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| 1 | Passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts and assessment of clinical outcomes显示文摘AIM To assess for passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts(TIPS) and compare outcomes with maximally dilated TIPS.METHODS Polytetrafluoroethylene covered TIPS(Viatorr) from July 2002 to December 2013 were retrospectively reviewed at two hospitals in a single institution. Two hundred and thirty patients had TIPS maximally dilated to 10 mm(m TIPS), while 43 patients who were at increased risk for hepatic encephalopathy(HE), based on clinical evaluation or low pre-TIPS portosystemic gradient(PSG), had 10 mm TIPS sub-maximally dilated to 8 mm(sm TIPS). Group characteristics(age, gender, Model for End-Stage Liver Disease score, post-TIPS PSG and clinical outcomes were compared between groups, including clinical success(ascites or varices), primary patency,primary assisted patency, and severe post-TIPS HE. A subset of fourteen patients with sm TIPS underwent follow-up computed tomography imaging after TIPS creation, and were grouped based on time of imaging(< 6 mo and > 6 mo). Change in diameter and crosssectional area were measured with 3D imaging software to evaluate for passive expansion.RESULTS Patient characteristics were similar between the sm TIPS and m TIPS groups, except for pre-TIPS portosystemic gradient, which was lower in the sm TIPS group(19.4 mm Hg ± 6.8 vs 22.4 mm Hg ± 7.1, P = 0.01). Primary patency and primary assisted patency between sm TIPS and m TIPS was not significantly different(P = 0.64 and 0.55, respectively). Four of the 55 patients(7%) with sm TIPS required TIPS reduction for severe refractory HE, while this occurred in 6 of the 218 patients(3%) with m TIPS(P = 0.12). For the 14 patients with follow-up computed tomography(CT) imaging, the median imaging follow-up was 373 d. There was an increase in median TIPS diameter, median percent diameter change, median area, and median percent area change in patients with CT follow-up greater than 6 mo after TIPS placement compared to follow-up within 6 mo(8.45 mm, 5.58%, 56.04 mm^2, and 11.48%, respectively, P = 0.01).CONCLUSION Passive expansion of sm TIPS does occur but clinical outcomes of sm TIPS and m TIPS were similar. Sub-maximal dilation can prevent complications related to overshunting in select patients. | Michael C Hsu Charles N Weber S William Stavropoulos Timothy W Clark Scott O Trerotola Richard D Shlansky Goldberg Michael C Soulen Gregory J Nadolski | 2017 | World Journal of Hepatology2017，9，12： | 11 |
| 2 | Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9显示文摘RBPjk-dependent Notch signaling regulates both the onset of chondrocyte hypertrophy and the progression to terminal chondrocyte maturation during endochondral ossification. It has been suggested that Notch signaling can regulate Sox9 transcription, although how this occurs at the molecular level in chondrocytes and whether this transcriptional regulation mediates Notch control of chondrocyte hypertrophy and cartilage development is unknown or controversial. Here we have provided conclusive genetic evidence linking RBPjk-dependent Notch signaling to the regulation of Sox9 expression and chondrocyte hypertrophy by examining tissuespecific Rbpjk mutant(Prx1Cre;Rbpjkf/f), Rbpjk mutant/Sox9 haploinsufficient(Prx1Cre;Rbpjkf/f;Sox9f/1),and control embryos for alterations in SOX9 expression and chondrocyte hypertrophy during cartilage development. These studies demonstrate that Notch signaling regulates the onset of chondrocyte maturation in a SOX9-dependent manner, while Notch-mediated regulation of terminal chondrocyte maturation likely functions independently of SOX9. Furthermore, our in vitro molecular analyses of the Sox9 promoter and Notch-mediated regulation of Sox9 gene expression in chondrogenic cells identified the ability of Notch to induce Sox9 expression directly in the acute setting, but suppresses Sox9 transcription with prolonged Notch signaling that requires protein synthesis of secondary effectors. | Anat Kohn Timothy P Rutkowski Zhaoyang Liu Anthony J Mirando Michael J Zuscik Regis J O'Keefe Matthew J Hilton | 2015 | Bone Research2015，3，3： | 8 |
| 3 | In vivo ionizing irradiations produce deletions in the hprt gene of human T-lymphocytes显示文摘 | Janice A Niklas J Patrick O' Neill Timothy C Hunter | 1991 | Mutat Res1991，250，： | 1 |
| 4 | Cervical arthroplasty : the begin- ning,the middle,the end? 显示文摘 | Richards O Choi D Timothy J | 2012 | Br J Neurosurg2012，26，1： | 1 |
| 5 | Cervical arthroplasty:the beginning,the middle ,the end 显示文摘 | Richards O Choi D Timothy J | 2012 | Br J Neurosurg2012，26，1： | 1 |
| 6 | Tumor Necrosis Factor α Is Toxic to Embryonic Mesencephalic Dopamine Neurons显示文摘 | Susan O McGuire Zao Dung Ling Jack W Lipton Caryl E Sortwell Timothy J Collier Paul M Carvey | 2001 | Experimental Neurology2001，，2： | 1 |
| 7 | Research and development of an implantable,axial-flow left ventricular assist device:the Jarvik 2000 heart显示文摘 | Frazier O H Timothy J M Jarvik R K | 2001 | Ann Thora Surg2001，71，3： | 1 |
| 8 | Metal-organic chemical vapour deposition of lead scandiumtantalate: chemical issues and precursor selection 显示文摘 | ANTHONY C J TIMOTHY J L HYWEL O D | 2000 | Polyhedron2000，19，： | 1 |
| 9 | Effect of Coagulant Type and Storage Temperature on the Functionality of Reduced-Fat Mozzarella Cheese显示文摘 | JEREMIAH J S KATHLEEN O S TIMOTHY P G | 2004 | EDP Sciences2004，84，： | 1 |
| 10 | Orbital Metastasis: Clinical Features, Management and Outcome显示文摘 | Alejandra A. Valenzuela Curtis W. Archibald Ben Fleming Lorraine Ong Brett O’Donnell John Crompton J Dinesh Selva Alan A. McNab Timothy J. Sullivan | 2009 | Orbit (-)2009，，2： | 1 |
| 11 | Associations between Recent Exposure to Ambient Fine Particulate Matter and Blood Pressure in the Multi-Ethnic Study of Atherosclerosis (MESA)显示文摘 | Auchincloss Amy H Roux Ana V Diez Dvonch J Timothy Brown Patrick L Barr R Graham Daviglus Martha L Goff David C Kaufman Joel D O’Neill Marie S | 2008 | Environmental Health Perspectives2008，，4： | 1 |
| 12 | Cervical arthroplasty:the beginning,the middle,the end显示文摘 | Richards O Choi D Timothy J | | 0，，01： | 1 |
| 13 | Comparison of acute myocardial infarct size to two-year mortality in patients <65 to those ≥65 years of age显示文摘 | Todd D Miller Timothy F Christian David O Hodge Mona R Hopfenspirger Bernard J Gersh Raymond J Gibbons | 1999 | The American Journal of Cardiology1999，，： | 1 |
| 14 | The composite nature of physical geography: Moving from linkages to integration显示文摘 | Malanson George P Scuderi Louis Moser Katrina A Willmott Cort J Resler Lynn M Warner Timothy A Mearns Linda O | 2014 | Progress in Physical Geography2014，，： | 1 |
| 15 | 2-Fluorine-18-luoro-2-deoxy-D glucose positron emission tomography in the pretreatment stagi of Hodgkin's disease: influence on patient management in a single institution显示文摘 | PARTRIDGE S TIMOTHY A O'DOHERTY M J | 2000 | Ann Oncol2000，11，： | 1 |
| 16 | Governance of Red Tourism in China:Per spec t ive s on Power a nd Gu a n x i显示文摘 | S h e n g n a n(Na n c y) Z h a o D a l l e n J Timothy | 2015 | Tou r i smManagement2015，，2： | 1 |
| 17 | Quasi-one-dimensional high-speed engine model with finite-rate chemistry显示文摘 | Timothy F O Ryan P S Mark J L | 2001 | Journal of Propulsion and Power2001，17，6： | 1 |
| 18 | Southern Ocean iron enrichment experiment: Carbon cycling in high-and low-Si waters 显示文摘 | Coale K H Johnson K S Chavez F P Buesseler K O Barber R T Brzezinski M A Cochlan W P Millero F J Falkowski P G Bauer J E Wanninkhof R H Kudela R M Altabet M A Hales B E Takahashi T Landry M R Bidigare R R Wang Xiujun Chase Z Strutton P G Friederich G E Gorbunov M Y Lance V P Hilting A K Hiscock M R Demarest M Hiscock W T Sullivan K F Tanner S J Gordon R M Hunter C N Elrod V A Fitzwater S E Jones J L Tozzi S Koblizek M Roberts A E Herndon J Brewster J Ladizinsky N Smith G Cooper D Timothy D Brown S L Selph K E Sheridan C C Twining B S Johnson Z I | 2004 | Science2004，304，5669： | 1 |
| 19 | 1999 update: ACC/AHA guidelines for the management of patients with acute myocardial infarction显示文摘 | Thomas J Ryan Elliott M Antman Neil H Brooks Robert M Califf L.David Hillis Loren F Hiratzka Elliot Rapaport Barbara Riegel Richard O Russell Earl E Smith W.Douglas Weaver Raymond J Gibbons Joseph S Alpert Kim A Eagle Timothy J Gardner Arthur Garson Gabri | 1999 | Journal of the American College of Cardiology1999，，3： | 1 |
| 20 | Using functional traits and phylogenetic trees to examine the assembly of tropical tree communities显示文摘 | Baraloto C Hardy O J Timothy Paine C E | 2012 | Journal of Ecology2012，100，： | 1 |
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