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| 1 | Effect of atrial natriuretic peptide on ischemia-reperfusion injury in a porcine total hepatic vascular exclusion model显示文摘AIM: To evaluate the effect of ANP on warm I/R injury in a porcine THVE model. METHODS: Miniature pigs (mini-pigs) weighing 16-24 kg were observed for 120 min after reperfusion following 120 min of THVE. The animals were divided into two groups. ANP (0.1 μg/kg per min) was administered to the ANP group (n = 7), and vehicle was administered to the control group (n = 7). Either vehicle or ANP was intravenously administered from 30 min before the THVE to the end of the experiment. Arterial blood was collected to measure AST, LDH, and TNF-α. Hepatic tissue blood ? ow (HTBF) was also measured. Liver specimens were harvested for p38 MAPK analysis and histological study. Those results were compared between the two groups. RESULTS: The AST and LDH levels were lower in the ANP group than in the control group; the AST levels were signifi cantly different between the two groups (60 min: 568.7 ± 113.3 vs 321.6 ± 60.1, P = 0.038 < 0.05, 120 min: 673.6 ± 148.2 vs 281.1 ± 44.8, P = 0.004 < 0.01). No signifi cant difference was observed in the TNF-α levels between the two groups. HTBF was higher in the ANP group, but the difference was not signif icant. A signifi cantly higher level of phosphorylated p38 MAPK was observed in the ANP group compared to the controlgroup (0 min: 2.92 ± 1.1 vs 6.38 ± 1.1, P = 0.011 < 0.05).Histological tissue damage was milder in the ANP group than in the control group. CONCLUSION: Our results show that ANP has a protective role in I/R injury with p38 MAPK activation in a porcine THVE model. | Katsumi Kobayashi Kiyohiro Oshima Masato Muraoka Takahiko Akao Osamu Totsuka Hisashi Shimizu Hiroaki Sato Kazumi Tanaka Kenjiro Konno Koshi Matsumoto Izumi Takeyoshi | 2007 | World Journal of Gastroenterology2007，13，25： | 4 |
| 2 | Effect of ONO-4057 and tacrolimus on ischemia-reperfusion injury of the liver显示文摘AIM: To investigate the effects of a novel Leukotriene B4 receptor antagonist and/or tacrolimus on ischemia-reperfusion in a rat liver model. METHODS: Male Lewis rats were pretreated with ONO-4057 (100 mg/kg) and/or tacrolimus (1 mg/kg) orally, and divided into four experimental groups; group 1 (control), group 2 (ONO-4057), group 3 (tacrolimus), group 4 (ONO-4057 + tacrolimus). RESULTS: There was a tendency for long survival in the groups treated with tacrolimus alone and ONO-4057 plus tacrolimus. Post-reperfusion serum aspartate aminotransferase levels decreased more signif icantly in ONO-4057 plus tacrolimus group (P < 0.01), than in the tacrolimus alone group (P < 0.05), compared to controls. CONCLUSION: This study demonstrated that pretreat-ment with ONO-4057 in combination with tacrolimus produced additive effects in a rat model of liver isch-emia-reperfusion injury. | Takayuki Takeichi Shinji Uemoto Sachiko Minamiguchi Izumi Takeyoshi Yukihiro Inomata Koichi Tanaka Eiji Kobayashi | 2009 | World Journal of Gastroenterology2009，15，45： | 3 |
| 3 | Smoke control in large spaces显示文摘 | Takeyoshi TANAKA Toshio YAMANA | 1985 | Fire Science and Technology1985，5，1： | 1 |
| 4 | Modeling the trajectory of window flames with regard to flow attachment to the adjacent wall显示文摘 | Keisuke Himoto Tsuneto Tsuchihashi Yoshiaki Tanaka Takeyoshi Tanaka | 2008 | Fire Safety Journal2008，，2： | 1 |
| 5 | Smoke control in large scale spaces (Partl : Analytic theories for simple smoke control problems)显示文摘 | Tanaka Takeyoshi Yamana Toshio | 1985 | Fire Science and Technology1985，5，1： | 1 |
| 6 | Smoke control in large scale spaces (Part Ⅰ):analytic theories for simple smoke control problems显示文摘 | Tanaka Takeyoshi Yamana Toshio | 1985 | Fire Science and Technology1985，5，1： | 1 |
| 7 | Living related liver transplantation for type Ⅱ citrullinemia using a graft from heterozygote donor 显示文摘 | Ohwada S Takeichi T Kaneko H Tomomasa T Morikawa A Yonemura K Asonuma K Tanaka K Kobayashi K Saheki T Takeyoshi I Morishita Y | 2001 | Transplantation2001，71，1： | 1 |
| 8 | Temperature profiles of window jet plume 显示文摘 | Yamaguchi Jun-ichi Tanaka Takeyoshi | 2005 | Fire Science and Tech- nology2005，24，1： | 1 |
| 9 | Hydrodynamic characteristics of a butterfly valve-prediction of pressure loss characteristics 显示文摘 | TAKEYOSHI Kimura TAKAHARU Tanaka KAYO Fujimotoa | 1995 | ISA Transactions1995，34，4： | 1 |
| 10 | Metallic Contaminant Detection using a High-Temperature Superconducting Quantum Interference Devices Gradiometer显示文摘我们为工业产品用高温度的超导的量干扰设备(HTS 枪乌) 开发磁性的金属性的沾染物察觉者。发现极端小的金属性的沾染物是为生产象锂离子电池那样的商业产品的制造商的一个重要问题。如果如此的沾染物引起损坏,产品的制造商由于不得不记起有缺点的产品承受大金融损失。以前,我们为在食物发现如此的极端小的粒子描述了一个系统。在这研究,我们描述系统的进一步的开发,为产品的残余领域的效果的减小,并且我们测试产品的平行磁化仅仅在产品的两结束产生残余领域。另外,我们代替磁强计使用枪乌 gradiometer 由测量磁场坡度减少边效果。我们测试系统的表演并且发现象一节锂离子电池的电极上的 50 x 50 mm2 一样小的粒子能清楚地是的那个微小的熨斗检测。当使用另外的方法时,这察觉水平是困难的完成。[从作者抽象] | Saburo Tanaka Tomohiro Akai Makoto Takemoto Yoshimi Hatsukade Takeyoshi Ohtani Yoshio Ikeda Shuichi Suzuki | 2010 | Chinese Physics Letters2010，27，8： | 0 |
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