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| 1 | Cloning of differentially expressed genes in human hepatocellular carcinoma and nontumor liver显示文摘INTRODUCTIONThe mechanism of hepatocellular carcinoma(HCC)is still unclear,although some genes have been found to play a role in the transformation of liver cells,and a variety of studies have described differences in gene expression which distinguished tumor from nontumor[1-6].The new genes,especially the functional genes directly related with tumor are still worth being found.The purpose of our study is to find the different genes between human liver tumor and normal tissues using suppression subtractive hybridization. | Xiao-Yan Cao Jie Liu Zhao-Rui Lian Marcy Clayton Jia-Lu Hu Ming-Hua Zh Dai-Ming Fan Mark Feitelson Institute of Digestive Diseases,Xijing Hospital,Fourth Military Medical University,Xi’an 710033,Shaanxi Province,ChinaDepartment of Pathology & Cell Biology,Thomas Jefferson University,Philadelphia,PA19107 USADepartment of Pathology,Second Military Medical University,Shanghai 200433,China | 2001 | World Journal of Gastroenterology2001，7，4： | 7 |
| 2 | 田园学校/北京四中房山校区显示文摘北京,2010-2014这个占地4.5ha的新建公立中学位于北京西南五环外的一个新城的中心,是著名的北京四中的分校区。新学校是避免早期单一功能的郊区开发模式、提倡更加健康和可持续发展的新城计划的重要部分,对新近城市化的周边地区发展起着至关重要的作用。学校的功能空间被组织成上下两部分,并在其间插入花园。垂直并置的上部建筑和下部空间在"中间地带"(架空的夹层)以不同方式相互接触、支撑或连接,这既是营造空间的策略,也象征了新学校中正式与非正式教学空间的关系。 | 李虎 黄文菁 Daijiro Nakayama 叶青 张浩 周亭婷 Thomas Batzenschlager 张畅 Jotte Seghers 王一帆 于清波 苏圣亮 夏至 Spirit of Space | 2018 | 城市环境设计2018，0，5： | 4 |
| 3 | Inducible resistance to Fas-mediated apoptosis in B cells显示文摘Apoptosis produced in B cells through Fas (APO-1, CD95) triggering is regulated by signals derived from other surface receptors: CD40 engagement produces upregulation of Fas expres. sion and marked susceptibility to Fas-induced cell death, whereas antigen receptor engagement, or IL-4R engagement, inhibits Fas killing and in so doing induces a state of Fas-resistance, even in otherwise sensitive, CD40-stimulated targets. Surfaceim. munoglobulin and IL-4R utilize at least partially distinct pathways to produce Fas-resistance that differentially depend on PKC and STAT6, respectively. Further, surface immunoglob- 'lin signaling for inducible Fas-resistance bypasses Bib, requires NF-GB, and entails new macromolecular synthesis. Terminal effectors of B cell Fas-resistance include the known anti-apoptotic gene products, Bcl-xL and FLIP, and a novel anti-apoptotic gene that encodes FAIM (Fas Apoptosis Inhibitory Molecule). faim was identified by differential display and exists in two alternatively spliced forms; maim-S is broadly expressed, but faim-L expression is tissue-specific. The FAIM sequence is highly evolu tionarily conserved, suggesting an important role for this molecule throughout phylogeny. Inducible resistance to Fas killing is hypothesized to protect foreign antigen-specific B cells during potentially hazardous interactions with FasL-bearing T cells, whereas autoreactive B cells fail to become Fas-resistant and are deleted via Fas-dependent cytotoxicity. Inadvertent or aberrant acquisition of Fas-resistance may permit autoreactive B cells to escape Fas deletion, and malignant lymphocytes to impede anti-tumor immunity. | ROTHSTEIN THOMAS L Departments of Medicine and Microbiology, and the Evans Memorial Department of Clinical Research, Boston University Medical Center, Boston, MA, USA | 2000 | Cell Research2000，10，4： | 4 |
| 4 | Studies on the Morphology of Natural Rubber/Polyacrylate Interpenetrating Polymer Networks显示文摘The interpenetrating polymer network(IPN) systems have attracted a lot of attention because of their unique two-phase structure and properties. There have been many publications concerning the IPNs in which poly (isoprene) (PIP) or polyacrylates (PAC) is formed as one of the networks.In the present study, Four serles of natural rubber(NR)/PAC IPNs were prepared and their morphologies were investigated with dynamic mechanics analysis(DMA) and transmission electron microscopy (TEM). | Llao Kalrong (Institute of Polymer Science, Zhangshan University, Guangzhou)Thomas C. Ward (Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA) | 1990 | Chemical Research in Chinese Universities1990，6，1： | 3 |
| 5 | Split liver transplantation: a reliable approach to expand donor pool显示文摘Orthotopic liver transplantation as a successful treatment of end-stage liver disease is hampered by a persistent lack of cadaveric organs. Split liver transplantation, which was first successfully performed by Medical School of Hannover in 1988, has become a mature surgical technique to expand the donor pool. Between 1993 and 1999, split liver transplantation activities have increased in Europe from 1. 2% to 10. 4% in all performed liver transplantations. Current data have strongly supported that the survival rate of patients after split liver transplantation is not significantly different from that of patients after whole-size orthotopic liver transplantation. The most important step of donor graft selection is surgeon’ s observation judged by the experience of individual transplant center. The paper aims to provide the guideline of donor selection, hepatic graft splitting, and recipient management as well. DATA SOURCES: Medical School of Hannover has accumulated plentiful experience of split liver transplantation for more than 10 cases ever since 1998. Besides that, we also reviewed a variety of literatures from other famous European and American centers specialized in this field for many years. RESULTS:According to our experience combined with the view points of others, the donor should meet the following criteria as well: (1) age less than 50 years; (2) hemodynamics stable; (3) ICU less than 5 days; (4) Na less than 170 mmol/L or better if less than 150 mmol/L. In 1996 and 1997, the Hamburg group and the UCLA group separately introduced a breakthrough technique performing split liver transplantation in situ. Evidently, the in situ technique has been limited by prolonged time of donor organ procurement , coordination with other organ procurement teams, and even extra burden on donor hospital. Some groups, therefore, have restored the ex situ or bench splitting technique , and fortunately the transplant outcomes of the ex situ technique are equivalent to those of the in situ one. Recently some new techniques have been introduced to split the liver for two adult patients, including the split-cava technique. CONCLUSIONS:It is clear that the most important factor for determining the prognosis of the patient is the time of receiving liver transplantation, not the type of liver transplantation. We still need to pay close attention to the graft to recipient weight ratio (GRWR) and the UNOS classification or MELD score before the patient is subjected to split liver transplantation. | Ji-Qi Yan, Thomas Becker, Cheng-Hong Peng, Hong-Wei Li and Juergen Klempnauer Department of Surgery, Ruijin Hospital Affiliated to Shanghai Second Medical University, Shanghai 200025, China ( Yan JQ, Peng CH and Li HW) Department of Abdominal and Transplant Surgery, Medical School of Hannover, Carl-Neuberg-Str. 1 , 30625 Hannover, Germany | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 3 |
| 6 | 直接评估吗啡刺激糖尿病人隐静脉内皮一氧化氮释放减少显示文摘to directly measure in real time basal and stimulated levels of NO released from human saphenous vein endothelium and to quantify the expression of the μopiate receptor, which has been linked with NO release. METHODS: Saphenous vein segments from patients with type 2 diabetes ( n = 12) and patients without diabetes (n =8) were obtained. The release of NO was measured directly from the endothelium using a NO-specific amperometric probe. NΩ-nitro-L-arginine methyl ester (L-NAME, 0.1 mmol/L), a NO synthase (NOS) inhibitor, or morphine (1 μmol/L), a stimulant, was administered and the measurements were repeated. Values were reported relative to the mean initial measurement of NO release from diabetic endothelium, which was defined as the relative zero level of NO release. A RT-PCR was then performed on the endothelium to measureμ opiate receptor expression. RESULTS: Diabetic patients (n = 12) showed a relative and significantly diminished basal level of released NO, (0.049± 0.012) nmol/L, compared | Thomas V BILHNGER, James A VOSSWINKEL, Patrick CADET, Christos M RIALAS, Harold I MAGAZINE, George B STEFANO(Division of Cardiothoracic Surgery, Department of Surgery, University Hospital and Medical Center, HSC, T19-080, Stony Brook, New York 11794-8191 Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York , USA) | 2002 | Acta Pharmacologica Sinica2002，23，2： | 3 |
| 7 | SEDIMENT DAMAGES AND RECENT TRENDSIN THE UNITED STATES显示文摘In the United States, cropland erosion has decreased by an estimated one billion tons or 42 Percent for the period 1982 to 1997 (USDA NRCS, 1998) through erosion reduction provisions of the Food Security Actof 1985 and the ongoing soil conservation programs administered by the United States Department ofAgriculture’s Soil Conservation Service (USDA-SCS), which became the Natural Resources ConservationService (USDA-NRCS) in 1997.The U.S. Geological Survey has measured suspended sediment loads at strearn gages from 198O through1989 and showed primarily decreases of from 1 to 12 percent for most regions and increases for only threeregions, ranging from 2 to l2 percent.A Reservoir Sediment Information System (RESIS) was created so that decades of dare on reservoir sediment deposits could be evaluated (Atwood, 1994, Steffen, 1994; Atwood and Steffen, 1994). Theresults of analyses show a major increase in unit-area sediment deposition rates during the period 1970through 1985, which may be attributable to increased cropland acreage, a switch from diversified farming tointensive monocultUred crops, with widespread adoption of soybeans. The most recent measured ratesshow that 25 percent of the United States reservoirs would be at least half-filled with sediment by 2O18,although there is a significant data gap since 1985. Relatively few reservoirs were surveyed since 1985 dueto lack of funding priority and increased survey labor costs. | Jerry M. Bernard (National Geologist) Thomas A. Iivari(Senior Hydrologist, United States Department of Agriculture-Natura ResourcesConservation Service, Washington, DC) | 2000 | International Journal of Sediment Research2000，15，2： | 3 |
| 8 | Consensus conference on sedation assessment显示文摘 | Abbott/American Association of Critical-Care Nurses Saint Thomas He-alth System Sedation Expert Panel Members | 2004 | Crit Care Nurse2004，24，2： | 1 |
| 9 | 显示文摘 | Benetos A Thomas F Joly L Pulse pressure amplification a mechanicalbiomarker of cardiovascular risk | 2010 | Journal of the American Collegeof Cardiology2010，55，10： | 1 |
| 10 | Consensu conference on sedation assessment 显示文摘 | Abbott Association of Critical-Care Nurses Saint Thomas Health System Sedation Expert Panel Members | 2004 | Crit Care Nurse2004，24，2： | 1 |
| 11 | Early Membrane Oxygenation for After Lung TransplantationImproves Outcome显示文摘 | Christopher HW Joshua DL Institution of Extracorporeal Primary Graft Dysfunction Thomas GS | 2007 | J of Heart and Lung Transplantation2007，26，4： | 1 |
| 12 | A pilot study 显示文摘 | Sandhya B Thomas S Isabel W et aL Ethnomedicinal plants used by the Valaiyan community of Piranmalai Hills (Reserved Forest) Tamil Nadu India | 2006 | Afr J Tradit Com- plementAltern Med2006，3，1： | 1 |
| 13 | Biaxial strength of multilaminated extracellular matrix scaffolds 显示文摘 | Donald OF Stephen FB Thomas JW | 2004 | Biomaterials2004，25，12： | 1 |
| 14 | Evidence of theexistence of different intracellular GLUT4 vesiclepopulations显示文摘 | Fischer Y Thomas J Sevilla L Insulin-inducedrecruitment of glucose transporter 4 (GLUT4) andGLUT1 in isolated rat cardiac myocytes | 1997 | J Biol Chem1997，272，11： | 1 |
| 15 | Effects on the variation for milk production traits of Holstein and Jersey cows in California显示文摘 | OJALA M THOMAS R of milk protein genotypes FAMULA | 1997 | J Dairy Sci1997，80，： | 1 |
| 16 | Diagnosis,management,and treatment of hepatitis C:an update显示文摘 | Ghany MG Strader DB Thomas DL et al American Association for the Study of Liver Diseases | | 0，，04： | 1 |
| 17 | Immunohistochemical evaluation of Bcl-2 gene family expression in liver hepatitis C and cirrhotic patients:a novel mechanism to explain the high incidence of hepatocarcinoma in cirrhotics显示文摘 | Thomas OF Sherri Y Edwin JI | 1999 | Am J Gastroenterol1999，94，： | 1 |
| 18 | Diagnosis,management,and treatment of hepatitis C:an update显示文摘 | Ghany MG Strader DB Thomas DL et al American Association for the Study of Liver Diseases | | Hepatology0，，： | 1 |
| 19 | effects and improvement potentials for reuse and recycling in Germany显示文摘 | GRIT W JENNY S THOMAS S Implementation of the WEEE-directive---economii S | 2010 | The International Journal of Advanced Manufacturing Technology2010，47，58： | 1 |
| 20 | Consensus conference on sedation assessment显示文摘 | Abbott/American Association of Critical-Care Nurses Saint Thomas Health System Sedation Expert Panel Members | 2004 | Crit Care Nurse2004，24，2： | 1 |
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