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1篇 您的检索式：作者名="Tongping She"

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		题名	作者	年代	出处	被引量
	1	Argon mitigates post-stroke neuroinflammation by regulating M1/M2 polarization and inhibiting NF-κB/NLRP3 inflammasome signaling显示文摘Neuroinflammation plays a vital role in cerebral ischemic stroke(IS).In the acute phase of IS,microglia are activated toward the pro-inflammatory(M1)and anti-inflammatory(M2)phenotypes.Argon,an inert gas,can reduce neuroinflammation and alleviate ischemia/reperfusion(I/R)injury.However,whether argon regulates M1/M2 polarization to protect against I/R injury as well as the underlying mechanism has not been reported.In this study,we analyzed the activation and polarization of microglia after I/R injury with or without argon administration and explored the effects of argon on NLRP3 inflammasome-mediated inflammation in microglia in vitro and in vivo.The results showed that argon application inhibited the activation of M1 microglia/macrophage in the ischemic penumbra and the expression of proteins related to NLRP3 inflammasome and pyroptosis in microglia.Argon administration also inhibited the expression and processing of IL-1β,a primary pro-inflammatory cytokine.Thus,argon alleviates I/R injury by inhibiting pro-inflammatory reactions via suppressing microglial polarization toward M1 phenotype and inhibiting the NF-κB/NLRP3 inflammasome signaling pathway.More importantly,we showed that argon worked better than the specific NLRP3 inflammasome inhibitor MCC950 in suppressing neuroinflammation and protecting against cerebral I/R injury,suggesting the therapeutic potential of argon in neuroinflammation-related neurodegeneration diseases as a potent gas inhibitor of the NLRP3 inflammasome signaling pathway.	Ke Xue Mian Qi Tongping She Zhenglin Jiang Yunfeng Zhang Xueting Wang Guohua Wang Lihua Xu Bin Peng Jiayi Liu Xinjian Song Yuan Yuan Xia Li	2022	Journal of Molecular Cell Biology2022，14，12：	0

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