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2篇 您的检索式：作者名="Tetsuro Higuchi"

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		题名	作者	年代	出处	被引量
	1	Expression of 5-Lipoxygenase in human colorectal cancer显示文摘AIM: To evaluate the 5-lipoxygenases (Loxs) expression level in human colorectal cancer specimens in order to determine its clinicopathologic significance in human tumorigenesis. METHODS: The relative quantity of 5-Lox mRNA in paired 91 colorectal tumor and adjacent normal mucosa samples was determined by real time quantitative PCR. Additionally, the expression of 5-Lox and cyclooxygenase (Cox)-2 proteins was also examined using immunohistochemical staining methods. RESULTS: There was a marked increase in 5-Lox mRNA levels in the tumor compared with paired normal mucosa samples (P < 0.0001). Sixty six (72.5%) tumors showed high 5-Lox mRNA levels. The positivity rate of 5-Lox and Cox-2 protein expression was 68.7% and 79.1% respectively. There was a significant association between tumoral 5-Lox mRNA level and tumor size (Rho = 0.392, P = 0.0002), depth or vessel invasion. CONCLUSION: These results suggest that 5-Lox is up-regulated in colorectal cancer and that inhibition of its expression might be valuable in the prevention and treatment of colorectal cancer.	Labile Togba Soumaoro Satoru Iida Hiroyuki Uetake Megumi Ishiguro Yoko Takagi Tetsuro Higuchi Masamichi Yasuno Masayuki Enomoto Kenichi Sugihara	2006	World Journal of Gastroenterology2006，12，39：	3
	2	Effect of classification based on combination of mutation and methylationin colorectal cancer prognosis显示文摘	Haruhiko Aoyagi Satoru Iida Hiroyuki Uetake Toshiaki Ishikawa Yoko Takagi Hirotoshi Kobayashi Tetsuro Higuchi Masamichi Yasuno Masayuki Enomoto Kenichi Sugihara	2011	Oncology Reports2011，，3：	1

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