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| 1 | Assessment of metastatic liver disease in patients with primary extrahepatic tumors by contrast-enhanced sonography versus CT and MRI显示文摘瞄准:与已知的额外的肝的原发性瘤对包括 CT, MRI 和临床 / 组织学的数据的联合标准答案在病人在肝转移的察觉用 SonoVue 评估提高对比的 ultrasonography (CEUS ) 。方法:它是一国际多集中学习,并且有 12 个中心和 125 个病人(64 男性, 61 女性,变老 59+/-11 年) 包含,与 102 个病人一起每协议。原发性瘤是在 35% 表面的颜色,在 27% 的胸,在 17% 胰腺并且其它在 21% 。用 SonoVue 的 CEUS 用西门子 Elegra, Philips HDI 5000 和 Acuson 红杉与一种 low-mechanical-index 技术和对比特定的软件被采用;为至少五分钟的连续扫描。结果:有 SonoVue 的 CEUS 显著地增加了检测的焦点的肝损害对 unenhanced sonography 的数字。在 31.4% 病人,更多的损害在对比改进以后被发现。检测的损害的全部的数字与 CEUS (55 ) 是可比较的,三倍阶段的螺线 CT (61 ) 和有一个肝特定的对比代理人(53 ) 的 MRI。变形疾病的察觉的精确性(即至少一变形损害) 比为 unenhanced sonography (81.4%) 为 CEUS (91.2%) 是显著地更高的并且类似于三倍阶段的螺线 CT (89.2%) 的。在其 CEUS 检查否定的 53 个病人,后续考试 3-6 瞬间以后在 50 个病人(94.4%) 证实了变形损害的缺席。结论:CEUS 被证明在在有已知的额外的肝的原发性瘤的病人的肝转移的察觉可靠并且怀疑肝损害。 | Christoph F Dietrich Wolfgang Kratzer Deike Strobel Etienne Danse Robert Fessl Alfred Bunk Udo Vossas Karlheinz Hauenstein Wilhelm Koch Wolfgang Blank Matthijs Oudkerk Dietbert Hahn Christian Greis | 2006 | World Journal of Gastroenterology2006，12，11： | 39 |
| 2 | Activation and dramatically increased cytolytic activity of tumor specific T lymphocytes after radio-frequency ablation in patients with hepatocellular carcinoma and colorectal liver metastases显示文摘瞄准:为了如果特定的细胞毒素的 T 房间回答能与恶意的肝在病人被导致,估计,肿瘤与无线电频率对待脱离(RFA ) 。方法:有颜色的肝转移的六个病人表面的癌症并且 6 与肝细胞,癌(HCC ) 经历了 RFA。血以前被取样,在 RFA 以后的 4 和 8 wk。测试抗原是活体检视从每个病人获得的自体同源的肝和肿瘤溶解产物。外部 T 房间激活被一个干扰素鲸鱼群妈(IFNgamma ) 估计分泌物试金和流动血细胞计数。T 房间是双 stained 让 CD4/CD8 和 IFNgamma 检测细胞毒素的 T 房间。积极的 IFNgamma 和 IFNgamma 否定 T 房间的比率作为刺激索引(SI ) 被决定。估计细胞溶解的活动, T 房间与人的 CaCo 颜色被共同孵化 cytosolic adenylate 激酶的表面的癌症和 HepG2 HCC 房间和版本被酶试金测量。结果:在 RFA SI 前是 0.021 (+/- 0.006 ) 为 CD4 (+) 并且 0.022 (+/- 0.004 ) 为对非恶意的肝织物的 CD8 (+) T 房间并且 0.018 (+/- 0.005 ) 为 CD4 (+) 并且 0.021 (+/- 0.004 ) 为对自体同源的肿瘤织物的 CD8 (+) 房间。在对肿瘤织物的 RFA SI 以后的四个星期增加了到 0.109 (+/- 0.005 )为 CD4 (+)并且 0.11 (+/- 0.012 )为对 HCC 的 CD8 (+) T 房间,并且到 0.115 (+/- 0.031 )为 CD4 (+)并且 0.15 (+/- 0.02 )为为颜色的 CD8 (+)房间表面的转移( P <
0.0001 )。没有增加的 SI 被观察与非,恶性瘤织物根本预定点。与 2.62 在对各自的癌症房间的 RFA 细胞溶解的的活动前是低的(+/- 0.37 ) 相对的光单位(RLU ) ,而是超过 100 合拢的玫瑰在 RFA 以后的 4 和 8 wk。自发的版本是 2% 最大值在所有实验释放的 <
。结论:病人与主要并且肝的继发性瘤在 RFA 以后与 CD8 (+) T 房间的一项戏剧性地增加的肿瘤 specific 细胞溶解的活动显示出重要肿瘤特定的细胞毒素的 T 房间刺激。 | Johannes Hansler Thaddaus Till Wissniowski Detlef Schuppan Astrid Witte Thomas Bernatik Eckhart Georg Hahn Deike Strobel | 2006 | World Journal of Gastroenterology2006，12，23： | 22 |
| 3 | Diagnostics in inflammatory bowel disease: Ultrasound显示文摘Diagnosis of chronic inflammatory bowel diseases (IBD) is based on a combination of clinical symptoms, laboratory tests and imaging data. Imaging of the morphological characteristics of IBD includes the assessment of mucosal alterations, transmural involvement and extraintestinal manifestations. No single imaging technique serves as a diagnostic gold standard to encompass all disease manifestations. Ultrasound, computed tomography (CT) or magnetic resonance imaging (MRI) allow cross-sectional imaging of the transmural alterations and extraintestinal manifestations. While in the USA the technique of choice is CT, in Europe the focus is more on MRI and ultrasound (US). Most patients with chronic IBD are diagnosed at a young age. After baseline diagnosis many of these young patients have to undergo repetitive imaging procedures during the variable clinical course of the disease, characterized by alternate periods of remission and active disease, and in monitoring the response to treatment. US has the advantage of being noninvasive, less costly, and easily repeatable, and thus can be very useful in following up patients with IBD. In addition, rising concern about radiation exposure in young adults indicates the demand for radiation-sparing techniques like US and MRI. This article focuses on the current clinical practice of US in IBD, describing the current technologies used in transabdominal intestinal US and the characteristic sonographic findings in Crohn′s disease and ulcerative colitis. | Deike Strobel Ruediger S Goertz Thomas Bernatik | 2011 | World Journal of Gastroenterology2011，17，27： | 20 |
| 4 | Enhanced microfracture techniques in cartilage knee surgery: Fact or fiction?显示文摘The limited intrinsic healing potential of human articular cartilage is a well-known problem in orthopedic surgery. Thus a variety of surgical techniques have been developed to reduce joint pain, improve joint function and delay the onset of osteoarthritis. Microfractures as a bone marrow stimulation technique present the most common applied articular cartilage repair procedure today. Unfortunately the deficiencies of fibrocartilaginous repair tissue inevitably lead to breakdown under normal joint loading and clinical results deteriorate with time. To overcome the shortcomings of microfracture, an enhanced microfracture technique was developed with an additional collagen Ⅰ/Ⅲ membrane(Autologous, Matrix-Induced Chondrogenesis, AMIC). This article reviews the pre-clinical rationale of microfractures and AMIC, presents clinical studies and shows the advantages and disadvantages of these widely usedtechniques. PubM ed and the Cochrane database were searched to identify relevant studies. We used a comprehensive search strategy with no date or language restrictions to locate studies that examined the AMIC technique and microfracture. Search keywords included cartilage, microfracture, AMIC, knee, ChondroGide. Besides this, we included our own experiences and study authors were contacted if more and non published data were needed. Both cartilage repair techniques represent an effective and safe method of treating full-thickness chondral defects of the knee in selected cases. While results after microfracture deteriorate with time, mid-term results after AMIC seem to be enduring. Randomized studies with long-term followup are needed whether the grafted area will maintain functional improvement and structural integrity over time. | Stefan Bark Tomasz Piontek Peter Behrens Sabiah Mkalaluh Deike Varoga Justus Gille | 2014 | World Journal of Orthopedics2014，5，4： | 3 |
| 5 | Effects of vitamin E on stroke: a systematic review with meta- analysis and trial sequential analysis显示文摘There are several previous studies on the association of vitamin E with prevention of stroke but the findings remain controversial.We have conducted a systematic review,meta-analysis together with trial sequential analysis of randomised controlled trials to evaluate the effect of vitamin E supplementation versus placebo/no vitamin E on the risk reduction of total,fatal,non-fatal,haemorrhagic and ischaemic stroke.Relevant studies were identified by searching online databases through Medline,PubMed and Cochrane Central Register of Controlled Trials.A total of 18 studies with 148016 participants were included in the analysis.There was no significant difference in the prevention of total stroke(RR(relative risk)=0.98,95% CI 0.92-1.04,p=0.57),fatal stroke(RR=0.96,95% CI 0.77-1.20,p=0.73)and non-fatal stroke(RR=0.96,95% CI 0.88-1.05,p=0.35).Subgroup analyses were performed under each category(total stroke,fatal stroke and non-fatal stroke)and included the following subgroups(types of prevention,source and dosage of vitamin E and vitamin E alone vs control).The findings in all subgroup analyses were statistically insignificant.In stroke subtypes analysis,vitamin E showed significant risk reduction in ischaemic stroke(RR=0.92,95% CI 0.85-0.99,p=0.04)but not in haemorrhagic stroke(RR=1.17,95%CI 0.98-1.39,p=0.08).However,the trial sequential analysis demonstrated that more studies were needed to control random errors.Limitations of this study include the following:trials design may not have provided sufficient power to detect a change in stroke outcomes,participants may have had different lifestyles or health issues,there were a limited number of studies available for subgroup analysis,studies were mostly done in developed countries,and the total sample size for all included studies was insufficient to obtain a meaningful result from meta-analysis.In conclusion,there is still a lack of statistically significant evidence of the effects of vitamin E on the risk reduction of stroke.Nevertheless,vitamin E may offer some benefits in the prevention of ischaemic stroke and additional well-designed randomised controlled trials are needed to arrive at a definitive finding.PROSPERO registration number:CRD42020167827. | Hong Chuan Loh Renly Lim Kai Wei Lee Chin Yik Ooi Deik Roy Chuan Irene Looi Yuen Kah Hay Nurzalina Abdul Karim Khan | 2021 | Stroke & Vascular Neurology2021，6，1： | 2 |
| 6 | 甲糖膏在连续煮糖装置VKT中的煮制显示文摘糖结晶的重要技术进展是连续煮糖罐的采用,因为它允许在糖厂用新的热经济和装备理念,使一次能耗大幅减少。BMA的立式连续煮糖装置VKT是基于成熟的间歇罐设计原理。强制循环的实践和保持低液位相结合,允许使用低压蒸汽加热。用非常低的温差煮糖,在立式连续煮糖装置(VKT)内甲糖膏连续结晶得到了验证。工艺自动化确保甲糖膏的质量稳定。在制糖工艺中第四效蒸汽用于连续煮糖节约蒸汽效果明显。 | Andreas Lehnberger Deike Laue Reinhold Hempelmann | 2017 | 广西糖业2017，37，5： | 2 |
| 7 | Understanding the Rayleigh instability in humping phenomenon during laser powder bed fusion process显示文摘The periodic undulation of a molten track’s height profile in laser-based powder bed fusion of metals(PBF-LB/M)is a commonly observed phenomena that can cause defects and building failure during the manufacturing process.However a quantitative analysis of such instabilities has not been fully established and so here we used Rayleigh–Plateau theory to determine the stability of a single molten track in PBF-LB/M and tested it with various processing conditions by changing laser power and beam shape.The analysis discovered that normalized enthalpy,which relates to energy input density,determines whether a molten track is initially unstable and if so,the growth rate for the instability.Additionally,whether the growth rate ultimately yields significant undulation depends on the melt duration,estimated by dwell time in our experiment. | Wenxuan Zhang Wenyuan Hou Luc Deike Craig Arnold | 2022 | International Journal of Extreme Manufacturing2022，4，1： | 2 |
| 8 | The systemic angiogenic response during bone healing显示文摘 | Stefan Weiss Gerald Zimmermann Thomas Pufe Deike Varoga Philipp Henle | 2009 | Archives of Orthopaedic and Trauma Surgery2009，，： | 1 |
| 9 | A new semi-rigid implant for instrumentation of scoliosis :preliminary report 显示文摘 | Pfeiffer M Deike B Clausen JD | 2001 | Eur Spine J2001，10，5： | 1 |
| 10 | Association of overall survival in patients with newly diagnosed glioblastoma with contrast-enhanced perfusion MRI: Comparison of intraindividually matched T1- and T*2 -based bolus techniques显示文摘 | Bonekamp D Deike K Wiestler B | 2014 | J Magn Reson Imaging2014，，： | 1 |
| 11 | Exact focusing of extracorporeal shock wave therapy for calcifying tendinopathy显示文摘 | HAAKE M DEIKE B THON A | 2002 | Clin Orthop Relat Res2002，，397： | 1 |
| 12 | The role of leptin and cortisol in hyperactivity in patients with acute and weight-recovered anorexia nervosa显示文摘 | Stefan Ehrlich Roland Burghardt Nora Schneider Martina Broecker-Preuss Deike Weiss Julia V. Merle Eugenia Maria Craciun Ernst Pfeiffer Klaus Mann Ulrike Lehmkuhl Johannes Hebebrand | 2009 | Progress in Neuropsychopharmacology & Biological Psychiatry2009，，4： | 1 |
| 13 | Substance abuse and movement disorders: complex interactions and comorbidities 显示文摘 | Deik A Saunders-Pullman R Luciano MS | 2012 | Curr Drug Abuse Rev2012，5，3： | 1 |
| 14 | A new in vitro model of the glial scar inhibits axon growth显示文摘 | Wanner IB Deik A Torres M | | 0，，： | 1 |
| 15 | Dhase inversion harmonic imaging versus Contrast -enhanced power Doppler Sonography for the characterization of focal liver lesions显示文摘 | Deike S Sabine R Peter M | 2003 | Int J Colorectal Dis2003，18，： | 1 |
| 16 | Aluminium-der werkstoff von morgen im motorenbau显示文摘 | Rohrig K Deike R | | Sonderausgabe von ATZ und0，，： | 1 |
| 17 | Detection of liver metastases: Comparison of contrast-enhanced wide-band harmonic imaging with conventional ultrasongraphy显示文摘 | Thomas B Deike S Eckhart GH | 2001 | J Ultrasound Med2001，20，： | 1 |
| 18 | Fish oil supplementation lowers C-reactive protein levels independent of triglyceride reduction in patients with end-stage renal disease显示文摘 | Bowden RG Wilson RL Deike E | 2009 | Nutr Clin Pract2009，24，： | 1 |
| 19 | Percutaneous ethanol injection and radio-frequency ablation for the treatment of nonresectable colorectal liver metastases – techniques and results显示文摘 | D. Becker Johannes M. H?nsler Deike Strobel Eckart G. Hahn | 1999 | Langenbeck’s Archives of Surgery1999，，4： | 1 |
| 20 | Phase inversion harmonic imaging versus contrast-enhanced power Doppler sonography for the characterization of focal liver lesions显示文摘 | Deike S Sabine R Peter M | 2003 | Int J Colorectal Dis2003，18，： | 1 |
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