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| 1 | Androgen receptor: structure, role in prostate cancer and drug discovery显示文摘Androgens and androgen receptors (AR) play a pivotal role in expression of the male phenotype. Several diseases, such as androgen insensitivity syndrome (AIS) and prostate cancer, are associated with alterations in AR functions. Indeed, androgen blockade by drugs that prevent the production of androgens and/or block the action of the AR inhibits prostate cancer growth. However, resistance to these drugs often occurs after 2-3 years as the patients develop castration-resistant prostate cancer (CRPC). In CRPC, a functional AR remains a key regulator. Early studies focused on the functional domains of the AR and its crucial role in the pathology. The elucidation of the structures of the AR DNA binding domain (DBD) and ligand binding domain (LBD) provides a new framework for understanding the functions of this receptor and leads to the development of rational drug design for the treatment of prostate cancer. An overview of androgen receptor structure and activity, its actions in prostate cancer, and how structural information and high-throughput screening have been or can be used for drug discovery are provided herein. | MH Eileen TAN Jun LI H Eric XU Karsten MELCHER Eu-leong YONG | 2015 | Acta Pharmacologica Sinica2015，36，1： | 39 |
| 2 | Structural basis of AMPK regulation by adenine nucleotides and glycogen显示文摘激活安培的蛋白质 kinase (AMPK ) 为糖尿病,肥胖,和癌症的治疗是一个中央细胞的精力传感器和精力动态平衡,和一个有希望的药目标的管理者。这里我们人的 α 的现在的低分辨率的水晶结构; 1 β 2 γ 1 holo-AMPK 建筑群跳了到它的 allosteric 调节的人安培和肝糖模仿 cyclodextrin,两个在 phosphorylated (4.05 Å) 并且 non-phosphorylated (4.60 Å) 状态。另外,我们解决了 2.95 Å人的 kinase 领域(KD ) 的结构跳了到邻近的 autoinhibitory 领域(帮助) 并且表现了广泛生物化学并且 mutational 研究。一起,这些研究由安培和肝糖说明 allosteric AMPK 调整的内在的机制,其绑定改变在交替的帮助(安培) 和糖类绑定模块(肝糖) 之间的 equilibria 相互作用。 | Xiaodan Li Lili Wang X Edward Zhou Jiyuan Ke Parker W de Waal Xin Gu M H Eileen Tan Dongye Wang Donghai Wu H Eric Xu Karsten Melcher | 2015 | Cell Research2015，25，1： | 8 |
| 3 | Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy显示文摘 | Ting-Ting Tan Kurt Degenhardt Deirdre A. Nelson Brian Beaudoin Wilberto Nieves-Neira Philippe Bouillet Andreas Villunger Jerry M. Adams Eileen White | 2005 | Cancer Cell2005，，3： | 2 |
| 4 | Durable easy-cleaning and antibacterial cotton fabrics using fluorine-free silane coupling agents and CuO nanoparticles显示文摘Multifunctional fabrics of high durability through a scalable and eco-friendly technique remains a great challenge hindering their commercialization.In this work,we report a facile synthesis technique for the fabrication of superhydrophobic antibacterial fabrics by employing fluorine-free silane coupling agents as cross-linkers for enhanced durability.Three silane cross-linkers,Aminoethylaminopropyltrimethoxysilane(AEAPTMS),Aminopropyltriethoxysilane(APTES),and Methacryloyloxypropyltrimethoxysilane(MPTMS),have been investigated.During the fabrication,a low surface energy polymer,polydimethylsiloxane(PDMS)was first deposited on cotton fabrics.Subsequently,antibacterial copper oxide(CuO)nanoparticles were anchored on the PDMS coated fabrics using the silane cross-linkers.The as-prepared fabrics displayed high superhydrophobicity and antibacterial performance with water contact angle(WCA)>153,water shedding angle(WSA)<5,and up to 99%antibacterial efficiency.Additionally,the as-prepared fabrics displayed high durability against abrasion,ultrasonic washing,and soaking in harsh chemical environments.The air permeability and flexibility of the fabric was not compromised after the coating.The above-reported technique is simple,cost-effective and holds tremendous potential for large-scale production of energy-saving clothing and healthcare products. | Neha Agrawal Pearlie Sijia Low Jasmine Si Jia Tan Eileen Wen Mei Fong Yuekun Lai Zhong Chen | 2020 | Nano Materials Science2020，2，3： | 2 |
| 5 | At the center of the action: innovation and technology strategy research in the small business setting 显示文摘 | Justin Tan Eileen Fischer Ron Mitchell | 2009 | Journal of Small Business Management2009，47，3： | 1 |
| 6 | Curing behavior and ther-mal mechanical properties of cyanate ester blends显示文摘 | Henry C Y Koh Jie Dai Eileen Tan | 2006 | Journal of Ap-plied Polymer Science2006，102，5： | 1 |
| 7 | Generating mESC-derived insulin-producing cell lines through an intermediate lineage-restricted progenitor line显示文摘 | GuoDong Li Ruihua Luo Jiping Zhang Keng Suan Yeo Qizhou Lian Fei Xie Eileen Khia Way Tan Dorothée Caille Oi Lian Kon Manuel Salto-Tellez Paolo Meda Sai Kiang Lim | 2008 | Stem Cell Research2008，，1： | 1 |
| 8 | Curing behavior and thermal mechanical properties of cyanate ester blends显示文摘 | KOH H C Y DAI Jie TAN Eileen | | 0，，102： | 1 |
| 9 | Catalytic effect of 2,2 prime-diallyl bisphenol A on thermal curing of cyanate esters显示文摘 | Koh Henry C Y Dai Jie Tan Eileen | 2006 | J Appl Polym Sci2006，101，3： | 1 |
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