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	题名	作者	年代	出处	被引量
1	Expression of 5-Lipoxygenase in human colorectal cancer显示文摘AIM: To evaluate the 5-lipoxygenases (Loxs) expression level in human colorectal cancer specimens in order to determine its clinicopathologic significance in human tumorigenesis. METHODS: The relative quantity of 5-Lox mRNA in paired 91 colorectal tumor and adjacent normal mucosa samples was determined by real time quantitative PCR. Additionally, the expression of 5-Lox and cyclooxygenase (Cox)-2 proteins was also examined using immunohistochemical staining methods. RESULTS: There was a marked increase in 5-Lox mRNA levels in the tumor compared with paired normal mucosa samples (P < 0.0001). Sixty six (72.5%) tumors showed high 5-Lox mRNA levels. The positivity rate of 5-Lox and Cox-2 protein expression was 68.7% and 79.1% respectively. There was a significant association between tumoral 5-Lox mRNA level and tumor size (Rho = 0.392, P = 0.0002), depth or vessel invasion. CONCLUSION: These results suggest that 5-Lox is up-regulated in colorectal cancer and that inhibition of its expression might be valuable in the prevention and treatment of colorectal cancer.	Labile Togba Soumaoro Satoru Iida Hiroyuki Uetake Megumi Ishiguro Yoko Takagi Tetsuro Higuchi Masamichi Yasuno Masayuki Enomoto Kenichi Sugihara	2006	World Journal of Gastroenterology2006，12，39：	3
2	Antitumor activity of trastuzumab in combination with chemotherapy in human gastric cancer xenograft models显示文摘	Kaori Fujimoto-Ouchi Fumiko Sekiguchi Hideyuki Yasuno Yoichiro Moriya Kazushige Mori Yutaka Tanaka	2007	Cancer Chemotherapy and Pharmacology2007，，6：	2
3	The susceptibility of various species of mosquitoes to DDT and dieldrin in Thailand显示文摘	Yasuno M Kerdpibule V	1967	Jpn J Exp Med1967，37，6：	1
4	Solitary mastocytoma treated with tranilast显示文摘	Kato HN Hirano S Yasuno H	1996	J Dermatol1996，23，：	1
5	Inflorescence meristem identity in rice is specified by overlapping functions of three AP1/FUL-Like MADS-box genes and PAP2, a SEPALLATA MADS box gene 显示文摘	Kobayashi K Yasuno N Sato Y	2012	Plant Cell2012，24，5：	1
6	Risk factors for carotid atherosclerosis and silent cerebral infarction in patient with coronary heart disease显示文摘	Nishino M Sueyoshi K Yasuno M	1993	Angiology1993，44，4：	1
7	Dependence of the autumn emergence of Tokunagayusurikd akamusi (Diptera: Chironomidae) on water temperature显示文摘	Iwakuma T S Yasuno M	1989	Jpn J Limnol1989，50，：	1
8	Risk factors for carotid atherosclerosis and silent cerebral infarction in patient with coronary heart disease显示文摘	Nishino M Sueyoshi K Yasuno M	1993	Angiology1993，44，4：	1
9	Antitumor activity of trastuzumab in combination with chemotherapy in human gastric cancer xenograft models显示文摘	Kaori Fujimoto-Ouchi Fumiko Sekiguchi Hideyuki Yasuno Yoichiro Moriya Kazushige Mori Yutaka Tanaka	2007	Cancer Chemotherapy and Pharmacology2007，，6：	1
10	Genome-wide association study of intracranial aneurysm identifies three new risk loci 显示文摘	Yasuno K Bilguvaar K Bjlnga P	2010	Nat Genet2010，42，：	1
11	Effect of plasma lipids,hypertension and APOE genotype on cognitive decline显示文摘	Yasuno F Tanimukai S Sasaki M	2012	Neurobil Aging2012，33，11：	1
12	Antitumor activity of trastuzumab in combination with chemotherapy in human gastric cancer xenograft models显示文摘	Fujimoto-Ouehi K Sekiguehi F Yasuno H	2007	Cancer Chemother Pharmacol2007，59，6：	1
13	Inhibitory effect of hippocampal 5-HT1A receptors on human explicit memory显示文摘	Suhara T Ichimiya T	2003	Am J Psychiatry2003，160，：	1
14	Blockade of angiotensin Ⅱtype Ⅰ receptor improves the arrhythmia morbidity in mice with left ventricular hypertrophy显示文摘	Zhang C Yasuno S Kumahara K	2006	Circ J2006，70，3：	1
15	Population dynamics and production of cladoceran zooplankton in the highly eutrophic Lake Kasumigaura 显示文摘	Nanazato T Yasuno M	1985	Hydrobiologia1985，124，1：	1
16	Evaluation of Microcystis as food for zooplankton in a eutrophic lake 显示文摘	Hanazato T Yasuno M	1987	Hydrobiologia1987，144，：	1
17	Population dynamics and production of cladoceran zooplankton in the highly eutrophic Lake Kasumigaura 显示文摘	Hanazato T Yasuno M	1985	Hydrobiologia1985，124，1：	1
18	Common variant near the endothelin receptor type A (EDNRA) gene is associated with intracranial aneurysm risk显示文摘	Yasuno K Bakircioglu M Low SK	2011	Proc Natl Acad Sci USA2011，108，19：	1
19	Susceptibility loci for intracranial aneurysm in European and Japanese populations 显示文摘	Bilguvar K Yasuno K Niemela M	2008	Nat Genet2008，40，12：	1
20	Genome-wide association study of intracranial aneurysm identifies three new risk loci显示文摘	Yasuno K Bilguvar K Bijlenga P	2010	Nat Genet2010，42，5：	1

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