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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Pericytes synthesize renin显示文摘AIM: To investigate renin expression in pericytes during normal kidney development and after deletion of angiotensinogen, the precursor for all angiotensins.METHODS: We examined the distribution of renin expressing cells by immunoshistochemistry in the interstitial compartment of wild type(WT) and angiotensinogen deficient(AGT-/-) mice at different developmental stages from embryonic day 18(E18: WT, n = 4; AGT-/-, n = 5) and at day 1(P1: WT, n = 5; AGT-/-, n = 5), 5(P5: WT, n = 7; AGT-/-, n = 8), 10(P10: WT, n = 3; AGT-/-, n = 5), 21(P21: WT, n = 7; AGT-/-, n = 5), 45(P45: WT, n = 3; AGT-/-, n = 3), and 70(P70: WT, n = 2; AGT-/-, n = 2) of postnatal life. We quantified the number of pericytes positive for renin at all the developmental stages mentioned above and comparedthe results of AGT-/- mice to their WT counterparts.RESULTS: In WT mice, renal interstitial pericytes synthesize renin in early life supporting a lineage relationship with renin cells in the vasculature. The number of pericytes positive for renin per area of 0.32 mm2(density) in WT mice was maintained from fetal life till weaning age(E18 = 4.25 ± 0.63, P1 = 3.75 ± 0.48, P5 = 3.75 ± 0.48, P10 = 4 ± 0.71, P21 = 3.8 ± 0.58) and markedly decreased in adult life(P45 = 1.2 ± 0.37, P70 = 0.8 ± 0.20). On the other hand, in AGT-/- mice the density of pericytes expressing renin was not significantly different from WT mice at E18 and P1: E18 = 5.75 ± 0.50 vs 4.25 ± 0.63(P = 0.106), P1 = 9.25 ± 3.50 vs 3.75 ± 0.48(P = 0.175) but significantly increased from P5 till P70: P5 = 38.25 ± 5 vs 3.75 ± 0.48(P = 0.0004), P10 = 173 ± 7.50 vs 4 ± 0.70(P = 5.24567 × 10-7), P21 = 83 ± 6.70 vs 3.8 ± 0.58(P = 2.97358 × 10-6), P45 = 49 ± 3.50 vs 1.2 ± 0.37(P = 8.18274 x 10-7) and P70 = 17.8 ± 2.30 vs 0.8 ± 0.20(P = 3.51151 × 10-5). The AGT-/- mice showed a marked increase in the number of pericytes per field studied starting from P5, reaching its peak at P10, and then a gradually decreasing until P70. CONCLUSION: Interstitial pericytes synthesize renin during development and the number of renin-expressing pericytes increases in response to a homeostatic threat imposed early in life such as lack of angiotensinogen. | Alison C Berg Catalina Chernavvsky-Sequeira Jennifer Lindsey R Ariel Gomez Maria Luisa S Sequeira-Lopez | 2013 | World Journal of Nephrology2013，2，1： | 2 |
| 3 | Application oftransient infrared and near infrared spectroscopy totransition metal complex excited states and inter-mediates显示文摘 | Jennifer M B Michael W G Jon R S | 2007 | Coord Chem Rev2007，251，： | 1 |
| 4 | Omega-3 fatty acids as treatments for mental illness: which disorder and which fatty acid显示文摘 | Brian M R Jennifer S Lee E S | 2007 | Lipids in Health and Disease2007，，6： | 1 |
| 5 | Utility of exhaled breath condensates in chronic obstructive pulmonary disease: a critical review 显示文摘 | Effros R M Jennifer S Casaburi R | 2005 | Curr Opin Pulm Med2005，11，2： | 1 |
| 6 | Copy number variation in Intron 1 of SOX5 causes the pea-comb phenotype ia chickens显示文摘 | Wright D Boije H Jennifer R S | 2009 | PLoS Genet2009，5，10： | 1 |
| 7 | Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25 A12 gene with autism 显示文摘 | Nicolas R Jennifer G R Christopher J S | 2004 | Am J Psychiatry2004，161，4： | 1 |
| 8 | State of the art in computer-assisted planning, intervention, and assessment of liver- tumor ablation 显示文摘 | Christian S Christian R Jennifer B | 2010 | Critical Reviews in Biomedical Engineering2010，38，1： | 1 |
| 9 | Enantioselective epoxidation of unfunctionalized olefins catalyzed by salen manganese complexes显示文摘 | WEI ZHANG JENNIFER L L WILSON S R | 1990 | J Am Chem SOC1990，112，7： | 1 |
| 10 | Regulation of Fasted Blood Glucose by Resistin 显示文摘 | Ronadip R Shamina M Jennifer S | 2004 | Science2004，303，5661： | 1 |
| 11 | Extraintestinal Manifestations of Pediatric Inflammatory Bowel Disease and Their Relation to Disease Type and Severity显示文摘 | Jennifer L Dotson Jeffrey S Hyams James Markowitz Neal S LeLeiko David R Mack Jonathan S Evans Marian D Pfefferkorn Anne M Griffiths Anthony R Otley Athos Bousvaros Subra Kugathasan Joel R Rosh David Keljo Ryan S Carvalho Gitit Tomer Petar Mamula Marsha H | 2010 | Journal of Pediatric Gastroenterology and Nutrition2010，，2： | 1 |
| 12 | Regional block versus general anaesthesia for caesarean section and neonatal outcomes:a population-based study显示文摘 | Charles S Algert Jennifer R Bowen Warwick B Giles | 2009 | BMC medicine2009，7，4： | 1 |
| 13 | Rapid identification of bacteria from positive blood cultures by terminal restriction fragment length polymorphism profile analysis of the 16S rRNA gene 显示文摘 | Jeffrey E C Jennifer A S Kurt D R | 2003 | J Clin Microbiol2003，41，8： | 1 |
| 14 | Dialectical behavior therapy for comorid personality 显示文摘 | Thomas R Lynch Jennifer S Cheavens | 2008 | Journal of Clinical Psychology2008，64，2： | 1 |
| 15 | Male-to-female sex reversal in mice lacking fibroblast growth factor 9显示文摘 | Jennifer S Green R P Schmahl J | 2001 | Cell2001，104，： | 1 |
| 16 | A semi-analytical model for transient flow to a subsurface tile drain显示文摘 | Stillman S Jennifer Haws W Nathan R S Govindaraju P Suresh C Rao | 2006 | Journal of Hydrology2006，317，2： | 1 |
| 17 | Worldwide assessment of dalbavancin activity and spectrum against over 6,000 clinical isolates显示文摘 | Jennifer M Streit Thomas R Fritsche Helio S Sader Ronald N Jones | 2004 | Diagnostic Microbiology & Infectious Disease2004，，2： | 1 |
| 18 | Predicting the flow mode from hoppers using the discrete element method 显示文摘 | WILLIAM R K JENNIFER S C CARL R W | 2009 | Powder Technology2009，195，： | 1 |
| 19 | OpenFlow: Enabling Innovation in CampusNetworks 显示文摘 | NICK M TOM A HARI B GURU P LARRYP JENNIFER R SCOTT S JONATHAN T | 2008 | ACM SIGCOMM ComputerCommunication Review2008，38，2： | 1 |
| 20 | Targeted Contrast-Enhanced Ultrasound Imaging of Tumor Angiogenesis with Contrast Microbubbles Conjugated to Integrin-Binding Knottin Peptides显示文摘 | Willmann Jürgen K Kimura Richard H Deshpande Nirupama Lutz Amelie M Cochran Jennifer R Gambhir Sanjiv S | 2010 | The Journal of Nuclear Medicine2010，，： | 1 |
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