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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial显示文摘 | Faramarz Ismail-Beigi Timothy Craven Mary Ann Banerji Jan Basile Jorge Calles Robert M Cohen Robert Cuddihy William C Cushman Saul Genuth Richard H Grimm Bruce P Hamilton Byron Hoogwerf Diane Karl Lois Katz Armand Krikorian Patrick O'Connor Rodica Pop-Bus | 2010 | The Lancet2010，，9739： | 2 |
| 3 | Structural and magnetic properties of nanoscale iron oxide particles synthesized in the presence of dextran or polyvinyl alcohol显示文摘 | Heath P Wanida C Timothy G | 2001 | J Magn Magn Mater2001，225，1： | 1 |
| 4 | Modeling,analysis and testing of autonomous operation of an inverterbased microgrid显示文摘 | Nagaraju P Milan P Timothy C | 2007 | IEEE Transactions on Power Electronics2007，22，2： | 1 |
| 5 | Autonomous vehicle navigation utilizing electrostatic potential fields and fuzzy logic显示文摘 | Tsourveloudis Nikos C Valavanis Kimon P Hebert Timothy | 2001 | IEEE Transactions on Robtics and Automation2001，17，4： | 1 |
| 6 | Startup and operation of a supercritical carbon dioxide Brayton cycle 显示文摘 | Eric M C Timothy L C Christopher P S | 2014 | Journal of Engineering for Gas Turbines and Power2014，136，： | 1 |
| 7 | An improved generalized Amber force field(GAFF)for urea显示文摘 | GUL A O WOLFGANG P TIMOTHY C | 2010 | Journal of Molecular Modeling2010，16，9： | 1 |
| 8 | Modeling, analysis and testing of autonomous operation of an inverter-based microgrid显示文摘 | NAGARA P MILAN P TIMOTHY C G | 2007 | IEEE Trans on Power Electronics2007，22，2： | 1 |
| 9 | Sleep-dependent consolidation of auditory discrimination learning in adult starlings 显示文摘 | Timothy P Brawn Howard C Nusbaum Daniel Margoliash | 2010 | J Neurosci2010，30，2： | 1 |
| 10 | Single nucleotide polyrnorphism discovery in rainbow trout by deep sequenc- ing of a reduced representation library显示文摘 | Cecilia C S Timothy P S Ralph T W | 2009 | BMC Genom2009，10，： | 1 |
| 11 | An enriched look at tyrosine phosphorylation显示文摘 | Thomas P C Timothy D V | 2005 | Nat Biotechnol2005，23，： | 1 |
| 12 | Isolated hepatocyte transplantation in an infant with a severe urea cycle disorder 显示文摘 | Simon P Horslen MB Timothy C | 2003 | Pediatrics2003，111，： | 1 |
| 13 | Influence of the molar mass distribution on the elongational behavior of polymer solutions in capillary breakup显示文摘 | Lucy E R Timothy P S Justin J C | | 0，，1： | 1 |
| 14 | Automated liquid dispensing pin for microarray applications 显示文摘 | Timothy C Suganya P Tong W | 2006 | IEEE transactions on automation science and engineering2006，3，2： | 1 |
| 15 | The Coevolution of New Organizational Forms 显示文摘 | LEWIN A Y LONG C P TIMOTHY N | 1999 | Organization Science1999，10，5： | 1 |
| 16 | Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial显示文摘 | Faramarz Ismail-Beigi Timothy Craven Mary Ann Banerji Jan Basile Jorge Calles Robert M Cohen Robert Cuddihy William C Cushman Saul Genuth Richard H Grimm Bruce P Hamilton Byron Hoogwerf Diane Karl Lois Katz Armand Krikorian Patrick O’Connor Rodica Pop-Bus | 2010 | 2010 (9739)2010，，9739： | 1 |
| 17 | Structural and magneticproperties of nanoscale iron oxide particles synthesized in the presence of dextran or polyvinyl alcohol 显示文摘 | HEATH P WANIDA C TIMOTHY G S P | 2001 | J Magn Magn Mater2001，225，： | 1 |
| 18 | The diagnostic accuracy of computed tomography angiography for traumatic or atherosclerotic lesions of the carotid and vertebral arteries: a systematic review显示文摘 | William Hollingworth Avery B Nathens Jeffrey P Kanne Marie L Crandall Timothy A Crummy Danial K Hallam Marjorie C Wang Jeffrey G Jarvik | 2003 | European Journal of Radiology2003，，1： | 1 |
| 19 | Interferon inducible T cell alpha chemoattractant (I-TAC):a novel Non-ELR CXC chemokine with potent activity on activated T cells through selective high afflnity Binding to CXCR3显示文摘 | Katherine E C Christine A S Timothy J P | 1998 | J Exp Med1998，187，12： | 1 |
| 20 | What Influences IT Ethical Behavior Intentions-Planned Behavior, Reasoned Action, Perceived Importance, or Individual Characteristics?显示文摘 | Leonard L N K Timothy P C Kreiec J | 2004 | Information and Management2004，，1： | 1 |
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