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| 1 | Jianpi Qingchang decoction alleviates ulcerative colitis by inhibiting nuclear factor-κB activation显示文摘AIM To inve s t igat e t he t he r ape ut ic e f f e c t of Jianpi Qingchang decoction(JPQCD) on dextran sulfate sodium(DSS)-induced ulcerative colitis(UC) in mice.METHODS C57BL/c mice were injected intragastrically with 5% DSS instead of drinking water for 7 d, and their body weight, diarrhea severity and fecal bleeding were monitored, while the mice in the control group were treated with standard drinking water, without DSS. After 7 d, the DSS drinking water was changed to normal water and the DSS group continued with DSS water. The control and DSS groups were given normal saline by intragastric injection. The 5-aminosalicylic acid(5-ASA) group was treated orally with 5-ASA at a dose of 100 mg/kg daily. The JPQCD group was treated orally with JPQCD at a dose of 17.1 g/kg daily. On day 14, the colon length was measured, the colorectalhistopathological damage score was assessed, and protein levels of interleukin(IL)-1β, IL-8 and tumor necrosis factor-alpha(TNF-α) in colon supernatants were measured by enzyme-linked immunosorbent assay. m RNA expression of IL-1β, IL-8, TNF-α and nuclear factor-kappa B(NF-κB) was detected by realtime quantitative polymerase chain reaction. Western blotting was used to detect the protein expression of NF-κB and inhibitor of kappa B. RESULTS Acute inflammation occurred in the mice administered DSS, including the symptoms of losing body weight, loose feces/watery diarrhea and presence of fecal blood; all these symptoms worsened at 7 d. The colons of mice treated with DSS were assessed by histological examination, and the results confirmed that acute inflammation had occurred, as evidenced by loss of colonic mucosa and chronic inflammatory cell infiltration, and these features extended into the deeper layer of the colon walls. The expression levels of IL-1β, IL-8 and TNF-α in the DSS group were higher than those in the control group(P < 0.05), and the expression levels of IL-1β, IL-8 and TNF-α in the JPQCD and 5-ASA groups were lower than those in the DSS group after treating with JPQCD and 5-ASA. Comparing with the DSS group, the mR NA level of IL-1β, IL-8, TNF-α and NF-κB was significantly reduced by 5-ASA and JPQCD. The difference between JPQCD and 5-ASA groups was not statistically significant(P > 0.05). Comparing with the DSS group, due to using JPQCD and 5-ASA, significant suppression of activation in DSSinduced NF-κB and increased phosphorylation of IκB in mice with experimental colitis occurred(P < 0.05). The difference between the JPQCD group and the 5-ASA group was not statistically significant(P > 0.05). CONCLUSION Activation of the NF-κB signaling pathway is inhibited by JPQCD, which shows the potential mechanism by which JPQCD treats UC. | Lie Zheng Ya-Li Zhang Yan-Cheng Dai Xuan Chen De-Liang Chen Yue-Ting Dai Zhi-Peng Tang | 2017 | World Journal of Gastroenterology2017，23，7： | 30 |
| 2 | Jianpi Qingchang decoction regulates intestinal motility of dextran sulfate sodium-induced colitis through reducing autophagy of interstitial cells of Cajal显示文摘AIM To investigate the underlying effect of Jianpi Qingchang decoction(JQD) regulating intestinal motility of dextran sulfate sodium(DSS)-induced colitis in mice. METHODS C57BL/6 mice were randomly divided into four groups: the control group, the DSS group, the JQD group, and the 5-aminosalicylic acid group. Except for the control group, colitis was induced in other groups by giving distilled water containing 5% DSS. Seven days after modeling, the mice were administered corresponding drugs intragastrically. The mice were sacrificed on the 15^(th) day. The disease activity index, macroscopic and histopathologic lesions, and ultrastructure of colon interstitial cells of Cajal(ICC) were observed. The levels of tumor necrosis factor-alpha(TNF-α), interleukin(IL)-1β, IL-10 and interferon gamma(IFN-γ), the expression of nuclear factor-kappa B(NF-κB) p65, c-kit, microtubule-associated protein 1 light chain 3(LC3-Ⅱ) and Beclin-l m RNA, and the colonic smooth muscle tension were assessed. RESULTS Acute inflammation occurred in the mice administered DSS. Compared with the control group, the levels of IL-1β, TNF-α, IL-10 and IFN-γ, the expression of LC3-Ⅱ, Beclin-1 and NF-κB p65 m RNA, and the contractile frequency increased(P < 0.05), the expression of c-kit m RNA and the colonic smooth muscle contractile amplitude decreased in the DSS group(P < 0.05). Compared with the DSS group, the levels of IL-10 and IFN-γ, the expression of c-kit m RNA, and the colonic smooth muscle contractile amplitude increased(P < 0.05), the levels of TNF-α and IL-1β, the expression of LC3-Ⅱ, Beclin-1 and NF-κB p65 m RNA, and the contractile frequency decreased in the JQD group(P < 0.05).CONCLUSION JQD can regulate the intestinal motility of DSS-induced colitis in mice through suppressing intestinal inflammatory cascade reaction, reducing autophagy of ICC, and regulating the network path of ICC/smooth muscle cells. | Yan-Cheng Dai Lie Zheng Ya-Li Zhang Xuan Chen De-Liang Chen Li-Juan Wang Zhi-Peng Tang | 2017 | World Journal of Gastroenterology2017，23，26： | 26 |
| 3 | Episodic crustal anatexis and the formation of Paiku composite leucogranitic pluton in the Malashan Gneiss Dome, Southern Tibet显示文摘The Paiku composite leucogranitic pluton in the Malashan gneiss dome within the Tethyan Himalaya consists of tourmaline leucogranite,two-mica granite and garnet-bearing leucogranite.Zircon U-Pb dating yields that(1)tourmaline leucogranite formed at28.2±0.5 Ma and its source rock experienced simultaneous metamorphism and anatexis at 33.6±0.6 Ma;(2)two-mica granite formed at 19.8±0.5 Ma;(3)both types of leucogranite contain inherited zircon grains with an age peak at^480 Ma.These leucogranites show distinct geochemistry in major and trace elements as well as in Sr-Nd-Hf isotope compositions.As compared to the two-mica granites,the tourmaline ones have higher initial Sr and zircon Hf isotope compositions,indicating that they were derived from different source rocks combined with different melting reactions.Combined with available literature data,it is suggested that anatexis at^35 Ma along the Himalayan orogenic belt might have triggered the initial movement of the Southern Tibetan Detachment System(STDS),and led to the tectonic transition from compressive shortening to extension.Such a tectonic transition could be a dominant factor that initiates large scale decompressional melting of fertile high-grade metapelites along the Himalayan orogenic belt.Crustal anatexis at^28 Ma and^20 Ma represent large-scale melting reactions associated with the movement of the STDS. | GAO LiE ZENG LingSen HOU KeJun GUO ChunLi TANG SuoHan XIE KeJia HU GuYue WANG Li | 2013 | Chinese Science Bulletin2013，58，28： | 23 |
| 4 | Gut microbiota contributes to the distinction between two traditional Chinese medicine syndromes of ulcerative colitis显示文摘BACKGROUND Ulcerative colitis(UC)is considered to be closely associated with alteration of intestinal microorganisms.According to the traditional Chinese medicine(TCM)theory,UC can be divided into two disease syndromes called Pi-Xu-Shi-Yun(PXSY)and Da-Chang-Shi-Re(DCSR).The relationships among gut microbiota,TCM syndromes,and UC pathogenesis have not been well investigated.AIM To investigate the role of gut microbiota in UC and the distinction of microbiota dysbiosis between PXSY and DCSR syndromes.METHODS From May 2015 to February 2016,UC patients presenting to LongHua Hospital who met the established inclusion and exclusion criteria were enrolled in this retrospective study.Fresh stool specimens of UC patients with PXSY or DCSR were collected.The feces of the control group came from the health examination population of Longhua Hospital.The composition of gut bacterial communities in stool samples was determined by the pyrosequencing of 16S ribosomal RNA.The high-throughput sequencing reads were processed with QIIME,and biological functions were predicted using Phylogenetic Investigation of Communities by Reconstruction of Unobserved States.RESULTS The composition of gut bacterial communities in 93 stool samples(30 healthy controls,32 patients with PXSY syndrome,and 31 patients with DCSR syndrome)was determined by the pyrosequencing of 16S ribosomal RNA.Beta diversity showed that the composition of the microbiota was different among the three groups.At the family level,Porphyromonadaceae,Rikeneliaceae,and Lachnospiraceae significantly decreased while Enterococcus,Streptococcus,and other potential pathogens significantly increased in UC patients compared to healthy subjects.At the genus level,Parabacteroides,Dorea,and Ruminococcus decreased while Faeca-libacterium showed increased abundance in UC compared to healthy controls.Five differential taxa were identified between PXSY and DCSR syndromes.At the genus level,a significantly increased abundance of Streptococcus was observed in DCSR patients,while Lachnoclostridium increased in PXSY patients.The differential functional pathways of the gut microbiome between the PXSY and DCSR groups mainly included lipid metabolism,immunity,and the metabolism of polypeptides.CONCLUSION Our study suggests that the gut microbiota contributes to the distinction between the two TCM syndromes of UC. | Ya-Li Zhang Li-Ting Cai Jun-Yi Qi Yun-Zheng Lin Yan-Cheng Dai Na Jiao You-Lan Chen Lie Zheng Bei-Bei Wang Li-Xin Zhu Zhi-Peng Tang Rui-Xin Zhu | 2019 | World Journal of Gastroenterology2019，25，25： | 19 |
| 5 | Transplantation of endothelial progenitor cells transfected with VEGF165 to restore erectile function in diabetic rats显示文摘现在的学习调查了移植 endothelial 祖先细胞(EPC ) 的效果有进有糖尿病的可勃起的机能障碍(编辑) 的老鼠的阴茎海绵体的脉管的 endothelial 生长因素基因(VEGF165 ) 的 transfected。糖尿病的编辑的一个老鼠模型经由 streptozotocin 的 intraperitoneal 注射被构造。在 streptozotocin 治疗以后,预先对待从每三组老鼠的 EPC 被移植进他们的阴茎海绵体。我们的结果,监视的后面的 intracavernosal 压力(ICP ) ,看了在试用组在老鼠之中显著地增加的那 ICP 什么时候在基础条件和电的刺激期间与从在 blank-plasmid 和控制的老鼠的结果相比组织(P < 0.01 为两比较) 。组织学的检查在试用组在老鼠的阴茎海绵体揭示了广泛的 neovascularisation。荧光显微镜学在熬过的试用组移植 EPC 显示了那许多,区分了房间进 endothelial 并且集成于 neovascularisation 的地点。基于这研究的结果,我们断定进有糖尿病的编辑的老鼠的阴茎海绵体的 VEGF165-transfected EPC 的移植恢复可勃起的功能。 | Xin Gou Wei-Yang He Ming-Zhao Xiao Ming Qiu Ming Wang Yuan-Zhong Deng Chao-Dong Liu Zao-Bing Tang lie Li Yong Chen | 2011 | Asian Journal of Andrology2011，13，2： | 17 |
| 6 | 复杂边界田块旋翼无人机自主作业路径规划显示文摘针对农用无人机复杂边界田块下的作业问题,提出一种对田块边界形状具有普适性意义的旋翼无人机作业路径规划算法,以快速获得凸多边形、凹多边形、带孔洞多边形甚至多个多边形形式的复杂边界田块情形下的飞行作业轨迹。首先,基于田块边界多边形顶点数据的存储规则,采用多边形分组法,区分所属不同田块的多边形,建立按区域即田块为单元进行航线计算的基础;针对单田块的内、外边界多边形,采用活性边表法实现单个多边形扫描线填充的快速求交解算,得到初始扫描线,再对处于同一航向位置上的内、外多边形两类扫描线组采用线段布尔运算“减法”操作处理,获得预设航向条件下的作业航线;以最小航线间转移路径总长度为优化目标,引入贪婪算法、凸多边形最小跨度法和步进旋转法,综合进行航线排序优化和航向优化,获得不考虑障碍物条件下的完整作业路径。为进一步扩大算法的应用范围,假设田块边界上存在障碍物,且高度大于作业高度,继续增加转移过程的安全性判断及处理算法。针对假想田块和实际田块边界的多组算法仿真试验结果表明,所设计的算法可处理各种复杂边界类型的田块;在不考虑障碍物影响时算法耗时15 ms^19.2 s;相比于只进行航线排序优化的情况,同时进行航向和航线排序优化后,航线间转移路径总长度下降了23.04%~45.98%;而考虑障碍物影响时处理耗时也在离线应用的可接受范围内。该算法的通用性、可靠性、效率和优化效果均可满足各种复杂边界二维田块无障碍物和有障碍物条件下的农用无人机作业的相关要求。 | 黄小毛 张垒 TANG Lie 唐灿 李小霞 贺小伟 | 2020 | 农业机械学报2020，51，3： | 14 |
| 7 | 含障碍物多田块下旋翼无人机作业返航补给规划研究显示文摘针对同一区域内相邻多田块的无人机单机作业任务路径规划问题,从续航、负重等实际问题出发,考虑种肥药液和油电能源等消耗品的按需多次返航补给,提出并实现一套含障碍物多田块条件下单机多架次作业的农用旋翼无人机自主飞行作业的路径规划算法。在给出作业路径规划优化目标模型的基础上,提出“先路径、后航次”两步优化法,先以最短路径为优化目标规划初始作业路径,然后考虑消耗品按需返航后的补给与续作问题进行航次规划。针对变量喷播和恒量喷播2种喷播模式,分别提出两种作业航向方向安排原则、航线调度原则、补给方式和续作模式,规划出4种不同航向及航线调度组合策略下的初始作业路径,并在此基础上进一步给出4种不同组合补给续作优化策略下的航次安排方案。针对假想田块和真实田块的算例仿真测试结果表明,规划初始作业路径的4种优化策略能够稳定高效运行,算法耗时78~105161 ms,转移路径优化效果为10.25%~33.81%;在航次优化算法方面,算法耗时略有增加,为21170~106393 ms,转移路径优化效果为14.00%~26.27%,补给次数的最好优化效果从15次降到10次。总体来说,相同条件下完全重置+重排续作的组合策略表现较优。 | 黄小毛 唐灿 TANG Lie 罗承铭 李文成 张垒 | 2020 | 农业机械学报2020，51，7： | 7 |
| 8 | Design of variable screw pitch rib snapping roller and residue cutter for corn harvesters显示文摘The blocking between two snapping rollers will seriously constrict the harvesting efficiency for corn harvester.A variable screw pitch rib snapping roller was developed to solve this problem.The comparative experiment between fixed screw pitch rib snapping rollers and variable screw pitch rib snapping rollers illustrated that variable screw pitch ribs can avoid corn-stalk blocking effectively,and it can improve working efficiency by 56.7%.Conservation tillage with standing corn residue was testified that it had a strong control of soil wind erosion.In order to implement this mode of conservation tillage at a production scale,a cutter was developed in this study.Subsequently,two experiments were conducted,one was to test the cutting ratio(defined as the totally cut off stalk population divided by total stalk population),and the other one was to test standing-residue height.The experiment results showed that the mean cutting ratio increased significantly(p<0.05)along with increasing height of cutter-head above the ground(cutting height);the cutting ratio’s mean value increased significantly(p<0.05)along with the decreasing angle between the cutter-head and the ground(cutting angle).The average standing-residue height increased along with the increase of cutting height from 300 mm to 500 mm.The average standing-residue height increased significantly(p<0.05)along with the decrease of cutting angle from 15°to 0°.Therefore,the newly designed snapping roller can improve the harvesting efficiency and prolong the working life of the cutting table;and the cutter can promote the popularization of the conservation tillage with standing corn residue in Northeast China. | Wang Gang Jia Honglei Tang Lie Zhuang Jian Jiang Xinming Guo Mingzhuo | 2016 | International Journal of Agricultural and Biological Engineering2016，9，1： | 6 |
| 9 | Extrusion process modeling for aqueous-based ceramic pastes-Partl : Constitu- tive model 显示文摘 | Li Mingyang Tang Lie Landers R G | 2013 | Journal of Manufacturing Science and Engi- neering2013，135，10： | 1 |
| 10 | Extrusion process modeling for aqueous- based ceramic pastes-Part2: Experi- mental verification 显示文摘 | Li Mingyang TANG Lie Robert G | 2013 | Journal of Manufacturing Science and Engineering2013，135，10： | 1 |
| 11 | Melt pool temperature modeling and control for laser metal deposition processes-part I: online temperature control 显示文摘 | Tang Lie Landers R G | 2010 | Journal of Manufacturing Science and Engineering2010，132，01： | 1 |
| 12 | Process plan- ning and control for functionally graded material fabrication using freeze-form extrusion fabricaion 显示文摘 | Brad Deuser Tang Lie Jeff Geldmeier | 2011 | Missouri Universi- ty of Science and Technology Rolla MO 654092011，2011，： | 1 |
| 13 | Freeze-form extru- sion fabrication of functionally graded materials显示文摘 | Leu Ming C Deuser B K Tang Lie | 2012 | CIRP An- nals-Manufacturing Technology2012，61，： | 1 |
| 14 | Melt pool temperature control for laser metal deposition processes-part II: layer-to-layer temperature control 显示文摘 | Tang Lie Landers R G | 2010 | Journal of Manufacturing Science and Engineering2010，132，01： | 1 |
| 15 | Clinicopathological characteristics and prognostic factors of asymptomatic IgA nephropathy显示文摘 | Shen PC lie LQ Tang Y | 2010 | J lnvestig Med2010，58，3： | 1 |
| 16 | Gradually modulating the three parts of D-π-A type polymers for high-performance organic solar cells显示文摘Organic solar cells(OSCs)have received great attention for the prominent advantage of low-cost,light-weight and potential for fabricating flexible and semi-transparent device via roll-to-roll printing toward making better use of inexhaustible renewable clean energy during the past years[1-4]. | Jialing Zhou Peiqing Cong Lie Chen Bao Zhanga Yanfang Geng Ailing Tang Erjun Zhou | 2021 | Journal of Energy Chemistry2021，30，11： | 1 |
| 17 | On the origin of the Tsushima Warm Current Water显示文摘OntheoriginoftheTsushimaWarmCurrentWater￥TangYuxiangandHeung-JaeLie(FirstinstituteOfOceanography,StateOceanicAdministration,Q... | Tang Yuxiang and Heung-Jae Lie (First institute Of Oceanography, State Oceanic Administration, Qingdao 266003, China2. Korea Ocean Research & Development Institute, Ansan, Korea) | 1996 | Acta Oceanologica Sinica1996，15，2： | 1 |
| 18 | High-performance impementation for graph based packet classification algorithm on network process sor communications 显示文摘 | TANG Yi-yah QIAN Lie | 2004 | IEEE International Conference2004，24，： | 1 |
| 19 | Plant identification in mosaicked crop row images for automatic emerged corn plant spacing measurement显示文摘 | Tang Lie Tian Lei F | 2008 | Transactions of the ASABE2008，51，6： | 1 |
| 20 | Jianpi Qingchang Bushen decoction improves inflammatory response and metabolic bone disorder in inflammatory bowel disease-induced bone loss显示文摘BACKGROUND Bone loss and osteoporosis are commonly described as extra-intestinal manifestations of inflammatory bowel disease(IBD).Jianpi Qingchang Bushen decoction(JQBD)is a prescription used in clinical practice.However,further studies are needed to determine whether JQBD regulates the receptor activator of nuclear factor kappa B(NF-κB)(RANK)/receptor activator of NF-κB ligand(RANKL)/osteoprotegerin(OPG)pathways and could play a role in treating IBD-induced bone loss.AIM To evaluate the therapeutic effect of JQBD in IBD-induced bone loss and explore the underlying mechanisms.METHODS An IBD-induced bone loss model was constructed by feeding 126-to-8-wk-old interleukin-10(IL-10)-knockout mice with piroxicam for 10 d.The mice were randomly divided into model and JQBD groups.We used wild-type mice as a control.The JQBD group was administered the JQBD suspension for 2 wk by gavage,while the control and model groups were given normal saline at the corresponding time points.All mice were killed after the intervention.The effect of JQBD on body weight,disease activity index(DAI),and colon length was analyzed.Histopathological examination,colon ultrastructure observation,and micro-computed tomographic scanning of the lumbar vertebrae were performed.The gene expression of NF-κB,tumor necrosis factor-α(TNF-α),IL-1β,IL-6,and IL-8 in the colon was evaluated by real-time polymerase chain reaction.Colon samples were assessed by Western blot for the expression of RANKL,OPG,RANK,and NF-κB proteins.RESULTS The model group lost body weight,had a shorter colon,and showed a dramatic increase in DAI score,whereas JQBD had protective and therapeutic effects.Treatment with JQBD significantly improved inflammatory cell infiltration and reduced crypt abscess and ulcer formation.Threedimensional imaging of the vertebral centrum in the model group revealed a lower bone mass,loose trabeculae,and“rod-shaped”changes in the structure compared to the control group and JQBD groups.The bone volume/total volume ratio and bone mineral density were significantly lower in the model group than in the control group.JQBD intervention downregulated the NF-κB,TNF-α,IL-1β,IL-6,and IL-8 m RNA expression levels.The RANKL and OPG protein levels were also improved.CONCLUSION JQBD reduces inflammation of the colonic mucosa and inhibits activation of the RANK/RANKL/OPG signaling pathway,thereby reducing osteoclast activation and bone resorption and improving bone metabolism. | Ya-Li Zhang Qian Chen Lie Zheng Zi-Wei Zhang Yu-Jun Chen Yan-Cheng Dai Zhi-Peng Tang | 2022 | World Journal of Gastroenterology2022，28，13： | 1 |
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