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| 1 | challenges of advanced hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is an aggressive malignancy,resulting as the third cause of death by cancer each year. The management of patients with HCC is complex,as both the tumour stage and any underlying liver disease must be considered conjointly. Although surveillance by imaging,clinical and biochemical parameters is routinely performed,a lot of patients suffering from cirrhosis have an advanced stage HCC at the first diagnosis. Advanced stage HCC includes heterogeneous groups of patients with different clinical condition and radiological features and sorafenib is the only approved treatment according to Barcelona Clinic Liver Cancer. Since the introduction of sorafenib in clinical practice,several phase Ⅲ clinical trials have failed to demonstrate any superiority over sorafenib in the frontline setting. Locoregional therapies have also been tested as first line treatment,but their role in advanced HCC is still matter of debate. No single agent or combination therapies have been shown to impact outcomes after sorafenib failure. Therefore this review will focus on the range of experimental therapeutics for patients with advanced HCC and highlights the successes and failures of these treatments as well as areas for future development. Specifics such as dose limiting toxicity and safety profile in patients with liver dysfunction related to the underlying chronic liver disease should be considered when developing therapies in HCC. Finally,robust validated and reproducible surrogate end-points as well as predictive biomarkers should be defined in future randomized trials. | Stefano Colagrande Andrea L Inghilesi Sami Aburas Gian G Taliani Cosimo Nardi Fabio Marra | 2016 | World Journal of Gastroenterology2016，22，34： | 19 |
| 2 | Advanced hepatocellular carcinoma and sorafenib: Diagnosis, indications, clinical and radiological follow-up显示文摘Advanced stage hepatocellular carcinoma(HCC) is a category of disease defined by radiological, clinical and hepatic function parameters, comprehending a wide range of patients with different general conditions. The main therapeutic option is represented by sorafenibtreatment, a multi-kinase inhibitor with anti-proliferative and anti-angiogenic effect. Trans-arterial Radio Embolization also represents a promising new approach to intermediate/advanced HCC. Post-marketing clinical studies showed that only a portion of patients actually benefits from sorafenib treatment, and an even smaller percentage of patients treated shows partial/complete response on follow-up examinations, up against relevant costs and an incidence of drug related adverse effects. Although the treatment with sorafenib has shown a significant increase in mean overall survival in different studies, only a part of patients actually shows real benefits, while the incidence of drug related significant adverse effects and the economic costs are relatively high. Moreover, only a small percentage of patients also shows a response in terms of lesion dimensions reduction. Being able to properly differentiate patients who are responding to the therapy from non-responders as early as possible is then still difficult and could be a pivotal challenge for the future; in fact it could spare several patients a therapy often difficult to bear, directing them to other second line treatments(many of which are at the moment still under investigation). For this reason, some supplemental criteria to be added to the standard modified Response Evaluation Criteria in Solid Tumors evaluation are being searched for. In particular, finding some parameters(cellular density, perfusion grade and enhancement rate) able to predict the sensitivity of the lesions to anti-angiogenic agents could help in stratifying patients in terms of treatment responsiveness before the beginning of the therapy itself, or in the first weeks of sorafenib treatment. This would bring a strongly desirable help in clinical managements of these patients. | Stefano Colagrande Francesco Regini Gian Giacomo Taliani Cosimo Nardi Andrea Lorenzo Inghilesi | 2015 | World Journal of Hepatology2015，7，8： | 6 |
| 3 | Ultrasound evaluation of liver fibrosis: preliminary experience with acoustic structure quantification (ASQ) software显示文摘 | Paolo Ricci Chiara Marigliano Vito Cantisani Andrea Porfiri Andrea Marcantonio Pietro Lodise Ugo D’Ambrosio Giancarlo Labbadia Elena Maggini Ester Mancuso Giovanna Panzironi Mattia Segni Caterina Furlan Raffaele Masciangelo Gloria Taliani | 2013 | La radiologia medica2013，，6： | 2 |
| 4 | Medicinal chemistry of indolylglyoxylamide TSPO high affinity ligands with anxiolytic-like effects显示文摘 | Simorini F Marini AM Taliani S | 2012 | CurrTop Med Chern2012，12，4： | 1 |
| 5 | Clearance of hepatitis B virus DNA and pre-S surface antigens in patients with markers of acute viral replication显示文摘 | Delfini C Colloca S Taliani G | 1989 | J Med Virol1989，28，3： | 1 |
| 6 | Correlation of preS antigensand clinical status during chronic hepatitis B virus infection显示文摘 | Taliani G Rapicetta M Francisci D | 1991 | Med Microbil Im munol1991，180，5： | 1 |
| 7 | Validity and reliability of the Italian version of the Chronic Liver Disease Question-naire (CLDQ-I) for the assessment of health-related quality of life 显示文摘 | Rucci P Taliani G Cirrineione L | 2005 | Digestive and liver disease2005，37，11： | 1 |
| 8 | Translocator protein ligandsa promising therapeutic tools for anxiety disorders 显示文摘 | Taliani S DaSettimo F DaPozzo E | 2009 | Curr Med Chem2009，16，26： | 1 |
| 9 | Structural requirements to obtain highly potent and selective 18 kDa translocator protein(TSPO)ligands显示文摘 | Taliani S Pugliesi I Da Settimo F | 2011 | Curr Top Med Chem2011，11，7： | 1 |
| 10 | Clearnce of Hepatitis B Virus DNA and Pre S Surface Antigens in Patients With Marckers of Acute Viral Replication显示文摘 | Delfini C Collca S Taliani G | 1989 | Journal of Medical Virology1989，28，： | 1 |
| 11 | Recent advances in the development of dual topoisomerase I and II inhibitors as anticancer drugs 显示文摘 | Salerno S Da Settimo F Taliani S | 2010 | Curr Med Chem2010，17，35： | 1 |
| 12 | Room temperature spin polarized injection in organic semiconductor显示文摘 | Dediu V Murgia M Matacotta F C Taliani C Barbanera S | 2002 | Solid State Communications2002，1224，： | 1 |
| 13 | Advantages of spectrophotometric reading of ELISA plates for determination of the HBs/anti-HB system显示文摘 | Taliani G Palombo G Tonelli MG | 1981 | Boll Soc Ital Biol Sper1981，57，21： | 1 |
| 14 | Electroluminescence in conjugated polymers 显示文摘 | FRIEND R H GYMER R W HOLMES A B BURROUGHES J H MARKS R N TALIANI C BRADLEY D D C DOS SANTOS D A BREDAS J L LOGDLUND M SALANECK W R | 1999 | Nature1999，397，： | 1 |
| 15 | Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the gamma-aminobutyric acid-A(GABAA)alpha2 benzodiazepine receptor显示文摘 | Taliani S Cosimelli B Da Settimo F | 2009 | J Med Chem2009，52，12： | 1 |
| 16 | Building effective propdylaxis of deep vein tdrombosis in tde outpatient setting显示文摘 | Agnelli G Taliani MR Verso M | 1999 | Blood Coagul Fibrinolysis1999，，10： | 1 |
| 17 | Clearance of hepatitis B virus DNA and pre-S surface antigens in patients with markers of acute viral replication 显示文摘 | Delfini C Colloca S Taliani G | 1989 | J Med Virol1989，28，3： | 1 |
| 18 | Clearance of hepatitis B virus DNA and Pre-S surface antigens in patients with markers of acute viral replication显示文摘 | Delfini C Colloca S Taliani G | 1989 | J Med Virol1989，28，3： | 1 |
| 19 | The diagnostic value of calcitoninmeasurement in wash-out fluid from fine-needle aspiration of thyroidnodules in the diagnosis of medullary thyroid cancer显示文摘 | Diazzi C Madeo B Taliani E | 2013 | EndocrinePractice2013，19，5： | 1 |
| 20 | Clearance of hepatitis B virus DNA and pre-S surface antigens in patients with markers of acute viral replication显示文摘 | Colloca S Taliani G | 1989 | J Med Virol1989，28，3： | 1 |
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