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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Reduced striatal volumes in Parkinson’s disease:a magnetic resonance imaging study显示文摘Background:The presence and extent of structural changes in the brain as a consequence of Parkinson’s disease(PD)is still poorly understood.Methods:High-resolution 3-tesla T1-weighted structural magnetic resonance images in sixty-five PD and 27 age-matched healthy control participants were examined.Putamen,caudate,and intracranial volumes were manually traced in the axial plane of 3D reconstructed images.Striatal nuclei volumes were normalized to intracranial volume for statistical comparison.Disease status was assessed using the Unified Parkinson’s Disease Rating Scale and Hoehn and Yahr scale.Cognitive status was assessed using global status tests and detailed neuropsychological testing.Results:Both caudate and putamen volumes were smaller in PD brains compared to controls after adjusting for age and gender.Caudate volumes were reduced by 11%(p=0.001)and putamen volumes by 8.1%(p=0.025).PD striatal volumes were not found to be significantly correlated with cognitive or motor decline.Conclusion:Small,but significant reductions in the volume of both the caudate and putamen occur in PD brains.These reductions are independent of the effects of age and gender,however the relation of these reductions to the functional loss of dopamine,which is characteristic of PD,remains unclear. | Toni L Pitcher Tracy R Melzer Michael R MacAskill Charlotte F Graham Leslie Livingston Ross J Keenan Richard Watts John C Dalrymple-Alford Tim J Anderson | 2012 | Translational Neurodegeneration2012，1，1： | 2 |
| 3 | Assessment of erosion haz- ard with the USLE and GIS A ease study of the Upper Ewaso Nglro North basin of Kenya显示文摘 | Bancy M Mati Royston P C Morgan Francis N Gichuki John N Quinton Tim R Brewer Hans P l iniger | 2000 | lnternation Journal of Applied Earth Ob- servation and Geoinformation2000，2，2： | 1 |
| 4 | Communication skills training in healthcare: A review of the literature 显示文摘 | Simon C Tim J Jacqueline R | 2002 | Nurs Edu Today2002，22，3： | 1 |
| 5 | Communication skills training in heahhcare: A review of the literature 显示文摘 | Simon C Tim J Jacqueline R l | 2002 | Nurs Edu Today2002，22，3： | 1 |
| 6 | Biochar adsorbed ammonia is bioavailable显示文摘 | Rezoo T T Tim J C Robert R S | 2012 | Plant Soil2012，350，12： | 1 |
| 7 | Organic compounds trapped in aqueous fluid inclusions 显示文摘 | Tim E R Simon C G Mark L Robinson A Q | 1998 | Organic Geochemistry1998，29，13： | 1 |
| 8 | Defining Spinal Mobility in Ankylosing Spondylitis (AS):The Bath AS Metrology Index显示文摘 | TIM R JENKINSON PATRICIA A MALLORIE HELEN C WHITELOCK | 1994 | Journal of Rheumatology1994，21，9： | 1 |
| 9 | Nucleotide sequence of A T Pase subunit 6 gene of maize mitochondria显示文摘 | Dewey R E Levings C S Tim D H | 1985 | Plant Physiology1985，79，： | 1 |
| 10 | A dual representation theory of posttraumatie stress disorder显示文摘 | Brewin C R Tim Dalgleish Stephen Joseph | 1996 | Psychological Review1996，103，： | 1 |
| 11 | Characterization of Polarization Diversity at the Mobile 显示文摘 | Tim W C Brown Simon R Saunders Stavros Stavro Mauro Fiacco | 2007 | IEEE Transactions on Vehicular Technology (S0018-9545)2007，56，5： | 1 |
| 12 | Communication skills training in healthcare: A review of the literature显示文摘 | Simon C Tim J Jacqueline R | 2002 | Nuts Edu Today2002，22，3： | 1 |
| 13 | Intentional occlusion of the left subclavian artery during stent-graft implantion in the thracic aorta:risk and relevance显示文摘 | Tim C R Michael P Hüseyin I | 2004 | J Endovasc Ther2004，11，6： | 1 |
| 14 | BiocharAdsorbed Ammonia Is Bioavailable显示文摘 | Arezoo T T Tim J C Robert R S | 2012 | Plant andSoil2012，350，2： | 1 |
| 15 | NRED: a database of long noncoding RNA expression 显示文摘 | Marcel E Dinger Ken C Pang Tim R Mercer | 2009 | Nucleic Acids Rese2009，37，： | 1 |
| 16 | Treatment by in vitro fertilisation with surrogacy: experience of one British Centre显示文摘 | BRINSDEN P R TIM C A ELIZABETH M | 2000 | British Medical Journal2000，320，7239： | 1 |
| 17 | Complementarity and the use of indicator groups for reserve selection in Uganda显示文摘 | Howard P C Viskanic P Tim R B D | | 0，，6692： | 1 |
| 18 | High- throughput massively parallel sequencing for fetal aneuploidy detection from maternal plasma 显示文摘 | Jensen T J Zwiefelhofer T Tim R C | 2013 | PLoS One2013，8，57： | 1 |
| 19 | An Exploratory Examination of Voice Behavior from an Impression Management Perspective显示文摘 | B F Jerry B Tim H C R Kim | | 0，，： | 1 |
| 20 | Measuring marketing productivity: current knowledge and future directions显示文摘 | Roland T R Tim A Gregory S C | 2004 | Journal of Marketing2004，68，4： | 1 |
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