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| 1 | Single small molecule-assembled nanoparticles mediate efficient oral drug delivery显示文摘Oral drug delivery,which requires surviving the harsh environment in the gastrointestinal(Gl)tract and penetrating the intestinal epithelium,has not bee n achieved using simple formulatio n nan oparticles(NPs).Medici nal natural products(MNPs)have bee n widely used in traditi onal medicine for disease management through oral consumption.However,most pharmacologically active compounds within MNPs do not have the properties suitable for oral applicatio ns.We hypothesize that some MNPs contain n atural nano materials that can convert those compounds into oral formulations by forming NPs.After screening 66 MNPs,we identified five classes of small molecules that form NPs,many of which are capable of efficient drug encapsulation and Gl penetration.We show that one of them,dehydrotrametenolic acid(DTA),is capable of mediating oral delivery for effective disease treatment.We determined that DTA NPs assemble through hydrogen bonding and penetra怕the Gl tract via apical sodium-depe ndent bile acid tran sporter.Our study reveals a no vel class of single comp orient,small molecule-assembled NPs for oral drug delivery,and suggests a n ovel approach to modernizi ng MNPs through nano material discovery. | Xin Yang Chao Ma Zeming Chen Jun Liu Fuyao Liu Rongbin Xie Haitian Zhao Gang Deng Ann TChen Ningbo Gong Lei Yao Pengjian Zuo Kangkang Zhi Jiacheng Wang Xiaobin Gao Jing Wang Louzhen Fan Jiangbing Zhou | 2019 | Nano Research2019，12，10： | 4 |
| 2 | Proteomics of ischemia and reperfusion iniunes in rabbit myocardium with and without intervention by an oxygen-free radical scavenger显示文摘 | White MY Tchen AS Mc Carron HC | 2006 | Proteomics2006，6，23： | 1 |
| 3 | Cognitive function,fatigue,and menopausal symptoms in women receiving adjuvant chemotherapy for breast eancer显示文摘 | Tchen N Juffs HG Downie FP | 2003 | J Clin Oncol2003，21，22： | 1 |
| 4 | Anew methodforsta-bilizationofnetworkedcontrolsystemswithrandomde-lays显示文摘 | LZhang YShi TChen etal | 2005 | IEEE Trans Autom Control2005，50，8： | 1 |
| 5 | Anew methodforstabi-lizationofnetworkedcontrolsystemswithrandom de-lays显示文摘 | LZhang YShi TChen etal | 2005 | IEEE Trans Automat Contr2005，50，8： | 1 |
| 6 | Proteomics of ischemia and reperfusion injuries in rabbit myoeardium with and without intervention by an oxygen-free radical scavenger 显示文摘 | White MY Tchen AS McCarron HC | 2006 | Proteomics2006，6，23： | 1 |
| 7 | Molecular characterizalion of a wheat Thinapyrum ponticum partial amphiploid and it derivatives for resistance to leaf rust 显示文摘 | IA H J tChen QConner R L | 2003 | Genome2003，46，5： | 1 |
| 8 | The relation between motorevoked potential and clinical motor status in stroke patients显示文摘 | TSAI SY TCHEN PH CHEN JD | 1992 | Electromyogr Clin Neurophysiol1992，32，： | 1 |
| 9 | Efficacy of rituximab in a case of refractory bullous pemphigoid 显示文摘 | Reguia'f Z Tchen T Perceau G | 2009 | Ann Dermatol Venereol2009，136，5： | 1 |
| 10 | 2D Laue focusing of X ray radiation by a double crystal system显示文摘 | TCHEN T | 2002 | Technical Physics2002，47，6： | 1 |
| 11 | Posttranslational regulation of tristetraprolin subcellular localization and protein stability by p38 mitogen-activated protein kinase and extracellular signal-regulated kinase pathways显示文摘 | Brook M Tchen CR Santalucia T | 2006 | Mol Cell Biol2006，26，6： | 1 |
| 12 | On the spectrum of energy in turbulent shear flow 显示文摘 | Tchen C M | 1953 | Journal of research of the national bureau of standards1953，50，： | 1 |
| 13 | Purification of Black Moor Goldfish melanophores and responses to epinephrine显示文摘 | Carl R. Clark John D. Taylor T. T. Tchen | 1987 | In Vitro Cellular & Developmental Biology1987，，6： | 1 |
| 14 | Chemically modified nucleic acids as immunodetectable probes in hybridization experiments显示文摘 | Tchen P Fuchs RPP Sage F | 1984 | Proc Natl Acad Sci USA1984，81，： | 1 |
| 15 | Quality of life and understanding of disease status among cancer patients of different ethnic显示文摘 | Tchen N Bedard P Yi Q-L | | 0，，04： | 1 |
| 16 | Posttranslational regulation of tristetraprolin subcellular localization and protein stability by p38 mitogen-activated protein kinase and extracellular signal-regulated kinase pathways显示文摘 | Brook M Tchen CR Santalucia T | 2006 | Mol Cell Biol2006，26，： | 1 |
| 17 | Omnidirectional gap and defect mode of one-dimensional photonic crystals with single-negative materials显示文摘 | Jiang H TChen H Li H Q | 2004 | Phys Rev B2004，70，24： | 1 |
| 18 | The relation between motor evoked potential and clinical motor status in stroke patients显示文摘 | Tsai S Y Tchen P H Chen J D | 1992 | Electromyogr-Clin-Neurophysiol1992，32，12： | 1 |
| 19 | Proteomics of ischemia and reperfusion injuries in rabbit myocardium with and without intervention by an oxygen-free radical scavenger显示文摘 | White MY Tchen AS McCarron HC | 2006 | Proteomics2006，6，23： | 1 |
| 20 | Efficacy of rituximab in a case of refractory bullous pemphigoid显示文摘 | ReguiaY Z Tchen T Perceau G | 2009 | Ann Dermatol Venereol2009，136，5： | 1 |
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