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| 1 | Methane production and small intestinal bacterial overgrowth in children living in a slum显示文摘AIM:To analyze small intestinal bacterial overgrowth in school-aged children and the relationship between hydrogen and methane production in breath tests.METHODS:This transversal study included 85 children residing in a slum and 43 children from a private school,all aged between 6 and 10 years,in Osasco,Brazil.For characterization of the groups,data regarding the socioeconomic status and basic housing sanitary conditions were collected.Anthropometric data was obtained in children from both groups.All children completed the hydrogen(H 2) and methane(CH 4) breath test in order to assess small intestinal bacterial overgrowth(SIBO).SIBO was diagnosed when there was an increase in H 2 ≥ 20 ppm or CH 4 ≥ 10 ppm with regard to the fasting value until 60 min after lactulose ingestion.RESULTS:Children from the slum group had worse living conditions and lower nutritional indices than children from the private school.SIBO was found in 30.9%(26/84) of the children from the slum group and in 2.4%(1/41) from the private school group(P = 0.0007).Greater hydrogen production in the small intestine was observed in children from the slum group when compared to children from the private school(P = 0.007).A higher concentration of hydrogen in the small intestine(P < 0.001) and in the colon(P < 0.001) was observed among the children from the slum group with SIBO when compared to children from the slum group without SIBO.Methane production was observed in 63.1%(53/84) of the children from the slum group and in 19.5%(8/41) of the children from the private school group(P < 0.0001).Methane production was observed in 38/58(65.5%) of the children without SIBO and in 15/26(57.7%) of the children with SIBO from the slum.Colonic production of hydrogen was lower in methaneproducing children(P = 0.017).CONCLUSION:Children who live in inadequate environmental conditions are at risk of bacterial overgrowth and methane production.Hydrogen is a substrate for methane production in the colon. | Carolina Santos Mello Soraia Tahan Lígia Cristina FL Melli Mirian Silva do Carmo Rodrigues Ricardo Martin Pereira de Mello Isabel Cristina Affonso Scaletsky Mauro Batista de Morais | 2012 | World Journal of Gastroenterology2012，18，41： | 3 |
| 2 | Gastro-retentive drug delivery systems and their in vivo success:A recent update显示文摘Gastro-retentive drug delivery system(GRDDS) has gained immense popularity in the field of oral drug delivery recently. It is a widely employed approach to retain the dosage form in the stomach for an extended period of time and release the drug slowly that can address many challenges associated with conventional oral delivery, including poor bioavailability.Different innovative approaches like magnetic field assisted gastro-retention, plug type swelling system, muco-adhesion technique, floating system with or without effervescence are being applied to fabricate GRDDS. Apart from in vitro characterization, successful GRDDS development demands well designed in vivo study to establish enhanced gastro-retention and prolonged drug release. Gama scintigraphy and MRI are popular techniques to evaluate in vivo gastric residence time. However, checking of their overall in-vivo efficacy still remains a major challenge for this kind of dosage form, especially in small animals like mice or rat.Reported in vivo studies with beagle dogs, rabbits, and human subjects are only a handful in spite of a large number of encouraging in vitro results. In spite of the many advantages,high subject variations in gastrointestinal physiological condition, effect of food, and variable rate of gastric emptying time are the challenges that limit the number of available GRDDS in the market. This review article highlights the in vivo works of GRDDS carried out in the recent past, including their limitations and challenges that need to be overcome in the near future. | Uttam Kumar Mandal Bappaditya Chatterjee Faria Gias Senjoti | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，5： | 3 |
| 3 | Low-level laser therapy enhances the number of osteocytes in calvaria bone defects of ovariectomized rats显示文摘Background : Osteoporosis can make bone repair difficult. Low-level laser therapy( LLLT) has been shown to be a promising tool for bone neoformation. This study aimed to analyze the effect of LLLT on calvaria bone defects of ovariectomized rats using stereology. Methods : Fifty-four Wistar rats were subjected to bilateral ovariectomy, and bone defects were created in calvaria after 150 days. The animals were divided into nine groups(n = ?6 per group), and 24 hours after the bone defects were created they received three, six or 12 sessions of LLLT at 0, 20 or 30 J/cm 2, using a 780-nm low-intensity GaAlAs laser. One-way ANOVA followed by Tukey ' s post hoc test was used for data processing. A difference of P < 0.05 was considered statistically significant. The parameters evaluated were osteocyte density( Nv_(ost)), total osteocyte number( Nto ost), trabecular surface density( Sv_t), and trabecular surface area( Sa_t). Results : Data obtained showed that Nto ost, Sv t, and Sa t in group G2 rats were significantly different from G1(0 J/cm^2)( P < 0.05). Compared to group G4, G5 presented higher values for the parameters Sv t and Sa t, and G6 presented significantly higher values for almost all the analyzed parameters( Nv _(ost), Nto_(ost), Sv_t, and Sa t)( P < 0.05). Compared to group G7, G8 showed a higher value only for the parameter Sa t, and G9 showed significantly higher values for parameters Nv ost, Nto ost, Sv_t, and Sa_t. Conclusion : We conclude that LLLT stimulated bone neoformation and contributed to an increase in the total number of osteocytes, especially with a laser energy density of 30 J/cm^2 given for six and 12 sessions. | Priscilla Hakime Scalize Luiz Gustavo de Sousa Lígia Maria Napolitano Goncalves Dimitrius Leonardo Pitol Marcelo Palinkas Antonio Augusto Coppi Mariah Acioli Righeti Vitória Ricardo Karina Fittipaldi Bombonato-Prado Simone Cecílio Hallak Regalo Selma Siessere | 2019 | Animal Models and Experimental Medicine2019，2，1： | 2 |
| 4 | Screening of phenolic compounds in australian grown grapes and their potential antioxidant activities显示文摘Grapes(Vitis Vinifera)are one of the world's most utilised and prized fruit.Grapes are a great source of antioxidants due to the abundance of phenolic compounds.Grape pulp is the main part of the grape being consumed.The pulp of five Australian grown grapes–Dawn Seedless(DS),Calmeria(CG),Golden Globe(GG),Menindee Seedless(MS),and Thompson Seedless(TS)will be qualitatively and quantitatively analysed for its phenolic composition and antioxidant capacity.The general trend followed:GG>TS>MS>DS>CG,and the phenolic content of the pulp also presented a significant positive correlation with the antioxidant capacity.GG revealing the highest levels of TPC(4.31±0.11 mg GAE/g)and TFC(0.48±0.09 mg QE/g)while TS were highest in TTC(0.94±0.12 mg CE/g).Similarly,GG exhibited higher antioxidant capacity in DPPH(5.84±0.17 mg AAE/g),FRAP(4.91±0.14 mg AAE/g),and TAC(6.78±0.12 mg AAE/g),while TS revealed highest radical scavenging ability for ABTS(4.56±0.19 mg AAE/g).The LC-ESI-QTOF-MS/MS tentatively identified 78 phenolic compounds consisting of flavonoids(36),phenolic acids(31),lignans(3),stilbenes(1),and other polyphenols(7)in five grapes samples.Ten most abundant fruit-based targeted polyphenols were quantified.GG had a higher phenolic concentration in HPLC-PDA quantification,particularly for phenolic acids(gallic acid and chlorogenic acid)and flavonoids(kaempferol).Our study provides relatively adequate information on grape pulp's phenolic content and antioxidant capacity,providing confidence and research prospects to promote grape pulp use in different food,pharmaceutical and supplement industries,and even influencing grape cultivation. | Gia Toan Vo Ziyao Liu Osbert Chou Biming Zhong Colin J.Barrow Frank R.Dunshea Hafiz A.R.Suleria | 2022 | Food Bioscience2022，47，3： | 2 |
| 5 | Effects of transcranial ultrasound stimulation pulsed at 40 Hz on Aβplaques and brain rhythms in 5×FAD mice显示文摘Background:Alzheimer's disease(AD)is the most common cause of dementia,and is characterized by amyloid-β(Aβ)plaques and tauopathy.Reducing Aβhas been considered a major AD treatment strategy in pharmacological and non-pharmacological approaches.Impairment of gamma oscillations,which play an important role in perception and cognitive function,has been shown in mouse AD models and human patients.Recently,the therapeutic effect of gamma entrainment in AD mouse models has been reported.Given that ultrasound is an emerging neuromodulation modality,we investigated the effect of ultrasound stimulation pulsed at gamma frequency(40 Hz)in an AD mouse model.Methods:We implanted electroencephalogram(EEG)electrodes and a piezo-ceramic disc ultrasound transducer on the skull surface of 6-month-old 5×FAD and wild-type control mice(n=12 and 6,respectively).Six 5×FAD mice were treated with two-hour ultrasound stimulation at 40 Hz daily for two weeks,and the other six mice received sham treatment.Soluble and insoluble Aβlevels in the brain were measured by enzyme-linked immunosorbent assay.Spontaneous EEG gamma power was computed by wavelet analysis,and the brain connectivity was examined with phase-locking value and cross-frequency phase-amplitude coupling.Results:We found that the total Aβ42 levels,especially insoluble Aβ42;in the treatment group decreased in pre-and infra-limbic cortex(PIL)compared to that of the sham treatment group.A reduction in the number of Aβplaques was also observed in the hippocampus.There was no increase in microbleeding in the transcranial ultrasound stimulation(tUS)group.In addition,the length and number of microglial processes decreased in PIL and hippocampus.Encel-phalographic spontaneous gamma power was increased,and cross-frequency coupling was normalized,implying functional improvement after tUS stimulation.Conclusion:These results suggest that the transcranial ultrasound-based gamma-band entrainment technique can be an effective therapy for AD by reducing the Aβload and improving brain connectivity. | Mincheol Park Gia Minh Hoang Thien Nguyen Eunkyung Lee Hyun Jin Jung Youngshik Choe Moon Hwan Lee Jae Youn Hwang Jae Gwan Kim Tae Kim | 2021 | Translational Neurodegeneration2021，10，4： | 2 |
| 6 | The significance of the dosage adjustment of octreotide in the treatment of acute pancreatitis of moderate severity 显示文摘 | Nikou GC Arnaoutis TP Gia narellos-Bourboulis EJ | 2001 | Hepatogastroenterology2001，48，42： | 1 |
| 7 | Sentinel surveillance for human enterovirus 71 in Sarawak,Malaysia: lessons from the first 7 years 显示文摘 | Podin Y Gias EL Ong F | 2006 | BMC Public Health2006，6，： | 1 |
| 8 | Assessing the test–retest repeatability of the V ietnamese version of the N ational E ye I nstitute 25‐item V isual F unction Q uestionnaire among bilateral cataract patients for a V ietnamese population显示文摘 | Kien Gia To Lynn Meuleners Huei‐Yang Chen Andy Lee Dung Van Do Dat Van Duong Tien Duy Phi Hoang Huy Tran Nguyen Do Nguyen | 2014 | Australasian Journal on Ageing2014，，： | 1 |
| 9 | Abrasion behaviour of polymeric textiles for endovascular stent-grafts显示文摘 | Alexandra Rodrigues Lígia Figueiredo Jo?o Bordado | 2012 | Tribology International2012，，： | 1 |
| 10 | Sentinel surveillance for human en- terovirus 71 in Sarawak, Malaysia: lessons from the first 7 years 显示文摘 | Podin Y Gias E Oug F | 2006 | BMC Public Health2006，6，1： | 1 |
| 11 | Sentinel surveillance for human enterovirus 71 in Sarawak Malaysia lessons from the first 7 years 显示文摘 | Podin Y Gias EL Ong F | 2006 | BMC Public Health2006，6，： | 1 |
| 12 | Rim versus sagittal mandibulectomyfor the treatment of squamous cell carcinoma : two types of mandibularpreservation显示文摘 | Guerra MF Campo FJ Gias LN | 2003 | Head Neck2003，25，： | 1 |
| 13 | Time used for orthodontic sur- gical treatment of dentofacial deformities in white patients显示文摘 | Diaz PM Garcia RG Gias LN | 2010 | J O- ral Maxillofae Surg2010，68，1： | 1 |
| 14 | Ethnopharmacological notes about ancient uses of medicinal plants in Trás-os-Montes (northern of Portugal)显示文摘 | José Manuel Neves Carla Matos Carla Moutinho Glória Queiroz Lígia Rebelo Gomes | 2009 | Journal of Ethnopharmacology2009，，2： | 1 |
| 15 | Influence ofwater activity, temperatre and incubation time on the simultaneous production of deoxynivalenol and zearalenone in corn ( Zea mays ) by Fusarium graminearum 显示文摘 | Ll' gia M Martins H' Marina Martins | 2002 | Food Chemistry2002，79，： | 1 |
| 16 | Analyzing costs and ac-forms 显示文摘 | HIRTH M HOFELD T’GIA PT | 2012 | Mathematical and Computer Modelling2012，，6： | 1 |
| 17 | Synthesis and antiproliferative activity of some new DNA-targeted alkylating pyrroloquinolines 显示文摘 | Ferlin M G Dalla Via L Gia 0 M | 2004 | Bioorganic & Medic- inal Chemistry2004，12，4： | 1 |
| 18 | Polarized erbium-doped superfluorescent fiber source utilizing double-pass backward configuration显示文摘 | Lon A Wang Chun Te Lee Gia Wei You | 2005 | Applied Optics2005，44，1： | 1 |
| 19 | High resolution NMR spectra of poly(N,N-Dimethylacrylamide) in CDCI3 solution 显示文摘 | Huynh Ba Gia McGrath J E | 1980 | Polymer Bulletin1980，2，： | 1 |
| 20 | Sensor management for multi- target tracking via multi-Bernoulli filtering 显示文摘 | Hung Gia Hoang Ba Tuong Vo | 2014 | Automatica2014，50，2： | 1 |
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