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| 1 | A novel Lyn-like protein tyrosine kinase identified in lamprey and its role in immune response显示文摘The avian sarcoma virus transforming gene(Src)kinase family,a type of nonmreceptor protein tyrosine kinases(nrTPKs),has been reported to play roles in cell growth,division,migration,adhesion,the immune response,and signal transduction berween cells[1,2].The Src family kinases can be divided into three subfamilies based on their conserved domains:SrcA subfamily(Sre,Yes,Fyn,and Fgr,SrcB subfamily(Lck,Hck,Blk,and Lyn),and Frk subfamily[3]. | Tingting Zhao Kedi Luo Xin Liu Shanshan Dong Yinglun Han Meng Gou Peng Su Qingwei Li Ting Zhu | 2020 | Acta Biochimica et Biophysica Sinica2020，52，5： | 2 |
| 2 | Contribution of non-Saccharomyces yeasts to aroma-active compound production,phenolic composition and sensory profile in Chinese Vidal icewine显示文摘To acquire candidate non-Saccharomyces strains for preparation of high-quality Vidal icewine,11 representative indigenous non-Saccharomyces strains were selected for analyzing their production of organic acids,phenolic compounds,aroma-active compounds and evaluating their sensory profile in Vidal juice.The results showed that the contents of organic acids in the wines were controlled and balanced well by the non-Saccharomyces strains as well as polyphenol concentrations were well improved during the fermentation.The strains differed from each other in their ability to produce aroma compounds,causing diversity and complexity of aroma characteristics in wine.Fermentation by Saccharomycopsis crataegensis YC30(Sc)and Hanseniaspora uvarum QTX22(Hu)could enhance the sweet and floral notes in Vidal icewine,especially Sc,which has never been reported before.It can not only enrich the aroma categories,but also increase the content ofδ-decalactone,γ-decalactone,ethyl isobutyrate,ethyl butyrate,phenethyl acetic acid,etc.The evaluation and optimization of non-Saccharomyces yeast strains could provide theoretical basis for the improvement of ice wine quality,and supply new ideas and strategies for the brewing of ice wine. | Qian Ge Chunfeng Guo Yue Yan Xiangyu Sun Tingting Ma Jing Zhang Caihong Li Chunlin Gou Tianli Yue Yahong Yuan | 2022 | Food Bioscience2022，46，2： | 1 |
| 3 | Novel wine in an old bottle:Preventive and therapeutic potentials of andrographolide in atherosclerotic cardiovascular diseases显示文摘Atherosclerotic cardiovascular disease(ASCVD)frequently results in sudden death and poses a serious threat to public health worldwide.The drugs approved for the prevention and treatment of ASCVD are usually used in combination but are inefficient owing to their side effects and single therapeutic targets.Therefore,the use of natural products in developing drugs for the prevention and treatment of ASCVD has received great scholarly attention.Andrographolide(AG)is a diterpenoid lactone compound extracted from Andrographis paniculata.In addition to its use in conditions such as sore throat,AG can be used to prevent and treat ASCVD.It is different from drugs that are commonly used in the prevention and treatment of ASCVD and can not only treat obesity,diabetes,hyperlipidaemia and ASCVD but also inhibit the pathological process of atherosclerosis(AS)including lipid accumulation,inflammation,oxidative stress and cellular abnormalities by regulating various targets and pathways.However,the pharmacological mechanisms of AG underlying the prevention and treatment of ASCVD have not been corroborated,which may hinder its clinical development and application.Therefore,this review summarizes the physiological and pathological mechanisms underlying the development of ASCVD and the in vivo and in vitro pharmacological effects of AG on the relative risk factors of AS and ASCVD.The findings support the use of the old pharmacological compound(‘old bottle’)as a novel drug(‘novel wine’)for the prevention and treatment of ASCVD.Additionally,this review summarizes studies on the availability as well as pharmaceutical and pharmacokinetic properties of AG,aiming to provide more information regarding the clinical application and further research and development of AG. | Tingting Gou Minghao Hu Min Xu Yuchen Chen Rong Chen Tao Zhou Junjing Liu Li Guo Hui Ao Qiang Ye | 2023 | Journal of Pharmaceutical Analysis2023，13，6： | 0 |
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