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| 1 | Activation and dramatically increased cytolytic activity of tumor specific T lymphocytes after radio-frequency ablation in patients with hepatocellular carcinoma and colorectal liver metastases显示文摘瞄准:为了如果特定的细胞毒素的 T 房间回答能与恶意的肝在病人被导致,估计,肿瘤与无线电频率对待脱离(RFA ) 。方法:有颜色的肝转移的六个病人表面的癌症并且 6 与肝细胞,癌(HCC ) 经历了 RFA。血以前被取样,在 RFA 以后的 4 和 8 wk。测试抗原是活体检视从每个病人获得的自体同源的肝和肿瘤溶解产物。外部 T 房间激活被一个干扰素鲸鱼群妈(IFNgamma ) 估计分泌物试金和流动血细胞计数。T 房间是双 stained 让 CD4/CD8 和 IFNgamma 检测细胞毒素的 T 房间。积极的 IFNgamma 和 IFNgamma 否定 T 房间的比率作为刺激索引(SI ) 被决定。估计细胞溶解的活动, T 房间与人的 CaCo 颜色被共同孵化 cytosolic adenylate 激酶的表面的癌症和 HepG2 HCC 房间和版本被酶试金测量。结果:在 RFA SI 前是 0.021 (+/- 0.006 ) 为 CD4 (+) 并且 0.022 (+/- 0.004 ) 为对非恶意的肝织物的 CD8 (+) T 房间并且 0.018 (+/- 0.005 ) 为 CD4 (+) 并且 0.021 (+/- 0.004 ) 为对自体同源的肿瘤织物的 CD8 (+) 房间。在对肿瘤织物的 RFA SI 以后的四个星期增加了到 0.109 (+/- 0.005 )为 CD4 (+)并且 0.11 (+/- 0.012 )为对 HCC 的 CD8 (+) T 房间,并且到 0.115 (+/- 0.031 )为 CD4 (+)并且 0.15 (+/- 0.02 )为为颜色的 CD8 (+)房间表面的转移( P <
0.0001 )。没有增加的 SI 被观察与非,恶性瘤织物根本预定点。与 2.62 在对各自的癌症房间的 RFA 细胞溶解的的活动前是低的(+/- 0.37 ) 相对的光单位(RLU ) ,而是超过 100 合拢的玫瑰在 RFA 以后的 4 和 8 wk。自发的版本是 2% 最大值在所有实验释放的 <
。结论:病人与主要并且肝的继发性瘤在 RFA 以后与 CD8 (+) T 房间的一项戏剧性地增加的肿瘤 specific 细胞溶解的活动显示出重要肿瘤特定的细胞毒素的 T 房间刺激。 | Johannes Hansler Thaddaus Till Wissniowski Detlef Schuppan Astrid Witte Thomas Bernatik Eckhart Georg Hahn Deike Strobel | 2006 | World Journal of Gastroenterology2006，12，23： | 22 |
| 2 | Diagnostics in inflammatory bowel disease: Ultrasound显示文摘Diagnosis of chronic inflammatory bowel diseases (IBD) is based on a combination of clinical symptoms, laboratory tests and imaging data. Imaging of the morphological characteristics of IBD includes the assessment of mucosal alterations, transmural involvement and extraintestinal manifestations. No single imaging technique serves as a diagnostic gold standard to encompass all disease manifestations. Ultrasound, computed tomography (CT) or magnetic resonance imaging (MRI) allow cross-sectional imaging of the transmural alterations and extraintestinal manifestations. While in the USA the technique of choice is CT, in Europe the focus is more on MRI and ultrasound (US). Most patients with chronic IBD are diagnosed at a young age. After baseline diagnosis many of these young patients have to undergo repetitive imaging procedures during the variable clinical course of the disease, characterized by alternate periods of remission and active disease, and in monitoring the response to treatment. US has the advantage of being noninvasive, less costly, and easily repeatable, and thus can be very useful in following up patients with IBD. In addition, rising concern about radiation exposure in young adults indicates the demand for radiation-sparing techniques like US and MRI. This article focuses on the current clinical practice of US in IBD, describing the current technologies used in transabdominal intestinal US and the characteristic sonographic findings in Crohn′s disease and ulcerative colitis. | Deike Strobel Ruediger S Goertz Thomas Bernatik | 2011 | World Journal of Gastroenterology2011，17，27： | 20 |
| 3 | Assessment of Crohn’s disease activity by confocal laser endomicroscopy显示文摘 | Helmut Neumann Michael Vieth Raja Atreya Martin Grauer Jürgen Siebler Thomas Bernatik Markus F. Neurath Jonas Mudter | 2012 | Inflamm Bowel Dis2012，，12： | 1 |
| 4 | Doppler measurements: a surrogate marker of liver fibrosis?显示文摘 | Thomas Bernatik Deike Strobel Eckhart Georg Hahn Dirk Becker | 2002 | European Journal of Gastroenterology & Hepatology2002，，4： | 1 |
| 5 | Assessment of Crohn’s disease activity by confocal laser endomicroscopy显示文摘 | Helmut Neumann Michael Vieth Raja Atreya Martin Grauer Jürgen Siebler Thomas Bernatik Markus F. Neurath Jonas Mudter | 2012 | Inflamm Bowel Dis2012，，12： | 1 |
| 6 | Echo-enhanced color- and power-Doppler EUS for the discrimination between focal pancreatitis and pancreatic carcinoma显示文摘 | Dirk Becker Deike Strobel Thomas Bernatik Eckhart G. Hahn | 2001 | Gastrointestinal Endoscopy2001，，7： | 1 |
| 7 | Assessment of Crohn’s disease activity by confocal laser endomicroscopy显示文摘 | Helmut Neumann Michael Vieth Raja Atreya Martin Grauer Jürgen Siebler Thomas Bernatik Markus F. Neurath Jonas Mudter | 2012 | Inflamm Bowel Dis2012，，12： | 1 |
| 8 | Doppler measurements: a surrogate marker of liver fibrosis?显示文摘 | Thomas Bernatik Deike Strobel Eckhart Georg Hahn Dirk Becker | 2002 | European Journal of Gastroenterology & Hepatology2002，，4： | 1 |
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