|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Postoperative Stimulated Thyroglobulin Level and Recurrence Risk Stratification in Differentiated Thyroid Cancer显示文摘 | Xue Yang Jun Liang Tian-Jun Li Ke Yang Dong-Quan Liang Zhuang Yu Yan-Song Lin | 2015 | Chinese Medical Journal2015，，8： | 24 |
| 2 | Increased frequency and clinical significance of myeloidderived suppressor cells in human colorectal carcinoma显示文摘AIM:To investigate the frequency and clinical significance of the myeloid-derived suppressor cells(MDSC) in human colorectal carcinoma(CRC).METHODS:Samples of peripheral blood and tumor tissue from 49 CRC patients were analyzed.Mononuclear cells were isolated by Ficoll-Hypaque density gradient centrifugation and were subjected to a flow cytometrybased immunophenotypic analysis.RESULTS:A considerable increase in the percentage of CD33+HLA-DR-MDSCs was observed in the peripheral blood(1.89% ± 0.75%) and tumor tissues(2.99% ± 1.29%) of CRC patients as compared with that in theperipheral blood of healthy controls(0.54% ± 0.35%).This expanded CD33+HLA-DR-subset exhibited immature myeloid cell markers,but not lineage markers,and showed up-regulation of CD18/CD11b expression as compared with the MDSCs from healthy donors.Further studies showed that the MDSC proportion in CRC peripheral blood was correlated with nodal metastasis(P = 0.023),whereas that in tumor tissues was correlated with nodal/distant metastasis(P = 0.016/P = 0.047) and tumor stage(P = 0.028),suggesting the involvement of MDSCs in CRC tumor development.CONCLUSION:Characterization of MDSCs in CRC suggests the clinical significance of circulating and tumorinfiltrating MDSCs and may provide new insights into the CRC immunotherapy targeting MDSCs. | Hong-Li Sun, Xin Zhou, Yi-Feng Xue Ke Wang, Yun-Feng ShenI Jing-Jue Mao Hong-Feng Guo Zong-Ning Miao | 2012 | World Journal of Gastroenterology2012，18，25： | 21 |
| 3 | Advances in locoregional therapy for hepatocellular carcinoma combined with immunotherapy and targeted therapy显示文摘Locoregional therapies(LRTs)of hepatocellular carcinoma(HCC)represented by ablation and TACE has become the main means for the clinical treatment of unresectable HCC.Among these,TACE is used throughout the stageⅠb toⅢb of HCC treatment.In recent years,immunotherapy led by immune checkpoint inhibitors has become a hot direction in clinical research.At the same time,targeted drugs such as Sorafenib and Apatinib have played an important role in the treatment and complementary therapy of advanced HCC,and their clinical application has been quite mature.HCC is the sixth most common malignant tumor in the world.When it comes to its treatment,different therapies have different indications,and their individual efficacies are not satisfactory,which makes the exploration of the use of combination therapy in HCC treatment become a new trend.In this paper,the status of the three therapies and the progress of their combined application are briefly reviewed. | Jian Xue Hongbo Ni Fan Wang Ke Xu Meng Niu | 2021 | Journal of Interventional Medicine2021，4，3： | 21 |
| 4 | Magnetostratigraphy and Anisotropy of Magnetic Susceptibility of the Lulehe Formation in the Northeastern Qaidam Basin显示文摘The timing of onset of deposition of the Lulehe Formation is a significant factor in understanding the genesis of the Qaidam basin and the evolution of the Tibetan Plateau. Here, we describe a detailed magnetostratigraphic and magnetic fabric study of the middle and lower parts of the Lulehe Formation. A total of 234 samples were collected from 117 sites throughout a thickness of almost 460 m of fluvial and lacustrine deposits at the Xitieshan section in the northeastern Qaidam basin. Out of these sites, 94 sites yielded well-defined characteristic remanent magnetization components by stepwise thermal demagnetization and were used to establish the magnetostratigraphy of the studied section. Based on correlation with the geomagnetic polarity timescale, the studied section spans the period from 53.8 Ma to 50.7 Ma. Our results show a three-fold decrease in sedimentation rates as well as marked change in facies from braided river to delta and shore-shallow lake around 52.6 Ma, which suggests tectonic uplift of the northeastern Qaidam basin margin ridge was rapid at the onset of formation of the Qaidam basin and subsequently weakened after 52.6 Ma. The anisotropy of magnetic susceptibility results indicate that tectonic compression stress had reached the northeastern Tibetan Plateau by the early stages of Indo-Eurasian plate collision and that the direction of stress in the study area was NE-SW. Furthermore, a weakening of tectonic compression stress around 52.6 Ma is consistent with sedimentary records. The age of initial deposition of the Qaidam basin (around 53.8 Ma) was almost synchronous with that of the Qiangtang, Hoh Xil, Xining, and Lanzhou basins, which implies that stress was transferred rapidly through the Tibetan Plateau during or immediately after the onset of Indo-Eurasian collision. | KE Xue JI Junliang ZHANG Kexin KOU Xiaohu SONG Bowen WANG Chaowen | 2013 | Acta Geologica Sinica(English Edition)2013，87，2： | 18 |
| 5 | Oligonucleotide-based targeted gene editing in C. elegans via the CRISPR/Cas9 system显示文摘 | Pei Zhao Zhe Zhang Hongmei Ke Yiren Yue Ding Xue | 2014 | Cell Research2014，24，2： | 17 |
| 6 | Thiolactone copolymer donor gifts organic solar cells a 16.72% efficiency显示文摘Since 1995,bulk-heterojunction organic solar cells consisting of one or two organic donors and one or two organic acceptors have been fighting for high power conversion efficiencies(PCEs)and good stability[1].Until recent years,this next-generation photovoltaic technology starts to offer decent PCEs,shedding the light on commercialization,and attracting great attention again[2-14].Compared w让h the continuously emerging highperformance nonfullerene acceptors,high-performance donors are rare. | Ji Xiong Ke Jin Yufan Jiang Jianqiang Qin Tan Wang Jinfeng Liu Qishi Liu Haili Peng Xiongfeng Li Anxin Sun Xianyi Meng Lixiu Zhang Ling Liu Wenting Li Zhimin Fang Xue Jia Zuo Xiao Yaqing Feng Xiaotao Zhang Kuan Sun Shangfeng Yang Shengwei Shi Liming Ding | 2019 | Science Bulletin2019，64，21： | 17 |
| 7 | Dermoscopy in China: current status and future prospective显示文摘Objective: Dermoscopy is a useful technique for improving the diagnostic accuracy of various types of skin disorders. In China, dermoscopy has been widely accepted, and domestic researchers have made tremendous progress in the field of dermoscopy. The main purpose of this review is to summarize the current status of dermoscopy in China and identify its future directions. Data sources: Articles included in this review were obtained by searching the following databases: Wanfang, China National Knowledge Infrastructure, PubMed, and the Web of Science. We focused on research published before 2019 with keywords including dermoscopy, dermoscopic, dermoscope and trichoscopy. Study selection: A total of 50 studies were selected. Of these studies, 20 studies were in Chinese and 30 in English, research samples of all the studies were collected from Chinese populations. Results: Since 2000, more than 380 articles about dermoscopy have been published in domestic or foreign journals. Dermoscopy can improve the diagnostic accuracy of neoplastic diseases, evaluating the therapeutic effect of treatment, and determining the treatment endpoint, and it can also assist in the differential diagnosis of inflammatory diseases and in the assessment of the severity of the disease. In addition, researches about the applications of dermoscopy during surgical treatment have been published. Training courses aiming to improve the diagnostic ability of dermatologists, either face-to-face or online, have been offered. The Chinese Skin Image Database, launched in 2017 as a work platform for dermatologists, has promoted the development of dermoscopy in China. Computer-aided diagnostic systems based on the Chinese population are ready for use. In the future, cooperation, resource sharing, talent development, image management, and computer-aided diagnosis will be important directions for the development of dermoscopy in China. Conclusion: Dermoscopy has been widely used and developed in China, however, it still needs to address more challenges in the future. | Xue Shen Rui-Xing Yu Chang-Bing Shen Cheng-Xu Li Yan Jing Ya-Jie Zheng Zi-Yi Wang Ke Xue Feng Xu Jian-Bin Yu Ru-Song Meng Yong Cui | 2019 | Chinese Medical Journal2019，，17： | 15 |
| 8 | Rapid and Accurate Sequencing of Enterovirus Genomes Using MinION Nanopore Sequencer显示文摘Objective Knowledge of an enterovirus genome sequence is very important in epidemiological investigation to identify transmission patterns and ascertain the extent of an outbreak.The MinION sequencer is increasingly used to sequence various viral pathogens in many clinical situations because of its long reads,portability,real-time accessibility of sequenced data,and very low initial costs.However,information is lacking on MinION sequencing of enterovirus genomes.Methods In this proof-of-concept study using Enterovirus 71(EV71) and Coxsackievirus A16(CA16) strains as examples,we established an amplicon-based whole genome sequencing method using MinION.We explored the accuracy,minimum sequencing time,discrimination and high-throughput sequencing ability of MinION,and compared its performance with Sanger sequencing.Results Within the first minute(min) of sequencing,the accuracy of MinION was 98.5% for the single EV71 strain and 94.12%-97.33% for 10 genetically-related CA16 strains.In as little as 14 min,99% identity was reached for the single EV71 strain,and in 17 min(on average),99% identity was achieved for 10 CA16 strains in a single run.Conclusion MinION is suitable for whole genome sequencing of enteroviruses with sufficient accuracy and fine discrimination and has the potential as a fast,reliable and convenient method for routine use. | WANG Ji KE Yue Hua ZHANG Yong HUANG Ke Qiang WANG Lei SHEN Xin Xin DONG Xiao Ping XU Wen Bo MA Xue Jun | 2017 | Biomedical and Environmental Sciences2017，30，10： | 11 |
| 9 | Surgical operation and re-operation for hepatocellular carcinoma with bile duct thrombosis显示文摘很少报告评估了的背景为在为有这研究的 .The 目的是调查起始的外科的功效的胆汁管血栓( BDT )的 hepatocellular 癌( HCC )的起始的外科以后的恶化的重新操作和为有 BDT 的 HCC 的随后的重新操作的功效,并且他们 prognosis.Methods 上的效果包括在我们的医院里经历了在 1998 和 2008 之间的激进的 hepatectomy 的有 BDT 的 28 个病人,有 HCC 的 880 个病人的临床的数据是 BDT 的 reviewed.The | WANG Ya-dong XUE Huan-zhou JIANG Qing-feng SHEN Quan WANG Lian-cai ZHANG Xiao LU Bing YU Miao LI Ke | 2010 | Chinese Medical Journal2010，，16： | 11 |
| 10 | Inhibitory Activity of Honeysuckle Extracts against Influenza A Virus In Vitro and In Vivo显示文摘Honeysuckle has been used in the treatment of influenza virus infection for thousands of years in China.However,its main active components and the functional mechanisms remain to be elucidated.Here,four honeysuckle extracts,including acids extract,flavonoids extract,total extract and acids-flavonoids mixture,were prepared to clarify the main active antiviral components.The cytopathic effect reduction assay showed that all the four extracts inhibited the replication of influenza viruses H1N1,H3N2 and the oseltamivir-resistant mutant strain H1N1-H275Y.The acids-flavonoids mixture had the strongest inhibitory effects in vitro with EC_(50) values of 3.8,4.1,and >20 lg/m L against H1N1,H3N2 and H1N1-H275Y,respectively,showing competitive antiviral activity with oseltamivir and ribavirin.Honeysuckle acids extract also showed the most significant antiviral activity in vivo.Oral administration of the acids extract at a dosage of 600 mg/kg/d effectively alleviated viral pneumonia,maintained body weight and improved the survival rate to 30% of the mice infected with a lethal dose of H1N1.The results of time-of-drug addition experiment and neuraminidase (NA) inhibition assay showed that honeysuckle extracts had a broad-spectrum inhibitory effect against influenza virus NAs.The flavonoid extract showed the strongest inhibitory effect on the NA of influenza virus H7N9 with an IC_(50) of 24.7 lg/m L.These results suggested that these extracts might exert their antiviral activity by suppressing the release of influenza viruses.Briefly,our findings demonstrate that acids and flavonoids extracts of honeysuckle are the major antiviral active components,and the acids extract has the potential to be developed into an antiviral agent against influenza virus,especially for oseltamivirresistant viruses. | Mengwei Li Yuxu Wang Jing Jin Jie Dou Qinglong Guo Xue Ke Changlin Zhou Min Guo | 2021 | Virologica Sinica2021，36，3： | 11 |
| 11 | Galectin-1 knockdown in carcinoma-associated fibroblasts inhibits migration and invasion of human MDA-MB-231 breast cancer cells by modulating MMP-9 expression显示文摘联系癌的成纤维细胞(CAF ) 在在乳癌便于肿瘤前进和转移起中央作用。Galectin-1 (Gal-1 ) , CAF 的一个标记,以前被报导与肿瘤的各种各样的类型的 tumorigenesis 和转移被联系。这研究的目的是在调停 CAF 的乳癌转移和它的内在的分子的机制调查 Gal-1 的角色。我们的结果显示出与配对的正常成纤维细胞,和显著地导致的 CAF 的调节媒介(厘米) 相比从 Gal-1 高级的表示的人的胸肿瘤纸巾孤立的那 CAF 人的 MDA-MB-231 乳癌房间的迁居和侵略。在 CAF 的 Gal-1 击倒戏剧性地禁止的 CAF-CM-induced 房间移植和侵略,可能由禁止矩阵 metalloprotein 的表达式 9 (MMP-9 ) 。我们的调查结果证明 Gal-1-regulated CAF 激活由 upregulating MMP-9 表示支持乳癌房间转移,它显示在 CAF 的 Gal-1 可能是为乳癌的一个潜在的新奇目标治疗。 | Xue Zhu Ke Wang Kai Zhang Fei Xu Yongxiang Yin Ling Zhu Fanfan Zhou | 2016 | Acta Biochimica et Biophysica Sinica2016，48，5： | 10 |
| 12 | An improved empirical wavelet transform method for rolling bearing fault diagnosis显示文摘Empirical wavelet transform(EWT)based on the scale space method has been widely used in rolling bearing fault diagnosis.However,using the scale space method to divide the frequency band,the redundant components can easily be separated,causing the band to rupture and making it difficult to extract rolling bearing fault characteristic frequency effectively.This paper develops a method for optimizing the frequency band region based on the frequency domain feature parameter set.The frequency domain feature parameter set includes two characteristic parameters:mean and variance.After adaptively dividing the frequency band by the scale space method,the mean and variance of each band are calculated.Sub-bands with mean and variance less than the main frequency band are combined with surrounding bands for subsequent analysis.An adaptive empirical wavelet filter on each frequency band is established to obtain the corresponding empirical mode.The margin factor sensitive to the shock pulse signal is introduced into the screening of empirical modes.The empirical mode with the largest margin factor is selected to envelope spectrum analysis.Simulation and experiment data show this method avoids over-segmentation and redundancy and can extract the fault characteristic frequency easier compared with only scale space methods. | HUANG HaiRun LI Ke SU WenSheng BAI JianYi XUE ZhiGang ZHOU Lang SU Lei PECHT Michael | 2020 | Science China(Technological Sciences)2020，63，11： | 10 |
| 13 | Association Between Serum Uric Acid and Prevalence of Type 2 Diabetes Diagnosed using HbA1c Criteria Among Chinese Adults in Qingdao,China显示文摘Objective To determine whether elevated serum uric acid(UA)levels are associated with type 2 diabetes diagnosed using Hb A1 c levels among Chinese adults.Methods We conducted two population-based cross-sectional studies in Qingdao in China in 2006 and 2009.A total of 6894(39.4% men)subjects aged 35-74 years were included in the data analysis.Newly diagnosed diabetes was defined as Hb A1 c level of ≥6.5%,and prediabetes was classified as Hb A1 c level between 5.7% and 6.4% according to the International Diabetes Federation criteria.Multivariate logistic regression was employed to assess the association between UA and prevalence of type 2 diabetes defined using Glycated hemoglobin A1c(Hb A1 c levels.Results Subjects with prediabetes had higher UA levels than those with normal glucose tolerance,newly diagnosed diabetes,and known diabetes,with corresponding values of 325.1(82.5)μmol/L,310.9(84.2)μmol/L,291.3(81.7)μmol/L,305.2(83.6)μmol/L,respectively(P<0.001 for all comparisons).Binary logistic regression analysis showed that UA was a possible predictor for the prevalence of type 2 diabetes diagnosed using Hb A1 c levels,and the second quartile of UA levels had a higher odds ratio(OR:4.088;95% CI:2.900-5.765)for Hb A1 c than the other quartiles after adjusting for age,body mass index,sex,marital status,education,income,alcohol consumption,smoking,and cardiometabolic parameters.Conclusion Serum UA is significantly associated with type 2 diabetes diagnosed using Hb A1 c levels,independent of other cardiometabolic parameters. | XUE Bai TAN Ji Bin NING Feng SUN Jian Ping ZHANG Ke Yi LIU Li WANG Shao Jie ZHANG Dong Feng QIAO Qing PANG Zeng Chang | 2015 | Biomedical and Environmental Sciences2015，28，12： | 9 |
| 14 | Normal Structure and Function of Endothecium Chloroplasts Maintained by ZmMs33-Mediated Lipid Biosynthesis in Tapetal Cells Are Critical for Anther Development in Maize显示文摘Genic male sterility(GMS)is critical for heterosis utilization and hybrid seed production.Although GMS mutants and genes have been studied extensively in plants,it has remained unclear whether chloroplast-associated photosynthetic and metabolic activities are involved in the regulation of anther development.In this study,we characterized the function of ZmMs33/ZmGPAT6,which encodes a member of the glycerol-3-phosphate acyltransferase(GPAT)family that catalyzes the first step of the glycerolipid synthetic pathway.We found that normal structure and function of endothecium(En)chloroplasts maintained by ZmMs33-mediated lipid biosynthesis in tapetal cells are crucial for maize anther development.ZmMs33 is expressed mainly in the tapetum at early anther developmental stages and critical for cell proliferation and expansion at late stages.Chloroplasts in En cells of wild-type anthers function as starch storage sites before stage 10 but as photosynthetic factories since stage 10 to enable starch metabolism and carbohydrate supply.Loss of ZmMs33 function inhibits the biosynthesis of glycolipids and phospholipids,which are major components of En chloroplast membranes,and disrupts the development and function of En chloroplasts,resulting in the formation of abnormal En chloroplasts containing numerous starch granules.Further analyses reveal that starch synthesis during the day and starch degradation at night are greatly suppressed in the mutant anthers,leading to carbon starvation and low energy status,as evidenced by low trehalose-6-phosphate content and a reduced ATP/AMP ratio.The energy sensor and inducer of autophagy,SnRK1,was activated to induce early and excessive autophagy,premature PCD,and metabolic reprogramming in tapetal cells,finally arresting the elongation and development of mutant anthers.Taken together,our results not only show that ZmMs33 is required for normal structure and function of En chloroplasts but also reveal that starch metabolism and photosynthetic activities of En chloroplasts at different developmental stages are essential for normal anther development.These findings provide novel insights for understanding how lipid biosynthesis in the tapetum,the structure and function of En chloroplasts,and energy and substance metabolism are coordinated to maintain maize anther development. | Taotao Zhu Ziwen Li Xueli An Yan Long Xiaofeng Xue Ke Xie Biao Ma Danfeng Zhang Yijian Guan Canfang Niu Zhenying Dong Quancan Hou Lina Zhao Suowei Wu Jinping Li Weiwei Jin Xiangyuan Wan | 2020 | Molecular Plant2020，13，11： | 9 |
| 15 | XBP-1u suppresses autophagy by promoting the degradation of FoxO1 in cancer cells显示文摘Autophagy 被激活响应滋养的饥饿维持细胞的精力动态平衡。然而, autophagy 固执地没被激活,它糟糕在机械学的水平被理解。这里,我们报导 FoxO1 的那周转涉及夫酸安饥饿引起的动态 autophagic 过程。X-box-binding protein-1u (XBP-1u ) 由招募在 FoxO1 降级有一个关键角色 FoxO1 到 20S proteasome。另外,由 Ser61 和 Ser176 上的细胞外的调整蛋白质 kinases1/2 (ERK1/2 ) 的 XBP-1u 的 phosphorylation 被发现在夫酸安饥饿之上为在 XBP-1u 和 FoxO1 之间的增加的相互作用批评。而且,引起 FoxO1 的持续水平和 autophagy 的坚持的激活的 XBP-1u 击倒,在房间生存能力导致重要减少。最后,在 XBP-1u 之间的反的关联和 FoxO1 表示同意很好,表示侧面在许多人的癌症纸巾观察了。因此,我们的调查结果连接到 XBP-1u-induced FoxO1 的 autophagy 的动态过程降级。 | Ying Zhao Xue Li Mu-Yan Cai Ke Ma Jing Yang Jingyi Zhou Wan Fu Fu-Zheng Wei Lina Wang Dan Xie Wei-Guo Zhu | 2013 | Cell Research2013，23，4： | 8 |
| 16 | Improved Relative-transformation Principal Component Analysis Based on Mahalanobis Distance and Its Application for Fault Detection显示文摘主要部件分析(PCA ) 广泛地在过程工业被使用了,它能维持最大的差错察觉率。尽管许多问题在 PCA 被处理了,一些必要问题仍然保持未解决。这研究以下列方法为差错察觉性能改进 PCA。第一,一个相对转变计划基于 Mahalanobis 距离(MD ) 被介绍消除数据的尺寸的效果而不是无尺寸的标准化,并且改进精确性和差错察觉的即时性能。理论推导证明那相对转变能直接基于 MD 消除尺寸的效果并且在结果显示出的相对空间,分析和模拟给 PCA 的合理解释它的优势和有效性。第二,一个改进摆平的预言错误(SPE ) 统计数值被给改进标准化 PCA 的差错察觉表演,它能使标准化基于 PCA 的差错察觉方法成为对实际工业过程合适的更多。最后,二个改进方法被联合更有效地检测差错。建议方法被使用在热连续滚动过程检测 looper 系统的单个差错和多差错,模拟结果以易感知,精确性和差错察觉的即时性能为差错察觉性能表明这些改进的有效性。 | SHI Huai-Tao LIU Jian-Chang XUE Peng ZHANG Ke WU Yu-Hou ZHANG Li-Xiu TAN Shuai | 2013 | 自动化学报2013，39，9： | 8 |
| 17 | Effect of residual dissolved oxygen on the corrosion behavior of low carbon steel in 0.1 M NaHCO3 solution显示文摘The effect of residual dissolved oxygen(DO)on the corrosion behavior of carbon steel in 0.1 M Na HCO_3solution was investigated by electrochemical measurements,corrosion mass loss test,scanning electron microscopy(SEM)and X-ray diffraction(XRD).In the initial immersion stage,the increase of the dissolved oxygen concentration led to the change of from a reductive state of active dissolution to an oxidizing state of pseudo passivation in low carbon steel.While in the final stage,all the steels transformed into the steady state of pseudo passivation.In the anaerobic solution,the formation ofα-Fe OOH was attributed to the chemical oxidization of the ferrous corrosion products and the final cathodic process only included the reduction ofα-Fe OOH,while in the aerobic solution,it included the reduction of oxygen andα-Fe OOH simultaneously.As the main corrosion products,the content ofα-Fe OOH was increased while that of Fe_6(OH)_(12)CO_3was decreased with increasing concentration of dissolved oxygen.The total corrosion mass loss of the steel was promoted with the increase of dissolved oxygen concentration. | Fang Xue Xin Wei Junhua Dong Ini-Ibehe Nabuk Etim Changgang Wang Wei Ke | 2018 | Journal of Materials Science & Technology2018，34，8： | 8 |
| 18 | Intramammary expression and therapeutic effect of a human lysozyme-expressing vector for treating bovine mastitis显示文摘To develop a gene therapy strategy for treating bovine mastitis, a new mammary-specific vector containing human lysozyme (hLYZ) cDNA and kanamycin resistance gene was constructed for intramammary expression and clinical studies. After one time acupuncture or intracisternal infusion of healthy cows with 400 μg of the p215C3LYZ vector, over 2.0 μg/ml of rhLYZ could be detected by enzymatic assay for about 3 weeks in the milk samples. Western blotting showed that rhLYZ secreted into milk samples from the vector-injected cows had molecular weight similar to that of the natural hLYZ in human colostrums. Twenty days after the primary injection, the quarters were re-injected with the same vector by quarter acupuncture and even higher concentrations of rhLYZ could be detected. Indirect competitive ELISA of milk samples showed that the vector injection did not induce detectable humoral immune response against hLYZ. Clinical studies showed that twice acupuncture of quarters with the p215C3LYZ vector had overt therapeutic effect on clinical and subclinical mastitis previously treated with antibiotics, including disappearance of clinical symptoms and relatively high microbiological cure rates. These data provide a solid rationale for using the vector to develop gene therapy for treating bovine mastitis. | SUN Huai-chang XUE Fang-ming QIAN Ke FANG Hao-xia QIU Hua-lei ZHANG Xin-yu YIN Zhao-hua | 2006 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2006，7，4： | 8 |
| 19 | Enzymatic properties of phenoloxidase from Pieris rapae (Lepidoptera) larvae显示文摘部分净化的 phenoloxidase 的运动参数(PO, EC.1.14.18.1 ) 从 Pieris 的第 5 中间形态幼虫, rapae (鳞翅目) 被决定,是使用 L-3,4-dihydroxyphenylalanine (L-DOPA ) 底层。为 L-DOPA 的氧化的酶的最佳的 pH 和温度决心在 pH 7.0 并且在 42 ° C 分别地。在 pH 之间的酶 wass 桌子 6.5 和 7.4 并且在比 37 ° C 低的温度。在 pH 6.8 和 37 ° C, theMichaelis 常数(K_m ) 和为 L-DOPA 的氧化的酶的最大的速度(V_m ) 我们分别地是 0.80 mmol/L 和 1.84 亩 mol/ L/min 的 redetermined。Tetra-hexylresorcinol and4-dodecylresorcinol 有效地分别地禁止了 phenoloxidase 的活动,这抑制可逆、竞争,与 1.50 和 1.12 亩 mol/L 的 IC_(50 ) 。抑制常数被估计分别地是 0.50 和 0.47 亩 mol/L。 | CHAO-BIN XUE WAN-CHUN LUO QING-XI CHEN QIN WANG LI-NA KE | 2006 | Insect Science2006，13，4： | 8 |
| 20 | Nodeless pairing in superconducting copper-oxide monolayer films on BieSreCaCueO8+δ显示文摘 | Yong Zhong Yang Wang Sha Han Yan-Feng Lv Wen-Lin Wang Ding Zhang Hao Ding Yi-Min Zhang Lili Wang Ke He Ruidan Zhong John A. Schneeloch Gen-Da Gu Can-Li Song Xu-Cun Ma Qi-Kun Xue | 2016 | Science Bulletin2016，61，16： | 8 |
您所在的机构暂未开通此部分的功能，请联系管理员