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| 1 | Secrecy Capacity Maximization for a UAV-Assisted MEC System显示文摘Unmanned aerial vehicle(UAV)communication has attracted wide attentions in the mobile edge computing(MEC)system owing to its high-flexibility and simple operation auxiliary communication mode.Users can offload computing tasks to UAVs,which serves as edge nodes.Meanwhile,UAVs forward the tasks onto a cloud center or base station for processing,thereby shortening the implementation time of tasks.Nevertheless,the offloading links of an UAV-assisted MEC system adopt a radio broadcasting mode.Several eavesdroppers might be present in the environment to eavesdrop the data sent by users and UAVs,thereby causing significant effects on the secrecy performance.An optimized iterative algorithm is proposed in this paper to realize the maximum secrecy capacity of the MEC system and further improve the secrecy performance of an UAV-assisted MEC system and assure secrecy transmit.By doing so,the secrecy transmit problems of the two-staged offloading model of the UAV-assisted MEC system are solved.The maximum secrecy capacity of the system is obtained through joint optimization of the UAV positions,transmit power of the UAV,task offloading ratio,and allocation of offloading users considering the limited time and energy of an UAV.Simulation results demonstrate that the proposed iterative algorithm can effectively improve the secrecy capacity of the system. | Dongsheng Han Tianhao Shi | 2020 | China Communications2020，17，10： | 7 |
| 2 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
| 3 | EGFR signaling promotes nuclear translocation of plasma membrane protein TSPAN8 to enhance tumor progression via STAT3-mediated transcription显示文摘TSPAN family of protei ns are gen erally con sidered to assemble as multimeric complexes on the plasma membra ne.Our previous work uncovered that TSPAN8 can translocate into the nucleus as a membrane-free form,a process that requires TSPAN8 palmitoylation and association with cholesterol to promote its extraction from the plasma membrane and subsequent binding with 14-3-30 and importin-p.However,what upstream signal(S)regulate(s)the nuclear translocation of TSPAN8,the potential function of TSPAN8 in the n ucleus,and the un derlying molecular mechanisms all remai n unclear.Here,we dem on strate that,epidermal growth factor receptor(EGFR)signaling induces TSPAN8 nuclear translocation by activating the kinase AKTZ which in turn directly phosphorylates TSPAN8 at Ser129,an event essential for its binding with 14-3-30 and importin B1.In the nucleus,phosphorylated TSPAN8 interacts with STAT3 to enhance its chromatin occupancy and therefore regulates transcription of downstream cancer-promoting genes,such as MYC,BCL2,MMP9,etc.The EGFR-AKT-TSPAN8-STAT3 axis was found to be hyperactivated in multiple human cancers,and associated with aggressive phe no type and dismal prog nosis.We further developed a humanized mono clonal antibody hT8Ab4 that specifically recognizes the large extracellular loop of TSPAN8(TSPAN8-LEL),thus being able to block the extract!on of TSPAN8 from the plasma membrane and consequently its nuclear localization.Importantly,both in vitro and in vivo studies demonstrated an antitumor effect of hT8Ab4.Collectively,we discovered an unconventional function of TSPAN8 and dissected the underlying molecular mechanisms,which not only showcase a new layer of biological complexity of traditional membrane proteins,but also shed light on TSPAN8 as a novel therapeutic target for refractory cancers. | Xiaoqing Lu Liwei An Guangjian Fan Lijuan Zang Weiyi Huang Junjian Li Jun Liu Weiyu Ge Yuwei Huang Jingxuan Xu Shaoqian Du Tianhao Zhou Huijing Yin Li Yu Shi Jiao Hongxia Wang | 2022 | Cell Research2022，32，4： | 1 |
| 4 | Effect of traffic tidal flow on pollutant dispersion in various street canyons and corresponding mitigation strategies显示文摘Increasing traffic emission presents a high risk of exposure to residents in near-road buildings.Traffic tidal flow(TTF)has gradually become one of the most important components of urban traffic congestion.By computational fluid dynamics simulation,the present study examines the airflow,spatial distribution of pollutant concentration,and personal intake fraction(IF_p)of CO in five street canyon structures(shallow,regular,deep,step-up,and step-down street canyons),with non-uniform TTF-induced traffic emission considered.Optimal urban design devices(wind catchers)are subsequently introduced to reduce IF_p.The results suggest that leeward IF_p is far higher in concentration than the windward wall in the shallow,regular,step-up,and step-down street canyons but lower than the windward side in the deep street canyon under different TTF conditions.Moreover,the TTF condition S L(leeward source)/S W(windward source)=3/1 leads to a higher leeward IF_p in the shallow,regular,deep,and step-up street canyons,compared with S L/S W=1/3;however,no significant difference in windward IF_p is found under the different TTF conditions.The highest IF_p and lowest IF_p for both TTF configurations occur in the step-down and shallow street canyons,respectively.Finally,the effect of wind catchers(WCs)varies between the street canyon structures under different TTF conditions.WCs can lead to at least 30.6%reduction in leeward overall average IF_p()in the shallow,regular,step-up,and step-down street canyons,as well as 12.8%-78.4%decrease in windwardowing to the WCs in the regular,deep,step-up,and step-down street canyons. | Zhengtong Li Tianhao Shi Yongjia Wu Hao Zhang Yu-Hsuan Juan Tingzhen Ming Nan Zhou | 2020 | Energy and Built Environment2020，1，3： | 0 |
| 5 | Effects of Er-doping on the Structure and Photoelectric Properties of 0.825K_(0.5)Na_(0.5)NbO_(3)-0.175Sr(Yb_(0.5)Nb_(0.5)) O_(3) Ceramics显示文摘Multifunctional ceramics of 0.825K_(0.5)Na_(0.5)NbO_(3)-0.175Sr(Yb_(0.5)Nb_(0.5))O_(3)-x%Er with ferroelectric,transparent and luminescent properties were obtained by doping Er.The effects of Er-doping on the structure,luminescence and electrical properties of the ceramics were studied.After Er doping,the ceramics have luminescent properties and the luminescence intensity reaches the maximum when x=0.75.The ceramics still have good light transmission,but the transmittance decreases with the increase of Er-doping content due to the change of phase structure from pseudo-cubic phase to three-phase orthogonality.The energy storage properties is also greatly improved,and the W_(rec) and the η of the ceramics reach the maximum value of 0.31 J/cm^(3) and 94.6% when x=0.25,respectively.At the same time,the maximum electro-induced strain value is 0.031%. | 关英文 SUN Yabing ZHAO Tianhao SHI Shaoyang FU Weining LIU Shimin 王华 XU Jiwen | 2022 | Journal of Wuhan University of Technology(Materials Science)2022，37，5： | 0 |
| 6 | Multiomics analysis reveals metabolic subtypes and identifies diacylglycerol kinase α (DGKA) as a potential therapeutic target for intrahepatic cholangiocarcinoma显示文摘Background:Intrahepatic cholangiocarcinoma(iCCA)is a highly heteroge-neous and lethal hepatobiliary tumor with few therapeutic strategies.The metabolic reprogramming of tumor cells plays an essential role in the develop-ment of tumors,while the metabolic molecular classification of iCCA is largely unknown.Here,we performed an integrated multiomics analysis and metabolic classification to depict differences in metabolic characteristics of iCCA patients,hoping to provide a novel perspective to understand and treat iCCA.Methods:We performed integrated multiomics analysis in 116 iCCA samples,including whole-exome sequencing,bulk RNA-sequencing and proteome anal-ysis.Based on the non-negative matrix factorization method and the protein abundance of metabolic genes in human genome-scale metabolic models,the metabolic subtype of iCCA was determined.Survival and prognostic gene analy-ses were used to compare overall survival(OS)differences between metabolic subtypes.Cell proliferation analysis,5-ethynyl-2’-deoxyuridine(EdU)assay,colony formation assay,RNA-sequencing and Western blotting were performed to investigate the molecular mechanisms of diacylglycerol kinaseα(DGKA)in iCCA cells.Results:Three metabolic subtypes(S1-S3)with subtype-specific biomarkers of iCCA were identified.These metabolic subtypes presented with distinct prog-noses,metabolic features,immune microenvironments,and genetic alterations.The S2 subtype with the worst survival showed the activation of some special metabolic processes,immune-suppressed microenvironment and Kirsten ratsar-coma viral oncogene homolog(KRAS)/AT-rich interactive domain 1A(ARID1A)mutations.Among the S2 subtype-specific upregulated proteins,DGKA was further identified as a potential drug target for iCCA,which promoted cell proliferation by enhancing phosphatidic acid(PA)metabolism and activating mitogen-activated protein kinase(MAPK)signaling.Conclusion:Viamultiomics analyses,we identified three metabolic subtypes of iCCA,revealing that the S2 subtype exhibited the poorest survival outcomes.We further identified DGKA as a potential target for the S2 subtype. | Weiren Liu Huqiang Wang Qianfu Zhao Chenyang Tao Weifeng Qu Yushan Hou Run Huang Zimei Sun Guiqi Zhu Xifei Jiang Yuan Fang Jun Gao Xiaoling Wu Zhixiang Yang Rongyu Ping Jiafeng Chen Rui Yang Tianhao Chu Jian Zhou Jia Fan Zheng Tang Dong Yang Yinghong Shi | 2024 | Cancer Communications2024，44，2： | 0 |
| 7 | Phonon-assisted upconversion in twisted two-dimensional semiconductors显示文摘Phonon-assisted photon upconversion(UPC)is an anti-Stokes process in which incident photons achieve higher energy emission by absorbing phonons.This letter studies phonon-assisted UPC in twisted 2D semiconductors,in which an inverted contrast between UPC and conventional photoluminescence(PL)of WSe2 twisted bilayer is emergent.A 4-fold UPC enhancement is achieved in 5.5°twisted bilayer while PL weakens by half.Reduced interlayer exciton conversion efficiency driven by lattice relaxation,along with enhanced pump efficiency resulting from spectral redshift,lead to the rotation-angle-dependent UPC enhancement.The counterintuitive phenomenon provides a novel insight into a unique way that twisted angle affects UPC and light-matter interactions in 2D semiconductors.Furthermore,the UPC enhancement platform with various superimposable means offers an effective method for lighting bilayers and expanding the application prospect of 2D stacked van der Waals devices. | Yuchen Dai Pengfei Qi Guangyi Tao Guangjie Yao Beibei Shi Zhixin Liul Zhengchang Liu Xiao He Pu Peng Zhibo Dang Liheng Zheng Tianhao Zhang Yongji Gong Yan Guan Kaihui Liu Zheyu Fang | 2023 | Light(Science & Applications)2023，12，1： | 0 |
| 8 | A Strategy to Reduce the Peak Temperature of the Chip Working under Dynamic Power Using the Transient Cooling Effect of the Thin-Film Thermoelectric Cooler显示文摘The thin-film thermoelectric cooler(TEC)is a promising solid-state heat pump that can remove the high local heat flux of chips utilizing the Peltier effect.When an electric current pulse is applied to the thin-film TEC,the TEC can achieve an instantaneous lower temperature compared to that created by a steady current.In this paper,we developed a novel strategy to reduce the peak temperature of the chip working under dynamic power,thus making the semiconductor chip operate reliably and efficiently.A three-dimensional numerical model was built to study the transient cooling performance of the thin-film TEC on chips.The effects of parameters,such as the current pulse,the heat flux,the thermoelement length,the number of thermoelements,and the contact resistance on the performance of the thin-film TEC,were investigated.The results showed that when a current pulse of 0.6 A was applied to the thin-film TEC before the peak power of the chip,the peak temperature of the chip was reduced by more than 10℃,making the thin-film thermoelectric cooler a promising technology for the temperature control of modern chips with high peak powers. | WU Yongjia CHEN Sen GONG Tingrui SHI Tianhao ZUO Lei YAN Yonggao FANG Yueping MING Tingzhen | 2022 | Journal of Thermal Science2022，31，4： | 0 |
| 9 | Recombinant human interferon-α1b inhibits SARS-CoV-2 better than interferon-α2b in vitro显示文摘Dear Editor,The coronavirus disease 2019(COVID-19)outbreak,has spread across the world(Wu et al.,2020).The causative agent of COVID-19,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is highly pathogenic and infectious,which become a major public health hazard that has had a devastating social and economic impact worldwide(Li Q.Q.et al.,2020).Variants of the virus have emerged that behave differently(CDC2021;Gobeil et al.,2020;Leung et al.,2021).Some of them show increased infectivity(Li Q.et al.,2020;Zhang et al.,2020)and may escape from neutralizing antibodies(Weisblum et al.,2020). | Danrong Shi Keda Chen Xiangyun Lu Linfang Cheng Tianhao Weng Fumin Liu Nanping Wu Lanjuan Li Hangping Yao | 2022 | Virologica Sinica2022，37，2： | 0 |
| 10 | The thermal analysis of the heat dissipation system of the charging module integrated with ultra-thin heat pipes显示文摘Electric vehicles(EV)played an important role fighting greenhouse gas emissions that contributed to global warming.The construction of the charging pile,which was called as the'gas station'of EV,developed rapidly.The charging speed of the charging piles was shorted rapidly,which was a challenge for the heat dissipation system of the charging pile.In order to reduce the operation temperature of the charging pile,this paper proposed a fin and ultra-thin heat pipes(UTHPs)hybrid heat dissipation system for the direct-current(DC)charging pile.The L-shaped ultra-thin flattened heat pipe with ultra-high thermal conductivity was adopted to reduce the spreading thermal resistance.ICEPAK software was used to simulate the temperature and flow profiles of the new design.And various factors that affected the heat dissipation performance of the system were explored.Simulation results showed that the system had excellent heat dissipation capacity and achieved good temperature uniformity.Rather than solely relied on the fans,this new design efficiently dissipated heat with a lower fan load and less energy consumption. | Tingzhen Ming Xiwang Liao Tianhao Shi Kui Yin Zhiyi Wang Mohammad Hossein Ahmadi Yongjia Wu | 2023 | Energy and Built Environment2023，4，5： | 0 |
| 11 | The effect of noise barriers on viaducts on pollutant dispersion in complex street canyons显示文摘The noise reduction effect of noise barriers has been extensively studied,but the effect on pollutant dispersion remains unclear.A computational fluid dynamics(CFD)simulation is conducted to investigate the effects of different heights,lengths,and types of noise barriers and different wind speeds on pollutant dispersion in street canyons with viaducts.The field synergy theory of the convective mass transfer process is used for quantitative analysis of pollutant dispersion in street canyons.The results show that as the height and length of the noise barrier increase,the pollutant dispersion capacity decreases.As the wind speed increases,the rate of decrease in the average CO concentration declines.The effect of the wind speed on the synergistic improvement of the speed and concentration gradient vectors differs for different types of noise barriers.The performance follows the order:fully-closed noise barrier>left noise barrier>right noise barrier>semi-closed noise barrier.The different noise barrier types significantly impact the flow field and pollutant dispersion and reduce the CO concentration to varying degrees,except for the fully-closed type.The average CO concentration in the pedestrian breathing zone is reduced by a maximum of 55.85%on the leeward side and by 53%on the windward side,indicating that an appropriate noise barrier on the viaduct reduces noise pollution and improves the air quality in street canyons,especially in the pedestrian breathing zone. | Tingzhen Ming Fangyan He Yongjia Wu Tianhao Shi Changrong Su Caixia Wang Zhengtong Li Wei Chen Renaud de Richter | 2023 | Energy and Built Environment2023，4，5： | 0 |
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