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| 1 | Beneficial effects of fucoidan in patients with chronic hepatitis C virus infection显示文摘AIM:To evaluate the effects of fucoidan,a complex sulfated polysaccharide extract from marine seaweed,on hepatitis C virus(HCV) RNA load both in vitro and in vivo.METHODS:HCV-1b replicon-expressing cells were cultured in the presence of fucoidan obtained from Cladosiphon okamuranus Tokida cultivated in Okinawa,Japan,and quantified the level of HCV replication.In an open-label uncontrolled study,15 patients with chronic hepatitis C,and HCV-related cirrhosis and hepatocellular carcinoma were treated with fucoidan(0.83 g/d) for 12 mo.The clinical symptoms,biochemical tests,and HCV RNA levels were assessed before,during,and after treatment.RESULTS:Fucoidan dose-dependently inhibited the expression of HCV replicon.At 8-10 mo of treatment with fucoidan,HCV RNA levels were significantly lower relative to the baseline.The same treatment also tended to lower serum alanine aminotransferase levels,and the latter correlated with HCV RNA levels.However,the improved laboratory tests did not translate into significant clinical improvement.Fucoidan had no serious adverse effects.CONCLUSION:Our findings suggest that fucoidan is safe and useful in the treatment of patients with HCVrelated chronic liver diseases.Further controlled clinical trials are needed to confirm the present findings. | Naoki Mori Kazunori Nakasone Koh Tomimori Chie Ishikawa | 2012 | World Journal of Gastroenterology2012，18，18： | 3 |
| 2 | Prevalence of incidental thyroid disease in a relatively low iodine intake area 显示文摘 | Tomimori E Pedrinola F Cavaliere H | 1995 | Thyroid1995，5，4： | 1 |
| 3 | Mast cell chymase regulates dermal mast cell number in mice显示文摘 | Muto T Fukami H | 2002 | Biochem Biophys Res Commun2002，290，5： | 1 |
| 4 | Studies on the constituents of Scutellaria Species X V II phenol glycosides of the root of ScuteUaria ba- icalensis Georgi 显示文摘 | Miyaichi Y Tomimori T | 1995 | Nat Med1995，49，3： | 1 |
| 5 | Usefulness of ultrasound in the diagnosis and management of well-differentiated thyroid carcinoma显示文摘 | De Camargo RY Tomimori EK | 2007 | Arq Bras Endocrinol Metabol2007，51，5： | 1 |
| 6 | Studies on the constituents of clem- atis species VI显示文摘 | Kizu H Shimana H Tomimori T | 1995 | Chem Pharm Bu111995，，43： | 1 |
| 7 | In vivo anti-influenza virus activity of plant flavonoids possessing inhibitory activity for influenza virus sialidase显示文摘 | Nagai T Miyaichi Y Tomimori T | 1992 | Antiviral Res1992，19，3： | 1 |
| 8 | Inhibition of mouse liver sialidase by plant flavonoids显示文摘 | Nagai T Miyaichi Y Tomimori T | 1989 | Biochem Biophys Res Commun1989，163，1： | 1 |
| 9 | Usefulness of ultrasound in the diagnosis and management of well-differentiated thyroid carcinoma显示文摘 | Camargo RY Tomimori EK | 2007 | Arq Bras Endocrinol Metabol2007，51，5： | 1 |
| 10 | Establishment of a new murine model of hypercalcemia with anorexia by overexpression of sol- uble receptor activator of NF-KB ligand using an adenovirus vector 显示文摘 | Enomnto T Furuya Y Tomimori Y | 2011 | J Bone MincrMetab2011，29，4： | 1 |
| 11 | The construction of an in vitro three-dimensional hematopoietic microenviroment for mouse bone marrow cells employing porous carriers 显示文摘 | Tomimori Y Takagi M Yoshida T | 2000 | Cytotechnology2000，34，： | 1 |
| 12 | Anti - tumor ac- tivity of fucoidan is mediated by nitric oxide released from macrophages 显示文摘 | Takede K Tomimori' K Kimura R | 2012 | International Journal of Oncology2012，40，1： | 1 |
| 13 | Usefulness of ul- trasound in the diagnosis and management of well- differentiated thyroid carcinoma显示文摘 | CAMARGO l Y TOMIMORI E K | 2007 | Arq Bras Ende- erinol Metabol2007，51，5： | 1 |
| 14 | Synthe- sis of π - expanded bodipys and their fluorescent prop- erties in the visible-near-infrared region 显示文摘 | Okujima T Tomimori Y Nakamura J | 2010 | Tetrahed- ton2010，34，66： | 1 |
| 15 | Prevalence of incidental thyroid disease in a relatively low iodine intake area显示文摘 | Tomimori E Pedrinola F Cavaliere H | 1995 | Thyroid1995，5，4： | 1 |
| 16 | On the flavonoid constituents from the roots of Scutellaria baica lensls Georgi Ⅰ 显示文摘 | Tomimori T Miyaichi Y Kizu H | 1982 | Yakugaku Zasshi1982，102，4： | 1 |
| 17 | Thyroid and the environment: exposure to excessive nutritional iodine increases the prevalence of thyroid disorders in Sao Panlo, Brazil 显示文摘 | Camargo RY Tomimori EK Neves SC et at | 2008 | Eur J Endocrinol2008，159，3： | 1 |
| 18 | NF-kappaB activation by Helicobacter pylori requires Akt-mediated phosphorylation of p65 显示文摘 | Takeshima E Tomimori K Kawakami H | 2009 | BMC Microbial2009，9，： | 1 |
| 19 | Excessive iodine intake and ultrasonOg raphic thyroid abnormalities in schoolchildren显示文摘 | Glaucia C Duarte K Tomimori | 2009 | Journal of pediatric Endocrinology & Metabolism2009，22，： | 1 |
| 20 | Prognostic value of serial serum thyroglobulin determinations 'after total thyroidctomy for differen- tiated thyroid cancer显示文摘 | Lima N Cavaliere H Tomimori E | 2002 | J Endocrinal Invest2002，25，2： | 1 |
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