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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | The surgical treat ment of metastatic disease of the spine显示文摘 | Hatrick N C Lucas J D Timothy A R | 2000 | Radiother Oncol2000，56，3： | 1 |
| 3 | Early psychological adjustment in breast cancer patients-A prospective study显示文摘 | Chiara N Jonathan V R Timothy C | 2002 | J Psycho Res2002，53，6： | 1 |
| 4 | Designing and Deploying a Building-Wide Cognitive Radio Network Testbed 显示文摘 | Timothy R N Shajedul H S M DePoy E | 2010 | IEEE Communication Magazines2010，48，9： | 1 |
| 5 | Growth and behavior of larval krill ( Euphausia superba) under the ice in late winter 2001 west of the Antarctic Peninsula 显示文摘 | ROBIN M R LANGDON B Q TIMOTHY N | 2004 | Deep-Sea Research II2004，，51： | 1 |
| 6 | Statistical topic models for muhi-la- bel document classification显示文摘 | Timothy N R | 2012 | Machine Learning2012，88，12： | 1 |
| 7 | Paleogeomorphology of the upper Arbuckle karst surface:Implications for reservoir and trap development in Kansas显示文摘 | Carr Timothy R Anderson N L Franseen E K | | 0，，： | 1 |
| 8 | The effect of substrate temperature and growth rate on the doping efficiency of single crystal boron doped diamond显示文摘 | SHANNON N D ROBERT R TIMOTHY G | 2014 | Diamond and Related Materials2014，49，10： | 1 |
| 9 | Operational performance of the TIMED doppler interferometer (TIDI) 显示文摘 | WILBERT R S RICK J N TIMOTHY L K | 2003 | Proceedings of SPIE2003，5175，： | 1 |
| 10 | Arch widths in adults with Class Ⅰ crowded and Class Ⅲ malocclusions compared with normal occlusions显示文摘 | TIMOTHY R K ROBERT N S HAROLD F B | 2008 | Angle Orthod2008，78，： | 1 |
| 11 | Early Results after Laparoscopic Gastric Bypass: EEA vs GIA Stapled Gastrojejunal Anastomosis显示文摘 | Timothy R Shope Robert N Cooney Janelle McLeod Cynthia A Miller Randy S Haluck | 2003 | Obesity Surgery2003，，3： | 1 |
| 12 | Southern Ocean iron enrichment experiment: Carbon cycling in high-and low-Si waters 显示文摘 | Coale K H Johnson K S Chavez F P Buesseler K O Barber R T Brzezinski M A Cochlan W P Millero F J Falkowski P G Bauer J E Wanninkhof R H Kudela R M Altabet M A Hales B E Takahashi T Landry M R Bidigare R R Wang Xiujun Chase Z Strutton P G Friederich G E Gorbunov M Y Lance V P Hilting A K Hiscock M R Demarest M Hiscock W T Sullivan K F Tanner S J Gordon R M Hunter C N Elrod V A Fitzwater S E Jones J L Tozzi S Koblizek M Roberts A E Herndon J Brewster J Ladizinsky N Smith G Cooper D Timothy D Brown S L Selph K E Sheridan C C Twining B S Johnson Z I | 2004 | Science2004，304，5669： | 1 |
| 13 | Growth and behavior of larval krill(Euphausia superba)under the ice in late winter2001 west of the Antarctic Peninsula显示文摘 | Robin M R Langdon B Q Timothy N | 2004 | Deep-Sea ResearchⅡ2004，51，： | 1 |
| 14 | Measurement of viscous sound absorption at 50-150kHz in a model turbid environment显示文摘 | TIMOTHY G RICHARDS L | 1998 | The Journal of the Acoustical Society of America1998，104，4： | 1 |
| 15 | Statistical topic models for multi-la-bel document classification显示文摘 | Timothy N R | 2012 | Machine Learning2012，88，12： | 1 |
| 16 | Phosphorus uptake by bean nodules显示文摘 | Thamir S A N Michael L K Timothy R M | 1998 | Plant Soil1998，198，： | 1 |
| 17 | Early psychological adjustment in breast cancer patients-A p rospective study显示文摘 | CHIARA N JONATHAN V R TIMOTHY C | 2002 | J Psycho Res2002，53，6： | 1 |
| 18 | 身高、体质指数和社会经济地位之关系:对英国生物样本库的孟德尔随机化研究显示文摘目的确定身高、体质指数(BMI)与社会经济状况的5个方面是否存在因果关系。方法孟德尔随机化研究测试身高、BMI与社会经济状况之间的因果关系有何不同。孟德尔随机化方法运用基因型随机分配理论,这样不会受到非基因混杂因素的干扰。 | Jessica Tyrrell Samuel E Jones Robin Beaumont Christina M Astley Rebecca Lovell Hanieh Yaghootkar Marcus Tuke Katherine S Ruth Rachel M Freathy Joel N Hirschhorn Andrew R Wood Anna Murray Michael N Weedon Timothy M Frayling 莫云凌 邓晓春 | 2016 | 英国医学杂志中文版2016，0，7： | 1 |
| 19 | Determination of glyphosate and related compounds by HPLC with tris(2,2'-bipy ridyl) ruthenium ( Ⅱ ) electrogenerated chemiluminescence detection 显示文摘 | Jennifer S R Gary J K Timothy A N | 1997 | Anal Chim Acta1997，341，： | 1 |
| 20 | Alkaline anion- exchange radiation-grafted membranes for possible electrochemical application in filel cells 显示文摘 | Timothy N D Robert C T S Jo]hn R V | 2003 | Journal of Materials Chemistry2003，13，4： | 1 |
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