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| 1 | 埃及尼罗河三角洲城市化监测显示文摘对1972、1984和1990年在尼罗河三角洲获取的Landsat MSS和TM影象(scenes)处理的和协同配准的(coregistered)数字镶嵌图比较表明,城镇增长正危及着埃及农业的生产力。在1972、1984和1990年尼罗河三角洲的城镇面积至少分别占3.6%、4.7%和5.7%,在这18年期间增长了58%。大约一半的增长出现在1984~1990年期间。如果这种趋势继续下去,到2010年埃及将因城市化而丧失农地总面积的12%。尽管事实上城镇增长主要出现在城市周围,但在几千个小村庄周围的增长却对尼罗河三角洲的农业生产构成最大的威胁。1972~1990年间,城市和大村庄的累积增长率为37%,而同期小村庄的累积增长率为77%。 | Mohamed Sultan Michael Fiske Thomas Stein Mohamed Gamal Yehia Abdel Hady Hesham El Araby Ahmed Madani Salah Mehanee Richard Becker 石培礼 | 1999 | AMBIO-人类环境杂志1999，28，7： | 9 |
| 2 | Ephrin-B2 is differentially expressed in the intestinal epithelium in Crohn's disease and contributes to accelerated epithelial wound healing in vitro显示文摘AIM: Eph receptor tyrosine kinases and their membrane bound receptor-like ligands, the ephrins, represent a bi-directional cell-cell contact signaling system that directs epithelial movements in development. The meaning of this system in the adult human gut is unknown. We investigated the Eph/ephrin mRNA expression in the intestinal epithelium of healthy controls and patients with inflammatory bowel disease (IBD).METHODS: mRNA expression profiles of all Eph/ephrin family members in normal small intestine and colon were established by real-time RT-PCR. In addition, differential expression in IBD was investigated by cDNA array technology, and validated by both real-time RT-PCR and immunohistochemistry. Potential effects of enhanced EphB/ephrin-B signaling were analyzed in an in vitro IEC-6 cell scratch wound model.RESULTS: Human adult intestinal mucosa exhibits a complex pattern of Eph receptors and ephrins. Beside the known prominent co-expression of EphA2 and ephrinA1,we found abundantly co-expressed EphB2 and ephrin-B1/2.Interestingly, cDNA array data, validated by real-time PCR and immunohistochemistry, showed upregulation of ephrin-B2 in both perilesional and lesional intestinal epithelial cells of IBD patients, suggesting a role in epithelial homeostasis. Stimulation of ephrin-B signaling in ephrinB1/2 expressing rat IEC-6-cells with recombinant EphB1Fc resulted in a significant dose-dependent acceleration of wound closure. Furthermore, fluorescence microscopy showed that EphB1-Fc induced coordinated migration of wound edge cells is associated with enhanced formation of lamellipodial protrusions into the wound, increased actin stress fiber assembly and production of laminin at the wound edge.CONCLUSION: EphB/ephrin-B signaling might represent a novel protective mechanism that promotes intestinal epithelial wound healing, with potential impact on epithelial restitution in IBD. | Christian Hafner Stefanie Meyer Thomas Langmann Gerd Schmitz Frauke Bataille Ilja Hagen Bernd Becker Alexander Roesch Gerhard Rogler Michael Landthaler Thomas Vogt | 2005 | World Journal of Gastroenterology2005，11，26： | 9 |
| 3 | 原子力显微镜评价奥氏体不锈钢晶间腐蚀敏感性的研究显示文摘由13Cr可焊马氏体不锈钢(WMSGSS)制造的油气管线由于价格便宜,相对于昂贵的耐腐蚀合金来说是一个很有竞争力的选择。但是实验室试验和现场经历表明,13Cr马氏体不锈钢焊接接头热影响区发生了沿晶应力腐蚀开裂(IGSCC)。对于低等级的马氏体不锈钢来说,沿晶应力腐蚀开裂机理被认为是在晶界的碳化物附近存在贫铬区。对于中等级和高等级马氏体不锈钢来说,只在实验室试验发现有应力腐蚀开裂。它们的应力腐蚀开裂机理还没有明确,虽然最可能的应力腐蚀开裂机理也被认为和低等级马氏体不锈钢的应力腐蚀开裂机理类似。原子力显微镜(AFM)已开始广泛用于材料显微组织和环境敏感断裂的研究中。高等级马氏体不锈钢焊接接头对晶间腐蚀/应力腐蚀开裂敏感性很有希望由原子力显微镜检测到。在原子力显微镜技术应用于这项研究之前,用由304不锈钢准备的不同敏化度的试样来确定它的适用性是十分有益的。本文用原子力显微镜研究了不同敏化程度的304不锈钢的晶间腐蚀敏感性并和SEM和EDS结果进行了对比。 | 黄彦良 Brian Kinsella Thomas Becker 黄偲迪 张杨扬 | 2008 | 材料开发与应用2008，23，3： | 5 |
| 4 | Targeting of Vacuolar Membrane Localized Members of the TPK Channel Family显示文摘Arabidopsis thaliana 的双人脚踏车毛孔钾隧道家庭的四个成员(TPK1, 2, 3,和 5 ) 居住在 vacuolar 膜,而 TPK4 是一条血浆膜 K+ 隧道。由构造在 TPK1 和 TPK4 之间的怪物,我们试图识别涉及 trafficking 进程并且发现 TPK1 细胞质的 C 终端域(CT ) 为 ER-是批评的隧道域 -- 象排序 Golgi 步一样。后面的指导地点的 mutagenesis,我们识别了为 TPK1 的嗯出口要求的一个 diacidic 主题(DLE ) 。然而,在 C 终点的这个 diacidic 主题没在 TPK 家庭的另外的成员之中被保存,并且排序的 TPK3 独立于它的 CT。而且, TPK1 的 14-3-3 绑定地点,为隧道激活必要,不涉及隧道排序。 | Marcel Dunkel Andreas Latz Karin Schumacher Thomas Muller Dirk Becker Rainer Hedrich | 2008 | Molecular Plant2008，1，6： | 5 |
| 5 | Salt Stress Triggers Phosphorylation of the Arabidopsis Vacuolar K+ Channel TPK1 by Calcium-Dependent Protein Kinases (CDPKs)显示文摘 | Andreas Latz Norbert Mehlmer Simone Zapf Thomas D. Mueller Bernhard Wurzinger Barbara Pfister Edina Csaszar Rainer Hedrich Markus Teige Dirk Becker | 2013 | Molecular Plant2013，6，4： | 5 |
| 6 | 老年供体肝移植的临床经验显示文摘目的:供肝来源的短缺日益成为肝移植的突出问题,本文旨意在探讨老年供体肝移植的疗效。方法:收集2004年3月至9月德国汉诺威医学院施行的69例肝移植的临床资料。供体年龄>60岁的肝移植有11例,占同期肝移植总数的15.9%,其中包括急诊肝移植2例,再移植1例,供体的平均年龄为66.7岁,年龄最大者为75岁。而供体年龄≤60岁的肝移植共58例,供体平均年龄为36.3岁,年龄最小者为10岁。结果:老年供体组病人肝移植的总体效果令人满意,两组病人的1年生存率分别为81.8%(9/11)和87.9%(51/58),移植肝1年存活率为72.7%(8/11)和82.7%(48/58),两组间无显著差异。结论:在审慎的选择下,老年供体的肝脏是能够安全运用的,供体年龄并非是影响肝移植预后的因素。 | 严佶祺 Thomas Becker 彭承宏 李宏为 Juergen Klempnauer | 2006 | 外科理论与实践2006，11，4： | 3 |
| 7 | First performance evaluation of a dual-source CT (DSCT) system显示文摘 | Thomas G. Flohr Cynthia H. McCollough Herbert Bruder Martin Petersilka Klaus Gruber Christoph Sü? Michael Grasruck Karl Stierstorfer Bernhard Krauss Rainer Raupach Andrew N. Primak Axel Küttner Stefan Achenbach Christoph Becker Andreas Kopp Bernd M. Ohnes | 2006 | European Radiology2006，，6： | 3 |
| 8 | Split liver transplantation: a reliable approach to expand donor pool显示文摘Orthotopic liver transplantation as a successful treatment of end-stage liver disease is hampered by a persistent lack of cadaveric organs. Split liver transplantation, which was first successfully performed by Medical School of Hannover in 1988, has become a mature surgical technique to expand the donor pool. Between 1993 and 1999, split liver transplantation activities have increased in Europe from 1. 2% to 10. 4% in all performed liver transplantations. Current data have strongly supported that the survival rate of patients after split liver transplantation is not significantly different from that of patients after whole-size orthotopic liver transplantation. The most important step of donor graft selection is surgeon’ s observation judged by the experience of individual transplant center. The paper aims to provide the guideline of donor selection, hepatic graft splitting, and recipient management as well. DATA SOURCES: Medical School of Hannover has accumulated plentiful experience of split liver transplantation for more than 10 cases ever since 1998. Besides that, we also reviewed a variety of literatures from other famous European and American centers specialized in this field for many years. RESULTS:According to our experience combined with the view points of others, the donor should meet the following criteria as well: (1) age less than 50 years; (2) hemodynamics stable; (3) ICU less than 5 days; (4) Na less than 170 mmol/L or better if less than 150 mmol/L. In 1996 and 1997, the Hamburg group and the UCLA group separately introduced a breakthrough technique performing split liver transplantation in situ. Evidently, the in situ technique has been limited by prolonged time of donor organ procurement , coordination with other organ procurement teams, and even extra burden on donor hospital. Some groups, therefore, have restored the ex situ or bench splitting technique , and fortunately the transplant outcomes of the ex situ technique are equivalent to those of the in situ one. Recently some new techniques have been introduced to split the liver for two adult patients, including the split-cava technique. CONCLUSIONS:It is clear that the most important factor for determining the prognosis of the patient is the time of receiving liver transplantation, not the type of liver transplantation. We still need to pay close attention to the graft to recipient weight ratio (GRWR) and the UNOS classification or MELD score before the patient is subjected to split liver transplantation. | Ji-Qi Yan, Thomas Becker, Cheng-Hong Peng, Hong-Wei Li and Juergen Klempnauer Department of Surgery, Ruijin Hospital Affiliated to Shanghai Second Medical University, Shanghai 200025, China ( Yan JQ, Peng CH and Li HW) Department of Abdominal and Transplant Surgery, Medical School of Hannover, Carl-Neuberg-Str. 1 , 30625 Hannover, Germany | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 3 |
| 9 | 劈离式肝移植中供肝分离的手术经验显示文摘目的探讨劈离式肝移植中供肝分离的手术经验.方法自2004年3月1日至9月1日,共计施行了10例体外供肝的劈离,将其分为左肝外侧叶(Ⅱ、Ⅲ段)和扩大右半肝(Ⅰ、Ⅳ~Ⅷ段)两部分,并为19位病人施行了劈离式肝移植.供体的平均年龄为32.7岁(15~51岁),平均体重64.5kg(45~75kg),ICU平均救治时间为2.4 d(1~8 d).结果劈离前整体供肝和劈离后左肝外侧叶的平均重量分别为1322.6 g(956~1665 g)和281.8 g(198~373 g),后者与前者的平均比值为0.215(0.178~0.274).左肝外侧叶部分的移植物与受体重量比(GRWR)的平均值为2.44%(1.22%~5.41%),而扩大右半肝部分GRWR的平均值为1.73%(1.31%~2.30%).供肝劈离平均花费的时间为105 min(85~135 min).共出现5例解剖变异,包括左肝静脉变异2例、肝动脉变异2例、胆管变异1例.结论劈离式肝移植已经成为扩大供肝来源的一种成熟的外科技术,且效果满意.在供肝劈离中需要正确应对各种可能的解剖变异,尤其是左肝静脉、左肝动脉和胆管的变异. | 严佶祺 Thomas Becker 彭承宏 李宏为 Juergen Klempnauer | 2005 | 中华肝胆外科杂志2005，11，11： | 3 |
| 10 | Consensus and Future Directions on the Definition of High On-Treatment Platelet Reactivity to Adenosine Diphosphate显示文摘 | Laurent Bonello Udaya S. Tantry Rossella Marcucci Ruediger Blindt Dominick J. Angiolillo Richard Becker Deepak L. Bhatt Marco Cattaneo Jean Philippe Collet Thomas Cuisset Christian Gachet Gilles Montalescot Lisa K. Jennings Dean Kereiakes Dirk Sibbing Die | 2010 | Journal of the American College of Cardiology2010，，12： | 3 |
| 11 | Combined evaluation of a panel of protein and miRNA serum‐exosome biomarkers for pancreatic cancer diagnosis increases sensitivity and specificity显示文摘 | Bindhu Madhavan Shijing Yue Uwe Galli Sanyukta Rana Wolfgang Gross Miryam Müller Nathalia A. Giese Holger Kalthoff Thomas Becker Markus W Büchler Margot Z?ller | 2015 | Int. J. Cancer2015，，11： | 2 |
| 12 | Loss of p53 in Enterocytes Generates an Inflammatory Microenvironment Enabling Invasion and Lymph Node Metastasis of Carcinogen-Induced Colorectal Tumors显示文摘 | Sarah Schwitalla Paul K. Ziegler David Horst Valentin Becker Irina Kerle Yvonne Begus-Nahrmann André Lechel K. Lenhard Rudolph Rupert Langer Julia Slotta-Huspenina Franz G. Bader Olivia Prazeres da Costa Markus F. Neurath Alexander Meining Thomas Kirchner | 2013 | Cancer Cell2013，，： | 2 |
| 13 | Material differentiation by dual energy CT: initial experience显示文摘 | Thorsten R. C. Johnson Bernhard Krau? Martin Sedlmair Michael Grasruck Herbert Bruder Dominik Morhard Christian Fink Sabine Weckbach Miriam Lenhard Bernhard Schmidt Thomas Flohr Maximilian F. Reiser Christoph R. Becker | 2007 | European Radiology2007，，6： | 2 |
| 14 | Long-Term Outcomes Following Liver Transplantation for Hepatic Hemangioendothelioma: The UNOS Experience from 1987 to 2005显示文摘 | Joel A. Rodriguez Natasha S. Becker Christine A. O’Mahony John A. Goss Thomas A. Aloia | 2008 | Journal of Gastrointestinal Surgery2008，，1： | 2 |
| 15 | Ephrin-B reverse signaling induces expression of wound healing associated genes in IEC-6 intestinal epithelial cells显示文摘AIM: Eph receptors and ephrin ligands play a pivotal role in development and tissue maintenance. Since previous data have indicated an involvement of ephrin-B2 in epithelial healing, we investigated the gene expression and downstream signaling pathways induced by ephrin-B mediated cell-cell signaling in intestinal epithelial cells.METHODS: Upon stimulation of ephrin-B pathways in IFC-6 cells with recombinant rat EphB1-Fc, gene expression was analyzed by Affymetrix(R) rat genome 230 high density arrays at different time points. Differentially expressed genes were confirmed by real-time RT-PCR. In addition, MAP kinase pathways and focal adhesion kinase (FAK) activation downstream of ephrin-B were investigated by immunoblotting and fluorescence microscopy.RESULTS: Stimulation of the ephrin-B reverse signaling pathway in IEC-6 cells induces predominant expression of genes known to be involved into wound healing/cell migration, antiapoptotic pathways, host defense and inflammation. Cox-2, c-Fos, Egr-1, Egr-2, and MCP-1 were found among the most significantly regulated genes.Furthermore, we show that the expression of repairrelated genes is also accompanied by activation of the ERK1/2 MAP kinase pathway and FAK, two key regulators of epithelial restitution.CONCLUSION: Stimulation of the ephrin-B reverse signaling pathway induces a phenotype characterized by upregulation of repair-related genes, which may partially be mediated by ERK1/2 pathways. | Christian Hafner Stefanie Meyer Ilja Hagen Bernd Becker Alexander Roesch Michael Landthaler Thomas Vogt | 2005 | World Journal of Gastroenterology2005，11，29： | 2 |
| 16 | 文拉法新与舍曲林治疗抑郁症疗效的Meta分析显示文摘目的:评价文拉法新与舍曲林治疗抑郁症疗效的差异。方法:对6项符合纳入标准的研究应用循证医学方法评价文拉法新与舍曲林治疗抑郁症疗效有效率、以及症状学变化的差异。结果:文拉法新组的有效率(122/177 vs 128/179,OR=1.22,95%CI:0.77~1.93,Z=0.86,P>0.05)与曲林组相似,但是文拉法新组在第1周末(WMD:-1.57,95%CI:-2.98^-0.15,Z=2.17,P=0.03)和第2周末(WMD:-1.53,95%CI:-2.83^-0.23,Z=2.30,P=0.02)症状改善明显于舍曲林,而在第6周末相似(WMD:0.13,95%CI:-0.91~1.17,Z=0.25,P=0.81)。结论:文拉法新与舍曲林治疗抑郁症有效率相似,但前者症状改善前2周改善比较快。 | 金卫东 Markus Kosters 马永春 Thomas Becker 王乃信 | 2010 | 中国医院用药评价与分析2010，10，1： | 2 |
| 17 | 肝细胞肝癌肝移植的预后因素分析显示文摘目的评价肝细胞肝癌(hepatocellular carcinoma,HCC)原位肝移植后的预后相关因素。方法回顾性分析1993年11月到2006年5月期间汉诺威医科大学对117例HCC进行肝移植的经验。结果经多因素分析,肿瘤大小和肿瘤数量(米兰标准或加州标准)、微血管侵犯、移植前治疗和肿瘤复发是影响患者生存预后的重要因素。结论原位肝移植是治疗HCC的理性术式;合适的选择标准,积极的移植前治疗,复发的有效控制,是患者获得良好预后的关键。 | 赵泽明 Thomas Becker 范跃祖 Bastian Ringe Jürgen Klempnauer | 2014 | 同济大学学报(医学版)2014，35，1： | 2 |
| 18 | 肝细胞肝癌肝移植术后复发因素分析——汉诺威经验显示文摘目的探讨肝细胞肝癌(hepatocellular carcinoma,HCC)原位肝移植后的复发特性及相关影响因素。方法回顾性分析1993年11月至2006年5月汉诺威医科大学对117例合并肝硬化HCC行原位肝移植的临床资料和随访结果,应用Kaplan.Meier作术后累积存活率分析,Log.Rank检验作相关临床病理因素分析。结果63例(58.3%)HCC原位肝移植患者符合米兰标准,45例(41.7%)超米兰标准,而符合和超加州大学标准分别为73例(67.6%)和35例(32.4%);尸体供肝肝移植(cadaveric donor liver transplantation, CDLT)103例,活体供肝肝移植(living donor liver transplantation,LDLT)14例;两组术后生存率比较差异无统计学意义(P=0.911)。移植后肿瘤复发与否与患者年龄(P=0.048)、有无微血管侵犯(P=0.001)、是否超出加州标准(P=0.013)和肿瘤分化程度(P=0.015)密切相关。结论合适的选择标准、围手术期的综合治疗及复发的有效控制,是提高肝癌肝移植患者生存率的关键。 | 赵泽明 范跃祖 Becker Thomas Ringe Bastian Klempnauer Jtirgen | 2017 | 中华普通外科杂志2017，32，11： | 2 |
| 19 | Common and epithelioid variants of hepatic angiomyolipoma exhibit clonal growth and share a distinctive immunophenotype显示文摘 | Peer Flemming Ulrich Lehmann Thomas Becker Jürgen Klempnauer Hans Kreipe | 2000 | Hepatology2000，，： | 2 |
| 20 | Prediction of survival after liver transplantation by pre-transplant parameters显示文摘 | Tobias J. Weismüller Jana Prokein Thomas Becker Hannelore Barg-Hock Jürgen Klempnauer Michael P. Manns Christian P. Strassburg | 2008 | Scandinavian Journal of Gastroenterology2008，，6： | 1 |
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