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| 1 | Colorectal endoscopic submucosal dissection: Recent technical advances for safe and successful procedures显示文摘Endoscopic submucosal dissection(ESD) is very useful in en bloc resection of large superficial colorectal tumors but is a technically difficult procedure because the colonic wall is thin and endoscopic maneuverability is poor because of colonic flexure and extensibility. A high risk of perforation has been reported in colorectal ESD. To prevent complications such as perforation and unexpected bleeding, it is crucial to ensure good visualization of the submucosal layer by creating a mucosal flap, which is an exfoliated mucosa for inserting the tip of the endoscope under it. The creation of a mucosal flap is often technically difficult; however, various types of equipment, appropriate strategy, and novel procedures including our clip-flap method, appear to facilitate mucosal flap creation, improving the safety and success rate of ESD. Favorable treatment outcomes with colorectal ESD have already been reported in many advanced institutions, and appropriate understanding of techniques and development of training systems are required for world-wide standardization of colorectal ESD. Here, we describe recent technical advances for safe and successful colorectal ESD. | Katsumi Yamamoto Tomoki Michida Tsutomu Nishida Shiro Hayashi Masafumi Naito Toshifumi Ito | 2015 | World Journal of Gastrointestinal Endoscopy2015,7,14: | 9 |
| 2 | Serum Mac-2 binding protein is a novel biomarker for chronic pancreatitis显示文摘AIM: To determine the efficacy of Mac-2 binding protein(Mac-2bp) for diagnosis of chronic pancreatitis.METHODS: Fifty-nine healthy volunteers(HV), 162 patients with chronic pancreatitis(CP), and 94 patients with pancreatic ductal adenocarcinoma(PDAC) were enrolled in this study. We measured serum Mac-2bp using our developed enzyme-linked immunosorbent assay kit. Additional biochemical variables were measured using an automated analyzer(including aminotransferase, alanine aminotransferase, γ-glutamyltransferase, alkaline phosphatase, triglyceride, C-reactive protein, and amylase levels) or chemiluminescent enzyme immunoassay(carbohydrate antigen 19-9 and carcinoembryonic antigen). The ability of Mac-2bp to predict CP diagnosis accurately was assessed using receiver operating characteristic(ROC) analyses.RESULTS: Serum Mac-2bp levels were significantly increased in CP patients compared to HV(P < 0.0001) and PDAC patients(P < 0.0001). Area under the ROC curve values of Mac-2bp for the discrimination of CP from HV and PDAC were 0.727 and 0.784, respectively. Multivariate analyses demonstrated that serum Mac-2bp levels were independent determinants for CP diagnosis from HV and PDAC patients. Immunohistological staining showed that Mac-2bp was expressed faintly in the pancreas tissues of both CP and PDAC patients. Serum aspartate aminotransferase, alanine aminotransferase, γ-glutamyltransferase, alkaline phosphatase, and triglyceride levels were significantly higher in patients with CP or PDAC. Serum Mac-2bp levels were highly correlated with protein levels of alanine aminotransferase, γ-glutamyltransferase, and C-reactive protein, but not amylase, suggesting that the damaged liver produces Mac-2bp. CONCLUSION: Measurement of serum Mac-2bp may be a novel and useful biomarker for CP diagnosis as well as liver fibrosis in the general population. | Tomohiro Maekawa Yoshihiro Kamada Yusuke Ebisutani Makiko Ueda Tomoki Hata Koichi Kawamoto Shinji Takamatsu Kayo Mizutani Mayuka Shimomura Tomoaki Sobajima Hironobu Fujii Kotarosumitomo Nakayama Kimihiro Nishino Makoto Yamada Takashi Kumada Toshifumi Ito Hidetoshi Eguchi Hiroaki Nagano Eiji Miyoshi | 2016 | World Journal of Gastroenterology2016,22,17: | 3 |
| 3 | The growth factor midkine regulates the renin-angiotensin system in mice显示文摘 | Hobo Akinori Yuzawa Yukio Kosugi Tomoki Kato Noritoshi Asai Naoto Sato Waichi Maruyama Shoichi Ito Yasuhiko Kobori Hiroyuki Ikematsu Shinya Nishiyama Akira Matsuo Seiichi Kadomatsu Kenji | 2009 | Journal of Clinical Investigation2009,,6: | 2 |
| 4 | Delayed perforation occurring after endoscopic submucosal dissection for early gastric cancer显示文摘 | Kenji Ikezawa Tomoki Michida Kiyoshi Iwahashi Kosaku Maeda Masafumi Naito Toshifumi Ito Kazuhiro Katayama | 2012 | Gastric Cancer2012,,1: | 2 |
| 5 | Late-onset severe biliary bleeding after endoscopic pigtail plastic stent insertion显示文摘Here, we report our experience with a case of severe biliary bleeding due to a hepatic arterial pseudoaneurysm that had developed 1 year after endoscopic biliary plastic stent insertion. The patient, a 78-year-old woman, presented with hematemesis and obstructive jaundice. Ruptured hepatic arterial pseudoaneurysm was diagnosed, which was suspected to have been caused by long-term placement of an endoscopic retrograde biliary drainage(ERBD) stent. This episode of biliary bleeding was successfully treated by transarterial embolization(TAE). Pseudoaneurysm leading to hemobilia is a rare but potentially fatal complication in patients with long-term placement of ERBD. TAE is a minimally invasive procedure that offers effective treatment for biliary bleeding. | Muneji Yasuda Hideki Sato Yuki Koyama Tomoki Sakakida Takumi Kawakami Takeshi Nishimura Hideki Fujii Yoshikazu Nakatsugawa Shinya Yamada Naoya Tomatsuri Yusuke Okuyama Hiroyuki Kimura Takaaki Ito Hiroyuki Morishita Norimasa Yoshida | 2017 | World Journal of Gastroenterology2017,23,4: | 2 |
| 6 | Platelet-derived RANK ligand enhances CCL17 secretion from dendritic cells mediated by thymic stromal lymphopoietin显示文摘 | Takahisa Nakanishi Muneo Inaba Noriko Inagaki-Katashiba Akihiro Tanaka Phan Thi Xuan Vien Kayoko Kibata Tomoki Ito Shosaku Nomura | 2014 | Platelets2014,,: | 1 |
| 7 | Low-temperature synthesis of anatase–brookite composite nanocrystals: the junction effect on photocatalytic activity显示文摘 | Toshiaki Ozawa Mitsunobu Iwasaki Hiroaki Tada Tomoki Akita Koji Tanaka Seishiro Ito | 2004 | Journal of Colloid And Interface Science2004,,2: | 1 |
| 8 | Thymic stromal lymphopoietin plays an adjuvant role in BCG -mediated CD8^+ cytotoxic T cell responses through dendritic cell activation显示文摘 | Hiroyuki Sugimoto Tomoki Ito Yoshitaro Torii | 2010 | Clinical hnmunology2010,136,2: | 1 |
| 9 | Properties of myofibrillar protein from Japanese stingfish ( Sebastes inermis ) dorsal muscle显示文摘 | Takeshi Nagai Masato Kurata Takashi Nakamura Tatsumi Ito Kazuhiro Fujiki Miki Nakao Tomoki Yano | 1999 | Food Research International1999,,6: | 1 |
| 10 | Thymie stromal lymphopoietin plays an adjuvant role in BCG-mediated CD8+ cytotoxic T cell responses through dendritic cell activation显示文摘 | Hiroyuki Sugimoto Tomoki Ito Yoshitaro Torii | 2010 | Clinical Immunology2010,136,2: | 1 |
| 11 | Thymic stromal lymphopoietin plays an adjuvant role in BCG-mediated CD8 + cyrotoxic T cell responses through dendritic cell activation显示文摘 | Hiroyuki Sugimoto Tomoki Ito Yoshitaro Torii | | 0,,02: | 1 |
| 12 | CT appearance of radiation injury of the lung and clinical symptoms after stereotactic body radiation therapy (SBRT) for lung cancers: Are patients with pulmonary emphysema also candidates for SBRT for lung cancers?显示文摘 | Tomoki Kimura Kanji Matsuura Yuji Murakami Yasutoshi Hashimoto Masahiro Kenjo Yuko Kaneyasu Koichi Wadasaki Yutaka Hirokawa Katsuhide Ito Motoomi Okawa | 2006 | International Journal of Radiation Oncology Biology Physics2006,,2: | 1 |