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| 1 | Inflammatory bowel disease in rats:Bacterial and chemical interaction显示文摘AIM: To develop a novel model of colitis in rats, using a combination of iodoacetamide and enteropathogenic E. coli (EPEC), and to elucidate the pathophysiologic processes implicated in the development of ulcerative colitis (UC). METHODS: Male Sprague-Dawley rats (n = 158) were inoculated intrarectally on a weekly basis with 4 different combinations: (a) 1% methylcellulose (MC), (b) 100 μL of 6% iodoacetamide (IA) in 1% MC, (c) 200 μL containing 4 × 108 colony factor units (CFU) of EPEC, and (d) combined treatment of (IA) followed by bacteria (B) after 2 d. Thirty days post treatment, each of the four groups was divided into two subgroups; the inoculation was stopped for one subgroup and the other subgroup continued with biweekly inoculation until the end of the experiment. Colitis was evaluated by the clinical course of the disease, the macroscopic and microscopic alterations, activity of myeloperoxidase (MPO), and by TNF-α gene expression. RESULTS: Findings indicative of UC were seen in the combined treatment (IA + B) as well as the IA conti-nued treatment groups: the animals showed slow rate of increase in body weight, diarrhea, bloody stools, high colonic ulcer score, as well as histological altera- tions characteristic of UC, with an extensive inflamma- tory reaction. During the course of the experiment, the MPO activity was consistently elevated and the TNF-α gene expression was upregulated compared to the control animals. CONCLUSION: The experimental ulcerative colitis model used in the present study resembles, to a great extent, the human disease. It is reproducible with characteristics indicative of chronicity. | Inaya Abdallah Hajj Hussein Rania Tohme Kassem Barada Mostafa Hassan Mostafa Jean-Noel Freund Rosalyn A Jurjus Walid Karam Abdo Jurjus | 2008 | World Journal of Gastroenterology2008，14，25： | 2 |
| 2 | Moesin functions as a lipopolysaccharide receptor on human monocytes显示文摘 | Tohme ZN Amar S van Dyke TE | 1999 | Infect Immun1999，67，： | 1 |
| 3 | Quantitative trait loci for yield and yield components in an Oryza sativa×Oryza rufipogon BC2F2 population evaluated in an upland environment显示文摘 | P. Moncada C. P. Martínez J. Borrero M. Chatel H. Gauch Jr E. Guimaraes J. Tohme S. R. McCouch | 2001 | TAG Theoretical and Applied Genetics2001，，1： | 1 |
| 4 | Simple sequence repeat(SSR)marker survey of the cassava(Manihot esculenta Crantz)genome:toward a SSR-based molecular genetic map of cassava显示文摘 | Mba R E C Stephenson P Edwards K Mezer S Nkumbira J Gulberg U Apel K Gale M Tohme J Fregene M A | | 0，，： | 1 |
| 5 | New vinegar production from onions显示文摘 | Jun-Iehi Horiuehi Tohm Kanno Masayoshi Kobayashi | 1999 | Journal of Bioscienee and Bioengineering1999，88，1： | 1 |
| 6 | Micro-PET imaging of alphavbeta3-integrin expression with ^18F-labeled dimeric RGD peptide 显示文摘 | Chen X Tohme M Park R | 2004 | Mol Imaging2004，3，2： | 1 |
| 7 | Micro-PET imaging of alphavbeta3-integrin expression with 18F-labeled dimeric RGD peptide显示文摘 | Chen X Tohme M Park R | 2004 | Mol Imaging2004，3，2： | 1 |
| 8 | AFLP analysis of gene pools of wild bean core collection显示文摘 | TOHME J GONZALEZ D O BEEBE S DUQUE M C | 1996 | Crop Sciences1996，36，： | 1 |
| 9 | TCP over satellite links: problems and solutions显示文摘 | OUESLAT-BOULAHIA S SERHROUCHN I TOHME S | 2000 | Telecommunication Systems2000，13，： | 1 |
| 10 | Coalition Structure generation with worst case guarantees显示文摘 | Sandholm T W Larson K Andersson M Shehory O Tohme F | 1999 | Artificial Intelligence1999，111，12： | 1 |
| 11 | Analyses of genetic diversity in Cuban rice varieties using isozyme, RAPD and AFLP markers显示文摘 | Jorge Luis Fuentes Fabio Escobar Alba Alvarez Geraldo Gallego Miriam Cristina Duque Mirle Ferrer Juan Enrrique Deus Joe M. Tohme | 1999 | Euphytica1999，，2： | 1 |
| 12 | Estrogen treatment of patients with established postmenopausal osteoporosis 显示文摘 | Lindsay R Tohme JF | 1990 | Obstet Gynecol1990，76，： | 1 |
| 13 | MicroPET and autoradiographic imaging of breast cancer αⅤ-integrin expression using 18F-and 64Cu-labeled RGD peptide显示文摘 | Chen X Park R Tohme M | 2004 | Bioconjugate Chem2004，15，1： | 1 |
| 14 | Pursley's aperiodic cross-correla- tion functions revisited 显示文摘 | KOHDA Tohm FUJISAKI Hiroshi | 2003 | IEEE Transaction on Circuits and Systems2003，50，6： | 1 |
| 15 | MicroPET and autoradio- graphic imaging of breast cancer alpha v-integrin expression using ^18F-and ^64Cu-labeled RGD peptide显示文摘 | Chen X Park R Tohme M | 2004 | Bioconjug Chem2004，15，1： | 1 |
| 16 | In vivo screening u- sing transgenic zebrafish embryos reveals new effects of HDAC inhibitors trichostatin A and valproic acid on organo- genesis显示文摘 | LI L BONNETON F TOHME M | 2016 | PLoSOne2016，11，01： | 1 |
| 17 | High-mobility group box-1 in sterile inflammation显示文摘 | Tsung A Tohme S Billiar TR | 2014 | J Intern Med2014，276，5： | 1 |
| 18 | Detergent alka- line proteases: enzymatic properties, genes, and crystal structures显示文摘 | Katsuhisa Saeki Katsuya Ozaki Tohm Kobayashi | 2007 | Journal of Bioscience and Bioengineering2007，103，6： | 1 |
| 19 | The prevalence of hypertension and its association with other cardiovascular disease risk factors in a representative sample of the Lebanese population 显示文摘 | Tohme RA Jurjus AR Estephan A | 2005 | Human Hypertension2005，19，： | 1 |
| 20 | Plasma soluble vascular adhesion molecule-1 levels are persistently elevated during the first month after colorectal cancer resection显示文摘 | H. Shantha Kumara Samer Tohme Sonali Herath Xiaohong Yan Anthony Senagore Abu Nasar Matthew Kalady Raymond Baxter Richard Whelan | 2012 | Surgical Endoscopy2012，，6： | 1 |
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