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| 1 | Removal of diminutive colorectal polyps: A prospective randomized clinical trial between cold snare polypectomy and hot forceps biopsy显示文摘AIM To compare the efficacy and safety of cold snare polypectomy(CSP) and hot forceps biopsy(HFB) for diminutive colorectal polyps.METHODS This prospective, randomized single-center clinical trial included consecutive patients ≥ 20 years of age with diminutive colorectal polyps 3-5 mm from December 2014 to October 2015. The primary outcome measures were en-bloc resection(endoscopic evaluation) and complete resection rates(pathological evaluation). The secondary outcome measures were the immediate bleeding or immediate perforation rate after polypectomy, delayed bleeding or delayed perforation rate after polypectomy, use of clipping for bleeding or perforation, and polyp retrieval rate. Prophylactic clipping after polyp removal wasn't routinely performed.RESULTS Two hundred eight patients were randomized into the CSP(102), HFB(106) and 283 polyps were evaluated(CSP: 148, HFB: 135). The en-bloc resection rate was significantly higher with CSP than with HFB [99.3%(147/148) vs 80.0%(108/135), P < 0.0001]. The complete resection rate was significantly higher with CSP than with HFB [80.4%(119/148) vs 47.4%(64/135), P < 0.0001]. The immediate bleeding rate was similar between the groups [8.6%(13/148) vs 8.1%(11/135), P = 1.000], and endoscopic hemostasis with hemoclips was successful in all cases. No cases of perforation or delayed bleeding occurred. The rate of severe tissue injury to the pathological specimen was higher HFB than CSP [52.6%(71/135) vs 1.3%(2/148), P < 0.0001]. Polyp retrieval failure was encountered CSP(7), HFB(2).CONCLUSION CSP is more effective than HFB for resecting diminutive polyps. Further long-term follow-up study is required. | Yoriaki Komeda Hiroshi Kashida Toshiharu Sakurai George Tribonias Kazuki Okamoto Masashi Kono Mitsunari Yamada Teppei Adachi Hiromasa Mine Tomoyuki Nagai Yutaka Asakuma Satoru Hagiwara Shigenaga Matsui Tomohiro Watanabe Masayuki Kitano Takaaki Chikugo Yasutaka Chiba Masatoshi Kudo | 2017 | World Journal of Gastroenterology2017，23，2： | 20 |
| 2 | Acute pancreatitis secondary to intramural duodenal hematoma:Case report and literature review显示文摘Nontraumatic intramural duodenal hematoma(IDH) is rare disease and it is generally related to coagulation abnormalities.Reports of nontraumatic IDH associated with pancreatic disease are relatively rare,and various conditions including acute or chronic pancreatitis are thought to be associated with nontraumatic IDH.However,the association between IDH and acute pancreatitis remains unknown.We report the case of a 45-year-old man who presented with vomiting and right hypochondrial pain.He had no medical history,but was a heavy drinker.The diagnosis of IDH was established by computed tomography,ultrasonography and endoscopy,and it was complicated by acute pancreatitis.The lesions resolved with conservative management.We discuss this case in the context of previously reported cases of IDH concomitant with acute pancreatitis.In our patient,acute pancreatitis occurred concurrently with hematoma,probably due to obstruction of the duodenal papilla,or compression of the pancreas caused by the hematoma.The present analysis of the published cases of IDH with acute pancreatitis provides some information on the pathogenesis of IDH and its relationship with acute pancreatitis. | Kazue Shiozawa Manabu Watanabe Yoshinori Igarashi Yasushi Matsukiyo Teppei Matsui Yasukiyo Sumino | 2010 | World Journal of Radiology2010，2，7： | 3 |
| 3 | Laparoscopic duodenojejunostomy for malignant stenosis as a part of multimodal therapy:A case report显示文摘BACKGROUND Laparoscopic duodenojejunostomy(LDJ) has become the standard surgical procedure for superior mesenteric artery syndrome due to its sufficient outcome in terms of safety and symptom relief. However, there are only a few reports about LDJ for malignant stenosis and its indication remains uncertain.CASE SUMMARY A 77-year-old woman with a history of pancreatic cancer(PC) treated with distal pancreatectomy with en bloc resection of the transverse colon 7 mo ago was admitted for recurrent vomiting. Imaging upon admission revealed marked distention of the duodenum and a tumor around the duodenojejunal flexure. She was diagnosed with malignant stenosis caused by local recurrence of PC. LDJ was performed with an uneventful postoperative course, followed by chemotherapy which gave her 10 mo overall survival.CONCLUSION We think that LDJ is a valuable method for unresectable malignant stenosis around the duodenojejunal flexure as a part of multimodal therapy. | Teppei Murakami Yugo Matsui | 2022 | World Journal of Clinical Cases2022，10，16： | 0 |
| 4 | 神经胶质细胞对平行记忆形成的调节显示文摘神经胶质细胞的活动可以影响学习和记忆的储备和效率。本研究采用小脑依赖水平光动力反应运动学习小鼠模型,研究在线训练期间短期记忆(STM)的形成和离线休息期间长期记忆(LTM)的形成。研究显示,在线和离线学习效果的差异很大。STM早期形成较好者的LTM形成往往受到抑制,而没有明显急性训练效果的STM形成较晚者常常在离线学习中有明显提高。含有LRRC8A的阴离子通道可释放谷氨酸。在星形胶质细胞(包括小脑伯格曼胶质细胞)中特异性地条件性敲除LRRC8A导致STM形成的完全丧失,而在休息期间LTM形成仍然存在。在线训练期间,通过通道视紫红质-2或古菌红素-T(ArchT)对神经胶质细胞的活性进行光遗传学调控,可分别导致STM形成的增强或抑制。STM和LTM可能在在线训练期间同时触发,但LTM在离线期的后期才表达。STM似乎并不稳定,在线培训期间的形成的记忆并没有在LTM中出现。此外,我们发现在休息期间,胶质细胞ArchT的光活化导致LTM形成的增加。这些数据表明STM的形成和LTM的形成是平行的独立过程。可以根据胶质细胞的反应来决定策略的重点是STM还是LTM。 | Teppei Kanaya Ryo Ito Yosuke M Morizawa Daichi Sasaki Hiroki Yamao Hiroshi Ishikane Yuichi Hiraoka Kohichi Tanaka Ko Matsui | 2023 | 神经损伤与功能重建2023，18，8： | 0 |
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