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| 1 | Increased proliferation activity measured by immunoreactive Ki67 is associated with survival improvement in rectal/recto sigmoid cancer显示文摘AIM: To assess the expression of Ki67 as prognosticator in rectal/recto sigmoid cancer.METHODS: Samples from 146 patients with rectal and recto sigmoid cancer were studied for expression of Ki67 and its prognostic significance in comparison with clinicopathological predictors of survival. Formalin-fixed, paraffin-embedded tissues from 6 (4.1%) patients with T1, 26 (17.8%) with T2, 94 (64.4%) with T3, and 20 (13.7%) with T4 tumors were studied. Ki67 expression was determined immunohistochemically. Samples were divided according to mean value into high (>40%) and low (≤40%) expression. Areas of extensive proliferation (>50%) were defined as 'hot spot' areas. RESULTS: Hot spot areas were present in samples regardless of histopathological grade. Lower TNM and Dukes stage and higher expression of Ki67 and presence of Ki67 hot spot areas in histopathological samples were associated with better survival, whereas no association was observed with histopathological grade (P = 0.78). In Cox multivariate regression analysis, significant prognostic factors were Dukes stage (P<0.001), presence of lymph node metastases (P = 0.015), age (P = 0.035) andpresence of Ki67 hot spot areas (P = 0.044). CONCLUSION: Proliferative activity as measured by Ki67 in rectal cancer is associated with survival improvement compared with patients with low Ki67. Areas of prognostically significant increased proliferation were found independently of histopathological tumor grade. | Eeva Salminen Salla Palmu Tero Vahlberg Peter J.Roberts Karl-Owe S(o|¨)derstr(o|¨)m | 2005 | World Journal of Gastroenterology2005，11，21： | 15 |
| 2 | A prospective randomized controlled multicenter trial comparing antibiotic therapy with appendectomy in the treatment of uncomplicated acute appendicitis(APPAC trial)显示文摘 | Hannu Paajanen Juha M Gronroos Tero Rautio | 2013 | BMC Surgery2013，，13： | 1 |
| 3 | Effects of Recombinant Human IGF-I/IGF-Binding Protein-3 Complex on Glucose and Glycerol Metabolism in Type 1 Diabetes显示文摘 | Tero Saukkone Fariba Shojaee-Moradie Rachel M | 2006 | Diabetes2006，55，： | 1 |
| 4 | Homogeneous duplex polymerase chain reaction assay using switchable lanthanide fluorescence probes显示文摘 | Ari Lehmusvuori Antti-Heikki Tapio Petra M?ki-Teeri Kaisu Rantakokko-Jalava Qi Wang Harri Takalo Tero Soukka | 2013 | Analytical Biochemistry2013，，： | 1 |
| 5 | Effect of femoral head size on risk of revision for dislocation after total hip arthroplasty显示文摘 | Inari Kostensalo Mika Junnila Petri Virolainen Ville Remes Markus Matilainen Tero Vahlberg Pekka Pulkkinen Antti Eskelinen Keijo T Mä kelä | 2013 | Acta Orthopaedica2013，，4： | 1 |
| 6 | Stability of frozen starch pastes:effect of freezing,storage and xanthan gum addition 显示文摘 | Fe~Tero C Martino M N Zaritzky N E | 1993 | Journal of Food Processing and Preservation1993，17，3： | 1 |
| 7 | Systematic Identification of MicroRNAs That Impact on Proliferation of Prostate Cancer Cells and Display Changed Expression in Tumor Tissue显示文摘 | Anna Aakula Pekka Kohonen Suvi-Katri Leivonen Rami M?kel? Petteri Hintsanen John Patrick Mpindi Elena Martens-Uzunova Tero Aittokallio Guido Jenster Merja Per?l? Olli Kallioniemi P?ivi ?stling | 2015 | European Urology2015，，： | 1 |
| 8 | Effects of recombinant hu man IGF-I/IGF-binding protein 3 complex on glucose and glyc erol metabolism in type 1 diabetes 显示文摘 | Tero S Fariba S M Rachel M | 2006 | Diabetes2006，55，： | 1 |
| 9 | Purification of major lignin peroxidase isoenzymes from Phanerochaete chrysosporium by chromatofo-cusing显示文摘 | Veli M L Tero A | 1995 | Protein Expression and Purification1995，6，： | 1 |
| 10 | Endovenous obliteration with radiofrequency-resistive heating for greater saphenous veinInsufficiency:a feasibility study显示文摘 | Rautio MD Jukka M | 2002 | J Vasc Interv Radiol2002，13，： | 1 |
| 11 | Increased diagnosis of primary aldosteronism, including surgically correctable forms in centers from five con,tinen,ts显示文摘 | Mula tero P S towasser M l oh KC e t al | | J Clin Endocrinol Me''tab 200 10，89，3： | 1 |
| 12 | Accuracy ofthe JustyⅡApex locator In determining working length insimulated horizontal and vertical fractures显示文摘 | Azabal M Garcia O tero D de la Macorra JC | 2004 | Int Endod J2004，37，3： | 1 |
| 13 | Inkjet printing of electrically conductive patterns of carbon nanotubes显示文摘 | Tero M Krisztián K Sami S | 2007 | Physica Status Solidi (b)2007，244，11： | 1 |
| 14 | Nitric oxide gas sensors with functionalized carbon nanotubes显示文摘 | Jani M Tero M Krisztián K | 2007 | Physica Status Solidi (b):Basic Research2007，244，11： | 1 |
| 15 | Extensive use of peripheral angioplasty,particularly infrapopliteal,in the treatment of ischaemic diabetic foot uleers :clinical results of a multicentrie study of 221 consecutive diabetic subjects显示文摘 | Faglia E Man tero M Caminiti M | 2002 | J Intern Med2002，252，3： | 1 |
| 16 | Effects of recombinant human IGF-Ⅰ/IGF-binding protein-3 complex on glucose and glycerol metabolism in type 1 diabetes显示文摘 | Tero S Fariba S M Rachel M l | 2006 | Diabetes2006，55，： | 1 |
| 17 | The expression of GLP-1 receptor mRNA and protein allows the effect of GLP 1 on glucose me tabolism in the human hypothalamus and brainstem显示文摘 | Alvarez E Martinez M D Roncero I Chowen J A Garcia-Cuar- tero B Gispert J D | 2005 | J Neu- rochem2005，92，： | 1 |
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