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| 1 | On the combined effect of soil fertility and topography on tree growth in subtropical forest ecosystems—a study from SE China显示文摘Aims The aim of our research was to understand small-scale effects of topography and soil fertility on tree growth in a forest biodiversity and ecosystem functioning(BEF)experiment in subtropical SE China.Methods Geomorphometric terrain analyses were carried out at a spatial resolution of 5×5 m.Soil samples of different depth increments and data on tree height were collected from a total of 566 plots(667 m2 each).The soils were analyzed for carbon(soil organic carbon[SOC]),nitrogen,acidity,cation exchange capacity(CEC),exchangeable cations and base saturation as soil fertility attributes.All plots were classified into geomorphological units.Analyses of variance and linear regressions were applied to all terrain,soil fertility and tree growth attributes.Important Findings In general,young and shallow soils and relatively small differences in stable soil properties suggest that soil erosion has truncated the soils to a large extent over the whole area of the experiment.This explains the concurrently increasing CEC and SOC stocks downslope,in hollows and in valleys.However,colluvial,carbon-rich sediments are missing widely due to the convexity of the footslopes caused by uplift and removal of eroded sediments by adjacent waterways.The results showed that soil fertility is mainly influenced by topography.Monte-Carlo flow accumulation(MCCA),curvature,slope and aspect significantly affected soil fertility.Furthermore,soil fertility was affected by the different geomorphological positions on the experimental sites with ridge and spur positions showing lower exchangeable base cation contents,especially potassium(K),due to leaching.This geomorphological effect of soil fertility is most pronounced in the topsoil and decreases when considering the subsoil down to 50 cm depth.Few soil fertility attributes affect tree height after 1-2 years of growth,among which C stocks proved to be most important while pH_(KCl)and CEC only played minor roles.Nevertheless,soil acidity and a high proportion of Al on the exchange complex affected tree height even after only 1-2 years growth.Hence,our study showed that forest nutrition is coupled to a recycling of litter nutrients,and does not only depend on subsequent supply of nutrients from the mineral soil.Besides soil fertility,topography affected tree height.We found that especially MCCA as indicator of water availability affected tree growth at small-scale,as well as aspect.Overall,our synthesis on the interrelation between fertility,topography and tree growth in a subtropical forest ecosystem in SE China showed that topographic heterogeneity lead to ecological gradients across geomorphological positions.In this respect,small-scale soil-plant interactions in a young forest can serve as a driver for the future development of vegetation and biodiversity control on soil fertility.In addition,it shows that terrain attributes should be accounted for in ecological research. | Thomas Scholten Philipp Goebes Peter Kühn Steffen Seitz Thorsten Assmann Jürgen Bauhus Helge Bruelheide Francois Buscot Alexandra Erfmeier Markus Fischer Werner Härdtle Jin-Sheng He Keping Ma Pascal A.Niklaus Michael Scherer-Lorenzen Bernhard Schmid Xuezheng Shi Zhengshan Song Goddert von Oheimb Christian Wirth Tesfaye Wubet Karsten Schmidt | 2017 | Journal of Plant Ecology2017，10，1： | 22 |
| 2 | High sustained virologic response rates in children with chronic hepatitis C receiving peginterferon alfa-2b plus ribavirin显示文摘 | Stefan Wirth Carmen Ribes-Koninckx Maria Angeles Calzado Flavia Bortolotti Lucia Zancan Paloma Jara Mark Shelton Nanda Kerkar Marcela Galoppo Alejandra Pedreira Norberto Rodriguez-Baez Mirta Ciocca Alain Lachaux Florence Lacaille Thomas Lang Ulrike Kullme | 2010 | Journal of Hepatology2010，，4： | 2 |
| 3 | Small-bowel MRI in children and young adults with Crohn disease: retrospective head-to-head comparison of contrast-enhanced and diffusion-weighted MRI显示文摘 | Henning Neubauer Thomas Pabst Anke Dick Wolfram Machann Laura Evangelista Clemens Wirth Herbert K?stler Dietbert Hahn Meinrad Beer | 2013 | Pediatric Radiology2013，，1： | 2 |
| 4 | The alteration of metamict zircon and its role in the remobilization of high-field-strength elements in the Georgeville granite,Nova Scotia显示文摘 | Anderson A J Wirth R Thomas R | | 0，，： | 1 |
| 5 | Translocation breakpoints in three patients with campomelic dysplasia and autosomal sex reversal map more than 130 kb from SOX9显示文摘 | Jutta Wirth Thomas Wagner Jobst Meyer Rudolf A. Pfeiffer Hans-Ulrich Tietze Werner Schempp Gerd Scherer | 1996 | Human Genetics1996，，2： | 1 |
| 6 | Three-step tumor targeting of paclitaxel using biotiny lated PLA-PEG nanoparticles and avidin biotin technol ogy: Formulation development and in vitro anticancer ac tivity显示文摘 | Mika Pulkkinen Jere Pikkarainen Thomas Wirth | 2008 | Eur J Pharm Biopharm2008，70，： | 1 |
| 7 | Polybrominated Diphenyl Ethers (PBDEs) in Blubber of Free-Ranging Bottlenose Dolphins (Tursiops Truncatus) from Two Southeast Atlantic Estuarine Areas显示文摘 | Patricia A. Fair Gregory Mitchum Thomas C. Hulsey Jeff Adams Eric Zolman Wayne McFee Ed Wirth Gregory D. Bossart | 2007 | Archives of Environmental Contamination and Toxicology2007，，3： | 1 |
| 8 | TNFα promotes osteogenic differentiation of human mesenchymal stem cells by triggering the NF-κB signaling pathway显示文摘 | Katrin Hess Alexey Ushmorov J?rg Fiedler Rolf E. Brenner Thomas Wirth | 2009 | Bone2009，，2： | 1 |
| 9 | Fast smooth-surface micro-finite element analysis of large-scale bone models 显示文摘 | Andreas J Wirth Cyril FIaig Thomas L Mueller | 2008 | Journal of Biomechanics2008，41，1： | 1 |
| 10 | Epithelial- mesenchymal transition : NF-kappaB takes center stage 显示文摘 | Huber M A Beug Hartmut Wirth Thomas | 2004 | Cell Cycle2004，3，12： | 1 |
| 11 | Performance during Face Processing Differentiates Schizophrenia Patients with Delusional Misidentifications显示文摘 | Walther Sebastian Federspiel Andrea Horn Helge Wirth Miranka Bianchi Piero Strik Werner Müller Thomas J | 2010 | Psychopathology2010，，2： | 1 |
| 12 | 手性高价碘试剂诱导的烯烃不对称官能团化反应研究进展显示文摘手性高价碘试剂诱导的烯烃官能团化是获得对映体富集的手性分子和具有生物活性天然产物的基本方法,是不对称合成中一个崭新且富有成效的领域之一.纵观20年来该领域的发展,在手性高价碘诱导下,一方面通过分子间的官能团化实现了双键的双磺酰氧基化、双乙酰氧基化、双卤化、双胺化、羟基化-磺酰氧基化、卤化-烷基化及羰基化等,对映选择性地合成了各种官能团化的产物;另一方面通过分子内的氧化内酯化、醚化、酰胺化、芳基化等反应,对映选择性地合成了γ-丁内酯、色满环、异色满环、噁唑烷酮、哌啶、吡咯烷、氮杂环丙烷等各种环状化合物,为手性杂环化合物的合成提供了有效途径.此外,由于手性高价碘高效诱导烯烃发生各种官能团化,提供了优秀的产率和对映选择性,因此,该方法学已被用于天然产物的全合成中.就近二十年来手性高价碘试剂诱导的烯烃官能团化及其在天然产物全合成中的应用进行综述. | 张怀远 Thomas Wirth | 2021 | 有机化学2021，41，1： | 1 |
| 13 | Polybrominated Diphenyl Ethers (PBDEs) in Blubber of Free-Ranging Bottlenose Dolphins (Tursiops Truncatus) from Two Southeast Atlantic Estuarine Areas显示文摘 | Patricia A. Fair Gregory Mitchum Thomas C. Hulsey Jeff Adams Eric Zolman Wayne McFee Ed Wirth Gregory D. Bossart | 2007 | Archives of Environmental Contamination and Toxicology2007，，3： | 1 |
| 14 | Recombinant alfa-interferon plus ribavirin therapy in children and adolescents with chronic hepatitis C显示文摘 | Stefan Wirth Thomas Lang Stephan Gehring Patrick Gerner | 2002 | Hepatology2002，，5： | 1 |
| 15 | High sustained virologic response rates in children with chronic hepatitis C receiving peginterferon alfa-2b plus ribavirin显示文摘 | Stefan Wirth Carmen Ribes-Koninckx Maria Angeles Calzado Flavia Bortolotti Lucia Zancan Paloma Jara Mark Shelton Nanda Kerkar Marcela Galoppo Alejandra Pedreira Norberto Rodriguez-Baez Mirta Ciocca Alain Lachaux Florence Lacaille Thomas Lang Ulrike Kullme | 2010 | Journal of Hepatology2010，，4： | 1 |
| 16 | Epstein-Barr Virus-Induced Gene-3 Is Expressed in Human Atheroma Plaques显示文摘 | Sybille Kempe Philipp Heinz Enik? Kokai Odile Devergne Nikolaus Marx Thomas Wirth | 2009 | The American Journal of Pathology2009，，1： | 1 |
| 17 | Circulating adipokines and the protective effects of hyperinsulinemia in inflammatory bowel disease显示文摘 | Luzia Valentini Eva Katrin Wirth Ulrich Schweizer Susanne Hengstermann Lennart Schaper Thomas Koernicke Ekkehart Dietz Kristina Norman Carsten Buning Brigitte M. Winklhofer-Roob Herbert Lochs Johann Ockenga | 2009 | Nutrition2009，，2： | 1 |
| 18 | A short perspective on gene therapy:Clinical experience on gene therapy of gliomablastoma multiforme显示文摘More than two decades have passed since the first gene therapy clinical trial was conducted.During this time,we have gained much knowledge regarding gene therapy in general,but also learned to understand the fear that persists in society.We have experienced drawbacks and successes.More than 1700 clinical trials have been conducted where gene therapy is used as a means for therapy.In the very first trial,patients with advanced melanoma were treated with tumor infiltrating lymphocytes genetically modified ex-vivo to express tumor necrosis factor.Around the same time the first gene therapy trial was conducted,the ethical aspects of performing gene therapy on humans was intensively discussed.What are the risks involved with gene therapy?Can we control the technology?What is ethically acceptable and what are the indications gene therapy can be used for?Initially,gene therapy was thought to be implemented mainly for the treatment of monogenetic diseases,such as adenosine deaminase deficiency.However,other therapeutic areas have become of interest and currently cancer is the most studied therapeutic area for gene therapy based medicines.In this review I will be giving a short introduction into gene therapy and will direct the discussion to where we should go from here.Furthermore,I will focus on the use of the Herpes simplex virus-thymidine kinase for gene therapy of malignant gliomas and highlight the efficacy of gene therapy for the treatment of malignant gliomas,but other strategies will also be mentioned. | Thomas Wirth | 2011 | World Journal of Experimental Medicine2011，1，1： | 0 |
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