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| 1 | Irritable bowel syndrome: A microbiome-gut-brain axis disorder?显示文摘Irritable bowel syndrome(IBS) is an extremely prevalent but poorly understood gastrointestinal disorder. Consequently, there are no clear diagnostic markers to help diagnose the disorder and treatment options are limited to management of the symptoms. The concept of a dysregulated gut-brain axis has been adopted as a suitable model for the disorder. The gut microbiome may play an important role in the onset and exacerbation of symptoms in the disorder and has been extensively studied in this context. Although a causal role cannot yet be inferred from the clinical studies which have attempted to characterise the gut microbiota in IBS, they do confirm alterations in both community stability and diversity. Moreover, it has been reliably demonstrated that manipulation of the microbiota can influence the key symptoms, including abdominal pain and bowel habit, and other prominent features of IBS. A variety of strategies have been taken to study these interactions, including probiotics, antibiotics, faecal transplantations and the use of germ-free animals. There are clear mechanisms through which the microbiota can produce these effects, both humoral and neural. Taken together, these findings firmly establish the microbiota as a critical node in the gut-brain axis and one which is amenable to therapeutic interventions. | Paul J Kennedy John F Cryan Timothy G Dinan Gerard Clarke | 2014 | World Journal of Gastroenterology2014，20，39： | 20 |
| 2 | Near stoichiometric silicon carbide from an economical polysilane precursor显示文摘 | SEYFERTH D TIMOTHY G HENRY J | 1992 | J Am Ceram Soc1992，75，5： | 2 |
| 3 | Effect of fluid thermal properties on the heat transfer characteristics in a double-pipe helical heat exchanger显示文摘 | Timothy J Rennie Vijaya G S Raghavan | 2006 | International Journal of Thermal Sciences2006，45，： | 1 |
| 4 | LIGHT, a New Member of the TNF Superfamily, and Lymphotoxin α Are Ligands for Herpesvirus Entry Mediator显示文摘 | Davide N Mauri Reinhard Ebner Rebecca I Montgomery Kristine D Kochel Timothy C Cheung Guo-Liang Yu Steve Ruben Marianne Murphy Roselyn J Eisenberg Gary H Cohen Patricia G Spear Carl F Ware | 1998 | Immunity1998，，： | 1 |
| 5 | Experimental studies of a double-pipe helical heat exchanger显示文摘 | Timothy J Rennie Vijaya G S Raghavan | 2005 | Experimental Thermal and Fluid Science2005，29，： | 1 |
| 6 | Firm,Strategic Group,and Industry Influences on Performance显示文摘 | Jeremy C Short David J Ketchen JR Timothy B Palmer G Tomas M Hult | 2007 | Strategic Management Journal2007，28，： | 1 |
| 7 | Transparent conducting Nnc oxide thin films doped with aluminum and molybdenum显示文摘 | JOEL N D TIMOTHY A G DAVID M W TERESA M B MATTHEW Y BOBBY T TIMOTHY J C | 2007 | Journal V-acuum Society Technology2007，25，4： | 1 |
| 8 | Enhancing Reverse Auc- tion Use Theory: An Exploratory Study 显示文摘 | TIMOTHY G MICHAEL J | 2010 | Supply Chain Management2010，15，1： | 1 |
| 9 | Suboptimal Minimum Cluster Volume Cover-Based Method for Measuring Fractal Dimension显示文摘 | Charles R T Timothy R M David J G | 2003 | IEEE Transactions on Geoscience and Remote Sensing2003，25，1： | 1 |
| 10 | Optimization of Fusion Splice Process for High Numerical Aperture Coupler Fiber and Erbium Doped Fiber显示文摘 | Jiang H G Li J Timothy McMahon | 2005 | Proc of SPIE2005，6019，： | 1 |
| 11 | Acute endophthalmitis following intravitreal triamcinolone acetonide injection显示文摘 | Darius M Moshfeghi Peter K Kaiser Ingrid U Scott Jonathan E Sears Matthew Benz Juan P Sinesterra Richard S Kaiser Sophie J Bakri Raj K Maturi Jonathan Belmont Paul M Beer Timothy G Murray Hugo Quiroz-Mercado William F Mieler | 2003 | American Journal of Ophthalmology2003，，5： | 1 |
| 12 | Interleukin-8 signaling attenuates TRAIL-and chemotherapyinduced apoptosis through transcriptional regulation of c-FLIP in prostate cancer cells显示文摘 | Catherine W Timothy W Patrick G J | 2008 | Mol Cancer Ther2008，7，9： | 1 |
| 13 | Enhancing reverse auction use theory:an exploratory study 显示文摘 | TIMOTHY G MICHAEL J | 2010 | Supply Chain Management2010，15，1： | 1 |
| 14 | The ultra high resolution XUV spectroheliograph 显示文摘 | WALKER A B C LINDBLOM J F TIMOTHY J G | 1990 | Optical Engineering1990，29，7： | 1 |
| 15 | Enhancing reverse auction use theory: An exploratory study显示文摘 | Timothy G Michael J | 2010 | Supply Chain Management2010，15，1： | 1 |
| 16 | Degradation of carbon tetrachloride by iron metal:Complexation effects on the oxide surface 显示文摘 | Timothy L J William F Yari A G | 1998 | Contaminant Hydrology1998，29，4： | 1 |
| 17 | Robust speaker recognition in noisy conditions 显示文摘 | Ji M Timothy J H James R G | 2007 | IEEE Transactions on Audio Speech and Language Processing2007，15，5： | 1 |
| 18 | Selling to tourists : Indonesian street vendors显示文摘 | Timothy D J Wall G | 1997 | Annals of Tourism Research1997，24，2： | 1 |
| 19 | Bi-cell surface plasmon resonance detection of aptamer mediated thrombin capture in serum显示文摘 | RINOSH J M ROMAN G D TIMOTHY A S | 2011 | Biosensors and Bioelectronics2011，26，12： | 1 |
| 20 | Effect of Coagulant Type and Storage Temperature on the Functionality of Reduced-Fat Mozzarella Cheese显示文摘 | JEREMIAH J S KATHLEEN O S TIMOTHY P G | 2004 | EDP Sciences2004，84，： | 1 |
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