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| 1 | Carbazole-type compounds in crude oils显示文摘Carbazole_type compounds were analyzed using GC and GC_MS_MS. A relatively high concentration of carbazole_type compounds was detected in crude oils of different types (marine and non_marine) and different maturities (low mature and mature) in Tarim, Liaohe and Keilu basins. The results suggest the ratios of 1, 8-dimethyl-/2, 7-dimethylcarbazole and benzo carbazole/benzo carbazole might be taken as petroleum migration parameters. | Min Zhang Tingsheng Xiang Bowen Mei | 1998 | Chinese Science Bulletin1998，43，8： | 3 |
| 2 | Proton pump inhibitor pantoprazole abrogates adriamycin-resistant gastric cancer cell invasiveness via suppression of Akt/GSK-β/β-catenin signaling and epithelial–mesenchymal transition显示文摘 | Bin Zhang Yan Yang Xiaoting Shi Wanyu Liao Min Chen Alfred Sze-Lok Cheng Hongli Yan Cheng Fang Shu Zhang Guifang Xu Shanshan Shen Shuling Huang Guangxia Chen Ying Lv Tingsheng Ling Xiaoqi Zhang Lei Wang Yuzheng Zhuge Xiaoping Zou | 2014 | Cancer Letters2014，，： | 2 |
| 3 | Crosstalk between IL-15Rα^(+)tumor-associated macrophages and breast cancer cells reduces CD8+T cell recruitment显示文摘Background:Interleukin-15(IL-15)is a promising immunotherapeutic agent owing to its powerful immune-activating effects.However,the clinical benefits of these treatments are limited.Crosstalk between tumor cells and immune cells plays an important role in immune escape and immunotherapy drug resistance.Herein,this study aimed to obtain in-depth understanding of crosstalk in the tumor microenvironment for providing potential therapeutic strategies to prevent tumor progression.Methods:T-cell killing assays and co-culture models were developed to determine the role of crosstalk between macrophages and tumor cells in breast cancer resistant to IL-15.Western blotting,histological analysis,CRISPR-Cas9 knockout,multi-parameter flow cytometry,and tumor cell-macrophage co-injection mouse models were developed to examine the mechanism by which IL-15Rα^(+)tumor-associated macrophages(TAMs)regulate breast cancer cell resistance to IL-15.Results:We found thatmacrophages contributed to the resistance of tumor cells to IL-15,and tumor cells induced macrophages to express high levels of theαsubunit of the IL-15 receptor(IL-15Rα).Further investigation showed that IL-15Rα^(+)TAMs reduced the protein levels of chemokine CX3C chemokine ligand 1(CX3CL1)in tumor cells to inhibit the recruitment of CD8^(+)T cells by releasing the IL-15/IL-15Rαcomplex(IL-15Rc).Administration of an IL-15Rc blocking peptide markedly suppressed breast tumor growth and overcame the resistance of cancer cells to anti-programmed cell death protein 1(PD-1)antibody immunotherapy.Interestingly,Granulocyte-macrophage colony-stimulating factor(GMCSF)inducedγchain(γc)expression to promote tumor cell-macrophage crosstalk,which facilitated tumor resistance to IL-15.Additionally,we observed that the non-transcriptional regulatory function of hypoxia inducible factor-1alpha(HIF-1α)was essential for IL-15Rc to regulateCX3CL1 expression in tumor cells.Conclusions:The IL-15Rc-HIF-1α-CX3CL1 signaling pathway serves as a crosstalk between macrophages and tumor cells in the tumormicroenvironment of breast cancer.Targeting this pathway may provide a potential therapeutic strategy for enhancing the efficacy of cancer immunotherapy. | Wenlong Zhang Qing Zhang Nanfei Yang Qian Shi Huifang Su Tingsheng Lin Zhonglei He Wenxin Wang Hongqian Guo Pingping Shen | 2022 | Cancer Communications2022，42，6： | 0 |
| 4 | Potential for energy conservation:A portable desktop paper reusing system for office waste paper显示文摘Renewable paper reusing plays a significant role in the sustainable environment under the background of the shortage in forest resources and the pollution from the paper industry.The conventional reusing stream of waste office paper appears to have low reusing rates while consuming massive amounts of energy in intermediate steps.In this study,we developed a novel portable renewable desktop paper reusing system based on font area detection and greyscale sensor.The proposed system consists of two main parts,namely,a greyscale sensor and font area detection model and a polishing mechanism.Acting as an ink mark detector for waste desktop paper,the greyscale sensor and font area detection model can detect the font in the waste desktop paper using an adaptive dynamic compensation schematic.The polishing mechanism will grind the font area of the wasted desktop paper,and this paper reusing processing is non-chemical,energy saving and environmentally friendly.The proposed system is demonstrated through simulations and experimental results,which show that the proposed renewable desktop paper reusing system is portable and is effective for reusing waste office paper in the office.An accuracy of 99.78%is demonstrated in the greyscale sensor and font area detection model,and the average reuse rate of one piece of paper is 2.52 times,verifying that the proposed portable system is effective and practical in renewable desktop paper reusing applications. | Tingsheng Zhang Xinglong Liu Yajia Pan Zutao Zhang Yanping Yuan | 2020 | Energy and Built Environment2020，1，2： | 0 |
| 5 | Efficient H_(2)O_(2)Electrosynthesis and Its Electro-Fenton Application for Refractory Organics Degradation显示文摘Hydrogen peroxide(H_(2)O_(2))in situ electrosynthesis by O_(2)reduction reaction is a promising alternative to the conventional Fenton treatment of refractory wastewater.However,O_(2)mass transfer limitation,cathodic catalyst selectivity,and electron transfer in O_(2)reduction remain major engineering obstacles.Here,we have proposed a systematic solution for efficient H_(2)O_(2)generation and its electro-Fenton(EF)application for refractory organic degradation based on the fabrication of a novel ZrO_(2)/CMK-3/PTFE cathode,in which polytetrafluoroethylene(PTFE)acted as a hydrophobic modifier to strengthen the O_(2)mass transfer,ZrO_(2)was adopted as a hydrophilic modifier to enhance the electron transfer of O_(2)reduction,and mesoporous carbon CMK-3 was utilized as a catalyst substrate to provide catalytic active sites.Moreover,feasible mass transfer of O_(2)from the hydrophobic to the hydrophilic layer was designed to increase the contact between O_(2)and the reaction interface.The H_(2)O_(2)yield of the ZrO_(2)/CMK-3/PTFE cathode was significantly improved by approximately 7.56 times compared to that of the co nventional gas diffusion cathode under the same conditions.The H_(2)O_(2)generation rate and Faraday efficiency reached125.98 mg·cm^(-2)·h^(-1)(normalized to 5674.04 mmol·g^(-1)·h^(-1)by catalyst loading)and 78.24%at-1.3 V versus standard hydrogen electrode(current density of-252 mA·cm^(-2)),respectively.The high H_(2)O_(2)yield ensured that sufficient OH was produced for excellent EF performance,resulting in a degradation efficiency of over 96%for refractory organics.This study offers a novel engineering solution for the efficient treatment of refractory wastewater using EF technology based on in situ high-yield H_(2)O_(2)electrosynthesis. | Lei Li Jing Bai Panyu Jiang Yan Zhang Tingsheng Zhou Jiachen Wang Changhui Zhou Jinhua Li Baoxue Zhou | 2023 | Engineering2023，，11： | 0 |
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