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| 1 | Efficacy and safety of Xinfeng capsule in patients with rheumatoid arthritis:a multi-center parallel-group double-blind randomized controlled trial显示文摘OBJECTIVE:To evaluate the efficacy and safety of Xinfeng capsule in patients suffering rheumatoid arthritis(RA).METHODS:A multi-center parallel-group designed,double-blind,randomized,controlled trial was conducted.Totally 304 RA patients were assigned to two groups:one group was administered Xinfeng capsule(XFC) plus the placebo of leflunomide and the other given leflunomide(LEF) plus the placebo of XFC for twelve weeks.The clinical and laboratory parameters were compared at baseline and fourth,eighth,and twelfth weeks.RESULTS:After twelve-week treatment,patients in two groups all showed some trend of effectiveness when compared in terms of American Rheumatism Association(ACR) recommended 20%,50%,70%improvement criteria,but it was insignificant.The validity in ameliorate modified disease activity score(DAS28) and laboratory indexes as erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),rheumatoid factor(RF) were also found no difference.The score of health assessment questionnaire(HAQ),self-rating anxiety scale(SAS),self-rating depression scale(SDS) and quality of life questionnaire with rheumatoid arthritis(RAQOL)both lower than the first week and the changes showed no difference.However,the score of SDS dropped more in XFC group than in the other.A total of 147 adverse reaction cases were reported,which shows no difference between the two groups.The most common adverse reactions were hepatic impairment,anemia,leukocytopenia,epigastric discomfort and phalacrosis.CONCLUSION:XFC demonstrated better improvement in the scores of SDS and compared with those of LEF group. | Liu Jian Wang Yuan Huang Chuanbing Xu Jianhua Li Zhijun Xu Liang He Liyun Sun Yue Wang Yali Xu Shengqian Zhao Ping Mao Tongjun Tan Bin Zhu Fubing Zhang Pingheng Fang Li | 2015 | Journal of Traditional Chinese Medicine2015，35，5： | 27 |
| 2 | Redundant CAMTA Transcription Factors Negatively Regulate the Biosynthesis of Salicylic Acid and N-Hydroxypipecolic Acid by Modulating the Expression of SARD1 and CBP60g显示文摘Two signal molecules, salicylic acid (SA) and N-hydroxypipecolic acid (NHP), play critical roles in plant immunity. The biosynthetic genes of both compounds are positively regulated by master immune-regulating transcription factors SARD1 and CBP60g. However, the relationship between the SA and NHP pathways is unclear. CALMODULIN-BINDING TRANSCRIPTION FACTOR 1 (CAMTA1), CAMTA2, and CAMTA3 are known redundant negative regulators of plant immunity, but the underlying mechanism also remains largely unknown. In this study, through chromatin immunoprecipitation and electrophoretic mobility shift assays, we uncovered that CBP60g is a direct target of CAMTA3, which also negatively regulates the expression of SARD1, presumably via an indirect effect. The autoimmunity of camta3-1 is suppressed by sard1 cbp60g double mutant as well as ald1 and fmo1, two single mutants defective in NHP biosynthesis. Interestingly, a suppressor screen conducted in the camta1/ 2/ 3 triple mutant background yielded various mutants blocking biosynthesis or signaling of either SA or NHP, leading to nearly complete suppression of the extreme autoimmunity of camta1/ 2/ 3, suggesting that the SA and NHP pathways can mutually amplify each other. Together, these results reveal that CAMTAs repress the biosynthesis of SA and NHP by modulating the expression of SARD1 and CBP60g, and that the SA and NHP pathways are coordinated to optimize plant immune response. | Tongjun Sun Jianhua Huang Yan Xu Vani Verma Beibei Jing Yulin Sun Alberto Ruiz Orduna Hainan Tian Xingchuan Huang Shitou Xia Laurel Schafer Reinhard Jetter Yuelin Zhang Xin Li | 2020 | Molecular Plant2020，13，1： | 5 |
| 3 | STREAMLINE DIFFUSION F.E.M. FOR SOBOLEV EQUATIONS WITH CONVECTION DOMINATED TERM显示文摘In this paper,a streamline diffusion F.E.M. for linear Sobolev equations with convection dominated term is given.According to the range of space time F.E mesh parameter h ,two choices for artifical diffusion parameter δ are presented,and for the corresponding computation schemes the stability and error estimates in suitable norms are estabilished. | Sun Tongjun Now address:Department of Mathematics and Physics, South Campus of Shandong University, Jinan 250061.Dept. of Math., South Campus of Shandong Univ.,Jinan 250061. | 2001 | Applied Mathematics(A Journal of Chinese Universities)2001，16，1： | 5 |
| 4 | Negative regulation of resistance protein-mediated immunity by master transcription factors SARD_1 and CBP60g显示文摘Salicylic acid(SA) is an essential defence hormone in plants. Upon pathogen infection, induced biosynthesis of SA is mediated by Isochorismate synthase 1(ICS1), whose gene transcription is controlled mainly through two redundant transcription factors, SAR Deficient 1(SARD_1) and Calmodulinbinding protein 60-like g(CBP60g). Although these master transcription factors regulate not only positive,but also negative regulators of immunity, how they control signaling events downstream of different immune receptors is unclear. Using autoimmune mutants activating immunity mediated by different receptors we show that, although the sard1 cbp60 g double mutant almost fully suppresses the activation of defence mediated by suppressor of npr1-1, constitutive 2(snc2), it strikingly enhances snc1, which carries a gain-of-function mutation in an intracellular nucleotidebinding leucine-rich repeat(NLR) immune receptor.This negative regulation of immunity is achieved through the transcriptional regulation of negative regulators, such as Nudix hydrolase homolog 6(NUDT6). Our study highlights the diverse roles,especially the negative ones, in the regulation of plant immunity by the two master immune transcription factors SARD_1 and CBP60g. | tongjun sun wanwan liang yuelin zhang xin li | 2018 | Journal of Integrative Plant Biology2018，60，11： | 2 |
| 5 | A SPARSE GRID STOCHASTIC COLLOCATION AND FINITE VOLUME ELEMENT METHOD FOR CONSTRAINED OPTIMAL CONTROL PROBLEM GOVERNED BY RANDOM ELLIPTIC EQUATIONS显示文摘在这份报纸,为一个椭圆形的方程在它的系数与随机的地管理的一个最佳的控制问题的一个 hybird 近似计划被考虑。随机的系数在物理空格是光滑的并且在概率空格取决于很多随机的变量。为最佳的控制问题的必要、足够的 optimality 条件被获得。计划被建立接近通过由使用有限的卷元素方法空间空格和一个稀少的格子的 discretization 的 optimality 系统随机的搭配方法基于为概率空格的 Smolyak 近似分别地。这个计划自然地导致一个解开的确定的问题的分离答案。分离答案的存在和唯一被证明。A priori 错误估计为状态被导出,有肋骨并且控制变量。数字例子被举说明我们的理论结果。 | Liang Ge Tongjun Sun | 2018 | Journal of Computational Mathematics2018，36，2： | 1 |
| 6 | Galerkin domain decomposition procedures for parabolic equation of genemal form on general domain显示文摘 | MA Keying SUN Tongjun YANG Danping | 2009 | Numer Methods Partial Differertial Equations2009，25，5： | 1 |
| 7 | Galerkin domain decomposition procedures for parabolic equation on rectangulardomain 显示文摘 | MA Keying SUN Tongjun | 2010 | In Numer Methods Fluids2010，62，4： | 1 |
| 8 | Parallel Galerkin domain decomposition procedures based on the streamline diffusion method for convection-diffusion problems显示文摘 | SUN Tongjun MA Keying | 2011 | J Comput Appl Math2011，235，： | 1 |
| 9 | Parallel Galerkin domain decomposition procedures for wave equation显示文摘 | SUN Tongjun MA Keying | 2010 | J Comput Appl Math2010，233，8： | 1 |
| 10 | The finite difference streamline diffusion methods for sobolev equation with convection-domi- nated term 显示文摘 | SUN Tongjun YANG Danping | 2002 | Applied Mathematics and Computation2002，125，： | 1 |
| 11 | Parapllel Galerkin domain decomposition procedures for wave euqation显示文摘 | SUN Tongjun MA Keying | 2010 | Journal of Computa- tional and Applied Mathematics2010，233，： | 1 |
| 12 | Galerkin domain decomposition procedures for parabolic equations on rectangular domain 显示文摘 | MA Keying SUN Tongjun | 2010 | In- ternational Journal for Numerical Methods in Fluids2010，62，4： | 1 |
| 13 | Fabrication of dodecagonal pyramid on nitrogen face GaN and its effect on the light extraction显示文摘Wet etching has been widely used in defect evaluation for Ga-face GaN and surface roughness for N-face GaN dodecagonal pyramids has been fabricated on laser-lift-off N-face GaN by hot phosphor acid etching.The dodecagonal pyramid shows twelve facets including six{20-2-3}and six{22-4-5}planes.From cross-sectional TEM image,it is shown that the pyramid corresponds to the top of the edge dislocation.Compared with hexagonal pyramid-surface light emitting diodes(LEDs)etched by commonly used photoelectrochemical(PEC)process in KOH aqueous,the dodecagonal pyramid-surface LEDs show improved light extraction efficiency because of more facets,which effectively reduces the total internal reflection. | QI ShengLi,CHEN ZhiZhong,SUN YongJian,FANG Hao,TAO YueBin,SANG LiWen,TIAN PengFei,DENG JunJing,ZHAO LuBing,YU TongJun,QIN ZhiXin&ZHANG GuoYi State Key Laboratory for Artificial Microstructure and Mesoscopic Physics,School of Physics,Peking University,Beijing 100871,China | 2010 | Science China(Technological Sciences)2010，53，3： | 0 |
| 14 | Phase reaction of Au/Sn solder bonding for GaN-based vertical structure light emitting diodes显示文摘Au/Sn solder bonding on Si substrates was used to fabricate the GaN-based vertical structure light emitting diodes (VSLEDs). The phase reaction of Au/Sn solder under different bonding conditions was investigated by the measurement of electron back scattering diffraction (EBSD), and the characteristics of VSLED were analyzed by scanning acoustic microscope (SAM), Raman scattering, current-voltage (I-V) and light output-current (L-I) curves. After the bonding process, horizontal stripes of Au/Sn phase (δ phase) and Au5Sn phase (ζ phase) were redirected to vertical stripes, and δ phase tended to move to the solder joint. Sn interstitial diffusion led to the distribution of δ phase and voids in Au/Sn solder, which could be seen in SAM and SEM images. Vertical distribution of the δ phase and ζ phase with proper voids in the Au/Sn bonding layer showed the best bonding quality. Good bonding quality led to little shift of the E2-high mode of Raman spectra peak in GaN after laser lift off (LLO). It also caused more light extraction and forward bias reduction to 2.9 V at 20 mA. | TIAN PengFei, SUN YongJian, CHEN ZhiZhong, QI ShengLi, DENG JunJing, YU TongJun, QIN ZhiXin & ZHANG GuoYi State Key Laboratory for Artificial Microstructure and Mesoscopic Physics, School of Physics, Peking University, Beijing 100871, China | 2010 | Science China(Technological Sciences)2010，53，2： | 0 |
| 15 | Batch synthesis of transfer-free graphene with wafer-scale uniformity显示文摘Scalable synthesis of transfer-free graphene over insulators offers exciting opportunity for next-generation electronics and optoelectronics.However,rational design of synthetic protocols to harvest wafer-scale production of directly grown graphene still remains a daunting challenge.Herein we explore a batch synthesis of large-area graphene with wafer-scale uniformity by virtue of direct chemical vapor deposition(CVD)on quartz.Such a controllable CVD approach allows to synthesize 30 pieces of 4-inch graphene wafers in one batch,affording a low fluctuation of optical and electrical properties.Computational fluid dynamics simulations reveal the mechanism of uniform growth,indicating thermal field and confined flow field play leading roles in attaining the batch uniformity.The resulting wafer-scale graphene enables the direct utilization as key components in optical elements.Our method is applicable to other types of insulating substrates(e.g.,sapphire,SiO2/Si,Si3N4),which may open a new avenue for direct manufacture of graphene wafers in an economic fashion. | Bei Jiang Qiyue Zhao Zhepeng Zhang Bingzhi Liu Jingyuan Shan Liang Zhao Mark H.Rümmeli Xuan Gao Yanfeng Zhang Tongjun Yu Jingyu Sun Zhongfan Liu | 2020 | Nano Research2020，13，6： | 0 |
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