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| 1 | Source Contributions to PM2.5 under Unfavorable Weather Conditions in Guangzhou City,China显示文摘Historical haze episodes(2013–16) in Guangzhou were examined and classified according to synoptic weather systems.Four types of weather systems were found to be unfavorable, among which 'foreside of a cold front'(FC) and 'sea high pressure'(SP) were the most frequent(> 75% of the total). Targeted case studies were conducted based on an FC-affected event and an SP-affected event with the aim of understanding the characteristics of the contributions of source regions to fine particulate matter(PM_(2.5)) in Guangzhou. Four kinds of contributions—namely, emissions outside Guangdong Province(super-region), emissions from the Pearl River Delta region(PRD region), emissions from Guangzhou–Foshan–Shenzhen(GFS region), and emissions from Guangzhou(local)—were investigated using the Weather Research and Forecasting–Community Multiscale Air Quality model. The results showed that the source region contribution differed with different weather systems. SP was a stagnant weather condition, and the source region contribution ratio showed that the local region was a major contributor(37%), while the PRD region, GFS region and the super-region only contributed 8%, 2.8% and 7%, respectively, to PM_(2.5) concentrations. By contrast, FC favored regional transport. The super-region became noticeable,contributing 34.8%, while the local region decreased to 12%. A simple method was proposed to quantify the relative impact of meteorology and emissions. Meteorology had a 35% impact, compared with an impact of-18% for emissions, when comparing the FC-affected event with that of the SP. The results from this study can provide guidance to policymakers for the implementation of effective control strategies. | Nan WANG Zhenhao LING Xuejiao DENG Tao DENG Xiaopu LYU Tingyuan LI Xiaorong GAO Xi CHEN | 2018 | Advances in Atmospheric Sciences2018，35，9： | 5 |
| 2 | Homogeneous PLGA-lipid nanoparticle as a promising oral vaccine delivery system for ovalbumin显示文摘In this study,a polymeric lipid nanoparticle(NP)(simplified as Lipid NP)was reported as a promising oral vaccine delivery system.The Lipid NPs composed of a hydrophobic polymeric poly(D,L-lactide-co-glycolide)(PLGA)core and a surface coating of lipid monolayer.Membrane emulsification technique was used to obtain uniform-sized Lipid NPs.Ovalbumin(OVA)was used as a model vaccine.Compared with the pure PLGA NPs,the Lipid NPs achieved higher loading capacity(LC)and entrapment efficiency(EE)for the encapsulated OVA.An in vitro oral release profile showed that the OVA-Lipid NPs were with lower initial burst and could protect the loaded OVA from the harsh gastrointestinal(GI)environment for a long time.In addition,a human microfold cell(M-cell)transcytotic assay demonstrated that due to a lipid layer structure on the particle surface,the Lipid NPs showed higher affinity to the M-cells.Since the M-cell in the intestinal epithelium played an important role in particle transportation as well as intimately associated with the underlying immune cells,the OVA-Lipid NPs effectively induced mucosal and humoral immune responses. | Tongtong Ma Lianyan Wang Tingyuan Yang Guanghui Ma Siling Wang | 2014 | Asian Journal of Pharmaceutical Sciences2014，9，3： | 4 |
| 3 | Optimization and evaluation of fish oil rnicrocapsules显示文摘 | Hui Liu Lia nyan Wang Tingyuan Yang Guifeng Zhang Jian Huang Jing Sun Junsheng Huo | 2016 | Particuology2016，14，6： | 4 |
| 4 | Electrical transport and photoresponse properties of single-crystalline p-type Cd_3As_2 nanowires显示文摘Cd3As2 is an important II–V group semiconductor with excellent electrical and optoelectronic properties. In this work, we report the large scale growth of single-crystalline Cd3As2 nanowires via a simple chemical vapor deposition method. Single nanowire field-effect transistors were fabricated with the as-grown Cd3As2 nanowires, which exhibited a high I on/I off of 104 with a hole mobility of 6.02 cm2V-1s-1. Photoresponse properties of the Cd3As2 nanowires were also investigated by illuminating the nanowires with white light by varying intensities. Besides, flexible photodetectors were also fabricated on flexible PET substrate, showing excellent mechanical stablility and flexible electro-optical properties under various bending states and bending cycles. Our results indicate that Cd3As2 nanowires can be the basic material of next generation electronic and optoelectronic devices. | DUAN TingYuan LOU Zheng SHEN GuoZhen | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，2： | 2 |
| 5 | Targeted Polymeric Micelle System for Delivery of Combretastatin A4 to Tumor Vasculature In Vitro显示文摘 | Yiguang Wang Tingyuan Yang Xun Wang Jiancheng Wang Xuan Zhang Qiang Zhang | 2010 | Pharmaceutical Research2010，，9： | 1 |
| 6 | Surface charge of PLA microparticles in regulation of antigen loading,macrophage phagocytosis and activation,and immune effects in vitro显示文摘The use of microparticles(MPs) as adjuvants has attracted increasing interest in vaccine delivery systems.Many physiochemical characteristics of MPs including hydrodynamic size,surface properties,and morphology can regulate the immune response.Surface charge is an important characteristic of MPs,but how it affects their adjuvanticity remains unknown.In this study,we prepared uniform-sized polylactide MPs coated with various polymers of different positive charge,and investigated how the surface charge affected antigen loading and macrophage phagocytosis and activation in vitro.A higher surface charge greatly enhanced antigen loading and antigen internalization into macrophages,promoted the expression of MHC 11 and CD80,and increased the secretion level of TNF-a.Taken together,these results indicated that surface charge was an important parameter for improving the adjuvanticity of MPs. | Yuying Liu Xiaoming Chen Lianyan Wang Tingyuan Yang Qipeng Yuan Guanghui Ma | 2014 | Particuology2014，12，6： | 1 |
| 7 | Peptide PHSCNK as an integrin α 5 β 1 antagonist targets stealth liposomes to integrin-overexpressing melanoma显示文摘 | Wenbing Dai Tingyuan Yang Yiguang Wang Xueqing Wang Jiancheng Wang Xuan Zhang Qiang Zhang | 2012 | Nanomedicine: Nanotechnology, Biology, and Medicine2012，，7： | 1 |
| 8 | Mechanistic studies for monodisperse exenatide-loaded PLGA micro-spheres prepared by different methods based on SPG membrane emulsification 显示文摘 | QI Feng WU Jie YANG Tingyuan | 2014 | Acta Biomaterialia2014，10，10： | 1 |
| 9 | Ex- pression of HSP90c and cyclin BI were related to prognosis of esophageal squamous cell careinonm and keratin pearl tbrmation 显示文摘 | TINGYUAN HUANG SIZE CHEN HONGYU HAN | 2014 | Int J Clin Exp Pathol2014，7，4： | 1 |
| 10 | Phase I trial of human umbilical cord-derived mesenchymal stem cells for treatment of severe bronchopulmonary dysplasia显示文摘Severe bronchopulmonary dysplasia(BPD)is a chronic lung disorder that primarily affects premature babies with extremely low birth weight and involves in multiple organ system;no effective pharmacotherapy for this disease exists,and mortality remains high.Based on the evidence from previous preclinical studies and phase I clinical trials,this study aims to test the safety of intravenous application of a single dose of human umbilical cord-derived mesenchymal stem cells(hUC-MSCs)in patients with severe BPD.The Mesenchymal Stem cells for Bronchopulmonary Dysplasia Treatment(MSBDT)trial is a single center,open-label,dose-escalation phase I clinical trial.Severe BPD patients were enrolled in Children Hospital of Chongqing Medical University,Chongqing,China.The first six patients were treated with low-dose hUC-MSCs(1×10^(6) cells/kg)and the next seven patients were treated with high-dose hUC-MSCs(5×10^(6) cells/kg).This study is registered with ClinicalTrials.gov,number NCT03558334.No prespecified infusion-associated adverse events,immediate complication,respiratory or cardiovascular compromise were observed during infusion and 24 h after infusion.No significant changes in safety laboratory values were observed.One death event occurred in the low-dose group on study day 10,and one death event occurred in the high-dose group on study day 24,while,after review in detail,the two cases are not believed to be infusion-associated events.In conclusion,intravenous application of a single dose of hUC-MSCs was tolerated in thirteen patients with severe BPD. | Yunqiu Xia Tingyuan Lang Yuqin Niu Xian Wu Ou Zhou Jihong Dai Lei Bao Ke Yang Lin Zou Zhou Fu Gang Geng | 2023 | Genes & Diseases2023，10，2： | 1 |
| 11 | Hierarchical metal-phenolic-polyplex assembly toward superwetting membrane for high-flux and antifouling oil-water separation显示文摘Superwetting membranes have emerged as promising materials for the efficient treatment of oily wastewater.Typically,superwetting membranes can be developed by ingeniously chemical modification and topographical structuration of microporous membranes.Herein,we report the hierarchical assembly of metal-phenolic-polyplex coating to manipulate membrane surface superwettability by integrating metal-phenolic(Fe^(Ⅲ)-tannic acid(TA))assembly with polyplex(tannic acid-polyethylenimine(PEI))assembly.The proposed Fe-TA-PEI coating can be deposited on microporous membrane via simply dipping into Fe^(Ⅲ)-TA-PEI co-assembly solution.Based on the catechol chemistry,the coordination complexation of Fe^(Ⅲ)and TA develops metal-phenolic networks to provide hydrophilic chemistries,and the electrostatic complexation of TA and PEI generates nanoconjugates to impart hierarchical architectures.Benefiting from the synergy of hydrophilic chemistries and hierarchical architectures,the resulting PVDF/Fe-TA-PEI membrane exhibits excellent superhydrophilicity(~0°)underwater superoleophobicity(~150°)and superior anti-oil-adhesion capability.The superhydrophilicity of PVDF/Fe-TA-PEI membrane greatly promotes membrane permeability,featuring water fluxes up to 5860 L m^(-2)h^(-1).The underwater superoleophobicity of PVDF/Fe-TA-PEI membrane promises potential flux(3393 L m^(-2)h^(-1)),high separation efficiency(99.3%)and desirable antifouling capability for oil-in-water emulsion separation.Thus,we highlight the reported hierarchical metal-phenolic-polyplex assembly as a straightforward and effective strategy that enables the synchronous modulation of surface chemistry and topography toward superwetting membranes for promising high-flux and antifouling oil-water separation. | Xueting Zhao Yuanyuan Jiang Lijuan Cheng Youyou Lan Tingyuan Wang Jiefeng Pan Lifen Liu | 2022 | Chinese Chemical Letters2022，33，8： | 0 |
| 12 | Development of a molecular feature-based survival prediction model of ovarian cancer using the deep neural network显示文摘Ovarian cancer(OC)is one of the most lethal gynecologic cancer worldwide,and survival prediction is meaningful for personalized treatment.^(1)The survival outcome of cancer patients mainly depended on the malignancy of the primary tumor which is tightly linked with the expression profile of the molecular features.^(2)Therefore,in this study,we developed a molecular feature-based survival prediction model of OC using a deep neural network(DNN). | Tingyuan Lang Muyao Yang Yunqiu Xia Jingshu Liu Yunzhe Li Lingling Yang Chenxi Cui Yunran Hu Yang Luo Dongling Zou Lei Zhou Zhou Fu Qi Zhou | 2023 | Genes & Diseases2023，10，4： | 0 |
| 13 | Disruption of KDM4C-ALDH1 A3 feed-forward loop inhibits sternness,tumorigenesis and chemoresistance of gastric cancer stem cells显示文摘Dear Editor,Gastric cancer(GC)is a considerable global health burden;the median survival of advaneed GC is less than 1 year.^(1)Cancer stem cells(CSCs),a small population of cancer cells with stem cell-like properties,are the major cause of treatme nt failure,in eluding GC,2 however,the mechanisms underlying stemness maintenanee of GC stem cells(GCSCs)are still poorly understood. | Tingyuan Lang Jia Xu Lei Zhou Zhiqi Zhang Xinli Ma Jiayi Gu Jingshu Liu Yunzhe Li Dongyan Ding Jiangfeng Qiu | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 0 |
| 14 | Design, synthesis, molecular modeling, and biological evaluation of acrylamide derivatives as potent inhibitors of human dihydroorotate dehydrogenase for the treatment of rheumatoid arthritis显示文摘Human dihydroorotate dehydrogenase(DHODH) is a viable target for the development of therapeutics to treat cancer and immunological diseases, such as rheumatoid arthritis(RA), psoriasis and multiple sclerosis(MS). Herein, a series of acrylamide-based novel DHODH inhibitors as potential RA treatment agents were designed and synthesized. 2-Acrylamidobenzoic acid analog 11 was identified as the lead compound for structureeactivity relationship(SAR) studies. The replacement of the phenyl group with naphthyl moieties improved inhibitory activity significantly to double-digit nanomolar range.Further structure optimization revealed that an acrylamide with small hydrophobic groups(Me, Cl or Br)at the 2-position was preferred. Moreover, adding a fluoro atom at the 5-position of the benzoic acid enhanced the potency. The optimization efforts led to potent compounds 42 and 53-55 with IC50 values of 41, 44, 32, and 42 nmol/L, respectively. The most potent compound 54 also displayed favorable pharmacokinetic(PK) profiles and encouraging in vivo anti-arthritic effects in a dose-dependent manner. | Fanxun Zeng Shiliang Li Guantian Yang Yating Luo Tiantian Qi Yingfan Liang Tingyuan Yang Letian Zhang Rui Wang Lili Zhu Honglin Li Xiaoyong Xu | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 0 |
| 15 | Dual-function baicalin and baicalin-loaded poly(lactic-co-glycolic acid) nanoparticles: Immune activation of dendritic cells and arrest of the melanoma cell cycle at the G2/M phase显示文摘 | Huimei Wang Shulan Han Lianyan Wang Tingyuan Yang Guifeng Zhang Lian Yu Yue Zhao | 2018 | Particuology2018，16，2： | 0 |
| 16 | Polaron mobility modulation by bandgap engineering in black phaseα-FAPbI_(3)显示文摘Lead halide hybrid perovskites(LHP)have emerged as one of the most promising photovoltaic materials for their remarkable solar energy conversion ability.The transportation of the photoinduced carriers in LHP could screen the defect recombination with the help of the large polaron formation.However,the physical insight of the relationship between the superior optical-electronic performance of perovskite and its polaron dynamics related to the electron-lattice strong coupling induced by the substitution engineering is still lack of investigation.Here,the bandgap modulated thin films ofα-FAPbI_(3)with different element substitution is investigated by the time resolved Terahertz spectroscopy.We find the polaron recombination dynamics could be prolonged in LHP with a relatively smaller bandgap,even though the formation of polaron will not be affected apparently.Intuitively,the large polaron mobility in(FAPb I_(3))0.95(MAPbI_(3))0.05thin film is~30%larger than that in(FAPb I_(3))0.85(MAPbBr_(3))0.15.The larger mobility in(FAPb I_(3))0.95(MAPb I_(3))0.05could be assigned to the slowing down of the carrier scattering time.Therefore,the physical origin of the higher carrier mobility in the(FAPb I_(3))0.95(MAPbI_(3))0.05should be related with the lattice distortion and enhanced electron–phonon coupling induced by the substitution.In addition,(FAPbI_(3))0.95(MAPbI_(3))0.05will lose fewer active carriers during the polaron cooling process than that in(FAPb I_(3))0.85(MAPbBr_(3)),indicating lower thermal dissipation in(FAPbI_(3))0.95(MAPbI_(3))0.05.Our results suggest that besides the smaller bandgap,the higher polaron mobility improved by the substitution engineering inα-FAPbI_(3)can also be an important factor for the high PCE of the black phaseα-FAPbI_(3)based solar cell devices. | Chunwei Wang Zeyu Zhang Zhuang Xiong Xingyu Yue Bo Zhang Tingyuan jia Zhengzheng Liu Juan Du Yuxin Leng Kuan Sun Ruxin Li | 2023 | Journal of Energy Chemistry2023，，1： | 0 |
| 17 | Mobility Oriented Next Generation Open System and Its Middleware显示文摘 | ZHANG Yunyong LI Tingyuan ZHANG Zhijiang LIU Yunjie WANG Minghui QING Zhiguang LIU Jinde | 2005 | Chinese Journal of Electronics2005，14，4： | 0 |
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