8篇
您的检索式：作者名="Tanjun Tong"
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| 1 | Upregulation of SIRT1 by 17β-estradiol depends on ubiquitin-proteasome degradation of PPAR-γ mediated by NEDD4-1显示文摘17β-estradiol (E2) treatment of cells results in an upregulation of SIRT1 and a down-regulation of PPARγ. The decrease in PPARγ expression is mediated by increased degradation of PPARγ. Here we report that PPARγ is ubiquitinated by HECT E3 ubiquitin ligase NEDD4-1 and degraded, along with PPARγ, in response to E2 stimulation. The PPARγ interacts with ubiquitin ligase NEDD4-1 through a conserved PPXY-WW binding motif. The WW3 domain in NEDD4-1 is critical for binding to PPARΓ. NEDD4-1 overexpression leads to PPARγ ubiquitination and reduced expression of PPARγ. Conversely, knockdown of NEDD4-1 by specific siRNAs abolishes PPARΓ ubiquitination. These data indicate that NEDD4-1 is the E3 ubiquitin ligase responsible for PPARγ ubiquitination. Here, we show that NEDD4-1 delays cellular senescence by degrading PPARΓ expression. Taken together, our data show that E2 could upregulate SIRT1 expression via promoting the PPARΓ ubiquitination-proteasome degradation pathway to delay the process of cell senescence. | Limin Han Pan Wang Ganye Zhao Hui Wang Meng Wang Jun Chen Tanjun Tong | 2013 | Protein & Cell2013，4，4： | 3 |
| 2 | Senescence Delay of Human Diploid Fibroblast Induced by Anti-sense P16INK4a Expression显示文摘 | Jianming Duan Zongyu Zhang and Tanjun Tong | 2001 | J Biol Chem2001，276，48： | 1 |
| 3 | Advances in the research on p38 kinase显示文摘 | Cai Jiaxin Tong Tanjun | 1993 | Progress in Physiological Sciences1993，24，2： | 1 |
| 4 | The molecular basis of Chinese herbs(Astragali and Angelica)on increasing serum albumin synthesis in nephritic rats显示文摘 | Li Liying Chen Menghua Tong Tanjun | | 0，，01： | 1 |
| 5 | The molecular basis of Cllinese herbs(Astragali and Angelica)on increasing serum albumin synthesis in nephritic rats显示文摘 | kiying Li Menghua chen Tanjun Tong et aI | 1998 | Nephrology1998，4，1： | 1 |
| 6 | The molecular basis of Chinese herbs(Astragali and Angelica)on increasing serum albumin synthesis in nephritic rats显示文摘 | Liying Li Menghua chen Tanjun Tong | 1998 | Nephrology1998，4，1： | 1 |
| 7 | The molecular ba- sis of Chinese herbs( Astragali and Angelica) on increasing ser- um albumin synthesis in nephrotic rats 显示文摘 | Liying Li Menghua Chen Tanjun Tong | 1998 | NePhrology1998，4，56： | 1 |
| 8 | Mitochondrion-processed TERC regulates senescence without affecting telomerase activities显示文摘Mitochondrial dysfunctions play major roles in ageing.How mitochondrial stresses invoke downstream responses and how specificity of the signaling is achieved, however, remains unclear. We have previously discovered that the RNA component of Telomerase TERC is imported into mitochondria, processed to a shorter form TERC-53, and then exported back to the cytosol. Cytosolic TERC-53 levels respond to mitochondrial functions, but have no direct effect on these functions, suggesting that cytosolic TERC-53 functions downstream of mitochondria as a signal of mitochondrial functions. Here, we show that cytosolic TERC-53 plays a regulatory role on cellular senescence and is involved in cognition decline in 10 months old mice, independent of its telomerase function. Manipulation of cytosolic TERC-53 levels affects cellular senescence and cognition decline in 10 months old mouse hippocampi without affecting telomerase activity, and most importantly, affects cellular senescence in terc^-/- cells. These findings uncover a senescence-related regulatory pathway with a non-coding RNA as the signal in mammals. | Qian Zheng Peipei Liu Ge Gao Jiapei Yuan Pengfeng Wang Jinliang Huang Leiming Xie Xinping Lu Fan Di Tanjun Tong Jun Chen Zhi Lu Jisong Guan Geng Wang | 2019 | Protein & Cell2019，10，9： | 0 |
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