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| 1 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | The Lancet . 2012 (9859)2012，，9859： | 7 |
| 2 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | The Lancet2012，，9859： | 5 |
| 3 | Distribution of pericellular matrix molecules in the temporomandibular joint and their chondroprotective effects against inflammation显示文摘The objectives of this study were to(1) determine the distribution and synthesis of pericellular matrix(PCM) molecules(collagen VI, collagen IV and laminin) in rat temporomandibular joint(TMJ) and(2) investigate the effects of PCM molecules on chondrocytes against inflammation in osteoarthritis. Four zones(fibrous, proliferating, mature and hypertrophic) of condylar cartilage and three bands(anterior, intermediate and posterior) of disc were analysed by immunohistochemistry for the presence of PCM molecules in rat TMJs. Isolated chondrocytes were pre-treated with PCM molecules before being subjected to interleukin(IL)-1β treatment to stimulate inflammation. The responses of the chondrocytes were analysed using gene expression, nitric oxide release and matrix metalloproteinase(MMP)-13 production measures. Histomorphometric analyses revealed that the highest areal deposition of collagen VI(67.4%), collagen IV(45.7%) and laminin(52.4%) was in the proliferating zone of TMJ condylar cartilage. No significant difference in the distribution of PCM molecules was noted among the three bands of the TMJ disc. All three PCM molecules were expressed intracellularly by chondrocytes cultured in the monolayer. Among the PCM molecules, pre-treatment with collagen VI enhanced cellular proliferation, ameliorated IL-1β-induced MMP-3, MMP-9, MMP-13 and inducible nitric oxide synthase gene expression, and attenuated the downregulation of cartilage matrix genes, including collagen I, aggrecan and cartilage oligomeric matrix protein(COMP). Concurrently, collagen VI pretreatment inhibited nitric oxide and MMP-13 production. Our study demonstrates for the first time the distribution and role of PCM molecules, particularly collagen VI, in the protection of chondrocytes against inflammation. | Wern Cui Chu Shipin Zhang Timothy J Sng Yu Jie Ong Wen-Li Tan Vivien Y Ang Casper B Foldager Wei Seong Toh | 2017 | International Journal of Oral Science2017，9，1： | 5 |
| 4 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | 2012 (9859)2012，，9859： | 2 |
| 5 | 少根根霉产孢能力、变种与发酵产物的相关性显示文摘【目的】探究少根根霉不同生态环境、不同地理位置、不同产孢能力和不同分类学变种的发酵产物多样性及相关性,为工业生产提供指导。【方法】代表性的68株少根根霉菌株于糯米培养基中进行液态发酵,利用高效液相色谱法测定各种发酵产物浓度,计算发酵产物间的Pearson相关系数,通过多因素方差分析和主成分分析解析各类菌株与发酵特性的相关性。【结果】总计检测到7种发酵产物,按照产量均值百分比从高到低分别是葡萄糖(70.96%)、乙醇(17.87%)、乳酸(6.63%)、麦芽糖(1.80%)、苹果酸(1.46%)、富马酸(0.92%)和甘油(0.36%)。麦芽糖独立代谢,其余6种产物分为2组,组间负相关:第一组为葡萄糖、乳酸和甘油,组内正相关;第二组为乙醇、苹果酸和富马酸,组内正相关。发酵特性与生态环境、地理位置的相关性较低,但与产孢能力、分类学变种高度相关。SM无孢菌株的发酵能力显著强于SM产孢菌株,尤其是菌株XY01957的葡萄糖产量高达138.30g/L,具有出色的生产潜力。原变种和东京变种的富马酸、苹果酸产量较低,而乳酸和甘油产量较高;德氏变种与前两个变种区分明显,富马酸、苹果酸产量较高,而乳酸和甘油产量较低。【结论】本研究发现少根根霉发酵产物之间以及发酵产物和产孢能力、分类学变种之间高度相关,为群体遗传学研究奠定了良好的基础;本研究筛选出优质的发酵菌株,为发酵工业提供了坚实的支撑。 | 刘晓玲 鞠笑 贾碧丝 Timothy Y James 乔敏 刘小勇 | 2022 | 微生物学报2022，62，3： | 2 |
| 6 | Clinical features of retinal diseases masquerading as retrobulbar optic neuritis显示文摘 | JIANG Li-bin SHEN Ce-ying CHEN Fei YAN Wei-yu Timothy Y. Y WANG Ning-li | 2013 | Chinese Medical Journal2013，，17： | 2 |
| 7 | A survey of the marching cubes algo-rithm显示文摘 | Timothy S N Hong Y | 2006 | Computer & Graphics2006，30，： | 1 |
| 8 | Day 4 estradiol levels predict pregnancy success in women undergoing controlled ovarian hyperstimulation for IVF显示文摘 | John Y Phelps Adam S Levine Timothy N | 1998 | Fertil Steril1998，69，6： | 1 |
| 9 | Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes 显示文摘 | Qin Y Timothy E Graham N M | 2005 | Nature2005，436，： | 1 |
| 10 | High performance work systems and employee well-being: a two stage study of a rural Australian hospital显示文摘 | Suzanne Y Timothy B Pauline S | 2010 | Journal of Health Organisation & Management2010，24，2： | 1 |
| 11 | Tourism growth, national development and regional inequality in Turkey 显示文摘 | Tosun C Timothy D J Ozturk Y | 2003 | Journal of Sustainable Tourism2003，11，23： | 1 |
| 12 | The formulation of aptamer-coated paclitaxel-polylactide nanoconjugates and their targeting to cancer cells 显示文摘 | Rong T Linda Y Timothy M F | 2010 | Biomaterials2010，31，： | 1 |
| 13 | DT40 cells lacking the Ca2+ - binding protein annexin 5 are resistant to Ca2+ -dependent apoptosis 显示文摘 | Timothy E Debipriya D Barry Y | 2002 | PNAS2002，99，12： | 1 |
| 14 | Photonic band gap architectures for holographic lithography显示文摘 | TOADER O TIMOTHY Y M JOHN S | 2004 | Phys Rev Lett2004，92，04： | 1 |
| 15 | Tourism and reconciliation between Mainland China and Taiwan 显示文摘 | Guo Y Kim S S Timothy D J | 2006 | Tourism Management2006，27，5： | 1 |
| 16 | Transparent conducting Nnc oxide thin films doped with aluminum and molybdenum显示文摘 | JOEL N D TIMOTHY A G DAVID M W TERESA M B MATTHEW Y BOBBY T TIMOTHY J C | 2007 | Journal V-acuum Society Technology2007，25，4： | 1 |
| 17 | Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products 显示文摘 | Egil L Timothy J S Atsutoshi Y | 1999 | J Biol Chem1999，274，33： | 1 |
| 18 | Improving carpet wastewater treatment 显示文摘 | Demmin T R Unrich KD Timothy Y | 1988 | American Dyestuff Reporter1988，77，6： | 1 |
| 19 | Tourism Growth National Develop- ment and Regional Inequality in Turkey显示文摘 | Tosun C Timothy D J Qzturk Y | 2013 | Journal of Sustainable Tourism2013，11，2： | 1 |
| 20 | Phase Ⅱ Study of Echinomycin in Patients with Hormone Refractory Prostate Carcinoma显示文摘 | CHANG A Y TIMOTHY M JAMES P | 1994 | Investigational New Drugs1994，12，： | 1 |
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