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| 1 | High prevalence of vitamin A deficiency in Crohn's disease patients according to serum retinol levels and the relative dose-response test显示文摘AIM:To assess the vitamin A status of patients with Crohn's disease(CD) by evaluating serum retinol levels and the relative dose response(RDR) test(liver retinol stores).METHODS:Vitamin A nutritional status was measured by serum retinol obtained by high performance liquid chromatography and the RDR test for evaluation of the hepatic stores.Body composition was performed by densitometry by dual-energy X-ray absorptiometry.Vitamin A dietary intake was assessed from a semiquantitative food frequency questionnaire.RESULTS:This study included 38 CD patients and 33 controls.Low serum retinol concentrations were detected in 29% of CD patients vs 15% in controls(P < 0.005).The RDR test was positive in 37% of CD patients vs 12% in controls,which indicated inadequate hepatic vitamin A stores(P < 0.005).Individuals with hypovitaminosis A had lower BMI and body fat compared with those without this deficiency.There was no association between vitamin A deficiency and its dietary intake,ileal location,presence of disease activity and prior bowel resections.CONCLUSION:Patients with CD have higher prevalence of vitamin A deficiency,as assessed by two independent methods. | Márcia Soares-Mota Tianny A Silva Luanda M Gomes Marco AS Pinto Laura MC Mendon?a Maria Lúcia F Farias Tiago Nunes Andrea Ramalho Cyrla Zaltman | 2015 | World Journal of Gastroenterology2015，21，5： | 4 |
| 2 | Target costing operationalization during product development:Model and application显示文摘 | Tiago P F Francisco J K N Michael R D | 2009 | Int J Production Economics2009，，118： | 1 |
| 3 | Catalyticall yActivepu-Oxodiiron(IV) Oxidants from Iron(III) and Dioxygen 显示文摘 | Ghosh A Tiago de Oliveira F Yano T | 2005 | J Am Chem Soc2005，127，： | 1 |
| 4 | Scanning electron microscopy and microbiological evaluation of equine burn wound repair after platelet-rich plasma gel treatment显示文摘 | Maciel F B De Rossi R Tiago J C Modolo | 2012 | Burns:Journal of the International Society for Burn Injuries2012，38，7： | 1 |
| 5 | Analysis and simulation of“low-cost”strategies to reduce fuel consumption and emissions in conventional gasoline light-duty vehicles显示文摘 | Carla S Marc R Tiago F | 2009 | Energy Conversion and Management2009，50，2： | 1 |
| 6 | Chitosan-coated solid lipid nanoparticles enhance the oral absorption of insulin 显示文摘 | PEDRO F TIAGO N CHRISTIANE G | 2011 | Drug Deliv Transl Res2011，1，4： | 1 |
| 7 | Basic Red 51, a per- mitted semi-permanent hair dye, is cytotoxic to human skin cells: Studies in monolayer and 3D skin model using human keratinocytes (HaCaT) 显示文摘 | Zanoni TB Tiago M Faiao-Flores F | 2014 | Toxicology Letters2014，227，2： | 1 |
| 8 | Direct-acting antivirals for chronic hepatitis C treatment: The experience of two tertiary university centers in Brazil显示文摘BACKGROUND Hepatitis C virus(HCV)treatment has undergone major changes in recent years.Previous interferon-based therapies have been replaced by oral direct-acting antivirals(DAA)regimens,with high sustained virologic response(SVR)rates,and a lower incidence of adverse events(AEs).AIM To evaluate the efficacy and safety of DAAs for HCV treatment in subjects from two tertiary university centers in Brazil.METHODS This is a multicenter retrospective cohort study of 532 patients with chronic hepatitis C(CHC),undergoing treatment with interferon-free regimens from November 2015 to November 2019.The therapeutic regimen was defined by the current Brazilian guidelines for HCV management at the time of treatment.Demographic,anthropometric,clinical,and laboratory variables were evaluated.SVRs were assessed at 12 to 24 wk after therapy by intention-to-treat(ITT),and modified ITT(m-ITT)analysis.AEs and serious adverse events(SAEs)were registered.In the statistical analysis,a P value of<0.05 was considered significant.RESULTS The mean age was 56.88 years,with 415(78.5%)being HCV genotype 1,followed by genotype 3(20.1%).Moreover,306(57.5%)subjects had cirrhosis,and a third of them had decompensated cirrhosis.Sofosbuvir(SOF)plus daclatasvir±ribavirin was the most frequently used treatment(66.9%),followed by SOF plus simeprevir(21.2%).The overall ITT SVR was 92.6%(493/532),while the m-ITT SVR was 96.8%(493/509).Variables associated with treatment failure via ITT evaluation were hepatic encephalopathy(OR:4.320;95%CI:1.920-9.721,P=0.0004),presence of esophageal varices(OR:2.381;95%CI:1.137-4.988,P=0.0215),previous portal hypertensive bleeding(OR:2.756;95%CI:1.173-6.471,P=0.02),higher model for end-stage liver disease scores(OR:1.143,95%CI:1.060–1.233,P=0.0005),lower serum albumin levels(OR:0.528,95%CI:0.322-0.867,P=0.0115),higher serum creatinine(OR:1.117,95%CI:1.056-1.312,P=0.0033),and international normalized ratio(INR)levels(OR:5.542,95%CI:2.023-15.182,P=0.0009).AEs were reported in 41.1%(211/514)of patients,and SAEs in 3.7%.The female gender,higher body mass index,esophageal varices,higher INR values,and longer treatment duration were independently associated with AE occurrence.CONCLUSION Treatment with oral DAAs attains a high SVR rate,with fewer SAEs in a real-life cohort of subjects with CHC,from two tertiary university centers in Brazil. | Mariana Sandoval Lourenço Patricia Momoyo Y Zitelli Marlone Cunha-Silva Arthur Ivan N Oliveira Cláudia P Oliveira Tiago Sevá-Pereira Flair JoséCarrilho Mario G Pessoa Daniel F Mazo | 2022 | World Journal of Hepatology2022，14，1： | 1 |
| 9 | Extending the understanding of mobile banking adoption:When UTAUT meets TTF and ITM显示文摘 | Tiago O Miguel F Manoj A T | 2014 | International Journal of Information Management2014，34，： | 1 |
| 10 | Antibiotic re- sistance of enterococci and related bacteria in an urban wastewater treatment plant 显示文摘 | Da Silva M F Tiago I Verissimo A | 2006 | FEMS Microbiology Ecol- ogy2006，55，2： | 1 |
| 11 | Aerobic exercise training-induced left ventricular hypertrophy involves reg- ulatory microRNAs, decreased angiotensin-convertiug en- zyme-angiotensin II, and synergistic regulation of angio- tensin-converting enzyme 2 -Angiotensin( 1 -7 ) 显示文摘 | Tiago F Nara YH Fldvio CM | 2011 | Hy- pertension2011，58，： | 1 |
| 12 | Antibioticresistance of enterococci and related bacteria in an urban wastewater treatment plant显示文摘 | DA SILVA M F TIAGO l VER|SSIMO A | 2006 | FEMS Microbiology Ecology2006，55，2： | 1 |
| 13 | Server consolida?tion with migration control for virtualized data centers显示文摘 | TIAGO C F MARCO AS N RODRIGO N C | 2011 | Future Gen?eration Comp Syst2011，27，8： | 1 |
| 14 | Trust zone: integrated hardware and software security enabling trusted computing in embedded system 显示文摘 | TIAGO A DON F | 2004 | Government Information Quarterly2004，3，4： | 1 |
| 15 | Antibiotic resistance of Enterococci and related bacteria in an urban wastewater treatment plant显示文摘 | Da Silva M F Tiago I Verissimo A | 2006 | FEMS Microbiol Ecol2006，55，2： | 1 |
| 16 | SNR approach for performance evaluation of time-stretching photonic analogue to digital converter system 显示文摘 | Tiago M F Alves Adolfo V T Cartaxo | 2011 | Opties Express(S1094-4087)2011，19，2： | 1 |
| 17 | SIRT1 and SIRT2:emerging targets in neurodegeneration 显示文摘 | Gizem Donmezl Tiago F | 2013 | Mol Med2013，，5： | 1 |
| 18 | An integrated method for the determination of set-back lines for coastal erosion hazards on sandy shores 显示文摘 | oscar F Tiago G Ana M Rui T | 2006 | Continental Shelf Research2006，26，9： | 1 |
| 19 | Relationship between cytokine levels in serum and gingival crevicular fluid(GCF) in pregnant wom- en显示文摘 | Tiago F Priseila V Patricia W | 2012 | Cytokine2012，58，1： | 1 |
| 20 | Analysis and Simulation of 'Low-Cost' Strategies to Reduce Fuel Consumption and Emissions in Conven- tional Gasoline Light-duty Vehicles 显示文摘 | Carla S Marc R Tiago F | 2009 | Energy Conversion and Management2009，50，2： | 1 |
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