronal injury 显示文摘 | Talhouk RS Zeinieh MP Mikati MA | 2008 | Prog Neurobiol2008，84，： | 1 |
| 6 | Discrepancies between mecA PCR and Conventional test used for detection of methicillin re- sistant Staphyloccoccus aureus显示文摘 | Araj GF Talhouk RS Simann C J | 1999 | Int J Antimicrob Agents1999，11，1： | 1 |
| 7 | Evaluation of enrofloxacin treatment program against Mycoplasma galliseticum infection in broilers显示文摘 | Barbour E K Hamadeh S Talhouk R | 1998 | Preventive Vet Med1998，35，2： | 1 |
| 8 | Bovinemammary lactoferrin: implications from messenger ribonucleic acid (mRNA)sequence and regulation contrary to other milk proteins 显示文摘 | Shaubacher F L Goodman R E Talhouk R S | 1992 | Dairy Sci1992，76，12： | 1 |
| 9 | In vitro culture of cryopreserved bovine mammary cells on collagen gels:synthesis and secretion of casein and lactoferrin 显示文摘 | TALHOUK R S NEISWANGER R L SCHANBACHER F L | 1990 | Tissue Cell1990，22，5： | 1 |
| 10 | Evaluation of a- nenrofloxacin treatment program against Mycoplasmagalliseptic- urn infection in broilers显示文摘 | Barbour EK Hamadeh S Talhouk B | 1998 | Preventive Vet Med1998，35，2： | 1 |
| 11 | Discrepanciesbetween mecA PCR and conventional tests used for the detection of methicillin-resistant Staphylococcus aureus显示文摘 | ARAJ G F TALHOUK R S Simaan C J | 1999 | Int J Antimicrob Agents1999，11，： | 1 |
| 12 | Developmental regulation and partial characterization of growth factors in the bovine mammary gland显示文摘 | TALHOUK R S NEISWANDER R L SCHANBACHER F L | 1996 | J Reprod Fertil1996，106，： | 1 |
| 13 | Developmental expression patterns and regulation of connexins in the mouse mammary gland : expression of connexin30 in lactogenesis 显示文摘 | Talhouk RS Elble RC Bassam R | 2005 | Cell Tissue Res2005，319，1： | 1 |
| 14 | Biology and origin of bioaetive peptides in milk 显示文摘 | Schanbacher F L Talhouk R S Murray F A | 1997 | Livest Prod Sei1997，50，： | 1 |
| 15 | 混合型上皮性卵巢癌的形态学及分子特征显示文摘上皮性卵巢癌(EOC)主要包含5种亚型:高级别浆液性癌(HGSC)、子宫内膜样癌(EC)、透明细胞癌(CCC)、黏液性癌(MC)及低级别浆液性癌(LGSC)。每种亚型都有非常宽泛的形态学表现,且不同亚型问的组织病理学特点可能会非常相似。曾经基于常规的组织病理学评估, | Mackenzie R Talhouk A Eshragh S 魏建国 许春伟 | 2016 | 临床与实验病理学杂志2016，32，4： | 1 |
| 16 | Differential expression of hippocampal connexins after acute hypoxia in the developing brain显示文摘 | Michele P Zeinieh Rabih S Talhouk Marwan-Sabban | | 0，，： | 1 |
| 17 | Bovine mammary lactoferrin: implications from messenger ribonucleic acid (mRNA) sequence and regulation contrary to other milk proteins显示文摘 | SHANBACHER F L GOODMAN R E TALHOUK R S | 1992 | J Dairy Sei1992，76，12： | 1 |
| 18 | Economic value of cedar relics in Lebanon : an application of contingent valuation method for conservation 显示文摘 | Sat tout E J Talhouk S N and Cagliari P D S | 2007 | Ecological Economics2007，61，3： | 1 |
| 19 | Modulation of Cx43 and Gap Junctional Intercellular Communication by Androstenedione in Rat Polycystic Ovary and Granu- losa Cells in vitro显示文摘 | Talhouk R Tarraf C Kobrossy L | 2012 | J Reprod Infertil2012，13，1： | 1 |
| 20 | In vitro culture of cryopreserved bovine mammary cells on col- lagen gels :synthesis and secretion of casein and lactoferrin 显示文摘 | TALHOUK R S NEISWANDER R L SCHANBACHER F L | 1990 | Tissue Cell1990，22，5： | 1 |
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