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| 1 | Long-term hepatic consequences of chemotherapy-related HBV reactivation in lymphoma patients显示文摘AIM: To investigate the long-term consequences of chemotherapy-related HBV reactivation in patients with lymphoma.METHODS: This study was based on the database of published prospective study evaluating HBV reactivation in HBV lymphoma patients during chemotherapy.Deteriorated liver reserve (DLR) was defined as development of either one of the following conditions during follow-up: (1) newly onset parenchyma liver disease, splenomegaly or ascites without evidence of lymphoma involvement; (2) decrease of the ratio (albumin/globulin ratio) to less than 0.8 or increase of the ratio of INR of prothrombin time to larger than 1.2 without evidence of malnutrition or infection. Liver cirrhosis was diagnosed by imaging studies.RESULTS: A total of 49 patients were included. The median follow-up was 6.2 years (range, 3.9-8.1 years).There were 31 patients with and 18 patients without HBV reactivation. Although there was no difference of overall survival (OS) and chemotherapy response rate between the two groups, DLR developed more frequently in patients with HBV reactivation (48.4% vs 16.7%; P= 0.0342). Among the HBV reactivators, HBV genotype C was associated with a higher risk of developing DLR (P = 0.0768) and liver cirrhosis (P = 0.003). Four of five patients with sustained high titer of HBV DNA and two of three patients with multiple HBV reactivation developed DLR. Further, patients with a sustained high titer of HBV DNA had the shortest OS among the HBV reactivators (P= 0.0000). No patients in the non-HBV reactivation group developed hepatic failure or liver cirrhosis.CONCLUSION: Chemotherapy-related HBV reactivation is associated with the long-term effect of deterioration of hepatic function. | Chi-Chung Wen Chao A.Hsiung Ih-Jen Su Ann-Lii Cheng Ming-Chih Chang Chao-Jung Tsao Woei-Yao Kao Wu-Ching Uen Chiun Hsu Chih-Hung Hsu Yen-Shen Lu Hwei-Fan Tien Tsu-Yi Chao Li-Tzong Chen Jacqueline Whang-Peng Pei-Jer Chen | 2005 | World Journal of Gastroenterology2005，11，34： | 8 |
| 2 | Long-term efficacy and safety of very-low-dose amiodarone treatment for the maintenance of sinus rhythm in patients with chronic atrial fibrillation after successful direct-current cardioversion显示文摘Background Long-term maintenance of sinus rhythm after successful conversion of chronic atrial fibrillation(CAF),often ameliorates patients’ symptoms,reduces the risk of ischemic stroke and improves cardiovascular hemodynamics.This prospective study aims to evaluate the long-term efficacy and safety of very low-dose amiodarone(100 mg daily) for the maintenance of sinus rhythm after successful direct-current(DC) cardioversion in patients with CAF and rheumatic heart disease(RHD) post intervention.Methods This study was a randomized prospective trial.One day after successful DC cardioversion(remained normal sinus rhythm) in patients with CAF and RHD post intervention for more than six months and adequate anticoagulation,all were randomly administered either amiodarone 200 mg daily in group A or amiodarone 100 mg daily in group B.Results A total of 76 patients(40 men and 36 women) were examined from February 1998 to December 1999.The mean age of the patients was(66±10) years,and the mean follow-up was(67±8) months(range 61 to 84 months).Actuarial rates of the maintenance of sinus rhythm were similar in the two groups after 5 years of follow-up.Four patients(11 %) in group A but none in group B experienced significant adverse effects that necessitated withdrawal of amiodarone.No death occurred during the study period.Conclusion A very low dose of amiodarone results in adequate long-term efficacy and is safe for maintaining sinus rhythm in patients with CAF and RHD post intervention after successful DC cardioversion. | JONG Gwo-ping, CHANG Mu-hsin, CHANG Ting-chuan, CHOU Pesus, FU Chong-yau, TIEN Li-yun,CHEN Chung-yin and MA Tso-chiang JONG Gwo-ping CHANG Mu-hsin CHANG Ting-chuan CHOU Pesus FU Chong-yau TIEN Li-yun CHEN Chung-yin MA Tso-chiang | 2006 | Chinese Medical Journal2006，，24： | 6 |
| 3 | Cytogenetic and molecular aberrations of multiple myeloma patients: a single-center study in Singapore显示文摘 | LIM Alvin Soon Tiong LIM Tse Hui SEE Karen Hsu Shien NG Yit Jun TAN Yu Min CHO0 Natasha Swee Lian LIM Sherry Xin Er YEE Yenny LAU Lai Ching TIEN Sim Leng Kumar Sathish TAN Daryl Chen Lung | 2013 | Chinese Medical Journal2013，，10： | 4 |
| 4 | Comparison of machine learning models for gully erosion susceptibility mapping显示文摘Gully erosion is a disruptive phenomenon which extensively affects the Iranian territory,especially in the Northern provinces.A number of studies have been recently undertaken to study this process and to predict it over space and ultimately,in a broader national effort,to limit its negative effects on local communities.We focused on the Bastam watershed where 9.3%of its surface is currently affected by gullying.Machine learning algorithms are currently under the magnifying glass across the geomorphological community for their high predictive ability.However,unlike the bivariate statistical models,their structure does not provide intuitive and quantifiable measures of environmental preconditioning factors.To cope with such weakness,we interpret preconditioning causes on the basis of a bivariate approach namely,Index of Entropy.And,we performed the susceptibility mapping procedure by testing three extensions of a decision tree model namely,Alternating Decision Tree(ADTree),Naive-Bayes tree(NBTree),and Logistic Model Tree(LMT).We dichotomized the gully information over space into gully presence/absence conditions,which we further explored in their calibration and validation stages.Being the presence/absence information and associated factors identical,the resulting differences are only due to the algorithmic structures of the three models we chose.Such differences are not significant in terms of performances;in fact,the three models produce outstanding predictive AUC measures(ADTree=0.922;NBTree=0.939;LMT=0.944).However,the associated mapping results depict very different patterns where only the LMT is associated with reasonable susceptibility patterns.This is a strong indication of what model combines best performance and mapping for any natural hazard-oriented application. | Alireza Arabameri Wei Chen Marco Loche Xia Zhao Yang Li Luigi Lombardo Artemi Cerda Biswajeet Pradhan Dieu Tien Bui | 2020 | Geoscience Frontiers2020，11，5： | 3 |
| 5 | Dye-sensitized solar cells based on functionalized truxene structure显示文摘Three new metal-free organic dyes(TX1, TX2 and TX3) based on truxene core structure, with triphenylamine as the electron donor, thiophene as the p spacers, and cyanoacetic acid or rhodanine-3-acetic acid as the electron acceptor are designed and synthesized. Their UV–vis absorption spectra,electrochemical and photovoltaic properties were investigated. The cyanoacrylic acid is verified to be a better acceptor unit(meanwhile the anchoring group) compared to the rhodanine-3-acetic acid. And also, two anchoring groups in TX2 could provide stronger adsorption ability on the Ti O2 surface. In addition, the EIS results indicate a slower charge recombination processes for TX2. As a result, dye TX2 bearing two cyanoacetic acid outperforms the other two dyes, exhibiting the photo-conversion efficiency of 2.64%, with Jsc= 5.09 m A cm–2, Voc= 729 m V, FF = 71.1. | Fei Wu Jian-Lin Liu Lawrence Tien Lin Lee Tao Chen Min Wang Lin-Na Zhu | 2015 | Chinese Chemical Letters2015，26，8： | 3 |
| 6 | Machine learning models compared to existing criteria for noninvasive prediction of endoscopic retrograde cholangiopancreatography-confirmed choledocholithiasis显示文摘Background and aims:Noninvasive predictors of choledocholithiasis have generally exhibited marginal performance characteristics.We aimed to identify noninvasive independent predictors of endoscopic retrograde cholangiopancreatography(ERCP)-confirmed choledocholithiasis and accordingly developed predictive machine learning models(MLMs).Methods:Clinical data of consecutive patients undergoing first-ever ERCP for suspected chol-edocholithiasis from 2015 to 2019 were abstracted from a prospectively-maintained database.Multiple logistic regression was used to identify predictors of ERCP-confirmed choledocholithiasis.MLMs were then trained to predict ERCP-confirmed choledocholithiasis using pre-ERCP ultrasound(US)imaging only as well as using all available noninvasive imaging(US,computed tomography,and/or magnetic reso-nance cholangiopancreatography).The diagnostic performance of American Society for Gastrointestinal Endoscopy(ASGE)“high-likelihood”criteria was compared to MLMs.Results:We identified 270 patients(mean age 46 years,62.2%female,73.7%Hispanic/Latino,59%with noninvasive imaging positive for choledocholithiasis)with native papilla who underwent ERCP for suspected choledocholithiasis,of whom 230(85.2%)were found to have ERCP-confirmed chol-edocholithiasis.Logistic regression identified choledocholithiasis on noninvasive imaging(odds ratio(OR)¼3.045,P¼0.004)and common bile duct(CBD)diameter on noninvasive imaging(OR¼1.157,P¼0.011)as predictors of ERCP-confirmed choledocholithiasis.Among the various MLMs trained,the random forest-based MLM performed best;sensitivity was 61.4%and 77.3%and specificity was 100%and 75.0%,using US-only and using all available imaging,respectively.ASGE high-likelihood criteria demonstrated sensitivity of 90.9%and specificity of 25.0%;using cut-points achieving this specificity,MLMs achieved sensitivity up to 97.7%.Conclusions:MLMs using age,sex,race/ethnicity,presence of diabetes,fever,body mass index(BMI),total bilirubin,maximum CBD diameter,and choledocholithiasis on pre-ERCP noninvasive imaging predict ERCP-confirmed choledocholithiasis with good sensitivity and specificity and outperform the ASGE criteria for patients with suspected choledocholithiasis. | Camellia Dalai John M Azizian Harry Trieu Anand Rajan Formosa C Chen Tien Dong Simon W Beaven James H.Tabibian | 2021 | Liver Research2021，5，4： | 3 |
| 7 | Chemotherapy‐induced hepatitis B reactivation in lymphoma patients with resolved HBV infection: A prospective study显示文摘 | Chiun Hsu Hsiao‐Hui Tsou Shyh‐Jer Lin Ming‐Chung Wang Ming Yao Wen‐Li Hwang Woei‐Yau Kao Chang‐Fang Chiu Sheng‐Fung Lin Johnson Lin Cheng‐Shyong Chang Hwei‐Fang Tien Tsang‐Wu Liu Pei‐Jer Chen Ann‐Lii Cheng | 2014 | Hepatology2014，，6： | 3 |
| 8 | Hepatitis B and C viruses are not risks for pancreatic adenocarcinoma显示文摘AIM:To investigate whether hepatitis B virus(HBV)and hepatitis C virus(HCV)increase risk of pancreatic ductal adenocarcinoma(PDAC).METHODS:We recruited 585 patients with cytological and/or pathologically confirmed PDAC in National Taiwan University Hospital from September 2000 to September 2013,and 1716 age-,sex-,and race-matched controls who received a screening program in a community located in Northern Taiwan.Blood samples were tested for the presence of HCV antibodies(anti-HCV),HBV surface antigen(HBsAg),antibodies against HBsAg(anti-HBs),and hepatitis B core antigen(anti-HBc)in all cases and controls.The odds ratio(OR)of PDAC was estimated by logistic regression analysis with adjustment diabetes mellitus(DM)and smoking.RESULTS:HBsAg was positive in 73 cases(12.5%)and 213 controls(12.4%).Anti-HCV was positive in22 cases(3.8%)and 45 controls(2.6%).Anti-HBs was positive in 338 cases(57.8%)and 1047 controls(61.0%).The estimated ORs of PDAC in multivariate analysis were as follows:DM,2.08(95%CI:1.56-2.76,P<0.001),smoking,1.36(95%CI:1.02-1.80,P=0.035),HBsAg+/anti-HBc+/anti-HBs-,0.89(95%CI:0.89-1.68,P=0.219),HBsAg-/anti-HBc+/anti-HBs+,1.03(95%CI:0.84-1.25,P=0.802).CONCLUSION:HBV and HCV infection are not associated with risk of PDCA after adjustment for age,sex,DM and smoking,which were independent risk factors of PDAC. | Ming-Chu Chang Chien-Hung Chen Ja-Der Liang Yu-Wen Tien Chiun Hsu Jau-Min Wong Yu-Ting Chang | 2014 | World Journal of Gastroenterology2014，20，17： | 2 |
| 9 | Microvascular Structure and Network in the Retina of Patients With Ischemic Stroke显示文摘 | Yi-Ting Ong Deidre A. De Silva Carol Y. Cheung Hui-Meng Chang Christopher P. Chen Meng Cheong Wong Tien Yin Wong Mohammad Kamran Ikram | 2013 | Stroke2013，，8： | 2 |
| 10 | Steroid-free chemotherapy decreases risk of hepatitis B virus (HBV) reactivation in HBV-carriers with lymphoma显示文摘 | Ann-Lii Cheng Chao A. Hsiung Ih-Jen Su Pei-Jer Chen Ming-Chih Chang Chao-Jung Tsao Woei-Yao Kao Wu-Ching Uen Chih-Hung Hsu Hwei-Fan Tien Tsu-Yi Chao Li-Tzong Chen Jacqueline Whang-Peng | 2003 | Hepatology2003，，6： | 2 |
| 11 | Assessing the test–retest repeatability of the V ietnamese version of the N ational E ye I nstitute 25‐item V isual F unction Q uestionnaire among bilateral cataract patients for a V ietnamese population显示文摘 | Kien Gia To Lynn Meuleners Huei‐Yang Chen Andy Lee Dung Van Do Dat Van Duong Tien Duy Phi Hoang Huy Tran Nguyen Do Nguyen | 2014 | Australasian Journal on Ageing2014，，： | 1 |
| 12 | Gap: a graphical environ- ment for matrix visualization and cluster analysis 显示文摘 | WU H M TIEN Y J CHEN C H | 2010 | Computationa Statistics and Data Analysis2010，54，3： | 1 |
| 13 | Preliminary proteome analysis of rabbit serum with hepatic failure 显示文摘 | TIEN CC CHEN JB WANG CC | 2003 | Enzy Mierob Teeh2003，33，4： | 1 |
| 14 | Invariant Fourier Wavelet Descriptor for Pattern Reeognition显示文摘 | Chen Guangyi Tien D B | 1999 | Pattern Recognition1999，32，7： | 1 |
| 15 | finite Anlytic Numerical Solutions For Unaturated Flow Irregular Boundaries显示文摘 | Whey-Fone Tsai Ching-Jen Chen Hui-Chun Tien | 1993 | ASCE Journal of Hydraulic Engineering1993，119，11： | 1 |
| 16 | Neural correlates of impulsive-violent behavior: an event-related potential study显示文摘 | Chen CY Tien YM Juan CH | 2005 | Neuroreport2005，16，11： | 1 |
| 17 | Predicting intention to purchase on group buying website in TaiwanVirtual community, critical mass and risk 显示文摘 | Cheng Shu- Yun Tsai Ming- Tien Cheng Nai- Chang Chen Kun - Shiang | 2012 | Online Informa- tion Review2012，36，5： | 1 |
| 18 | Thermal eonductivities of quantum well structures显示文摘 | Chen G Tien C L | 1993 | J Thermophysics Heat Transfer1993，7，2： | 1 |
| 19 | A new forecasting method of discrete dynamic system显示文摘 | Chen C K Tien T L | 1997 | Applied Mathematics and Computation1997，86，1： | 1 |
| 20 | Challenges in microscale conductive and radiative heat-transfer 显示文摘 | TIEN C L CHEN G | 1994 | ASME Journal of Heat Transfer1994，116，： | 1 |
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