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| 1 | Is Extended Hepatectomy for Hepatobiliary Malignancy Justified?显示文摘 | Jean-Nicolas Vauthey Timothy M. Pawlik Eddie K. Abdalla James F. Arens Rabih A. Nemr Steven H. Wei Debra L. Kennamer Lee M. Ellis Steven A. Curley | 2004 | Annals of Surgery2004，，5： | 2 |
| 2 | Total and segmental liver volume variations: Implications for liver surgery显示文摘 | Eddie K Abdalla Alban Denys Patrick Chevalier Rabih A Nemr Jean-Nicolas Vauthey | 2004 | Surgery2004，，4： | 2 |
| 3 | Insight into molecular mechanisms underlying hepatic dysfunction in severe COVID-19 patients using systems biology显示文摘BACKGROUND The coronavirus disease 2019(COVID-19),a pandemic contributing to more than 105 million cases and more than 2.3 million deaths worldwide,was described to be frequently accompanied by extrapulmonary manifestations,including liver dysfunction.Liver dysfunction and elevated liver enzymes were observed in about 53%of COVID-19 patients.AIM To gain insight into transcriptional abnormalities in liver tissue of severe COVID-19 patients that may result in liver dysfunction.METHODS The transcriptome of liver autopsy samples from severe COVID-19 patients against those of non-COVID donors was analyzed.Differentially expressed genes were identified from normalized RNA-seq data and analyzed for the enrichment of functional clusters and pathways.The differentially expressed genes were then compared against the genetic signatures of liver diseases including cirrhosis,fibrosis,non-alcoholic fatty liver disease(NAFLD),and hepatitis A/B/C.Gene expression of some differentially expressed genes was assessed in the blood samples of severe COVID-19 patients with liver dysfunction using qRT-PCR.RESULTS Analysis of the differential transcriptome of the liver tissue of severe COVID-19 patients revealed a significant upregulation of transcripts implicated in tissue remodeling including G-coupled protein receptors family genes,DNAJB1,IGF2,EGFR,and HDGF.Concordantly,the differential transcriptome of severe COVID-19 liver tissues substantially overlapped with the disease signature of liver diseases characterized with pathological tissue remodeling(liver cirrhosis,Fibrosis,NAFLD,and hepatitis A/B/C).Moreover,we observed a significant suppression of transcripts implicated in metabolic pathways as well as mitochondrial function,including cytochrome P450 family members,ACAD11,CIDEB,GNMT,and GPAM.Consequently,drug and xenobiotics metabolism pathways are significantly suppressed suggesting a decrease in liver detoxification capacity.In correspondence with the RNA-seq data analysis,we observed a significant upregulation of DNAJB1 and HSP90AB1 as well as significant downregulation of CYP39A1 in the blood plasma of severe COVID-19 patients with liver dysfunction.CONCLUSION Severe COVID-19 patients appear to experience significant transcriptional shift that may ensue tissue remodeling,mitochondrial dysfunction and lower hepatic detoxification resulting in the clinically observed liver dysfunction. | Sarah Musa Hammoudeh Arabella Musa Hammoudeh Poorna Manasa Bhamidimarri Bassam Mahboub Rabih Halwani Qutayba Hamid Mohamed Rahmani Rifat Hamoudi | 2021 | World Journal of Gastroenterology2021，27，21： | 2 |
| 4 | Usefulness of biodegradable polydioxanone stents in the treatment of postsurgical colorectal strictures and fistulas显示文摘 | F. Pérez Roldán P. González Carro M. Villafá?ez García S. Aoufi Rabih M. Legaz Huidobro N. Sánchez-Manjavacas Mú?oz O. Roncero García-Escribano M. Ynfante Ferrús E. Bernardos Martín F. Ruiz Carrillo | 2012 | Endoscopy2012，，03： | 2 |
| 5 | Current Management of Extracranial Carotid Artery Disease显示文摘 | Faries B Rabih A | 2006 | Vascular and Endovascular Surgery2006，40，： | 1 |
| 6 | Treatment of Infections Associated with Surgical Implants显示文摘 | Rabih O Darouiche | 2004 | New England Journal of Medicine2004，350，14： | 1 |
| 7 | Localchemical vapor deposition of carbon na-nofihers from photoresist显示文摘 | Zaouk Rabih Madou Marc | 2006 | Carbon2006，44，： | 1 |
| 8 | Bacterial translocation across ePTFE vascular graft surfaces显示文摘 | Supriya Narasimhan Saima Aslam Peter H. Lin Carlos F. Bechara Mohammad D. Mansouri Rabih O. Darouiche | 2010 | Journal of Infection2010，，6： | 1 |
| 9 | Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency显示文摘 | Sancho-Shimizu Vanessa de Diego Rebeca Pérez Lorenzo Lazaro Halwani Rabih Alangari Abdullah Israelsson Elisabeth Fabrega Sylvie Cardon Annabelle Maluenda Jerome Tatematsu Megumi Mahvelati Farhad Herman Melina Ciancanelli Michael Guo Yiqi AlS | 2011 | Journal of Clinical Investigation2011，，12： | 1 |
| 10 | Adsorption of phosphate and nitrate anions on ammonium-functionalized MCM-48: Effects of experimental conditions 显示文摘 | Rabih Saad Khaled Belkacemi Safia Hamoudi | 2007 | Journal of Colloid and Interface Science2007，311，2： | 1 |
| 11 | Radial Distribution Load Flow Using Conic Programming显示文摘 | RABIH A J | 2006 | IEEE Transactions on Power Systems2006，21，3： | 1 |
| 12 | Total and segmental liver volume variations: Implications for liver surgery显示文摘 | Eddie K Abdalla Alban Denys Patrick Chevalier Rabih A Nemr Jean-Nicolas Vauthey | 2004 | Surgery2004，，4： | 1 |
| 13 | Melanotic schwannoma with drop metastases to the caudal spine and high expression of CD117 (c-kit)显示文摘 | Rabih G. Tawk Dongfeng Tan Laszlo Mechtler Robert A. Fenstermaker | 2005 | Journal of Neuro - Oncology2005，，2： | 1 |
| 14 | Robust Self-Scheduling Under Price Uncertainty Using Conditional Value- at-Risk 显示文摘 | Rabih A Jabr | 2005 | IEEE TRANSACTIONS ON POWER SYSTEMS2005，20，4： | 1 |
| 15 | Neural Networks for Reahime Nonlinear Control of a Variable Geometry Turbocharged Diesel Engine显示文摘 | Omran Rabih Younes Rafic Champoussin | 2008 | International Journal of Robust and Nonlinear Control2008，，12： | 1 |
| 16 | Primary intestinal diffuse large B-cell non-Hodgkin’s lymphoma: Clinical?features, management, and prognosis of 66 patients显示文摘 | E. M. Ibrahim A. A. Ezzat A. N. El-Weshi J. M. Martin Y. M. Khafaga W. Al Rabih D. S. Ajarim M. O. Al-Foudeh E. Zucca | 2001 | Annals of Oncology2001，，1： | 1 |
| 17 | Primary intestinal diffuse large B-cell non-Hodgkin’s lymphoma: Clinical?features, management, and prognosis of 66 patients显示文摘 | E. M. Ibrahim A. A. Ezzat A. N. El-Weshi J. M. Martin Y. M. Khafaga W. Al Rabih D. S. Ajarim M. O. Al-Foudeh E. Zucca | 2001 | Annals of Oncology2001，，1： | 1 |
| 18 | Reference ranges for Doppler-assessedpulmonary venous blood flow velocities and pulsatility indices innormal human fetuses显示文摘 | FrakaL Rabih C | 2002 | Prenat Diagn2002，22，： | 1 |
| 19 | Current management of ex- tracranial carotid artery disease显示文摘 | Peter L Faries B Rabih A | 2006 | Vascular and Endovascular Surgery2006，40，： | 1 |
| 20 | Efficacy of combination of chlorhexidine and protamine sulphate against device-associated pathogens显示文摘 | Rabih OD | 2008 | Antimicrob Chemother2008，61，3： | 1 |
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