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您的检索式：作者名="Thomas Minor"
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| 1 | Experimental small bowel preservation using Polysol: A new alternative to University of Wisconsin solution, Celsior and histidine-tryptophan-ketoglutarate solution?显示文摘AIM: To evaluate the potential of Polysol, a newly developed preservation solution, in cold storage of small bowel grafts, compared with the current standards, University of Wisconsin solution (UW), Celsior and histidine-tryptophan-ketoglutarate solution (HTK). METHODS: Male Wistar rats were used as donors. Small bowels were retrieved, flushed and then stored in the respective 4 solutions for 18 h at 4℃. Functional integrity of the grafts was evaluated by isolated reperfusion with oxygenated Krebs-Henseleit buffer at 37℃ for 30 min in all 4 groups. RESULTS: Polysol preservation exhibited the highest tissue ATP concentration and the lowest release of LDH. Malondialdehyde, an index for tissue lipid peroxidation, was also the lowest in Polysol. Tissue oxygen consumption was significantly higher in Polysol than in the others. Of interest, UW-storage promoted 10-fold higher apoptosis than in the others. Moreover, electron microscopy revealed that the mucosal villi/micro-villi formation and the cell organelles, including mitochondria, were both significantly better preserved in Polysol, while deleterious alterations were apparent in the others, most notably in UW. Although Celsior and HTK exhibited the better trend of results than UW in some parameters, but could not reach the over-all superiority to UW.CONCLUSION: Cold storage using Polysol resulted in significantly better integrity and function of small bowel grafts than UW. Hence, Polysol may be a novel alternative for the small bowel preservation. | Lai Wei Koichiro Hata Benedict Marie Doorschodt Reinhard Büttner Thomas Minor René H Tolba | 2007 | World Journal of Gastroenterology2007，13，27： | 9 |
| 2 | 腺苷A2a受体介导利血平引起的行为性抑郁(英文)显示文摘研究腺苷在利血平引起的大鼠行为性抑郁中的作用。应用Porsolt游泳试验 ,观察注射利血平引起的大鼠行为性抑郁 ,通过腹腔注射非特异性腺苷受体阻断剂咖啡因和特异性A1和A2腺苷受体阻断剂 ,确定腺苷在利血平诱导的大鼠行为性抑郁中的作用以及介导这种作用的受体。结果发现 :腹腔注射利血平 (4、6和 8mg/kg)可导致大鼠在游泳试验中漂浮时间明显延长 ,咖啡因和A2a腺苷受体阻断剂能明显缩短利血平导致的漂浮时间的延长。结论 :腺苷通过A2a受体介导利血平引起的大鼠的行为性抑郁。 | 黄庆军 郝新玲 Thomas R Minor | 2003 | 心理学报2003，35，1： | 2 |
| 3 | Impact of polysol, a newly developed preservation solution, on cold storage of steatotic rat livers显示文摘 | Koichiro Hata Rene Hany Tolba Lai Wei Benedict Marie Doorschodt Reinhard Büttner Yuzo Yamamoto Thomas Minor | 2006 | Liver Transpl2006，，1： | 1 |
| 4 | Use of a New Modified HTK Solution for Machine Preservation of Marginal Liver Grafts显示文摘 | Judith Stegemann Andreas Hirner Ursula Rauen Thomas Minor | 2010 | Journal of Surgical Research2010，，1： | 1 |
| 5 | 利血平诱导脑内白介素-1β的产生显示文摘目的 :在既往关于白介素 1β受体阻断剂可部分反转利血平引起的大鼠的行为性抑郁研究的基础上 ,探讨腹腔注射利血平对脑内白介素 1β含量的影响。 方法 :采用Porsolt游泳实验 ,检测腹腔注射利血平 (2、6和 8mg kg)后大鼠的行为抑郁。ELISA法检测脑内白介素 1β的含量。 结果 :发现在腹腔注射利血平 1~ 72小时内 ,引起大鼠的行为性抑郁。大脑皮质、海马和下丘脑中白介素 1β的含量在利血平注射后 2 4小时开始升高 ,4 8小时达到高峰 ,其中以下丘脑为最明显。 结论 :利血平增加脑内白介素 1β的含量 ,可能是利血平引起的行为性抑郁的机制之一。 | 黄庆军 郝新玲 Thomas R Minor | 2003 | 中国免疫学杂志2003，19，11： | 0 |
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