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您的检索式：作者名="Thomas Schaffer"
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| 1 | In- novative system designs for DMFC 显示文摘 | Thomas Schaffer Viktor Hacker Jurgen O Besenhard | 2006 | Journal of Power 'Sources2006，153，2： | 1 |
| 2 | Innovative system designs for DMFC显示文摘 | Thomas Schaffer Viktor Hacker Jürgen O. Besenhard | 2005 | Journal of Power Sources2005，，2： | 1 |
| 3 | Partial overlap of anti-mycobacterial,and anti-Saccharomyces cerevisiae mannan antibodies in Crohn's disease显示文摘AIM:To test whether humoral immune reaction against mycobacteria may play a role in anti-Saccharomyces cerevisiae antibodies(ASCA) generation in Crohn's disease(CD) and/or whether it correlates with clinical subtypes. METHODS:The dominant ASCA epitope was detected by Galanthus nivalis lectin(GNL)-binding assay. ASCA and IgG against mycobacterial lysates(M avium,M smegmatis,M chelonae,M bovis BCG,M avium ssp. paratuberculosis(MAP)] or purified lipoarabinomannans(LAM) were detected by ELISA. ASCA and anti-mycobacterial antibodies were affinity purified to assess cross-reactivities. Anti-mycobacterial IgG were induced by BCG-infection of mice. RESULTS:GNL bound to different extents to mycobacterial lysates,abundantly to purified mannose-capped(Man) LAM from M tuberculosis,but not to uncapped LAM from M smegmatis . Fifteen to 45%of CD patients but only 0%-6% of controls were seropositive against different mycobacterial antigens. Anti-mycobacterial IgG correlated with ASCA(r = 0.37-0.64;P = 0.003-P < 0.001). ASCA-positivity and deficiency for mannan-binding lectin synergistically associated with anti-mycobacterial IgG. In some patients,anti-mycobacterial antibodies represent cross-reactive ASCA. Vice-versa,the predominant fraction of ASCA did not cross-react with mycobacteria. Finally,fistulizing disease associated with antibodies against M avium,M smegmatis and MAP(P = 0.024,0.004 and 0.045,respectively). CONCLUSION:Similar to ASCA,seroreactivity against mycobacteria may define CD patients with complicated disease and a predisposition for immune responses against ubiquitous antigens. While in some patients anti-mycobacterial antibodies strongly cross-react with yeast mannan;these cross-reactive antibodies only represent a minor fraction of total ASCA. Thus,mycobacterial infection unlikely plays a role in ASCA induction. | Stefan Müller Thomas Schaffer Alain M Schoepfer Annamarie Hilty Thomas Bodmer Frank Seibold | 2008 | World Journal of Gastroenterology2008，14，23： | 0 |
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