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| 1 | What does it mean to be just 177 显示文摘 | Taro C O'shea J | 2006 | Nature2006，441，11： | 1 |
| 2 | Adrenocorticotropic hormone-secreting pancreatic neuroendocrine carcinoma with multiple organ infections and widespread thrombosis:A case report显示文摘BACKGROUND Ectopic adrenocorticotropic hormone(ACTH)-secreting neuroendocrine tumors are rare diseases.Patients with ACTH-secreting pancreatic neuroendocrine carcinomas have a poor prognosis.Infections and coagulopathies have been reported as the cause of death.However,detailed clinical descriptions of the morbid complications of ACTH-secreting neuroendocrine carcinomas have not been reported.CASE SUMMARY A 78-year-old Japanese woman consulted a medical center due to systemic edema and epigastric discomfort.Laboratory analysis revealed hypercortisolemia with increased ACTH secretion without diurnal variation in serum cortisol level.An enhanced computed tomography(CT)scan revealed a 3-cm tumor in the pancreatic head.The cytological material from endoscopic ultrasound-guided fine-needle aspiration was compatible with ACTHsecreting pancreatic neuroendocrine carcinoma.The Ki-67 index was 40%.She was transferred to Mie University Hospital for surgical treatment.The patient was diagnosed with urinary tract infection,cytomegalovirus hepatitis,esophageal candidiasis,pulmonary infiltrates suspicious for Pneumocystis carinii pneumonia,peripheral deep vein thrombosis,pulmonary embolism,and disseminated intravascular coagulation.The multiple organ infections and thromboses responded well to antimicrobial and anticoagulant therapy.Radioisotope studies disclosed a pancreatic tumor and a metastatic lesion in the liver,whereas somatostatin receptor scintigraphy showed negative findings,suggesting the primary and metastatic tumors were poorly differentiated.A CT scan before admission showed no metastatic liver lesion,suggesting that the pancreatic tumor was rapidly progressing.Instead of surgery,antitumor chemotherapy was indicated.The patient was transferred to another hospital to initiate chemotherapy.However,she died four months later due to the rapidly progressive tumor.CONCLUSION ACTH-secreting pancreatic neuroendocrine neoplasm is a rare disease with a very poor prognosis.The clinical course and acute complications of the tumor remain unreported.Here we report the clinical course of a rapidly progressive case of ACTH-secreting pancreatic neuroendocrine tumor that developed infectious complications due to many types of pathogens in multiple organs,widespread thromboses,pulmonary embolism,and disseminated intravascular coagulation. | Akihiro Yoshihara Kota Nishihama Chisa Inoue Yuko Okano Kazuhito Eguchi Soichiro Tanaka Kanako Maki Valeria Fridman D'Alessandro Atsuro Takeshita Taro Yasuma Mei Uemura Toshinari Suzuki Esteban C Gabazza Yutaka Yano | 2022 | World Journal of Clinical Cases2022，10，17： | 1 |
| 3 | Endostatin reguhtes endothelial cell adhesion and cytoskeletal organization显示文摘 | Johan D Michael C Taro M | 2002 | Cancer Res2002，62，7： | 1 |
| 4 | Sodium-glucose co-transporter-2 inhibitor-associated euglycemic diabetic ketoacidosis that prompted the diagnosis of fulminant type-1 diabetes:A case report显示文摘Fulminant type 1 diabetes mellitus(FT1DM)is a subtype of type 1 diabetes mellitus characterized by an abrupt onset and a rapid and complete functional loss of isletβcells.It is a very rare disease generally associated with ketoacidosis and the absence of circulating pancreatic islet-related autoantibodies.Diabetic ketoacidosis with normal blood glucose levels has been reported during sodiumglucose co-transporter 2(SGLT2)inhibitor therapy.CASE SUMMARY The patient was a 43-year-old woman that consulted a medical practitioner for malaise,thirst,and vomiting.Blood analysis showed high blood glucose levels(428 mg/dL),a mild increase of hemoglobin A1c(6.6%),and increased ketone bodies in urine.The patient was diagnosed with type 2 diabetes mellitus.The patient was initially treated with insulin,which was subsequently changed to an oral SGLT2 inhibitor.Antibodies to glutamic acid decarboxylase were negative.Four days after receiving oral SGLT2 inhibitor,she consulted at Mie University Hospital,complaining of fatigue and vomiting.Laboratory analysis revealed diabetic ketoacidosis with almost normal blood glucose levels.The endogenous insulin secretion was markedly low,and the serum levels of islet-related autoantibodies were undetectable.We made the diagnosis of FT1DM with concurrent SGLT2 inhibitor-associated euglycemic diabetic ketoacidosis.The patient's general condition improved after therapy with intravenous insulin and withdrawal of oral medication.She was discharged on day 14 with an indication of multiple daily insulin therapy.CONCLUSION This patient is a rare case of FT1DM that developed SGLT2 inhibitor-associated diabetic ketoacidosis with almost normal blood glucose levels.This case report underscores the importance of considering the diagnosis of FT1DM in patients with negative circulating autoantibodies and a history of hyperglycemia that subsequently develop euglycemic diabetic ketoacidosis following treatment with a SGLT2 inhibitor. | Taro Yasuma Yuko Okano Soichiro Tanaka Kota Nishihama Kazuhito Eguchi Chisa Inoue Kanako Maki Akihiro Uchida Mei Uemura Toshinari Suzuki Corina N D'Alessandro-Gabazza Esteban C Gabazza Yutaka Yano | 2021 | World Journal of Clinical Cases2021，9，13： | 1 |
| 5 | Diffusion-weighted whole- body imaging'with background body signal suppression ( DWIBS ) : features andpotential application inoncology 显示文摘 | Thomas C Kwee Taro Takahara | 2008 | EurRaio12008，18，19： | 1 |
| 6 | Complete withdrawal of glucocorticoids after dupilumab therapy in allergic bronchopulmonary aspergillosis:A case report显示文摘BACKGROUND Allergic bronchopulmonary aspergillosis(ABPA)is an allergic reaction to Aspergillus species that aggravates bronchial asthma.Previous studies demonstrated the glucocorticoid-sparing effect of dupilumab in patients with ABPA.There is no report of complete withdrawal of glucocorticoids after dupilumab.CASE SUMMARY The patient was a 54-year-old woman with bronchial asthma treated with inhaled corticosteroids and a long-acting beta-2 agonist.She consulted our institution for productive cough and fever in March 2017.Chest computed tomography scan revealed mucoid impaction,and the bronchial lavage fluid culture was positive for Aspergillus fumigatus.The diagnosis was ABPA.The patient was treated with oral glucocorticoids from April 2017 to November 2017.In January 2019,she had bronchial asthma exacerbation,and a chest computed tomography scan showed recurrent mucoid impaction.She was treated with oral glucocorticoids and itraconazole.In February 2020,during tapering of oral glucocorticoid,she had the third episode of bronchial asthma exacerbation and a mucoid impaction.The patient was treated with dupilumab in addition to oral glucocorticoid and itraconazole.The clinical response improved,and oral glucocorticoid was discontinued in June 2020.CONCLUSION This is the first case of ABPA in which complete withdrawal of glucocorticoid was possible after treatment with dupilumab. | Tadashi Nishimura Tomohito Okano Masahiro Naito Chikashi Tsuji Soichi Iwanaka Yasumasa Sakakura Taro Yasuma Hajime Fujimoto Corina N D'Alessandro-Gabazza Yasuhiro Oomoto Tetsu Kobayashi Esteban C Gabazza Hidenori Ibata | 2021 | World Journal of Clinical Cases2021，9，23： | 1 |
| 7 | The incidence of thyroid carcinoma in Hashimoto's thyroiditis显示文摘 | Ott RA Mchenry C Taros H | 1987 | Am Surg1987，53，8： | 1 |
| 8 | Distinct regulation of interleukin-17 in human T helper lymphocytes显示文摘 | Chen Z Taro C M Muul L | 2007 | Arthritis Rheum2007，56，9： | 1 |
| 9 | The interleukin 23 receptor is essential for the tenninal differentiation of interleukin 17-producing effector T helper cells in vivo 显示文摘 | McGeachy M J Chen Y Taro C M | 2009 | Nat Immunol2009，10，3： | 1 |
| 10 | 妊娠期母牛限饲对胎儿胃肠道的影响显示文摘研究旨在评估妊娠期母牛限饲对胎儿胃肠道(GIT)发育的影响。试验组奶牛喂养饲料限制在维持水平的120%而对照组随意采食。妊娠母牛在第136、189、239和269天被屠杀并对胎儿的胃肠道进行评估。试验结果表明,限饲对胎儿的体重(P=0.17)、身体长度(P=0.13)和GIT质量(P=0.51)没有显著影响。然而,在限制性水平下胎儿小肠的重量比对照组高11.24%(P=0.04)。此外,与对照组相比,限饲的胎儿小肠的长度和其绒毛分别极显著提高为12.93%和16.44%(P<0.01)。研究结果表明,母体限饲不会影响大部分胎儿胃肠道的发育,但会提高小肠表面积。 | Duarte M S Gionbelli M P Paulino P V R Sero N V L Martins T S Tótaro P I S Nevesd C A Valadares Filho S C Dodson M V Zhu M Du M | 2013 | 饲料博览2013，，7： | 0 |
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