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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | A cost-effectiveness study of a randomised trial of laparoscopy versus laparotomy for ectopic pregnancy 显示文摘 | Gray DT Thorbum J Lundorff P | 1995 | Lancet1995，345，： | 1 |
| 3 | Variations in stream water uptake by Eucalyptus camaldulensis with differing access to stream water 显示文摘 | Thorbum P J Walker G R | 1994 | Oecologia1994，100，： | 1 |
| 4 | Differ- ential and genetically separable associations of leptin with obesity-related traits 显示文摘 | Thorbum A W Holdsworth A Proietto J | 2000 | International Journal of Obesity2000，24，6： | 1 |
| 5 | Volume preloading is not essential to prevent spinal - induced hypotension at caesarean section 显示文摘 | Jackson R Reid JA Thorbum | 1995 | Br anaesth1995，75，： | 1 |
| 6 | Pneumococcal conjugate vaccine-induced regulatory T cells suppress the development of allergic airways disease显示文摘 | THORBUM AN O'SULLIVAN BJ THOMAS R | 2010 | Thorax2010，65，12： | 1 |
| 7 | Autophagy in cancer, good, bad, or both?显示文摘 | Hippert MM O'Toole PS Thorbum A | 2006 | Cancer Res2006，66，19： | 1 |
| 8 | Peroxide-scavenging deficit underlies oligodendrocyte susceptibility to oxidative stress显示文摘 | Juurlink BH Thorbume SK Hertz L | 1998 | Glia1998，22，4： | 1 |
| 9 | Activation of Caspase pathways during iron chelator- mediated apoptosis显示文摘 | Greene BT Thorbum J Willingham MC | 2002 | J Biol Chem2002，277，25： | 1 |
| 10 | Autophagy and metastasis: another double-edged sword 显示文摘 | Kenific CM Thorbum A Debnath J | 2010 | Curr Opin Cell Biol2010，22，2： | 1 |
| 11 | Risk factors for cctop ic pregnancyin ass isted reproduction 显示文摘 | StrandeU A Thorbum J Hamberger L | 1999 | Fcrtil Steril1999，71，： | 1 |
| 12 | A comparison of heat pulse and deuterium tracing techniques for estimating sap flow in Eucalyptus grandis trees显示文摘 | Kalma S J Thorbum P J Dunn G M | 1998 | Tree Physiology1998，18，10： | 1 |
| 13 | Nitrate in groundwater of intensive agricultural areas in coastal Northeastern Australia 显示文摘 | THORBUM P J BIGGS J S WEIER K L | 2003 | Agriculture Ecosystems and En- vironment2003，，94： | 1 |
| 14 | Sources of water used by riparian Eucalyptus camaldulensis oberlying highly saline ground water 显示文摘 | Mensforth L J Thorbum P J Tyerman S D | 1994 | Oecologia1994，100，： | 1 |
| 15 | Low glutathione and high iron govem the susceptibility of oligodendroglial precursors to oxidative stress 显示文摘 | Thorbume SK Juurlink BH | 1996 | J Neurochem1996，67，3： | 1 |
| 16 | WetUp:A software tool to display approximate wetting patterns from drippers显示文摘 | Cook F J Thorbum P J Fitch P | | 0，，3： | 1 |
| 17 | Right ventricular function in children with severe respiratory syncytial virus (RSV) bronchiolitis显示文摘 | Thorbum K Eisenhut M | 2011 | Minerva Anestesiologica2011，77，1： | 1 |
| 18 | Rapid analysis of ecstasy and related phenthylamines in seized tab- lets by Raman spectroscopy 显示文摘 | Steven E J Bell Thorbum Bums D | 2000 | Analyst2000，125，： | 1 |
| 19 | Hospltatlzations for coronary artery disease among patients with systemic lupus erythematosus显示文摘 | Thorbum CM Ward MM | 2003 | Arthritis Rheum2003，48，： | 1 |
| 20 | Time Stepping Finite Element Analysis of a Variable Speed Synchronous Generator with Rectifier显示文摘 | Karin Thorbum Karl-Erik Karlsson Ame Wolfbrandt | 2006 | Applied Energy2006，83，： | 1 |
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